Intracellular calcium erythroid precursor cells. Medical search. Frequent questions

Because modulation of [Ca 2+ ] i is an important signaling pathway in erythroid proliferation and differentiation, Trpc2, Trpc3, and Trpc2/Trpc3 double knockout mice were utilized to explore the roles of these channels in erythropoiesis. (psu.edu)
that critically influences cell proliferation, differentiation and apoptosis ( Miele and Osborne, 1999 ). (elifesciences.org)
Atherosclerosis starts with dysfunctional changes in the endothelium induced by disturbed shear stress which can lead to endothelial and platelet activation, adhesion of monocytes on the activated endothelium, and differentiation into proinflammatory macrophages, which increase the uptake of oxidized LDL (oxLDL) and turn into foam cells, exacerbating the inflammatory signalling. (hindawi.com)
EPO supports the proliferation and differentiation of erythroid progenitor cells and is critical for their survival [ 1 ]. (biomedcentral.com)
Sequential rounds of division and differentiation give rise to an enormous amplification of cell numbers, necessary for the production of mature blood cells. (justia.com)
This process of division and differentiation is subject to regulation at many levels to control cell production. (justia.com)
Despite their enormous importance, the molecular circuits that control the differentiation of Th17 cells remain largely unknown. (gsea-msigdb.org)
The two modules contain 12 novel regulators with no previous implication in Th17 differentiation, which may be essential to maintain the appropriate balance of Th17 and other CD4+ T cell subsets. (gsea-msigdb.org)
Overall, our study identifies and validates 39 regulatory factors that are embedded within a comprehensive temporal network and identifies novel drug targets and organizational principles for the differentiation of Th17 cells. (gsea-msigdb.org)

The present invention relates generally to improved methods and pharmaceutical compositions for mobilizing hematopoietic stem and progenitor cell from bone marrow into peripheral blood by administration of at least one inhibitor of a GTPase, such as Rac1 and/or Rac2 GTPase. (justia.com)
The various mature blood cell types are all ultimately derived from a single class of progenitor cell known as hematopoietic stem cells. (justia.com)
Enhancement of human erythroid progenitor cell growth by media conditioned by a human t-lymphocyte line. (shengsci.com)

Transient receptor potential (TRP) channels Trpc2 and Trpc3 are expressed on normal murine erythroid precursors, and erythropoietin stimulates an increase in intracellular calcium ([Ca 2+ ] i ) through TRPC2 and TRPC3. (psu.edu)
Although the erythropoietin-induced increase in [Ca 2+ ] i was reduced, these knockout mice showed no defects in red cell production. (psu.edu)
Although erythropoietin-induced calcium influx through TRPC2 or TRPC3 is not critical for erythroid production, these data demonstrate that TRPC2 plays an important role in oxidative stress-induced hemolysis, which may be related to reduced calcium entry in red cells in the presence of Trpc2 depletion. (psu.edu)

Signaling is induced through binding of five independent ligands, Delta-like ligands (DLL)-1, 3, 4 and Jagged (Jag)-1 and -2 ( Kopan and Ilagan, 2009 ), to four isoforms of cognate Notch receptors, Notch1 to Notch4, on surface of adjacent cells. (elifesciences.org)
In the first one, first messenger cross through the cell membrane, binding and activating intracellular receptors localized at nucleus or cytosol, which then act as transcriptional factors regulating directly gene expression. (wikipedia.org)
The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. (thermofisher.com)
EPO and its receptors (EPOR) are expressed in multiple brain cells during brain development and upregulated in the adult brain after injury. (biomedcentral.com)
However, agonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. (embl.de)
Following docking of SARS-CoV-2 onto ACE2 receptors (mostly in lungs and GI), and virus-cell membrane fusion via TMPRSS2 and FURIN , a cascade of enzymatic steps and subsequent immune system mobilization occurs. (mthfrsupport.com)

Whether the cargo is a membrane-bound organelle, precipitated protein aggregate, or an intracellular pathogen, the solution is the same: erect a barrier, direct destructive agents into the newly-formed com-partment, and recycle or remove the debris. (1library.net)
The IRE1α-XBP1 signaling axis supports this glycolytic switch in macrophages when activated by lipopolysaccharide (LPS) stimulation or infection with the intracellular bacterial pathogen Brucella abortus. (biomed.news)

