• Two types of aquaporins are expressed in the CNS: aquaporin-1, which is expressed by specialized epithelial cells of the choroid plexus, and aquaporin-4 (AQP4), which is expressed by astrocytes. (wikipedia.org)
  • ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. (thermofisher.com)
  • While Lgr5 + cells are long-lived and act as stem cells during homeostatic conditions, experimental models have demonstrated that Lgr5 + stem cells per se are not essential for maintaining epithelial integrity 3 . (nature.com)
  • surround the apical regions of epithelial cells as in intestinal mucosa, choroid plexus, and renal tubules. (vivekkarn.com.np)
  • Mounting evidence has demonstrated that AQP4, a water channel protein, is closely correlated with brain edema and could be an optimal therapeutic target for the reduction of ischemic brain edema. (benthamscience.com)
  • AQP4 is prevalently distributed in the central nervous system, and mainly regulates water flux in brain cells under normal and pathological conditions. (benthamscience.com)
  • Clearance of soluble proteins, waste products, and excess extracellular fluid is accomplished through convective bulk flow of ISF, facilitated by astrocytic aquaporin 4 (AQP4) water channels. (wikipedia.org)
  • Of particular interest is the water channel aquaporin-4 (AQP4) which mislocalises in epilepsy. (dcu.ie)
  • Takata K, Matsuzaki T, Tajika Y. Aquaporins: water channel proteins of the cell membrane. (benthamscience.com)
  • This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. (hindawi.com)
  • This notion has been challenged by the discovery of new membrane transport functions, especially those exerted by aquaporins (AQPs), a family of membrane channel proteins widespread in nature [ 10 , 11 ]. (hindawi.com)
  • Aquaporin proteins were demonstrated to play an important regulatory role in transporting water and other small molecules. (chinaagrisci.com)
  • To better understand physiological functions of aquaporins in extremophile plants, a novel ThPIP1 gene from the Thellungiella halophila was isolated and functionally characterized in the transgenic rice. (chinaagrisci.com)
  • we previously demonstrated that aquaporin 3 (AQP3) is expressed in goblet cells and is positively correlated with GIM severity. (oncotarget.com)
  • 수분통로단백질인 aquaporin 3 (AQP3)은 백반증, 건선 등 다양한 피부 관련 질병의 발현에 중요한 역할을 한다. (e-ajbc.org)
  • Aquaporin 3 (AQP3) plays an important role in the expression of various skin-related diseases such as vitiligo and psoriasis. (e-ajbc.org)
  • Steve F. Perry ABSTRACT The present study tested the hypothesis that zebrafish ( Danio rerio ) aquaporin -1a1 (AQP1a1) serves as a multi-functional channel for the transfer of the small gaseous molecules, CO 2 and ammonia, as well as water. (silverchair.com)
  • Aquaporins are multifunctional water and solute transporters highly divergent in living organisms. (benthamscience.com)
  • This has been studied mainly in the small intestine, where different cell types such as enterocyte progenitors 4 , more differentiated secretory Bmi1 + cells 3 , or even fully differentiated Paneth cells can repopulate crypts upon injury. (nature.com)
  • Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport. (gu.se)
  • Yang B, Ma T, Verkman A. cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel evidence for distinct transcriptional units. (benthamscience.com)
  • Soluble fiber absorbs water to form a gel, which can aid the formation of softer stools to ease constipation. (healthline.com)
  • Soluble fiber, such as that in chia seeds, absorbs water in the gut to form a gel-like substance that helps soften stools. (healthline.com)
  • Soluble fiber absorbs water and forms a gel-like consistency. (healthline.com)
  • The enterohepatic cycling of some drugs is dependent on intestinal bacteria that hydrolyze drug conjugates excreted by the bile and thereby enable the more lipid-soluble parent compound to be reabsorbed into the circulation. (spiritsong.org)
  • alpha of the intestinal rRNA, soluble to the density-fluctuation of bacterium requirements, domains in vasodilator of microenvironment from its domain. (erik-mill.de)
  • Igarashi H, Huber VJ, Tsujita M, Nakada T. Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. (benthamscience.com)
  • Aquaporins are membrane-bound channels that play critical roles in regulating the flux of water into and out of cells. (wikipedia.org)
  • Membrane enriched extracts (40 µg lysate) of Caco-2 (Lane 1), Caco-2 treated with IFN Gamma (50 ng/mL for 24hrs) (Lane 2), A-431 (Lane 3), HEL 92.1.7 (Lane 4) and Jurkat (Lane 5). (thermofisher.com)
  • These help the colon retain more water, increasing the frequency of bowel movements. (healthline.com)
  • Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues. (benthamscience.com)
  • It may help pull water into the colon and cause a laxative effect in a small number of people. (healthline.com)
  • Insoluble fiber does not absorb water but moves through the body intact, increasing the bulk of stool for easier passage. (healthline.com)
  • S. Tanaka SUMMARY The ventral pelvic skin of the tree frog Hyla japonica expresses two kinds of arginine vasotocin (AVT)-stimulated aquaporins (AQP-h2 and AQP-h3), which affect the capacity of the frog's skin to absorb water. (silverchair.com)
  • He studied the gradient of "irritability" of small intestinal muscle, reflecting the frequency and amplitude of contractions (2). (mayo.edu)
  • Coconut water is rich in carbohydrates and electrolytes such as potassium, sodium, and magnesium. (medlineplus.gov)
  • The brain water content, oxidative stress, transvascular leakage and pro-inflammatory parameters were examined at these different durations. (turmericforhealth.com)
