Intracellular antigens cd95. Medical search. Frequent questions

negative selection, in which those double-positive T cells that bind too strongly to MHC-presented self antigens undergo apoptosis because they could otherwise become autoreactive, leading to autoimmunity. (wikipedia.org)
Apoptosis -the process of programmed cell death whereby signaling through various "death receptors" on the surface of cells (e.g., tumor necrosis factor [TNF] receptors, CD95) leads to a signaling cascade that involves activation of the caspase family of molecules and leads to DNA cleavage and cell death. (mhmedical.com)
2 , 3 A key feature of apoptosis has been defined as the maintenance of an intact cellular membrane (detectable as exclusion of impermeable dyes such as propidium iodide, PI) throughout the apoptotic program to prevent intracellular protein release and subsequent immunological activation. (nature.com)
E5 impairs ligand-mediated apoptosis by reducing the amount of surface CD95 proteins or inhibiting the formation of the DISC complex [ 12 ], and affects the normal functioning of a number of membrane associated proteins, probably by modifying the composition and the interactions in the cell membranes [ 13 ]. (biomedcentral.com)
α-TEA induces apoptosis via activation of extrinsic death receptors Fas (CD95) and DR5, JNK/p73/Noxa pathways, and suppression of anti-apoptotic mediators Akt, ERK, c-FLIP and survivin in breast, ovarian and prostate cancer cells. (biomedcentral.com)

Most cytotoxic T cells express T-cell receptors (TCRs) that can recognize a specific antigen. (wikipedia.org)
Instead, the DNA in millions of white blood cells in the bone marrow is shuffled to create cells with unique receptors, each of which can bind to a different antigen. (wikipedia.org)
Immune responses by these cells are based on specific antigen recognition by clonotypic receptors that are products of genes that rearrange during development and throughout the life of the organism. (mhmedical.com)
Ligation of these receptors results either in diminution of intracellular signaling by ITIM-associated phosphatase activity for inhibitory receptors with a long cytoplasmic tail or in ITAM-associated signaling through adaptor molecules recruited by activating receptors with a short cytoplasmic tail. (ashpublications.org)
The interaction of trimeric TNFSF ligands with their specific cell surface receptors leads to clustering of these receptors, followed by intracellular signal transduction. (apogenix.com)
Assembly of the clustered receptors outside of the cell in turn leads to close proximity of their intracellular portions (3). (apogenix.com)

Park DR, Thomsen AR, Frevert CW, Pham U, Skerrett SJ, Kiener PA, Liles WC: Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macrophages. (exbio.cz)
View intracellular cytokine staining protocol. (biolegend.com)
Thus, the antigen-dependent Th responses observed in the animals immunized with different vaccines were shaped by the antigen-independent cytokine-inducing profiles of their adjuvant. (ijbs.com)

The double-positive T cells are exposed to a wide variety of self-antigens in the thymus and undergo two selection criteria: positive selection, in which those double-positive T cells that bind to foreign antigen in the presence of self MHC. (wikipedia.org)
The immune system not only has the power to respond to a foreign antigen, but it also has the amazing ability to remember it and then act quickly to a re-exposure. (flowmetric.com)

The antibody LT95 reacts with an extracellular epitope on CD95 (Fas/APO-1), a 46 kDa single chain type I glycoprotein of the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells. (exbio.cz)
Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD95 (LT95) PE-DyLight® 594 antibody (4 μl reagent / 100 μl of peripheral whole blood). (exbio.cz)
Separation of human CD95 positive T cells (red-filled) from CD95 negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD95 (LT95) PE-DyLight® 594 antibody (4 μl reagent / 100 μl of peripheral whole blood). (exbio.cz)
Inadequate antibody responses directed against bacterial polysaccharide antigens cause an increased risk for sinopulmonary infections caused by encapsulated organisms. (medscape.com)
Antibody -B cell-produced molecules encoded by genes that re-arrange during B cell development consisting of immunoglobulin heavy and light chains that together form the central component of the B cell receptor (BCR) for antigen. (mhmedical.com)
Antibody can exist as B cell-surface antigen-recognition molecules or as secreted molecules in plasma and other body fluids. (mhmedical.com)
Antigens -foreign or self-molecules that are recognized by the adaptive and innate immune systems resulting in immune cell triggering, T cell activation, and/or B cell antibody production. (mhmedical.com)
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis . (biolegend.com)
The fluorochrome-labeled 359-81-11 antibody is useful for intracellular immunofluorescent staining and flow cytometric analysis to identify LT-α -producing cells within mixed cell populations. (biolegend.com)

CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. (exbio.cz)
FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor of the TNFR (tumor necrosis factor receptor) superfamily. (thermofisher.com)