Recent studies have shown that soluble factors elaborated by human T lymphocytes enhance erythroid burst formation by human peripheral blood null cells. (shengsci.com)
Multiple myeloma (Millimeter) is a malignancy of W lymphocytes or plasma cells. (forgetmenotinitiative.org)
Most of them generally follow the same pathway to make immune-activated cytotoxic T lymphocytes (CTLs) abundantly infiltrate into tumor tissues and destroy tumor cells [ 6 ]. (thno.org)

Peripherally administered EPO crosses the blood-brain barrier and activates in the brain anti-apoptotic, anti-oxidant and anti-inflammatory signaling in neurons, glial and cerebrovascular endothelial cells and stimulates angiogenesis and neurogenesis. (biomedcentral.com)

Hematopoiesis is the development of immune and other blood cells from a small population of stem cells known as hematopoietic stem cells (HSCs). (brainimmune.com)

A biochemical cascade, also known as a signaling cascade or signaling pathway, is a series of chemical reactions that occur within a biological cell when initiated by a stimulus. (wikipedia.org)
Equipped with a mouse model of stress (5-HT1A-R-/- mice) and a 5-HT1A-R-expressing hippocampal neuron-derived cell line, HN2-5, our earlier studies have reported that a 5-HT1A-R-mediated signaling pathway functions via extracellular receptor-activated kinase 1/2 (ERK1/2)-catalyzed activation of protein kinase C alpha (PKC) to promote synaptogenesis at P15 in the hippocampal CA1 region [12,16]. (thetechnoant.info)

CD19 appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. (thermofisher.com)
BNIP3 regulates mitophagy during hypoxia, whereas NIX is required for mitophagy during development of the erythroid lineage. (1library.net)
Adipose tissue residing progenitors (adipocyte lineage progenitors and adipose derived stem cells (ADSC). (mainehealth.org)

As a postdoc in Manoj Duraisingh's lab at Harvard School of Public Health she performed a genetic screen to identify critical host factors for Plasmodium falciparum malaria using red blood cells derived from hematopoietic stem cells. (stanford.edu)
Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. (justia.com)
In particular, embodiments of the method involve inhibition of both Rac1 and Rac2 GTPases to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject. (justia.com)
Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. (justia.com)
Other cell types derived from hematopoietic stem cells include platelets and erythrocytes. (justia.com)
The use of high-dosage chemotherapy or radiotherapy for bone marrow ablation requires subsequent incorporation of hematopoietic stem cells into the patient, in which case prior harvesting of such cells is required. (justia.com)
In many cases, successfully mobilization is not effected in the patient and inadequate numbers of hematopoietic stem cells are harvested from these patients using current methods. (justia.com)

Notch signaling dictates cell fate decisions in mammalian cells including megakaryocytes. (elifesciences.org)
For a recent review of macroautophagy in mammalian cells, please see Yang and Klionsky[2]. (1library.net)
Whether this reﬂects the greater complexity (and redundancy) of macroautophagy in mammalian cells or differences speciﬁc to selective autophagy is not clear. (1library.net)
Recent studies have reconstructed regulatory networks in mammalian cells, but have focused on short-term responses and relied on perturbation approaches that cannot be applied to primary T cells. (gsea-msigdb.org)

Applications Tested: This HIB19 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
Several drug therapies are valuable in the treatment of symptomatic MM. Clinicians treat many patients with high-dose therapy and peripheral blood or bone marrow stem cell transplantation. (medscape.com)
Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. (justia.com)
At least 6.5 x 10(8) [corrected] mononuclear cells/kg patient weight were collected from the peripheral blood of each patient, cyropreserved, and returned intravenously following CBV administration. (shengsci.com)

Competitive antagonism of TLR8 with non-targeting locked nucleic acids was found to prevent native LDL-induced macrophage polarization in vitro, and re-organize lesion macrophage phenotypes in vivo, as determined by single-cell RNA sequencing. (biomed.news)
DC-SIGNR knockdown inhibited the proliferation, migration and invasion of gastric cancer cells in vitro and suppressed the liver metastasis in vivo. (biomedcentral.com)

With respect to the contribution of oxidative stress to diabetic complications, promoters of mitophagy and mitochondrial biogenesis, UCP2 inducers, inhibitors of NAPDH oxidase, recouplers of eNOS, glutathione precursors, membrane oxidant scavengers, Nrf2 activators, and correction of diabetic thiamine deficiency should help to quell this. (bvsalud.org)
Gaseous - can be widespread through cell membrane and cytosol, including nitric oxide and carbon monoxide. (wikipedia.org)

