• Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. (duke.edu)
  • Productive interaction between receptors and G proteins involves multiple intracellular receptor domains, but the role of individual receptor amino acids in directing the selection of specific signaling pathways has not yet been identified. (aspetjournals.org)
  • While the molecular nature of intracellular cobalamin metabolism in mammals remains poorly understood, the proteins MMACHC, MMADHC, LMBD1 and ABCD4 are implicated in its early uptake and processing. (mcgill.ca)
  • Two important pathways were examined in the current study: (1) a basic pathway of exocytosis that brings new proteins to the cell surface and permits the cell to grow, and (2) synaptic transmission, a specialized form of exocytosis, regulated by Ca 2+ entry, in which vesicles already present at synapses fuse with the membrane and recycle locally (Murthy, 2003). (sdbonline.org)
  • GABA may stimulate Ca2+ influx in RB neurons because the intracellular GABA EREV is above the threshold for low voltage- activated Ca2+ channels. (jneurosci.org)
  • In WKY, Mg ++ actions are dependent primarily on Ca ++ influx through l -type Ca ++ channels, whereas in SHR, the modulatory effects of [Mg ++ ] e are mediated both by Ca ++ influx through Ca ++ channels and by intracellular Ca ++ release. (aspetjournals.org)
  • i elevation (influx and intracellular mobilization) in response to thrombin, but suppressed one to low concentration of A23187 or STA_2. (nii.ac.jp)
  • mobilization (probably Ca influx) in responses to A23187 or STA_2, and different from TMB-8 treated normal paltelets. (nii.ac.jp)
  • Yoda1, a specific PIEZO1 agonist, activates a small membrane current and thereby triggers β-cell electrical activity with resultant stimulation of Ca 2+ -influx and insulin secretion. (lu.se)
  • Ca(2+) release-activated Ca(2+) (crac) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, stim1. (lu.se)
  • Crac channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. (lu.se)
  • Bullseye Analysis: A Fluorescence Microscopy Technique to Detect Local Changes in Intracellular Reactive Oxygen Species (ROS) Production. (bvsalud.org)
  • Different receptors use inositol trisphosphate to mobilize Ca(2+) from different intracellular pools. (cam.ac.uk)
  • In cells expressing different receptors linked to Ins(1,4,5)P(3) formation, maximal stimulation of any one of them often releases all the Ins(1,4,5)P(3)-sensitive Ca(2+) stores, suggesting that Ins(1,4, 5)P(3) is used similarly by many receptors. (cam.ac.uk)
  • This study assessed whether the dust generated inside hog confinement facilities contains compounds that alter Ca(2+) mobilization via ryanodine receptors (RyRs), key intracellular channels responsible for mobilizing Ca(2+) from internal stores to elicit an array of physiologic functions. (cdc.gov)
  • In contrast, its effect on Sph-1-P-induced intracellular Ca(2+) mobilization was marginal. (nih.gov)
  • Because RyRs are present in many cell types, impairment in Ca(2+) mobilization from internal stores via these channels is a possible mechanism by which HBD may trigger these seemingly unrelated pathophysiologies. (cdc.gov)
  • 1994). High-res- belongs to the family of intracellular lipid bind- olution crystal structures (Sacchetti ni et al. (lu.se)
  • Mechanistically, intracellular mature IL-37 directly bound to the CAAX motif in the C-terminal hypervariable region of Rac1, and then inhibited Rac1 membrane translocation and subsequent downstream signaling. (nature.com)
  • This subclass comprises research and experimental development in intracellular signaling, signal transduction, receptor and membrane biology. (ubc.ca)
  • We provide evidence that KRas translocation occurs through sequestration of the polybasic-prenyl motif by Ca 2+ /calmodulin (Ca 2+ /CaM) and subsequent release of KRas from the PM, in a process reminiscent of GDP dissociation inhibitor-mediated membrane recycling of Rab and Rho GTPases. (rupress.org)
  • Upon prolonged high intracellular rises in Ca 2+ , platelets develop a procoagulant phenotype that is characterized by the surface membrane exposure of phosphatidylserine and by the inactivation of integrin α IIb β 3 (procoagulant platelet population) ( 5 ). (frontiersin.org)
  • have begun to reveal new components and new mechanisms associated with intracellular membrane traffic in a variety of cell types. (wormbook.org)
  • Junctophilin-2 (JPH2), a protein expressed in the junctional membrane complex, is necessary for proper intracellular calcium (Ca(2+)) signaling in cardiac myocytes. (duke.edu)