Heterogeneous antigen expression is a key barrier influencing the activity of chimeric antigen receptor (CAR) T cells in solid tumors. (nature.com)
Due to the artificial nature of drug/chemical-T-cell epitopes, it is not clear whether thymic selection of drug/chemical-specific T cells is a common phenomenon or remains limited to few donors or simply does not exist, suggesting T-cell receptor (TCR) cross-reactivity with other antigens. (frontiersin.org)
The intracellular domain of the p75 neurotrophin receptor (p75ICD) lacks catalytic activity but contains a motif similar to death domains found in the cytoplasmic regions of members of the tumor necrosis factor receptor family and their downstream targets. (embl-heidelberg.de)
An antagonist decoy receptor (designated as TRID for TRAIL receptor without an intracellular domain) that may explain the resistant phenotype of normal tissues was identified. (embl-heidelberg.de)
CD47 is a 50 kDa membrane receptor that has extracellular N-terminal IgV domain , five transmembrane domains , and a short C-terminal intracellular tail. (wikidoc.org)
Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)

Antigens inside a cell are bound to class I MHC molecules, and brought to the surface of the cell by the class I MHC molecule, where they can be recognized by the T cell. (wikipedia.org)
This activation initiates the coordinate assembly of the signalosome, composed of a variety of intracellular signaling molecules and includes BTK, phosphatidylinositol 3-kinase (PI3K), Vav and PLCγ. (biomedcentral.com)
Inositol( gp41) is a benefit and junction been for able molecules in central antigens. (erik-mill.de)
A. The linear model describes the activation of naïve T-cells by the presentation of antigen-peptide on major histocompatibility complex (MHC) molecules by the antigen presenting cells (APCs) during the contraction phase of a T-cell response. (flowmetric.com)

Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. (exbio.cz)
Antigen stimulation via BCR in normal B cells initiates phosphorylation of the immunoreceptor tyrosine-based activation motifs (ITAMs) in the cytoplasmic tails of CD79a and CD79b. (biomedcentral.com)
After antigen stimulation, these cells migrate into tissue areas that are inflamed where they exhibit a strong proliferative response and express and release cytokines that help to eliminate infection. (flowmetric.com)

We find that a structurally rigid IgG4H and CD28TM domain brings the two D4 fragments in proximity, driving CAR dimerization and leading to enhanced T-cell signaling and tumor regression in pancreatic cancer models with low antigen density in female mice. (nature.com)
Furthermore, by investigating the impact of hinge (CD8 and IgG4) and TM (CD8 and CD28) on D4 CAR T cells, we discover that IgG4H-CD28TM mediated D4 CAR dimerization, leading to enhanced T-cell signaling and tumor regression in pancreatic cancer models with low antigen density. (nature.com)
They are expressed by a wide variety of immune cells including T cells and antigen-presenting cell populations, such as dendritic cells and macrophages, as well as by tumor cells themselves. (apogenix.com)
CD8+ T-cell mediated immune responses are important in protection against various pathogens and specific tumor antigens associated with various cancers. (flowmetric.com)

This intracellular clustering allows signaling proteins (4) inside the cell to be recruited (5), thereby initiating a response from the cell. (apogenix.com)
download of been proteins appears the architectural subunit of including acids within enzymes and represents the inhibitor gene conjugation SSA to intracellular families that initiate dramatically synaptic from those short at the thyroid beta. (erik-mill.de)
It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. (thermofisher.com)

A cytotoxic T cell (also known as TC, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8+ T-cell or killer T cell) is a T lymphocyte (a type of white blood cell) that kills cancer cells, cells that are infected by intracellular pathogens (such as viruses or bacteria), or cells that are damaged in other ways. (wikipedia.org)
An antigen is a molecule capable of stimulating an immune response and is often produced by cancer cells, viruses, bacteria or intracellular signals. (wikipedia.org)
The vast majority of T cells express alpha-beta TCRs (αβ T cells), but some T cells in epithelial tissues (like the gut) express gamma-delta TCRs (gamma delta T cells), which recognize non-protein antigens. (wikipedia.org)
In this case, the cells would have been presented antigen in the context of MHC1. (wikipedia.org)
Only those T cells that bind to the MHC-self-antigen complexes weakly are positively selected. (wikipedia.org)
Those cells that survive positive and negative selection differentiate into single-positive T cells (either CD4+ or CD8+), depending on whether their TCR recognizes an MHC class I-presented antigen (CD8) or an MHC class II-presented antigen (CD4). (wikipedia.org)
Here, we develop CAR T cells targeting glypican-1 (GPC1), an oncofetal antigen expressed in pancreatic cancer. (nature.com)
Additional cells of the adaptive immune system include various types of antigen-presenting cells (APCs). (mhmedical.com)
Continuous ligation of LILRB1 modulated cellular differentiation, conferred a unique phenotype upon the resultant cells, induced a profound resistance to CD95-mediated cell death, and inhibited secretion of cytokines IL-10, IL-12p70, and TGF-β. (ashpublications.org)
During thymic selection, T cells that have not yet encountered their cognate antigen are considered naive T cells. (frontiersin.org)
Apogenix is developing asunercept , a CD95L inhibitor which blocks CD95/CD95L signaling, thus protecting activated T cells and enabling them to fight tumors. (apogenix.com)
The proportions of gut-homing T-central memory space (TCM) and TEM defined by the manifestation of α4β7 and CD95 and differential manifestation of CD28 were improved in CD4 and CD8 cells under replication proficient conditions and gut-homing CD4 TCM were also significantly improved under nonpermissive conditions. (crispr-reagents.com)
These are referred to as CD8+ memory T-cells because they 'remember' this previous encounter with the specific antigen, and they are programmed to elicit a faster and stronger immune response to that same antigen. (flowmetric.com)

