Intestinal injury and inflammation inflammation ischemia reperfusion. Medical search. Frequent questions

To investigate the effects of hydrogen-rich saline (HRS) combined with hyperbaric oxygen (HBO) on acute lung injury (ALI) and its clinical significance. (researchsquare.com)
Excess release and over-expression of immflammatory mediators and related immflammatory cytokines could stimulate excess immflammatory reaction, resulting in damage to alvelar-cappilary membrane and increased vascular permeability and ultimately acute lung injury (ALI) [ 5 - 7 ] . (researchsquare.com)
In our experiment, adult SD rat model of acute lung injury was established by injecting lipopolysaccharide (LPS) into treachea, and life signs and dry-wet ratio of pulmonary tissue were closely observed. (researchsquare.com)

Antioxidant therapy has been suggested to be efficient in preventing or attenuating oxidative stress and hence I/R injury. (biomedcentral.com)
Curcumin protects the rat liver from chemically-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. (greenmedinfo.com)
Post-resuscitation myocardial injury is evidently due to oxidative stress, calcium overload, neutrophil accumulation, microvascular damage, and abnormal energy metabolism, among other causes. (dirjournal.org)
1,2,3 As one of the most common pathological mechanisms after the ROSC, energy metabolism disorder in the myocardium leads to a series of detrimental changes in the energy supply and substrate metabolism related to the regulation of mitochondrial function, oxidative stress, and inflammation. (dirjournal.org)
Livers treated with NMP combined with BMMSCs showed better liver function, relieved histopathological damage, reduced oxidative stress injury and ferroptosis, and the mechanism of reduction was associated with downregulation of intracellular reactive oxygen species (ROS) and free Fe²⁺ levels. (medscimonit.com)
Green tea polyphenols upregulate the Nrf2 signaling pathway and suppress oxidative stress and inflammation markers in D-galactose-induced liver aging in mice. (inventbiotech.com)

In mice, intestinal-specific Pcdh20 knockout causes defects in enterocyte proliferation and differentiation, while causing morphological abnormalities. (biomedcentral.com)
By administering a selective ATF6 activator, the impairment of intestinal barrier integrity and dysregulation of CHOP/β-catenin/p-p120-catenin pathway was reversed in Pcdh20 -ablated mice with colitis and PCDH20 -deficient colonic cell lines. (biomedcentral.com)
Specifically, the loss of PCDH20 impairs intestinal barrier function by unzipping adherens junctions in mice with colitis via targeting the ATF6/CHOP/β-catenin/p120-catenin axis. (biomedcentral.com)
Curcumin attenuates Concanavalin A-induced liver injury in mice. (greenmedinfo.com)
Curcumin protects mice from P. acnes-induced liver injury through reduction of HMGB1 cytoplasmic translocation and expression. (greenmedinfo.com)
In this study, we investigated the role and mechanism of action of TBHQ on 5-fluorouracil-induced (5-FU-induced) human intestinal epithelial cell (HIEC) injury and intestinal mucositis in mice. (biomedcentral.com)
NPC1L1 −/− mice had significant lower intestinal inflammation scores and expressed inflammatory markers p-c-Jun, p-ERK and Caspase-1 p20 lower than wild-type. (biomedcentral.com)
Intrahepatic inflammation markers and HCC-related cytokines were decreased in mice with reduced NET formation due to neutrophil elastase (NE) deletion, and liver-related symptoms of alcohol were also alleviated in NE KO mice. (researchsquare.com)

What is molecular hydrogen, and how can it reduce inflammation? (water-for-health.co.uk)
RLS-0071 was demonstrated to increase survival and reduce inflammation in a pre-clinical model of intestinal necrosis demonstrating its potential utility as a clinical therapeutic for various disease processes associated with intestinal necrosis such as intestinal infarction (i.e. ischemia reperfusion injury of intestinal tissue). (realtalifesciences.com)
Additionally, evidence has revealed that enhancing Sirt1 activity can reduce ROS production, reduce inflammation of neurons and glial cells, so as to reduce neuronal cell death ( 8 ). (frontiersin.org)
NPC1L1 knockout decreasing plasma lipid, especially cholesterol, to reduce inflammation and decreasing β-catenin, p-c-Jun and p-ERK may be involved in the mechanism. (biomedcentral.com)