  • Excitable tissues rely on junctional membrane complexes to couple cell surface signals to intracellular channels. (duke.edu)
  • IL-37, a newly found anti-inflammatory cytokine of the IL-1 family, has both extracellular and intracellular functions. (nature.com)
  • Intracellular mature form of IL-37, but not its extracellular form, markedly inhibited migration of multiple kinds of tumor cells through inhibiting Rac1 activation. (nature.com)
  • Intracellular nitrate concentrations exceeded extracellular concentrations by three orders of magnitude. (frontiersin.org)
  • Effects of increasing extracellular Mg ++ concentration ([Mg ++ ] e ) on vasopressin (AVP)-induced [Ca ++ ] i responses were determined in primary cultured unpassaged vascular smooth muscle cells from mesenteric and aortic vessels (representing resistance and conduit arteries, respectively) of Wistar Kyoto rats (WKY) and SHR. (aspetjournals.org)
  • Extracellular Ca ++ withdrawal and diltiazem abolished the attenuating effects of high [Mg ++ ] e in WKY but not in SHR. (aspetjournals.org)
  • The IP 3 R converts IP 3 signaling into Ca 2+ signaling, and thus plays crucial roles in a wide range of cellular functions such as embryonic development, differentiation of cells, proliferation, phagocytosis, granule secretion, motion and actions in nerve system, and it is especially important for the IP 3 R to normally function in cells in order to keep the homeostasis of cells. (justia.com)
  • Calreticulin plays a central role in intracellular Ca homeostasis. (bio.net)
  • A common element underlying these diverse pathophysiologies is perturbation of intracellular Ca(2+) homeostasis. (cdc.gov)
  • To study the mechanisms underlying this distinctive response, intracellular and patch-clamp recordings were made from RB neurons in situ. (jneurosci.org)
  • More particularly, the present invention relates to a regulator for the activity of inositol-1,4,5-triphosphate (IP 3 ) receptor (IP 3 R) comprising carbonic anhydrase-related protein (CARP), a control agent for intracellular calcium release comprising carbonic anhydrase-related protein (CARP), and a method of control therewith. (justia.com)
  • Calreticulin, a 60 kDa Ca-binding protein, is a major ER component of non-muscle cells. (bio.net)
  • Given the crucial roles of Rac1 in tumor angiogenesis and metastasis, intracellular mature IL-37 might serve as a potential strategy for the control of Rac1 activity and tumor progression. (nature.com)
  • In both studies, the changes in intracellular Cl - were reversible, and there was complete recovery of electrophysiological parameters measured during reoxygenation. (jneurosci.org)
  • Moreover, we uncovered a novel mechanism by which IL-37 suppressed tumor cell migration via its intracellular mature form (amino acids 46-218). (nature.com)
  • In single HEK-293 cells, ATP and carbamylcholine (CCh) stimulated Ca(2+) release from intracellular stores via a pathway that was entirely dependent on Ins(1,4,5)P(3). (cam.ac.uk)
  • Lipids have been shown to have important roles in an intracellular signal transmission system. (justia.com)
  • This study investigated the modulatory effect of magnesium (Mg ++ ) on basal and agonist-stimulated intracellular free calcium (Ca ++ ) concentration ([Ca ++ ] i ) in vascular smooth muscle cells from spontaneously hypertensive rats (SHR). (aspetjournals.org)
  • Intracellular Calibration of the Fluorescent Calcium Indicator Fura-2. (dojindo.com)
  • Since some of the aggregate-forming diatom species store nitrate intracellularly, we explored the fate of intracellular nitrate and its availability for microbial metabolism within anoxic diatom-bacteria aggregates. (frontiersin.org)
  • We conclude that the polybasic-prenyl motif acts as a Ca 2+ /CaM-regulated molecular switch that controls PM concentration of KRas and redistributes its activity to internal sites. (rupress.org)
  • RME-2 contains a typical NPXY internalization motif in its intracellular domain that is known to direct other members of the LDL-receptor family into clathrin-coated pits. (wormbook.org)
  • These results implicate mechanotransduction and activation of PIEZO1, via intracellular accumulation of glucose metabolites, as an important physiological regulator of insulin secretion. (lu.se)
  • Underlying mechanisms for Mg ++ actions were determined in Ca ++ -free buffer and in the presence of diltiazem (10 −6 M), an l -type Ca ++ channel blocker. (aspetjournals.org)
  • KRas translocation was accompanied by partial intracellular redistribution of its activity. (rupress.org)
  • To ensure that the correct sets of molecules talk to each other, the intracellular space is highly structured and special signals are employed to move specific molecules from one structure to another. (alzforum.org)