Defects in CD95/Fas and Fas ligand lead to autoimmune cytopenias, lymphadenopathy, and hepatosplenomegaly. (medscape.com)
A recent addition to the list of immune checkpoint inhibitors is the CD95 ligand (CD95L). (apogenix.com)

The affinity between CD8 and the MHC molecule keeps the TC cell and the target cell bound closely together during antigen-specific activation. (wikipedia.org)

It has also been proposed that DCs are intimately involved in the prevention of inappropriate immune responses to "self"-antigens. (ashpublications.org)
CpG-2722 induced antigen-dependent T helper (Th)1 and Th17 responses, while 2'3'-c-di-AM(PS)2 induced a Th2 response. (ijbs.com)
The combination of CpG-2722 and 2'3'-c-di-AM(PS)2 generated a distinct antigen-dependent Th response profile characterized by higher Th1 and Th17, but lower Th2 responses. (ijbs.com)

Analysis of small intestine tissues shown marked variations in vRNA and Env antigen staining intensity and distribution between macaques infected with SIV-rtTAΔunder replication permissive. (crispr-reagents.com)

Recent observations raise the hypothesis that not only the drug/chemical, but also parts of the haptenated protein or peptides may constitute the important structural determinants for antigen recognition by the TCR. (frontiersin.org)

This down-regulation might result in diminished antigen-presentation and decreased adaptive immunoresponse of the host. (biomedcentral.com)

There are fewer than 30,000 genes in the human body, so it is impossible to have one gene for every antigen. (wikipedia.org)
TRID is a distinct gene product with an extracellular TRAIL-binding domain and a transmembrane domain but no intracellular signaling domain. (embl-heidelberg.de)

CAR T-cell potency is highly dependent on target antigen expression, and CARs often fail to exert their antitumor activities when antigen expression is low or below a certain threshold. (nature.com)
Maintenance of gut-homing α4+β7+ TEM (CD95+CD28-) also was dependent on replication permissivity whereas improved proportions of CD4 and CD8 α4+β7+ TCM (CD95+CD28+) were observed in SIV-rtTAΔ-infected macaques in both the continued presence of dox and following withdrawal of dox. (crispr-reagents.com)

The immune system must recognize millions of potential antigens. (wikipedia.org)

The molecular mechanisms that lead to this impaired intracellular trafficking are unknown. (biomedcentral.com)

If the TCR is specific for that antigen, it binds to the complex of the class I MHC molecule and the antigen, and the T cell destroys the cell. (wikipedia.org)

The latter are characterised by their ability to recognise antigens that are not presented. (wikipedia.org)

B-1 cells are found in peritoneal and pleural cavities where they provide first-line defence through antibodies able to bind polysaccharide antigens and repeated motifs that are typically found in microbial cell walls and macromolecules [ 2 , 3 ]. (biomedcentral.com)

If the TCR is specific for that antigen, it binds to the complex of the class I MHC molecule and the antigen, and the T cell destroys the cell. (wikipedia.org)
However, MHC-E also binds diverse foreign and neoplastic self-peptide antigens for presentation to CD8+ T cells. (shengsci.com)
It consists of 5 cadherin repeats (EC1 ~ EC5) in the extracellular domain, one transmembrane domain, and an intracellular domain that binds p120-catenin and beta-catenin . (wikidoc.org)

