• Influence of Ketotifen, Cromolyn Sodium, and Compound 48/80 on the survival rates after intestinal ischemia reperfusion injury in rats. (medscape.com)
  • In the present study, we have examined the molecular and functional variations of ileum P-glycoprotein using rats after ischemia-reperfusion treatment. (elsevierpure.com)
  • Aim To investigate the effects of hydrogen-rich saline (HRS) on intestinal epithelial tight junction (TJ) barrier in rats with intestinal ischemia-reperfusion injury (IIRI). (hydrogenstudies.com)
  • Methods Seven male Wistar rats were subjected to 90 minutes of partial 70% liver ischemia and topic liver 26°C hypothermia (H group). (bvsalud.org)
  • Other seven male Wistar rats were subjected to 90 minutes of partial 70% normothermic liver ischemia (N group). (bvsalud.org)
  • Five additional rats underwent a midline incision and section of liver ligaments under normothermic conditions and without any liver ischemia (sham group). (bvsalud.org)
  • Both in Hannover and Homburg he initiated important research projects to minimize bronchial complications and to minimize ischemia-reperfusion injury after lung transplantation. (wikipedia.org)
  • Ischemia-reperfusion injury is an unavoidable problem for organ transplantation including small bowel transplantation, and causes a large intra-individual variation of tacrolimus (FK506) pharmacokinetics. (elsevierpure.com)
  • 14. Intravoxel Incoherent Motion and Dynamic Contrast-Enhanced Magnetic Resonance Imaging to Early Detect Tissue Injury and Microcirculation Alteration in Hepatic Injury Induced by Intestinal Ischemia-Reperfusion in a Rat Model. (nih.gov)
  • Necrotizing enterocolitis (NEC), which typically occurs in the second to third week of life in premature, formula-fed infants, is characterized by variable damage to the intestinal tract, ranging from mucosal injury to full-thickness necrosis and perforation (see the image below). (medscape.com)
  • Observations that nitric oxide (NO) plays a key role in ischemia preconditioning compelled us to postulate that the neuroprotective effect of PHB could be regulated by NO. Here, we test this hypothesis in a neuronal model of ischemia-reperfusion injury and show that NO and PHB are mutually required for neuronal resilience against oxygen and glucose deprivation stress. (jneurosci.org)
  • Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work? (hindawi.com)
  • This is potentiated by the incompletely understood ischemia-reperfusion injury (IRI). (hindawi.com)
  • Although a large number of drugs and agents (including Ca 2+ -channel blockers, mannitol, acadesine, adenosine, Na + /H + -exchange inhibitors, and N-acetylcysteine (an antioxidant)) have been shown to protect against ischemia-reperfusion injury (IRI) in the kidney in vitro and in vivo (in either rat or mouse), all have failed in either large animal or human trials [ 5 - 8 ]. (hindawi.com)
  • I am interested in the role played by complememt in various types of kidney injury including, glomerular disease, interstitial inflammation and ischaemia reperfusion injury. (ncl.ac.uk)
  • Objective: Sepsis-associated intestinal injury has a higher morbidity and mortality in patients with sepsis, but there is still no effective treatment. (hydrogenstudies.com)
  • The injury an organ sustains during recovery, preservation, and transplantation occurs primarily as a result of ischemia and hypothermia. (medscape.com)
  • The purpose of this review is to summarise recent findings on complement activation and acquired brain or spinal cord injury, i.e. ischaemic-reperfusion injury or stroke, traumatic brain injury (TBI) and spinal cord injury (SCI), highlighting the potential for complement-targeted therapeutics to alleviate the devastating consequences of these neurological conditions. (biomedcentral.com)
  • Injury to the central nervous system (CNS) elicits a complex series of pathophysiological events, including ischaemia, excitotoxicity and inflammation. (biomedcentral.com)
  • Experimental data from both human and animal studies suggest that alcohol perturbs the intestinal barrier and its function, which is exacerbated by a "second hit" from traumatic injury. (nih.gov)
  • It is found that both chlorogenic acid and caffeic acid had effects on intestinal ischemia-reperfusion injury, and it is possible that caffeic Acid plays a major role in the protective effect of chlorogenic Acid against ischemIA-rePerfusion Injury. (typeset.io)
  • We found that both chlorogenic acid and caffeic acid had effects on intestinal ischemia-reperfusion injury. (typeset.io)
  • Since caffeic acid has a stronger antioxidant activity than that of chlorogenic acid and chlorogenic acid is hydrolyzed into caffeic acid in the intestine, it is possible that caffeic acid plays a major role in the protective effect of chlorogenic acid against ischemia-reperfusion injury. (typeset.io)
  • The complement system has been implicated in a variety of clinical conditions, from autoimmune diseases to ischemia-reperfusion injury in transplantation. (akjournals.com)
