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  • homeostasis
  • Disturbances of the delicate balancing systems for systemic and/or local iron homeostasis are emerging as underlying causes of common hematological, metabolic and neurodegenerative diseases. (embl.de)
  • liver
  • Universal screening for hereditary hemochromatosis is not recommended, but testing should be performed in first-degree relatives of patients with classical HFE -related hemochromatosis, those with evidence of active liver disease, and patients with abnormal iron study results. (aafp.org)
  • A diagnosis of hereditary hemochromatosis should be considered in all patients with evidence of liver disease or abnormal iron study results. (aafp.org)
  • The resulting clinical manifestations of this disorder (and of other forms of iron overload) are related to the iron deposition in organs, such as the liver, pancreas, heart, and pituitary, and in the cartilage and synovial tissues of the joints. (uptodate.com)
  • Other major clinical manifestations of iron accumulation include liver disease, skin pigmentation, diabetes mellitus, impotence in males, and cardiac enlargement with or without heart failure or conduction defects ( table 1 ). (uptodate.com)
  • cells
  • Iron is essential for fundamental metabolic processes in cells and organisms. (embl.de)
  • hepcidin
  • The small hepatic peptide hormone hepcidin (Hamp, LEAP1) orchestrates these iron fluxes and controls the amount of available extracellular iron by interacting with the iron exporter ferroportin: binding of hepcidin induces ferroportin internalization and degradation, thus reducing the levels of iron in circulation. (embl.de)
  • Disruption of the Hepcidin/Ferroportin Regulatory System Causes Pulmonary Iron Overload and Restrictive Lung Disease. (embl.de)