  • The incubation and fledging durations 23±3 days 43±6 days (Medway 1957;Langham 1980;Lim 2002) Swiftlets engage in yearround breeding activities between the months of October and February (Langham 1980) Construction of a single nest by swiftlets typically requires around 30-45 days during the breeding season, but in the nonbreeding season, this process takes approximately 60-80 days (Aowphol et al. (researchgate.net)
  • This reaction continues to move to the left as long as CO 2 is constantly eliminated or until HCO 3 - is significantly depleted, making less HCO 3 - available to bind H + . That HCO 3 - and PaCO 2 can be managed independently (kidneys and lungs, respectively) makes this a very effective buffering system. (medscape.com)
  • Researchers have long known that astrocytes express water channels called aquaporins. (wikipedia.org)
  • Evidence from animal studies suggests that aquaporin channels that regulate IWL are developmentally regulated. (medscape.com)
  • Aquaporin-4 expression in astrocytes is highly polarized to the endfoot processes ensheathing the cerebral vasculature. (wikipedia.org)
  • The insoluble fiber in prunes, known as cellulose , may increase the amount of water in the stool, which can add bulk. (healthline.com)
  • The kidneys regenerate the HCO 3 - consumed during this reaction. (medscape.com)
  • Methylation error has been linked to high cholesterol, Melatonin deficiency (waking up at around 3 AM), and Estrogen dominance (family history of uterine fibroids, breast cancer, and/or fibroids). (joyfullivingservices.com)
  • GPxs are members of a multiple-isozyme family that catalyze the reduction of H 2 O 2 or organic hydroperoxides to generate water or corresponding alcohols using reduced glutathione (GSH) as an electron donor [ 11 ]. (biomedcentral.com)
  • Strawberries contain 1.8 grams of fiber per 3/4 cup (100 grams), blueberries provide 3.6 grams of fiber per cup (150 grams), and blackberries boast just under 8 grams of fiber per cup (150 grams). (healthline.com)
  • One 1/4-cup (40-gram) serving contains nearly 3 grams of fiber. (healthline.com)
  • A PubMed search identifies 225 articles, with the first being a paper in the California State Journal of Medicine on "Intestinal Indigestion in Adults" and the last, an editorial published when he was 90 years old entitled "The Folly of Retirement at Age 65" (8). (mayo.edu)
  • Structural diversity-driven synthesis of cycloalkane-based heterocycles and 1,3-bifunctional compounds. (u-szeged.hu)
  • 2 3 4 5 6 ] However, a more recent population-based survey conducted in urban Mangalore has shown a prevalence of 8.3/100,000 for MS and 2.6/100,000 for neuromyelitis optic spectrum diseases (NMOSD). (lww.com)
  • During this multistep procession, gastric intestinal metaplasia (GIM) is considered to be a precancerous lesion of GC and to play a pivotal role in GC tumorigenesis [ 4 , 5 ]. (oncotarget.com)
  • Role of aquaporin-4 in cerebral edema and stroke. (benthamscience.com)
  • Vella J, Zammit C, Di Giovanni G, Muscat R, Valentino M. The central role of aquaporins in the pathophysiology of ischemic stroke. (benthamscience.com)
  • It consists mostly of water lost via evaporation through the skin (two thirds) or respiratory tract (one third). (medscape.com)
  • Unlike these drugs which can cause side effects like ulcers or intestinal bleeding with long term use, curcumin does not demonstrate any side effects. (turmericforhealth.com)
  • Hydrochloric acid (HCl) is considered a strong acid because it is present only in a completely ionized form in the body, whereas carbonic acid (H 2 CO 3 ) is a weak acid because it is ionized incompletely, and, at equilibrium, all three reactants are present in body fluids. (medscape.com)
  • These increase the amount of water absorbed by stools to make them softer and easier to pass. (healthline.com)
  • Sixteen patients with intestinal-type GC were enrolled in this study. (oncotarget.com)
  • There isn't enough reliable information to know if coconut water is safe to use as medicine when pregnant or breast-feeding. (medlineplus.gov)
  • Excessive accumulation of brain water content causes a gradual expansion of brain parenchyma, decreased blood flow and increased intracranial pressure and, ultimately, cerebral herniation and death. (benthamscience.com)
  • Small for gestational age (SGA) preterm infants may also have a particularly high body water content (90% for SGA infants vs 84% for appropriate for gestational age [AGA] infants at 25-30 weeks' gestation). (medscape.com)
  • These move through the body undigested, absorbing water and swelling to form stools. (healthline.com)
  • The skin, as well as many other organs in the amphibian body, has undergone the most extensive rearrangement in the adaptation from water to land. (mdpi.com)
  • The percentage of the body composed of water is higher for a term neonate than it is for an adult, with a newborn being 75% water (40% ECF, 35% ICF) and an adult being 60% water (20% ECF, 40% ICF). (medscape.com)
  • We aim to procure extensive and updated information on the evolutionary history of amphibians and their transition from water to land-that is, the changes seen in their skin from the larval stages to adulthood from the points of morphology, physiology, and immunology. (mdpi.com)
  • So far, it is well recognized that a multistep process is involved in the progression from normal gastric mucosa to intestinal-type GC, including chronic gastritis, chronic atrophic gastritis, intestinal metaplasia, dysplasia and invasive carcinoma, which was originally proposed by Correa [ 2 , 3 ]. (oncotarget.com)