Previous studies showed that Sirt1 can regulate diabetes-induced cardiac dysfunction and brain ischemic reperfusion injuries by preventing mitochondrial dysfunction and alleviating hepatic steatosis ( 2 - 4 ). (frontiersin.org)

The intestinal ischemia and reperfusion injury (intestinal-I/R) is a clinical problem associated with systemic inflammation, pulmonary microcirculation dysfunction and Acute Respiratory Distress Syndrome (ARDS). (fapesp.br)
An UCCAO caused a slight cerebral ischemia (cerebral blood flow [CBF] 70%) without hypotension (MABP 85 mmHg), systemic inflammation, multiple organs injuries, or neurological injury. (medsci.org)
An HS caused a moderate cerebral ischemia (52% of the original CBF levels), a moderate hypotension (MABP downed to 22 mmHg), systemic inflammation, and peripheral organs injuries. (medsci.org)
However, combined an UCCAO and an HS caused a severe cerebral ischemia (18% of the original CBF levels), a moderate hypotension (MABP downed to 17 mmHg), systemic inflammation, peripheral organs damage, and neurological injury, which can be attenuated by whole body cooling. (medsci.org)

Intestinal ischemia-reperfusion (IR) injury is a consequence of acute mesenteric ischemia, caused by inadequate blood flow through the mesenteric vessels, resulting in intestinal damage. (uthscsa.edu)

Ischemia/reperfusion (I/R) injury during small intestinal transplantation (SITx) frequently causes complications including dysmotility, inflammation and organ failure. (elsevierpure.com)

This model of intestinal IR injury can be utilized to study the cellular and molecular mechanisms of injury and regeneration. (uthscsa.edu)
The TNF?ARE Mouse as a Model of Intestinal Fibrosis. (ucdenver.edu)
Dr. Kumar is the presenting author of "RLS-0071 improves survival in rat model of intestinal necrosis" in the Microbial Pathogens session. (realtalifesciences.com)
We established a cell model of HIEC injury and a mouse model of intestinal mucositis via treatment with 5-FU. (biomedcentral.com)

Intestinal ischemia is a life-threatening condition associated with a broad range of clinical conditions including atherosclerosis, thrombosis, hypotension, necrotizing enterocolitis, bowel transplantation, trauma and chronic inflammation. (uthscsa.edu)
Polarization of macrophage and its significance in acute rejection after intestinal transplantation[J]. ORGAN TRANSPLANTATION. (organtranspl.com)
Objective To investigate the changes of macrophage polarization during acute rejection (AR) after intestinal transplantation. (organtranspl.com)
Results HE staining and TUNEL assay showed that the intestinal epithelial morphology and structure were normal and no evident apoptotic bodies were found in the sham operation and syngeneic transplantation groups. (organtranspl.com)
At 7 d after transplantation, the epithelial villi structure of intestinal graft tissues was severely damaged, the number of crypts was decreased, the number of apoptotic bodies was increased, and inflammatory cells infiltrated into the whole intestinal wall, manifested with moderate to severe AR in the allogeneic transplantation group. (organtranspl.com)

Curcumin and saikosaponin A inhibit chemical-induced liver inflammation and fibrosis in rats. (greenmedinfo.com)

1. We revealed roles of intestinal CD169-positive macrophages in colitis, and identified the transcriptional factor regulating the function of these macrophages. (nii.ac.jp)
Surface markers of M1 and M2 macrophages of intestinal graft tissues in each group were co-localized and counted by immunofluorescence staining. (organtranspl.com)

Additionally, CGRP might be important in processes such as control of fetoplacental vascular tone, regulation of calcium metabolism and insulin secretion, acetylcholine receptor synthesis, peripheral nerve regeneration, and neurogenic inflammation. (bachem.com)
Augmenter of liver regeneration ameliorates ischemia-reperfusion injury in steatotic liver via inhibition of the TLR4/NF-κB pathway. (inventbiotech.com)

