IntestinesIntestinal AbsorptionCytochrome P-450 CYP3ABiological AvailabilityOxidoreductases, N-DemethylatingGlucuronidesEnterocytesIntestine, SmallKetoconazoleBiotransformationJejunumMicrosomesGlucuronosyltransferaseCytochrome P-450 Enzyme SystemCaco-2 CellsMicrosomes, LiverP-GlycoproteinLiverAdministration, OralArea Under CurveIntestinal MucosaSwineDrug InteractionsRats, Sprague-DawleyEnergy MetabolismLipid MetabolismMetabolismGlucoseGlycolysisOxidation-ReductionMetabolic Networks and PathwaysMetabolism, Inborn ErrorsFatty AcidsChromatography, High Pressure LiquidKineticsOxygen ConsumptionCarbon IsotopesCarbon RadioisotopesLactic AcidModels, BiologicalInsulinCarbonLactatesCitric Acid CycleAryl Hydrocarbon HydroxylasesAcetatesNitrogenMagnetic Resonance SpectroscopyTriglyceridesCholesterolTime FactorsBlood GlucoseMolecular Sequence DataHydroxylationPyruvic AcidBrainLipidsMitochondriaBasal MetabolismRNA, MessengerCarbon DioxideCells, CulturedRats, Inbred StrainsGene Expression ProfilingBiological TransportAdenosine TriphosphateMixed Function OxygenasesHomeostasisMutationMetabolomeOxygenMass SpectrometryPyruvatesMuscle, SkeletalLipid Metabolism DisordersSignal TransductionBody WeightAdipose TissueDietGene Expression RegulationFatty Acids, NonesterifiedTissue DistributionRats, WistarGas Chromatography-Mass SpectrometryMetabolic Clearance RateGlycerolDose-Response Relationship, DrugMice, Inbred C57BLHepatocytesMetabolic Detoxication, DrugDeoxyglucoseIronAmmoniaAnaerobiosisDealkylationPentose Phosphate PathwayIsoenzymesAerobiosisPhosphatesChromatography, Thin Layer