Recently, we developed a hematopoietic stem cell-based approach to tackle this issue, in which we can genetically alter nucleated hematopoietic precursor cells and differentiate them ex-vivo to mature erythrocytes that can be infected by P. falciparum. (stanford.edu)

Tachykinins are small neuropeptides from 10-12 amino acids long synthesized in various nuclei of the central nervous system such as the substania gelatinosa of the dorsal spinal cord and certain nuclei of the limbic lobes as well as in a number of non-neuronal tissues like stromal cells of the BM [3]. (brainimmune.com)
Recent studies point to the role of hedgehog signaling in regulating adult stem cells involved in maintenance and regeneration of adult tissues. (wikipedia.org)
In particular, glial cells in nerve tissues include astrocytes and microglial cells and are accessory cells that aid in promoting the functions and survival of neurons. (justia.com)
Chronic Granulomatous Disease , autoimmune diseases Autoimmune diseases Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides. (lecturio.com)
Therefore, we propose that damage to and subsequent release of mtDNA elicits a protective signalling response that enhances nDNA repair in cells and tissues, suggesting that mtDNA is a genotoxic stress sentinel. (regenerativemedicine.net)

Transferrin-bound iron enters target cells (erythroid, immune, and hepatic cells) is stored as ferritin (the major iron storage protein). (vitaminexpert.co.uk)
GPR91 is a G protein-coupled cell surface receptor for extracellular succinate (Sucnr1). (haematologica.org)
LCN2 protein induced upregulation of glial fibrillary acidic protein (GFAP), cell migration, and morphological changes similar to characteristic phenotypic changes termed reactive astrocytosis. (jneurosci.org)
First described in 1848, MM is characterized by a proliferation of malignant plasma cells and a subsequent overabundance of monoclonal paraprotein (M protein). (medscape.com)
The NAMPT protein manifestation in siRNA-treated cells was estimated by enzyme-linked immunosorbent assay. (forgetmenotinitiative.org)
amyloid beta precursor protein binding f. (gsea-msigdb.org)

Our results indicated that lcn2 is critical for cell death sensitization, stimulation of cell migration, and morphological changes of reactive astrocytes. (jneurosci.org)
Agonist (100 nM 8-OH-DPAT) (D) treatment of freely dividing HN2-5 cells caused stimulation of PKC (Physique 1a) [25,26,27,28,29], which was blocked by the 5-HT1A-R antagonist WAY100635 (WAY) (10 M) but not by an inhibitor of the ERK1/2 kinase MEK (U0126) (U) (10 M) (Physique 1a). (thetechnoant.info)

In the latest years, people discovered that there is certainly a little subpopulation of cells in tumors, which play a essential function in the resistance of cancer to radiotherapy and chemotherapy. (immune-source.com)
cells could initiate tumors in rodents. (immune-source.com)
T cell homing to tumors detected by 3D-coordinated positron emission tomography and magnetic resonance imaging. (mdc-berlin.de)
Immunotherapy is currently considered as a promising next-generation therapeutic strategy for various cancers thanks to its ability to modulate cell-specific immune responses toward tumors [ 1 ], which has gradually remodeled the landscape of clinical anticancer modality [ 2 ]. (thno.org)

Cerebral function requires the cooperative interaction between different cell types, namely neurons, astrocytes, microglia and oligodendrocytes, and depends on high metabolic activity supported by continuous supply of oxygen and glucose from the blood ( Siesjö, 1978 ). (frontiersin.org)
Astrocytes, the most abundant glial cell type in the brain, provide metabolic and trophic support to neurons and modulate synaptic activity. (jneurosci.org)
These findings support that Nurr1 exerts a protective effect on adult mDA neurons in a cell-autonomous manner Indeed, several intrinsic mechanisms associated with Nurr1-mediated cell survival have been identified. (justia.com)
Cell 137: 47-59) has identified an unexpected effect of Nurr1 which is expressed in glial cells in response to stimuli which trigger inflammation, and this Nurr1 suppresses the production of pro-inflammatory cytokines that cause the death of mDA neurons, but does not suggest a therapeutic effect through induction of Nurr1 expression. (justia.com)
However, under a pathologic condition, the glial cells are instead activated to set up an environment in which the glial cells cause damage to neurons (M1 activation). (justia.com)
Meanwhile, it is known that glial cells with an M1 phenotype which set up a diseased environment can be converted into glial cells with an M2 phenotype which promote a therapeutic environment in which the survival and regeneration of neurons is set up. (justia.com)
Enriched monolayer precursor cell cultures from micro-dissected adult mouse dentate gyrus yield functional granule cell-like neurons. (mdc-berlin.de)