  • Interfaces 2021 Oct 13;13(40):47313-47326, Dual-Functional Dendrimer Micelles with Glycyrrhizic Acid for Anti-Inflammatory Therapy of Acute Lung Injury. (bioimagingsystem.com)
  • Disruption of the microbiome leads to changes in intestinal barrier function, which could lead to bacterial translocation and result in chronic inflammation. (metabiom.org)
  • Kucukaydin M, Kocaoğlu C, Kojdak F, Kontat O: Detection of intestinal bacterial translocation in subclinical ischemia-reperfusion using the polymerase chain reaction technique. (jpccr.eu)
  • However, while the majority of cancers are suitable for partial nephrectomy, concern about the warm ischemia time has meant that only around 25% of small kidney cancers are treated with nephron-sparing surgery [ 3 ]. (hindawi.com)
  • Current clinical data support a "safe" warm ischemia time of 25 minutes, or a cold ischemia time (when the kidney is placed on ice slush) of 35 min while up to two hours can be tolerated [ 4 ]. (hindawi.com)
  • A pharmacological agent that could reduce the risk of IRI and prolong the "safe" warm ischemia time would cause a global transformational change in the utilization of partial nephrectomy, with broader implications for renal transplantation, cardiac surgery, and the myriad other surgeries that involve IRI. (hindawi.com)
  • At 24 h after reperfusion, the ileum P-glycoprotein level was transiently increased to two-fold, and the absorption rate of dihydro-[ 3 H]FK506 from in situ ileum loop into portal vein was markedly low in comparison with the control. (elsevierpure.com)
  • nutrient and fluid digestive problems, including intestinal failure absorption and secretion (e.g., diarrhea and and obesity. (nih.gov)
  • The physiological importance of an orally administered compound depends on its availability for intestinal absorption and subsequent interaction with target tissues. (typeset.io)
  • TFR2 -related hereditary hemochromatosis ( TFR2 -HHC) is characterized by increased intestinal iron absorption resulting in iron accumulation in the liver, heart, pancreas, and endocrine organs. (nih.gov)
  • We recently presented a three-pronged association study that integrated human intestinal microbiome data derived from shotgun-based sequencing with untargeted serum metabolome data and measures of host physiology. (nature.com)
  • The use of prior knowledge to overcome functional redundancy across microbiome species is one central advance of our method over available alternative approaches. (nature.com)
  • H2 produced by the intestinal microbiome from indigestible components is the major source of exogenous H2. (hydrogenstudies.com)
  • In this study, we screened a wide variety of indigestible components that induce H2 production by the intestinal microbiome, which exhibits large diversity, and developed a beverage composed of cows' milk with galactooligosaccharide, maltitol, and glucomannan (H2-producing milk). (hydrogenstudies.com)
  • Photomicrograph showing expression of the Lgr5-lacZ reporter gene in the base of small intestinal crypts in adult mice. (nih.gov)
  • ASMase and Bax deficiency protect C57BL/6 intestinal mucosa against radiation-induced microvascular endothelial apoptosis. (justia.com)
  • ASMase deficiency protects intestinal mucosa against radiation-induced microvascular endothelial apoptosis and crypt stem cell lethality. (justia.com)
  • The intra-individual variation in the absorptive rate of tacrolimus was suggested to be regulated by the morphological status of the intestinal epithelium and enterocyte expression level of P-glycoprotein. (elsevierpure.com)
  • VCA involves transplantation of a vascularized human body part containing multiple tissues as a functional unit. (nih.gov)
  • Further research attempted to clarify the mechanisms of intestinal perfusion problems after cardiac surgery and the etiology of aortic aneurysms in the presence of congenital aortic valve malformations, in particular bicuspid aortic valves and unicuspid aortic valves. (wikipedia.org)
  • Prolonged renal ischemia may lead to irreversible nephron damage in the remaining tissue and, ultimately, chronic kidney disease. (hindawi.com)
  • Beyond this period, critical ischemia ensues, where renal cells are irreversibly injured, eventually resulting in nephron loss and chronic kidney disease in 5-17% patients [ 4 ]. (hindawi.com)
  • The gut is the largest reservoir of bacteria in the body, and under healthy conditions, it maintains a barrier preventing bacteria from translocating out of the intestinal lumen. (nih.gov)
  • The intestinal barrier is compromised following alcohol exposure, which can lead to life-threatening systemic complications including sepsis and multiple organ failure. (nih.gov)
  • 13. Evaluating the Treatment Efficacy of Nano-Drug in a Lung Cancer Model Using Advanced Functional Magnetic Resonance Imaging. (nih.gov)
