Glucose and KCl, which depolarize the cell membrane, as well as the Ca2+-mobilizing agonist, carbachol (CCh), cause substantial increases in [Ca2+]m which are associated with smaller rises in [Ca2+]c. (123dok.net)
Zhang W, Tan YF, Atwood HL , Martin Wojtowicz J. Biphasic effects of the cholinergic agonist carbachol on long-term potentiation in the dentate gyrus of the mammalian hippocampus. (neurotree.org)
Mucus1
We used mass-spectrometry based proteomic analysis of unstimulated and carbachol stimulated newborn wild-type (WT) and cystic fibrosis transmembrane conductance regulator (CFTR) null (CF) piglet airways to study proteins in the airway surface liquid and mucus, to investigate if levels of MUC5AC and MUC5B were affected by carbachol stimulation and whether the proteins clustered according to function. (biomedcentral.com)
Secretion4
In exocrine acinar cells regulation of intracellular calcium plays a pivotal role in controlling fluid and protein secretion. (rochester.edu)
To investigate the role of Ca2+ in mitochondrial function, insulin secretion from INS-1 cells stably expressing the Ca2+-sensitive photoprotein aequorin in the appropriate compartments was correlated with changes in cytosolic calcium ([Ca2+]c) and mitochondrial calcium ([Ca2+]m). (123dok.net)
supplementary to carbachol-induced boosts in intracellular [Ca2+] had been sufficient and essential to elicit alkaline secretion and pepsinogen secretion Minoxidil unbiased of intracellular [Ca2+] adjustments. (hiv-proteases.com)
Alkaline secretion: aftereffect of carbachol and bilateral adjustments in [Ca2+]ext. (hiv-proteases.com)
Inhibits2
Intracellular ATP inhibits TRPC5 currents. (downstate.edu)
These results suggest that propofol inhibits endothelin-1-induced intracellular signaling in vascular smooth muscle cells. (silverchair.com)
19891
1998 This switch in Vt is definitely caused by the opening of basolateral Ca2+-activated K+ channels (Ueda and Okada 1989 and indirectly shows adjustments in intracellular [Ca2+]. (hiv-proteases.com)
Extracellular3
The signal source can be either extracellular, such as nitric oxide (NO) (114), or intracellular, such as bicarbonate (189). (pancreapedia.org)
This calcium mobilizing effect of DA was observed in the absence of extracellular calcium and was abolished by a D 2 blocker (L-741,626). (biomedcentral.com)
These findings claim that extracellular Ca2+ can become a "third messenger" via Ca2+ sensor(s) to modify particular subsets of tissues function previously assumed Minoxidil to become under the immediate control of intracellular Ca2+. (hiv-proteases.com)
Elevation1
Exposure of cells to neurotransmitters and hormones results in a rapid elevation of intracellular calcium. (rochester.edu)
Luminal1
1998 As proven previous carbachol-induced luminal alkalinization is normally delicate to particular inhibitors of anionic pathways like the stilbene derivative 4 4 2 acidity (DIDS) since it is normally driven with a basolateral Na+-(HCO3? (hiv-proteases.com)
Receptors2
It is suggested that G-protein-coupled receptors might modulate cytoskeletal dynamics, intracellular traffic, and cellular architecture. (jneurosci.org)
A previous study showed D 2 in human GCs, which are linked to cAMP, and the present study reveals the full spectrum of DA receptors present in these endocrine cells, which also includes D 2 -like receptors, linked to calcium. (biomedcentral.com)
Regulation3
A further project relates to the organization and regulation of calcium release sites in exocrine cells. (rochester.edu)
Role of ATP-dependent calcium regulation in modulation of Drosophila synaptic thermotolerance. (neurotree.org)
Hyperthermic preconditioning of presynaptic calcium regulation in Drosophila. (neurotree.org)
Modulation1
We are working on the modulation of calcium current in dorsal raphe serotonergic neurons of the rat brain and have discovered a profound inhibitory modulation of this voltage-activated current by the neurotransmitter serotonin. (downstate.edu)
Influx1