Moreover, mitochondria control cell death through apoptosis and supply Ca 2+ and metabolites required for cellular homeodynamics [ 3 ]. (hindawi.com)
Cell proliferation was decided using MTT assay, while apoptosis was analyzed with circulation cytometry using Annexin V-fluorescein isothiocyanate/propidium iodide assay. (forgetmenotinitiative.org)
or gene silencing significantly inhibited cell proliferation and induced apoptosis in RPMI 8226 cells ( (forgetmenotinitiative.org)

The atherosclerotic process is accelerated by a myriad of factors, such as the release of inflammatory chemokines and cytokines, the generation of reactive oxygen species (ROS), growth factors, and the proliferation of vascular smooth muscle cells. (hindawi.com)
We propose that lcn2 is an autocrine mediator of reactive astrocytosis based on the multiple roles of lcn2 in the regulation of cell death, morphology, and migration of astrocytes. (jneurosci.org)
Our results suggest that lcn2 acts in an autocrine manner to induce cell death sensitization and morphological changes in astrocytes under inflammatory conditions and that these phenotypic changes may be the basis of reactive astrocytosis in vivo . (jneurosci.org)

Oxidative and dicarbonyl stress, driven by excess accumulation of glycolytic intermediates in cells that are highly permeable to glucose in the absence of effective insulin activity, appear to be the chief mediators of the complications of diabetes. (bvsalud.org)

Follicular dendritic cells also express CD19. (thermofisher.com)
Dendritic cells play a key role in processing and presenting antigens to naïve T cells to prime adaptive immunity. (biomed.news)
however, the role of circadian rhythms in dendritic cell function is still unclear. (biomed.news)
Of note, the TME is rich in immunosuppressive cells (e.g., tumor-associated macrophages (TAMs), regulatory T cells (Tregs), immature dendritic cells (iDCs) and myeloid-derived suppressor cells (MDSCs)), that can suppress antitumor immunity as a result of secretion of various cytokines and chemokines, which enables tumor escape from immune surveillance [ 8 ]. (thno.org)

Each signal transduction occurs with a primary extracellular messenger that binds to a transmembrane or nuclear receptor, initiating intracellular signals. (wikipedia.org)

The majority of iron is intracellular, bound within the iron storage proteins (ferritin and haemosiderin) or associated with proteins in the form of haem. (vitaminexpert.co.uk)
Signaling proteins give cells information to make the embryo develop properly. (wikipedia.org)
Iron and BIM (Bcl-2-interacting mediator of cell death) proteins were involved in the cytotoxic sensitization process. (jneurosci.org)
Through our study of these proteins, we hope to gain a better apprecia-tion of the relaapprecia-tionship between mitochondria and cells. (1library.net)
The ER is the 'port of entry' for proteins destined for the cell surface and beyond. (stanford.edu)
Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)

While, DC-SIGNR overexpression promoted cell proliferation, migration and invasion. (biomedcentral.com)

There is currently no cure for MM. However, advances in therapy, such as autologous stem cell transplantation, radiation, and surgical care in certain cases, have helped to lessen the occurrence and severity of adverse effects of this disease and to manage associated complications. (medscape.com)

The inhibition of NAMPT is usually shown to induce cell death and reduce osteoclastogenesis in MM [10,11]. (forgetmenotinitiative.org)

Between February 1986 and March 1990, 56 patients with relapsed Hodgkin's disease treated with high-dose cyclophosphamide, carmustine, and etoposide (CBV) received an autologous peripheral stem cell transplantation (PSCT) rather than an autologous bone marrow transplantation (ABMT) because each patient had a marrow abnormality, either hypocellularity or tumor involvement. (shengsci.com)
Preemptive immunotherapy in childhood acute myeloid leukemia for patients showing evidence of mixed chimerism after allogeneic stem cell transplantation. (shengsci.com)
Previous studies have shown that children with acute myeloid leukemia (AML) who developed mixed chimerism (MC) were at high risk for relapse after allogeneic stem-cell transplantation (allo-SCT). (shengsci.com)