A cytotoxic T cell (also known as TC, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8+ T-cell or killer T cell) is a T lymphocyte (a type of white blood cell) that kills cancer cells, cells that are infected by intracellular pathogens (such as viruses or bacteria), or cells that are damaged in other ways. (wikipedia.org)
Although the determinants of MHC-E-restricted T cell priming remain unknown, these cells are induced in humans infected with pathogens containing genes that inhibit the transporter associated with antigen processing (TAP). (shengsci.com)

FasL intracellular domain: Cytoplasmic form induces gene transcription inhibition. (nih.gov)

There are fewer than 30,000 genes in the human body, so it is impossible to have one gene for every antigen. (wikipedia.org)
As a series of biomarkers, the human leukocyte antigen genes with its related proteomics play cortical roles on the antigen presentation of major histocompatibility complex molecules to stimulate the differentiation of T lymphocytes and i-proteasome activities under their immune response to the PD-related environmental alteration and genetic variation. (biomedcentral.com)

Results In MS, GA diminished transitional B-cell and plasmablast frequency, downregulated CD69, CD25, and CD95 expression, and decreased TNF-α production, whereas IL-10 secretion and MHC Class II expression were increased. (neurology.org)

35. Peptide linkage to the α-subunit of MHCII creates a stably inverted antigen presentation complex. (nih.gov)

Continuous ligation of LILRB1 modulated cellular differentiation, conferred a unique phenotype upon the resultant cells, induced a profound resistance to CD95-mediated cell death, and inhibited secretion of cytokines IL-10, IL-12p70, and TGF-β. (ashpublications.org)

Antigen presentation stimulates T cells to become either "cytotoxic" CD8+ cells or "helper" CD4+ cells . (relationship983.cfd)

The level of expression of specific antigens can be examined in each of the populations defined by FSC and SSC profiles when flow cytometry is combined with fluorescent staining using antibodies against these antigens. (medilib.ir)
Human serum usually contains natural IgG, IgM and IgA antibodies, generated independently of any exposure to foreign antigens or vaccines or elicited in the course of infectious or autoimmune diseases. (biomedcentral.com)

HN - 2010 MH - Adaptive Immunity UI - D056704 MN - G12.450.50 MS - Protection from an infectious disease agent that is mediated by B- and T- LYMPHOCYTES following exposure to specific antigen, and characterized by IMMUNOLOGIC MEMORY. (nih.gov)

It has also been proposed that DCs are intimately involved in the prevention of inappropriate immune responses to "self"-antigens. (ashpublications.org)

No intracellular components are massively dispersed in the extracellular milieu. (medscape.com)
The extracellular region of the FAS possesses three cystein-rich domains characteristic of the TNF superfamily, and the intracellular region includes a death domain (DD). (biolegend.com)

Objective We examined the effect of glatiramer acetate (GA) on B-cell maturation, differentiation, and antigen presentation in MS and experimental autoimmune encephalomyelitis (EAE). (neurology.org)

22. Modulation of antigen presentation and class II expression by a class II-associated invariant chain peptide. (nih.gov)
34. MHC class II-associated invariant chain peptide replacement by T cell epitopes: engineered invariant chain as a vehicle for directed and enhanced MHC class II antigen processing and presentation. (nih.gov)

Enhancement of sindbis virus self-replicating RNA vaccine potency by linkage of herpes simplex virus type 1 VP22 protein to antigen. (shengsci.com)

Recently, we have demonstrated that Fas antigen expression is induced by low-dose irradiation of some types of lymphomas, and we also demonstrated that irradiation-induced Fas antigen expression increased with the passage of time until peaking at 48 h after irradiation in CML-C1, CML-C2, DL-40, and DL-95 cell lines. (nih.gov)

The intracellular domain contains a highly- phosphorylated region vital to beta-catenin binding and, therefore, to E-cadherin function. (wikidoc.org)

24. Intracellular and cell surface heterotypic associations of human leukocyte antigen-DR and human invariant chain. (nih.gov)

Exons 7-9 encode the intracellular region ( 1 , 2 ). (frontiersin.org)

CD10, also called the common acute lymphoblastic leukemia antigen (CALLA) and neutral endopeptidase (NEP), is a type II integral membrane glycoprotein. (web.app)

Concerning HD-70 cell line, for which soluble Fas antigen has been identified, the killing effects were clearly observed in samples pre-treated with PBS washings. (nih.gov)

Anatomy29

Organisms10

Diseases3

Chemicals and Drugs156

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes32

Disciplines and Occupations1

Information Science3

Health Care3

Apoptosis5

Receptors6

Cytokine3

Foreign antigen2

Antibody9

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Receptor6

Molecules4

Stimulation3

Tumor4

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Cells13

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Activation1

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Tissues1

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Gene2

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Recognize1

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Polysaccharide antigens1

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FASL1

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CD691

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Lymphocytes1

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Extracellular2

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