The effect of propofol on the endothelin-1-induced Ca2+ influx into A10 cells was evaluated by measuring intracellular 45Ca2+. (silverchair.com)
Cells4
A specific and time-dependent association of tubulin with plasma membranes was observed when SK-N-SH cells were treated with carbachol. (jneurosci.org)
In SK-N-SH cells, carbachol induced a rapid and transient translocation of tubulin to the plasma membrane, microtubule reorganization, and a change in cell shape as demonstrated by confocal immunofluorescence microscopy. (jneurosci.org)
The effects of propofol on endothelin-1-induced intracellular signaling in an aortic smooth muscle cell line, A10 cells, were examined. (silverchair.com)
It is generally assumed which the functional implications of arousal with Ca2+-mobilizing agonists are derived exclusively from the next messenger actions of intracellular Ca2+ functioning on targets in the cells. (hiv-proteases.com)
Levels1
Results of additional RT-PCR and Western blots showed two splice variants (D 2 L, D 2 S). Irrespective of these variants, D 2 proved to be functional, as DA raised intracellular calcium levels. (biomedcentral.com)
Control2
There are multiple mechanisms of activation of TRPC channels, and we hypothesize that intracellular ATP may be a general "gain control" affecting all forms of activation or that it may function as a selective "filter" that modulates only some forms of activation. (downstate.edu)
Cytoskeletal proteins appear to be involved in the control of intracellular signaling. (jneurosci.org)
Protein1
My recent work has involved characterization of the receptor (5-HT1A), the mechanism (G-protein type), possible second messengers and the calcium channel type that is affected (N, and "N-" channels). (downstate.edu)
Potential1
Noteworthy the response to bilateral [Ca2+]ext changes was not Minoxidil accompanied by the increase in transepithelial potential (Fig. 2 Vt) typically observed in response to carbachol (Debellis et al. (hiv-proteases.com)
Activation1
5-HT receptor activation reduces calcium current in an isolated adult central neuron. (downstate.edu)
Activates3
We have proposed that the Phase 1 response results from the combined depolarizing influences of potassium channel closure and an inward, nonselective cation current (ICRAN) that activates as intracellular calcium stores empty during exposure to basal glucose (Bertram et al. (nih.gov)
16. Carbachol activates a novel sodium current in isolated guinea pig ventricular myocytes via M2 muscarinic receptors. (nih.gov)
L-glutamate activates several subtypes of receptors leading to an increase in intracellular calcium ion concentration ([Ca 2 +] i ). (silverchair.com)
Jouaville LS, Pinton P, Bastianutto C, Rutter GA, Rizzuto R. Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic priming. (ukrbiochemjournal.org)
The agonist-sensitive calcium pool in the pancreatic acinar cell. (eurekamag.com)
Concentration1
3. Effect of cholinergic drugs on the concentration of intracellular free calcium of rat pituitary intermediate lobe cells. (nih.gov)
Proteins2
It is predominantly found bound to G proteins of class Gq that use upregulation of phospholipase C and, therefore, inositol trisphosphate and intracellular calcium as a signalling pathway. (wikipedia.org)
The calcium acts as an intracellular messenger by activating calcium-responsive proteins. (lookformedical.com)
Secretagogues bind to their receptors at the basolateral membrane of acinar cells and trigger the activation of intracellular signaling pathways to elicit fusion of secretory granules with the apical plasma membrane that is followed by exocytosis of digestive pro-enzymes (the "zymogens") into the lumen. (pancreapedia.org)
Increases1
First, the duration of the Phase 1 transient increases with duration of prior exposure to basal (2.8 mM) glucose, reflecting the increased time required to fill calcium stores that have been emptying for longer periods. (nih.gov)
Mechanisms1
Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. (lookformedical.com)