Bloodstream examples had been acquired at the College or university Children's Medical center Zurich, Swiss, or mononuclear cells had been bought as a item from the Welsh bloodstream loan company in Cardiff, UK. (immune-source.com)
Mononuclear cells had Rabbit Polyclonal to p130 Cas (phospho-Tyr410) been separated from heparinized venous bloodstream on a Ficoll-Paque In addition gradient relating to the process offered by GE-Healthcare (Dietikon, Swiss). (immune-source.com)

SARS-CoV-2 infects alveolar endothelial cells (see, ACE2 below) and/or macrophages. (mthfrsupport.com)

Further study will be required in the future to better understand succinate biology in blood cells. (haematologica.org)

However, the precise role of lcn2 in the cell survival and death has yet to be determined. (jneurosci.org)
They can also be used for increasing white blood cell survival and for chemotherapy. (justia.com)
Amino acid metabolism is essential for cell survival, while the byproduct ammonia is toxic and can injure cellular longevity. (biomed.news)

Among most immunosuppressive cells, TAMs, as crucial drivers of immunosuppressive TME, account for the largest proportion of immune cells in the TME (approximately 50% of tumor mass) [ 9 , 10 ], which possess highly heterogeneity and play a complex regulatory role in tumor immunity and immunotherapy due to helping tumor evade immune surveillance [ 11 ]. (thno.org)

Specifically, a method of converting glial cells from an M1 phenotype to an M2 phenotype, wherein Nurr1 and Foxa2 are introduced into the glial cells to be overexpressed in the glial cells and a method of preventing or treating an inflammatory neurologic disorder, which includes glial cells into which Nurr1 and Foxa2 are introduced, or a viral vector loaded with Nurr1 and Foxa2, are provided. (justia.com)
Therefore, the present inventors have found that various neurologic disorders based on inflammation may be treated since transcription factors Nurr1 and Foxa2 interact with each other to convert glial cells from an M1 phenotype to an M2 phenotype which sets up a therapeutic environment, when the transcription factors are overexpressed in the glial cells. (justia.com)

Nonetheless, when cells rely on anaerobic glycolysis, like cancer cells and certain innate immune cells upon activation, other metabolic pathways sustain succinate levels, including glutamine-dependent anerplerosis to α-ketoglutarate, and eventually citrate by reductive carboxylation. (haematologica.org)
Immune cells must be able to adjust their metabolic programs to effectively carry out their effector functions. (biomed.news)

Lung tumor stem cells are a subpopulation of cells important for lung tumor development, metastasis, and medication resistance. (immune-source.com)
Within the bone marrow, the tachykinins have been shown to have critical effects on the microenvironment, including metastasis and dormancy of cancer cells during clinical remission. (brainimmune.com)
Despite surgical resection and chemoradiotherapy can control most cancer cells [ 5 ], a surgical resection has been rarely indicated for liver metastasis from gastric cancer [ 6 ]. (biomedcentral.com)
In experimental metastasis studies, researchers demonstrate that liver sinusoidal endothelial cell lectin (LSECtin) mediated colon cancer cells metastasis to liver displays enhanced abilities to the specific organ [ 8 ]. (biomedcentral.com)

The most abundant mammalian haemproteins, haemoglobin and myoglobin, serve as oxygen carriers in the erythroid tissue and in the muscle, respectively. (vitaminexpert.co.uk)

Although the notion that malaria has helped shape the human genome is well- accepted, the lack of a nucleus in human erythrocytes has hindered our ability to study genetic interactions between these unusual host cells and P. falciparum parasites. (stanford.edu)

Signaling through CD19 induces tyrosine phosphorylation, calcium flux and proliferation of B cells. (thermofisher.com)
Mitochondria are the energy producing organelles in eukaryotic cell providing ATP through oxidative phosphorylation (OXPHOS). (hindawi.com)