Ischemia-reperfusion (I/R) injury occurs when the blood supply returns (reperfusion) to a tissue that temporarily has been deprived of blood supply (ischemia) and triggers an intense inflammatory response [ 1 ]. (biomedcentral.com)
ARDS is a form of acute pulmonary injury characterized by tissue and microvascular injury. (fapesp.br)
It is clear from these studies that ferroptosis involves multiple types of tissue injury and inflammation. (biomedcentral.com)

Resveratrol sustains intestinal barrier integrity, improves antioxidant capacity, and alleviates inflammation in the jejunum of ducks exposed to acute heat stress. (inventbiotech.com)

In this study primary cultures of endothelial cells will be established and kept in contact with neutrophils of I/R-intestinal rats. (fapesp.br)
Curcumin has a protective effect on experimentally induced inflammation, hepatotoxicity and cardiotoxicity in rats. (greenmedinfo.com)
Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats. (inventbiotech.com)

Curcumin treatment attenuates lipopolysaccharide induced liver injury. (greenmedinfo.com)
Curcumin treatment attenuates liver lesions induced by intestinal ischemia/reperfusion. (greenmedinfo.com)
PPAR γ Alleviates Sepsis-Induced Liver Injury by Inhibiting Hepatocyte Pyroptosis via Inhibition of the ROS/TXNIP/NLRP3 Signaling Pathway. (nih.gov)
Ulinastatin protects against acetaminophen-induced liver injury by alleviating ferroptosis via the SIRT1/NRF2/HO-1 pathway. (nih.gov)
In addition, neutrophil extracellular traps (NETs) could contribute to liver injury after binge alcohol use 7 . (researchsquare.com)
showed that damage was decreased significantly when NETs were depleted in the context of bacterial-induced liver injury 11 . (researchsquare.com)

When combined with an HS, an UCCAO is associated with ischemic neuronal injury in the ipsilateral hemisphere of adult rat brain, which can be attenuated by therapeutic hypothermia. (medsci.org)

CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates inflammation and transcriptional dysregulation in Huntington's disease 2. (inventbiotech.com)

Furthermore, it influences feeding and digestion since it has been shown to decrease food intake, gastric secretion, and intestinal motility. (bachem.com)

Curcumin and capsaicin treatments attenuated hepatic fat accumulation and increased leptin levels related to inflammation. (greenmedinfo.com)

Vasoactive intestinal peptide(VIP) has demonstrated immunomodulatory properties in autoimmune murine and ex vivo human models. (phoenixpeptide.com)

Ischemia-reperfusion (I/R) in the intestines is an inflammatory condition which activates leukocytes and reactive oxygen species (ROS) and leads to lipid peroxidation and DNA damage. (biomedcentral.com)
After hypoxia and ischemia, the production of reactive oxygen species (ROS) rapidly accumulates and leads to mitochondrial dysfunction and delayed neuronal death. (frontiersin.org)

There is an ever-increasing body of evidence supporting the effectiveness of molecular hydrogen with overall inflammation in the body, as well as playing a role in various diseases and infection. (water-for-health.co.uk)
The anti-inflammatory action of molecular hydrogen, along with its other capabilities, has the potential to positively affect various diseases, including metabolic syndrome, cardiovascular disease and organ injury. (water-for-health.co.uk)
Hydrogen produced in the colon may also help to improve intestinal motor function, reducing food transit time, preventing constipation. (water-for-health.co.uk)
Hydrogen inhalation significantly ameliorates intestinal transplant injury and prevents remote organ inflammation via its antioxidant effects. (elsevierpure.com)
Administration of perioperative hydrogen gas may be a potent and clinically applicable therapeutic strategy for intestinal I/R injury. (elsevierpure.com)