  • The amplitude of the high- frequency dispersion corresponds to 10-20 moderately ordered water molecules, with a correlation time of ca. 1 ns that may re¯ect a transient opening of the cavity required for exchange with external water. (lu.se)
  • Transmitted by ticks, ehrlichae are obligate intracellular, gram-negative bacteria that infect animals and humans ( 1 ). (cdc.gov)
  • After stimulation with maximal concentrations of ATP or CCh in Ca(2+)-free medium, there was no response to a second stimulation with the same agonist, indicating that each agonist had emptied the Ins(1,4,5)P(3)-sensitive stores to which it had access. (cam.ac.uk)
  • The accumulation of Na + and Ca 2+ during ischemia or oxygen-glucose deprivation (OGD), an in vitro model for transient global ischemia, has been investigated extensively. (jneurosci.org)
  • β-cell-specific Piezo1-knockout mice show impaired glucose tolerance in vivo and reduced glucose-induced insulin secretion, β-cell electrical activity and Ca 2+ elevation in vitro. (lu.se)
  • Stable 15 N isotope incubations under dark and anoxic conditions revealed that axenic S. marinoi is able to reduce intracellular nitrate to ammonium that is immediately excreted by the cells. (frontiersin.org)
  • Intracellular nitrate was used up within 2-3 days after shifting diatom-bacteria aggregates to dark and anoxic conditions. (frontiersin.org)
  • Conversely, the PIEZO1 antagonist GsMTx4 reduces glucose-induced Ca 2+ -signaling, electrical activity and insulin secretion. (lu.se)
  • However, the mechanism and its intracellular target are unclear. (nature.com)
  • multicellular interactions, including intracellular and Addresses intercellular biochemical signaling. (lu.se)
  • Department of Biology, University of California at San Diego, La Jolla 92093-0357, USA. (jneurosci.org)
  • Dear colleague, I have a pleasure of announcing a Special Interest Subgroup Meeting on CALRETICULIN during the International Congress of Cell Biology & American Society for Cell Biology Conference in San Francisco, CA, USA. (bio.net)
  • The Ca Signal from Fura-2 Loaded Mast Cells Depends Strongly on the Method of Dye-loading. (dojindo.com)
  • Pretreating differentiated mouse skeletal myotubes (C2C12 cells) with F13 blunted the amplitudes of ryanodine- and K(+)-induced Ca(2+) transients. (cdc.gov)
  • Optical imaging of live cells in cultures and tissue preparations to monitor intracellular Ca 2+ fluctuations and to identify population of interest. (lu.se)
  • In particular, control of the activity of intracellular Ca2+ release. (justia.com)
  • The present invention relates to control of the function of intracellular Ca 2+ release. (justia.com)
  • The released inositol-1,4,5-triphosphate (IP3) binds to an IP 3 receptor (IP 3 R) residing on the surface of an endoplasmic reticulum of a cell and release Ca 2+ stored in endoplasmic reticula into the cytoplasm, thereby activating a variety of Ca 2+ dependent enzymes. (justia.com)
  • However, the Ca(2+) release evoked by the second agonist was unaffected by prior stimulation with the first. (cam.ac.uk)
  • Mg ++ ] e dose-dependently reduced basal and agonist-induced [Ca ++ ] i responses. (aspetjournals.org)
  • In 2002, a California county health department reported three cases of TB disease occurring in association with infliximab therapy. (cdc.gov)
  • In 2003, the state of California Department of Health Services asked local jurisdictions to report TB cases associated with TNF-α antagonists since January 2002. (cdc.gov)
  • For PCR testing, samples were shipped (US Department of Agriculture import permit no. 13846) to the Intracellular Pathogens Research Laboratory, Center for Comparative Medicine and Translational Research, North Carolina State University, College of Veterinary Medicine. (cdc.gov)
  • Previously, we demonstrated in hippocampal slices from immature rats that OGD induced an immediate increase in intracellular Cl - ( Inglefield and Schwartz-Bloom, 1998a ). (jneurosci.org)
  • An increase in intracellular Ca 2+ is well established, but there are few studies of changes in intracellular Cl - ([Cl - ] i ) after ischemia. (jneurosci.org)
  • The meeting was organized by Peter St George-Hyslop (who is moving from the University of Toronto, Canada, to the University of Cambridge, U.K.), William Mobley (Stanford University School of Medicine, Palo Alto, California), and Yves Christen (Fondation IPSEN, Paris). (alzforum.org)
  • Download instantly Intracellular Delivery II - Fundamentals and Applications by Ales Prokop, Yasuhiko Iwasaki, Atsushi Harada. (booksca.ca)