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  • interactions
  • Yet, ApV-ER interactions were unhindered in cells in which Rab10 had been knocked down, demonstrating that the GTPase is dispensable for the bacterium to parasitize the ER. (frontiersin.org)
  • replication
  • We characterized the FPI mutant Δ pdpC of the live vaccine strain (LVS) of F . tularensis and found that it exhibited lack of intracellular replication, incomplete phagosomal escape, and marked attenuation in the mouse model, however, unlike a phagosomally contained FPI mutant, it triggered secretion of IL-1β, albeit lower than LVS, and markedly induced LDH release. (biomedcentral.com)
  • Protein
  • Alternatively, the green fluorescent protein (GFP) and its variants can be applied as genetically encoded intracellular probes that are specifically expressed and can be selectively targeted within defined cells and tissues. (pubmedcentralcanada.ca)
  • How uropathogenic E. coli use a copper-binding protein to treat copper as a nutrient or a toxin, and Antarctic soil bacteria that survive on trace atmospheric gases. (asm.org)
  • By binding to a cell surface receptor composed of IFN-α receptor 1 (IFNAR1) and IFNAR2 chains, IFN-α/β generate an intracellular signal, which is relayed to the receptor-associated Janus protein tyrosine kinases Janus kinase 1 and Tyk2. (jimmunol.org)
  • Dependency
  • Our approach is innovative, because cholesterol dependency of bacteria has not been used as a basis for the development of interventions. (grantome.com)
  • genes
  • DNA microarrays are widely used for transcription profiling of arthropod-borne bacteria in response to different environmental changes and provide a more comprehensive screen for differentially expressed genes. (beds.ac.uk)
  • A fungus destroying salamanders in Europe, and genes for flagella in intracellular bacteria. (asm.org)
  • innate
  • How intracellular bacteria survive: surface modifications that promote resistance to host innate immune responses. (nih.gov)
  • These findings indicate that host innate immune responses to bacterial DNA may contribute to the induction of protective immunity to bacteria and the subsequent development of memory. (jimmunol.org)
  • determinant
  • Although it is known that cholesterol is essential for this bacterium, and cholesterol is a critical determinant of HGA pathogenesis, how this bacterium acquires cholesterol is unknown. (grantome.com)
  • Thus
  • They have thus been the subject of extensive studies aimed to clarify how they evolve and whether their patterns of divergence are informative about the biology of host-bacteria dynamics. (beds.ac.uk)
  • Thus, the HGE bacterium specifically bound to fucosylated leukocyte PSGL-1. (sciencemag.org)
  • survive
  • This episode is all about saliva: how certain bacteria survive in it, and how swallowing saliva might cause intestinal inflammation. (asm.org)
  • phenotype
  • Gasset-Rosa F, Coquel AS, Moreno-del Álamo M et al (2014) Direct assessment in bacteria of prionoid propagation and phenotype selection by Hsp70 chaperone. (springer.com)
  • coli
  • Although bacteria such as E. coli and P. aeruginosa are termed noninvasive, they frequently spread rapidly to various tissues once they gain access to the body. (microbeonline.com)
  • In this context, at least two 'passive' GFP-based oxygen sensors have been developed for estimating intracellular oxygen levels in E. coli . (pubmedcentralcanada.ca)
  • species
  • The versatility of this medium should encourage its use as a replacement for the cell-based culture systems currently used for growing several facultative and putative intracellular bacterial species. (ird.fr)
  • The objectives of this research were to determine the effect of lactic acid and low pH on the intracellular pH in three species of lactic acid bacteria. (unl.edu)
  • bladder
  • This would take some of the forces off the adhesive molecules that are attached to the bladder, and help the bacteria to remain in place when urine flows out. (elifesciences.org)
  • chromosome
  • From Indiana University, Vincent speaks with Ankur, Julia, and Xindan about their careers and their work on horizontal gene transfer, quorum sensing, and chromosome organization in bacteria. (asm.org)
  • For the first time within the Chlamydiales order, a CRISPR system, the immune system of bacteria, was discovered on the chromosome. (haldanessieve.org)
  • concentration
  • Conventional leukocyte esterase and nitrite dipstick tests, and microscopic pyuria counts (in 1 μl), ATP concentration measurements, and identification of intracellular bacteria in shed urothelial cells, were performed on fresh unspun samples and compared to 'gold-standard' bacterial culture results. (springeropen.com)
  • A significant association of the 'gold-standard' test with urinary ATP concentration combined with visualization of intracellular bacteria in shed urothelial cells was determined using the Fisher's exact test. (springeropen.com)
  • molecular
  • The experiments show that pili with certain mutations in these units unwind much more easily when the bacteria carrying them are 'tugged on' with molecular tweezers. (elifesciences.org)
  • whereas
  • Of the 53 RTRs, 22% were deemed to have a UTI by 'gold-standard' conventional bacteria culture, whereas 87%, 8% and 4% showed evidence of UTIs according to leukocyte esterase dipstick, nitrite dipstick, and a combination of both dipsticks, respectively. (springeropen.com)
  • indicate
  • Data from this model indicate that a specific subset of monocytes, distinguished in part by high expression of the Ly-6C antigen, become parasitized in the bone marrow and have a key role in transporting intracellular bacteria across the blood-brain barriers and into the central nervous system. (academicconcepts.net)
  • hypothesis
  • The hypothesis of the single-hit model is that bacteria act independently- independent action -and that each of the bacteria has a chance of alone invoking response (say p hit ). (royalsocietypublishing.org)
  • Our central hypothesis is that Anaplasma modulates the normal LDL- derived cholesterol (LDL-CHOL) intracellular traffic at a critical step in order to appropriate cholesterol. (grantome.com)