Acute inflammation is your body's natural way of healing and repairing itself when it comes into contact with a harmful pathogen (bacteria or virus), allergens (from food, pollen, dust etc.), or you have an injury. (water-for-health.co.uk)
Many factors such as enteric #infection , #antibiotics , low-fiber diets, #circadian rhythm disruption, and psychological #stress can affect gut barrier integrity and lead to systemic, low-grade #inflammation due to translocation of bacteria and their components. (ojcius.net)
The gut barrier consists of the mucus layer, commensal bacteria, epithelial cells, and immune cells residing in the lamina propria (see Glossary ) ( Figure 1 A). In the intestinal epithelium, goblet cells secrete mucus glycoproteins that prevent direct contact between gut microbes and colonocytes [ 2 ], while the mucus in the small intestine is loose and allows passage of bacteria [ 3 ]. (ojcius.net)
BACKGROUND/AIMS: Nucleotide-binding oligomerization domain 1 (NOD1) is required for primary intestinal epithelial cells (IECs) to respond to natural mucopeptides secreted by gram-negative bacteria. (koreamed.org)
Removal of intestinal bacteria with antibiotics led to decreases in markers of NETs formation and inflammatory cytokines upon chronic alcohol consumption, and genesis of alcoholic hepatosteatosis and HCC was also attenuated. (researchsquare.com)

Intestinal barrier dysfunction plays a central role in the pathological onset of Crohn's disease. (biomedcentral.com)
PCDH20 is an essential factor in maintaining intestinal epithelial homeostasis and barrier integrity. (biomedcentral.com)
Destruction of intestinal barrier integrity is one of the first phases of CD pathogenesis [ 2 ], while its repair is the final, yet most important, phase of mucosal healing in CD treatment [ 3 ]. (biomedcentral.com)
The apical junctional complex comprises tight junctions, adhesion junctions, and desmosomes, which seal adjacent cells, regulate paracellular transportation, and maintain intestinal barrier function, acting as a dynamic mechanical barrier [ 5 ]. (biomedcentral.com)
The intestinal barrier protects the host against gut microbes, food antigens, and toxins present in the gastrointestinal tract. (ojcius.net)
Chronic disruption of the gut barrier can lead to translocation of microbial components into the body, producing systemic, low-grade inflammation. (ojcius.net)
While the association between gut barrier integrity and inflammation in intestinal diseases is well established, we review here recent studies indicating that the gut barrier and microbiota dysbiosis may contribute to the development of metabolic, autoimmune, and aging-related disorders. (ojcius.net)
When sequestered into the lumen, microbe-associated molecular patterns (MAMPs) such as flagellin, lipopolysaccharide (LPS), and peptidoglycan strengthen the gut barrier by binding to Toll-like receptors (TLRs) on the apical surface of intestinal cells to induce production of antimicrobial proteins [ 5 ]. (ojcius.net)

Inflammation of the COLON due to colonic ISCHEMIA resulting from alterations in systemic circulation or local vasculature. (bvsalud.org)

Recently we showed that the magnitude of the inflammation and the pulmonary microvascular injury caused by the intestinal-I/R is modulated by factors drained from lymph of the mesenteric system. (fapesp.br)
This is achieved by inducing ischemia in the region of the distal ileum by temporally occluding the peripheral and terminal collateral branches of the superior mesenteric artery for 60 min using microvascular clips. (uthscsa.edu)

12 ] found that ferroptosis is involved in intestinal epithelial cell death in ulcerative colitis and suggested it as a potential therapeutic target for that disease. (biomedcentral.com)

Although neutrophils exert a pivotal role in this disorder, a definitive pharmacological approach to ARDS treatment is yet unavailable probably due the complexity of mechanisms involved to pulmonary inflammation. (fapesp.br)

At postoperative 7 d, the intestinal graft tissues in all groups were collected for hematoxylin-eosin (HE) staining and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay. (organtranspl.com)

Brain edema primarily occurs as a consequence of various cerebral injuries including ischemic stroke. (benthamscience.com)

The patients with SSNHL may benefit from investigating markers related to inflammation. (bvsalud.org)

HBOT could obviously enhance aterial oxygen level, increase partial pressure of oxygen and improve ischemia in various organs or tissues, decrease acid metabolites and hasten functional recovery of various organs. (researchsquare.com)

I/R-injury was induced by holding superior mesenteric artery clamped for 30 minutes followed by reperfusion for 240 minutes. (biomedcentral.com)