Trpc2, Trpc3, and Trpc2/Trpc3 double knockout mice were not anemic, and had similar red blood cell counts, hemoglobins, and reticulocyte counts as wild-type littermate controls. (psu.edu)
Iron deficiency anemia develops when body stores of iron drop too low to support normal red blood cell (RBC) production. (medscape.com)
An erythrocyte has a lifespan of 120 days so that 0.8% of red blood cells are destroyed and replaced each day. (medscape.com)
The adult human body contains approximately 3-5 g of iron, with more than two-thirds incorporated in the haemoglobin of developing erythroid precursors and mature red blood cells. (vitaminexpert.co.uk)
Population genetic studies dating back to the mid-20th century first proposed that erythrocytes (red blood cells), the host cell for P. falciparum, have been under natural selection due to malaria. (stanford.edu)
Recent evidence obtained in mouse models shows its essential role regulating blood cell function through various mechanisms that include pseudohypoxia responses by hypoxia-inducible factor-1α activation, post-translational modifications like succinylation, and communication mediated by succinate receptor 1. (haematologica.org)
Here, we further discuss current suggestions of the possible contribution of succinate to blood stem cell function and blood formation. (haematologica.org)
This promising field may open new avenues to modulate inflammatory responses and to preserve blood cell homeostasis in the clinical setting. (haematologica.org)
As the Bone Marrow (BM) develops and becomes functional, it becomes the main site of blood and immune cell formation. (brainimmune.com)
Yet, the maturation and activations of these cells occurs throughout the body, either in secondary lymphoid organs or the blood itself. (brainimmune.com)
Autoimmune hemolytic anemia Hemolytic Anemia Hemolytic anemia (HA) is the term given to a large group of anemias that are caused by the premature destruction/hemolysis of circulating red blood cells (RBCs). (lecturio.com)
This is characterized by a marked increase in fecal urobilinogen excretion and a normal or near-normal red blood cell lifespan. (medscape.com)
These therapies decrease a patient's white blood cell counts, suppress bone marrow hematopoietic activity, and increase the patient's risk of infection and/or hemorrhage. (justia.com)
Provided herein are methods and compositions useful for the replenishment of blood cells in a mammal after exposure to therapeutic radiation or drugs. (patentsencyclopedia.com)

DLL-4, in turn, instigated neighbouring platelets to switch to 'activated' phenotype through cleavage of Notch receptor and release of its intracellular domain (NICD), which was averted by inhibition of γ-secretase and phosphatidylinositol-3-kinase (PI3K). (elifesciences.org)

The cells were maintained in incubator at 37C and 5% CO2. (immune-source.com)
All cells were cultured in a humidified incubator at 37C made up of 5% CO2. (forgetmenotinitiative.org)

It is important to note that a common pathway to neuronal injury resulting from the various forms of brain insult mentioned above is believed to be that of induction of intracellular OS. (biomedcentral.com)

Multiple myeloma (MM) is a debilitating malignancy that is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. (medscape.com)
Bone marrow aspirate demonstrating plasma cells of multiple myeloma. (medscape.com)
Engraftment, clinical, and molecular follow-up of patients with multiple myeloma who were reinfused with highly purified CD34+ cells to support single or tandem high-dose chemotherapy. (shengsci.com)
Eighty-two patients with advanced multiple myeloma (MM) were enrolled in 2 sequential clinical studies of 1 or 2 courses of myeloablative therapy with stem cell support. (shengsci.com)

Mitochondrial health must be monitored carefully, because mi-tochondria are hardwired to the major metabolic pathways of the cell, and, due to their exceptional origin[1], are prone to cause cell death and a variety of other problems. (1library.net)

Intracellular calcium in hypertrophic smooth muscle from rat urinary bladder. (mdc-berlin.de)

This response is quick, as it involves regulation of molecules that are already present in the cell. (wikipedia.org)

In this ongoing work, we examined the impact of thioridazine on LCSCs world development, chemoresistance, cell cycle, and in vivo prohibitory function. (immune-source.com)
In zebrafishes, forced expression of rat lcn2 gene increased the number and thickness of cellular processes in GFAP-expressing radial glia cells, suggesting that lcn2 expression in glia cells plays an important role in vivo . (jneurosci.org)
In addition, mtDNA stress in TFAM-deficient mouse melanoma cells produces tumours that are more resistant to doxorubicin in vivo. (regenerativemedicine.net)

Mitochondria are highly dynamic organelles that provide essential metabolic functions and represent the major bioenergetic hub of eukaryotic cell. (hindawi.com)
In line with this notion, mitochondria are highly dynamic organelles that undergo fission and fusion and move into the cell along the microtubules to generate the mitochondrial network [ 6 ]. (hindawi.com)

functional ATP by a full cell signal reticulum 1. (evakoch.com)
Cells require a full and functional cellular machinery to live. (wikipedia.org)
The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation, and is expressed in all B cell precursor leukemias. (thermofisher.com)

This stimulus, known as a first messenger, acts on a receptor that is transduced to the cell interior through second messengers which amplify the signal and transfer it to effector molecules, causing the cell to respond to the initial stimulus. (wikipedia.org)

