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  • abnormal
  • Dysplasias vary from an abnormal epithelium that can closely resemble the normal cells to an epithelium that is so disorganized from the architectural and cytologic point of view that malignancy is clearly evident. (aacrjournals.org)
  • treatment
  • This mechanism also explains the selection of HER2/neu (also called ERBB2) and the overexpressing (lineage-addicted) cancer cells during the process of carcinogenesis, and the efficacy of targeted therapy against the Her-2 receptor with trastuzumab ( Herceptin ) in the treatment of adenocarcinomas at the gastroesophageal junction. (wikipedia.org)
  • further
  • Preliminary data gathered from these experiments would allow us to further investigate mechanisms of stromal epithelial interaction in BE as well as identify evidence based molecular targets for the chemoprevention of neoplasia in BE and launch clinical trials for chemopreventive agents. (labome.org)
  • addition
  • In addition we will also assess stromal epithelial interaction in BE using co-culture models and attempt to block this interaction by using inhibitors of stromal derived growth factors. (labome.org)