Necrotizing enterocolitis (NEC), which typically occurs in the second to third week of life in premature, formula-fed infants, is characterized by variable damage to the intestinal tract, ranging from mucosal injury to full-thickness necrosis and perforation (see the image below). (medscape.com)
This data demonstrates that immunomodulation of the complement system and neutrophil effectors by RLS-0071 may have utility as a therapeutic for the treatment of intestinal necrosis in humans. (realtalifesciences.com)
PURPOSE: To research the effects of iloprost (IL) and hyperbaric oxygen (HBO) combination treatment on lung injury and on tumor necrosis factor alpha (TNF-Î±), myeloperoxidase (MPO), malondialdehyde (MDA), and soluble. (koreamed.org)

This study aimed to investigate whether resuscitation after a hemorrhagic shock (HS) and/or mild cerebral ischemia caused by a unilateral common carotid artery occlusion (UCCAO) can cause brain injury and concomitant neurological dysfunction, and explore the potential mechanisms. (medsci.org)
However, it is not known whether resuscitation after a [ 10 - 12 ] HS can cause cerebral injury and concomitant neurological dysfunction, and its potential mechanisms. (medsci.org)

Intestinal-specific deletion of Pcdh20 damages epithelial cell proliferation and differentiation and causes morphological changes, including shortened crypts and microvilli. (biomedcentral.com)

AhR ligands derived from food, environmental contaminants and intestinal microbiota strategically activated AhR signaling and regulated multiple stages of cancer. (bvsalud.org)

EP4 also interacts with Prostaglandin E receptor 4-associated protein (EPRAP) to inhibit phosphorylation of the proteasome protein, p105, thereby suppressing a cells ability to activate nuclear factor kappa B, a transcription factor that controls genes coding for cytokines and other elements that regulate inflammation, cell growth, and cell survival (see NF-κB#Structure). (wikipedia.org)

A resuscitation from an HS regards as a reperfusion insult which may induce neurological injury in patients with an UCCAO disease. (medsci.org)

The resuscitation after an HS causes a reperfusion or reoxygenation insult [ 2 - 4 ], gut injury, and multiple organ dysfunctions [ 5 , 6 ]. (medsci.org)

The commercial information included with the device recommends the consumption of 1-1.5 L of water per day, not only for gastro-intestinal disorders but also for numerous other illnesses such as diabetes, cancer, inflammation , etc. (mdpi.com)
showed that EX527 could increase ROS production by inhibiting Sirt1 activity, which aggravates myocardial injuries caused by diabetes ( 15 ). (frontiersin.org)

At the same time, the effect of the intestinal-I/R after longer periods of reperfusion (1, 3 and 5 days) on the pulmonary injury and the regulating mechanisms of the pulmonary tecidual repair will be analyzed. (fapesp.br)
The mechanisms of IR injury are complex and poorly understood. (uthscsa.edu)
Hypoxic ischemia (HI) involves multiple mechanisms, but the detailed pathogenesis is still unclear. (frontiersin.org)

Inflamación del COLON debida a ISQUEMIA cólica por alteraciones en la circulación sistémica o vascularización local. (bvsalud.org)

If severe enough, this inflammatory response may result not only in local but also in distant organ injury. (biomedcentral.com)

TBHQ attenuates ferroptosis in 5-FU-induced intestinal mucositis, making it a potential novel protective agent against intestinal mucositis. (biomedcentral.com)

Issues arise when for various reasons, you develop low-level chronic (longer lasting) inflammation which can lead to an increased risk of infection and disease. (water-for-health.co.uk)

Polytrauma can be defined as a combination of multiple, simultaneous injuries to more than one body part or organ system. (medsci.org)
Penetrating injuries may or may not penetrate the peritoneum and, even if they do, they may not cause organ injury. (msdmanuals.com)

We previously reported that early arthritis (EA) patients with low vasoactive intestinal peptide (VIP) serum levels demonstrate a worse clinical disease course. (phoenixpeptide.com)
Therefore, it is crucial in the clinical setting to detect myocardial metabolism conditions in real-time to evaluate the latent cardiac injury and make optimum treatment plans during the ROSC. (dirjournal.org)

Anatomy29

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Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes39

Disciplines and Occupations1

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Reduce inflammation4

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