2013) and with family p85 cytosol 6( HNF6) in oligonucleotide cell bone( Vanderpool et al. (evakoch.com)
Stem cells represent a very small percentage of bone marrow cells, and are normally quiescent. (justia.com)
Current treatments to manage the problems that result from prolonged bone marrow suppression include the reinfusion of a patient's own previously harvested hematopoietic stem and progenitor cells. (justia.com)
In such procedures, patients undergo successive treatments with cell mobilization agents to cause mobilization of hematopoietic progenitor cells from the bone marrow to the peripheral circulation for harvesting. (justia.com)
After harvesting, the patient is given high dose chemotherapy or radiotherapy and the bone marrow function is reconstituted by infusion of the cells harvested earlier. (justia.com)
The success of treatment crucially depends on the mobilization of the bone marrow stem cells, the subsequent return of which permits the patient to achieve reconstitution of a functioning hematopoietic system. (justia.com)

They are named tumor control cancers or cells initiating cells [4]. (immune-source.com)
Leukemia control cells are the AZD1080 KIAA0901 initial reported kind of tumor control cells [5]. (immune-source.com)
This is certainly the initial function on tumor control cells in solid growth [6]. (immune-source.com)
After that, tumor control cells had been reported in different types of malignancies, including lung tumor, gastric tumor, human brain cancers, liver organ cancers, and digestive tract cancers [7C11]. (immune-source.com)
After the breakthrough discovery of tumor control cells, analysts attempted to appearance for effective techniques to focus on cancers control cells. (immune-source.com)
Nevertheless, till today, no one provides reported whether thioridazine could focus on lung tumor control cells. (immune-source.com)
Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix. (uni-freiburg.de)

CD8+ TM cells use β-hydroxybutyrylation to upregulate CP synthetase 1 and trigger the CP metabolic cascade to form arginine in the cytosol. (biomed.news)

The manifestation of is usually shown to impact lysosomal size, granule size, and autophagy in human cells [12]. (forgetmenotinitiative.org)

These communications between cells triggers intracellular signaling cascades, termed signal transduction pathways, that regulate specific cellular functions. (wikipedia.org)
Our results indicate that rhythmic changes in mitochondrial calcium, which are associated with changes in mitochondrial morphology, regulate antigen processing. (biomed.news)

Our study exhibited that and play pivotal functions in the molecular pathogenesis of MM. This is usually the first statement describing the possible functions of in myelomagenesis and its potential role as a SU 11654 therapeutic target in MM. gene promotes tumorigenesis through constant NAD resynthesis to provide adequate energy for rapidly proliferating malignancy cells [9]. (forgetmenotinitiative.org)

through targeting lung cancer stem cells. (immune-source.com)
Lung cancer majorly consists of small-cell lung carcinoma and non-small-cell lung carcinoma (NSCLC). (immune-source.com)
Sphere Formation The lung cancer stem cells were accumulated by sphere formation. (immune-source.com)
Once infected, GI/lung cells are hijacked into making more viruses. (mthfrsupport.com)

Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. (thermofisher.com)

Anatomy33

Organisms8

Diseases13

Chemicals and Drugs64

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes30

Disciplines and Occupations1

Information Science3

Differentiation9

Progenitor cell3

Erythropoietin3

Receptors6

Pathogen2

Lymphocytes3

Stimulates1

Known as hematopoietic stem1

Signaling pathway2

Lineage3

Hematopoietic stem7

Mammalian cells4

Peripheral blood4

Vitro2

Membrane2

Differentiate1

Tissues5

Protein6

Stimulation2

Tumors4

Neurons7

Apoptosis3

Reactive3

Intermediates1

Dendritic4

Transmembrane1

Proteins6

Promoted cell proliferation1

Autologous stem cell trans1

Induce cell death1

Stem cell transplant3

Mononuclear cells2

Endothelial cells1

Biology1

Survival3

Immunity1

Glial2

Immune cells2

Metastasis4

Tissue1

Nucleus1

Phosphorylation2

Blood14

Inhibition1

Incubator at 37C2

Induction1

Multiple myeloma4

Metabolic pathways1

Urinary1

Regulation1

Vivo3

Mitochondria2

Functional3

Effector1

Bone6

Tumor7

Cytosol1

Granule1

Regulate2

Malignancy1

Lung4

Leukemia1