  • We then used an intestinal ischemia-reperfusion model to evaluate antioxidant activities in vivo. (typeset.io)
  • This genus includes the species Akkermansia muciniphila which is known for residing in the human intestinal tract and having effects on human metabolism. (nih.gov)
  • However, the mechanisms of PHB functional regulation are still unknown. (jneurosci.org)
  • Studies have shown that metabolic diseases, such as obesity, are significantly associated with intestinal flora imbalance. (hydrogenstudies.com)
  • The amplification of opportunistic pathogens induced by the glyoxylic acid cycle contributes to intestinal flora imbalance. (hydrogenstudies.com)
  • Simon GL, Gorbach SL: Intestinal Flora in Health and Disease. (jpccr.eu)
  • Methods Patients who underwent an intestinal anastomosis during primary abdominal surgery in our tertiary referral centre between 1998 and 2018 were retrospectively included. (bmj.com)
  • The clinical overlap between functional dyspepsia and irritable bowel syndrome based on Rome III criteria. (medscape.com)
  • It is reported here for the first time that ferulic acid, which is widely used as a functional food, affects the transport of clinical agents and should be aware of the potential of food-drug interactions and to act in order to prevent undesirable and harmful clinical consequences. (typeset.io)
  • We report here for the first time that ferulic acid, which is widely used as a functional food, affects the transport of clinical agents. (typeset.io)
  • Structural analysis of U3 small nucleolar RNA of Chlamydomonas reinhardtii in vivo: functional implications. (u-szeged.hu)
  • In brain, PHB resides in mitochondria, where it forms a large protein complex with PHB2 in the inner TFmembrane, which serves as a scaffolding platform for proteins involved in mitochondrial structural and functional integrity. (jneurosci.org)
  • POLYPROTEINS to produce functional proteins and enzymes. (nih.gov)
  • Nightignale J: Intestinal Failure, London: Greenwich Medical Media Limited 2001, pp1-177. (jpccr.eu)
  • The National Cancer Institute awarded a grant for researchers to develop the nutraceutical phenolic compound as a functional food in the prevention of breast cancer. (oliveoiltimes.com)
  • Thus, our study reveals a previously unknown mechanism of functional regulation of PHB that has potential therapeutic implications for neurologic disorders. (jneurosci.org)
  • Little information is available about the regulation of the intestinal P-glycoprotein expression during tissue regeneration. (elsevierpure.com)
  • Functional enrichment analyses of the PPI network and subnetworks were subsequently carried out. (nih.gov)
  • All animals were sacrificed 24-h after reperfusion, and livers were sampled for analyses. (bvsalud.org)
  • Reduced diversity and increased virulence-gene carriage in intestinal enterobacteria of coeliac children. (medscape.com)
  • Erythromycin lacks colon prokinetic effect in children with functional gastrointestinal disorders: a retrospective study. (medscape.com)
  • Stoll B, McNelly S, Buscher HP, Ha¨ussinger D: Functional hepatocyte heterogeneity in glutamate, aspartate and a-ketoglutarate uptake: A histoautoradiographical study. (jpccr.eu)
  • 1. Monitoring Treatment Efficacy of Antiangiogenic Therapy Combined With Hypoxia-Activated Prodrugs Online Using Functional MRI. (nih.gov)
  • 5. Monitoring tumour microenvironment changes during anti-angiogenesis therapy using functional MRI. (nih.gov)
  • Polyphenols are commercially prepared and used as functional foods. (typeset.io)
  • P-glycoprotein was detected in the crypt area as well as in villous cells at 6 h after reperfusion, and then localized to the apical surface at 24 h consistent with the cell proliferation and differentiation. (elsevierpure.com)
  • This article highlights the role of alcohol-mediated alterations of the intestinal epithelia and its defense against bacteria within the gut, and the impact of alcohol on intestinal immunity, specifically on T cells and neutrophils. (nih.gov)
  • The two key factors that contribute to postoperative loss of renal function are ischemia time and degree of parenchymal loss [ 2 ]. (hindawi.com)
  • Gln and its derivatives are important factors affecting intestinal function, growth and development as a main source for energy and structure component. (jpccr.eu)
  • A reverse transcription-coupled competitive PCR and Western blot analysis revealed that the intestinal expression of P-glycoprotein recovered with time after reperfusion. (elsevierpure.com)
  • This is a time-critical step due to the critical ischemia period of renal tissue. (hindawi.com)
  • The functional significance of certain activation steps is shown in red . (biomedcentral.com)
  • Anastomotic leakage developed in 5% (22/477) of the patients, with the highest occurrence in patients with intestinal atresia (6%, 9/143). (bmj.com)
  • Ahlman B, Ljunquist O, Persson B, Bindslev L, Wernerman J: Intestinal amino acid content in critically ill patients. (jpccr.eu)