Intestinal epithelial cells. Medical search. Frequent questions

Several functional components of the epithelium contribute to this unique role, among them the secretion of a mucus layer and life-long regeneration of the different epithelial cell types from a stem cell compartment, allowing for quick repair of barrier defects 2 . (nature.com)
alpha]9[bêta]1 was shown to be absent in mature intestinal epithelium. (usherbrooke.ca)
Binding of Trichinella spiralis C-type lectin with syndecan-1 on intestinal epithelial cells mediates larval invasion of intestinal epithelium. (bvsalud.org)
Previous studies showed that recombinant T. spiralis C-type lectin (rTsCTL) promotes larval invasion of intestinal epithelium cells (IEC), whereas anti-rTsCTL antibodies inhibits larval invasion. (bvsalud.org)
IEC expulsion was accompanied by a major actin rearrangement in neighboring cells that maintained epithelium integrity but did not absolutely require Caspase-1 or Gasdermin D. Analysis of Casp1 -/- Casp8 -/- mice revealed a functional Caspase-8 inflammasome in vivo. (elsevierpure.com)
Intestinal dysbiosis, as well as immaturity of the gut and mucosal immunity, then contribute to a loss of epithelium integrity and the translocation of microorganisms from the lumen to the peripheral blood supply. (springer.com)
Mechanisms of diarrhea production by intestinal protozoa are related to direct cytotoxic effects, the ability to invade, and/or effects of the immune response on the intestinal epithelium. (medscape.com)
A prerequisite to amebic invasion is the parasite's ability to colonize and penetrate colonic mucins overlying the intestinal epithelium. (medscape.com)
Our findings demonstrate that the presence of C. albicans is associated with upregulation of genes important for GBS colonization, adhesion and translocation in the intestinal epithelium. (groupbstrepinternational.org)
The gastrointestinal epithelium is comprised of cells that have gaps between them, making them selectively permeable and providing a barrier that keeps out pathogens, toxins, and antigens from entering the gut, while allowing the absorption of nutrients. (scienceblog.com)
We show that some recent EV-D68 isolates have decreased sensitivity to acid and temperature compared with earlier isolates and that the respiratory, but not intestinal, epithelium induces a robust type III interferon (IFN) response that restricts infection. (cdc.gov)
Our findings define the differential responses of the respiratory and intestinal epithelium to contemporary EV-D68 isolates and suggest that a subset of isolates have the potential to target both the human airway and gastrointestinal tracts. (cdc.gov)
Cells which lack ER expression at diagnosis arise from an ER compart- were harvested at 60 - 80% confluency and used as a reference in all hybrid- ment within the mammary epithelium or represent evolution from an izations. (lu.se)

The involved intestinal mucosa of UC patients in remission shows persistent histological changes suggesting that the composition and architecture of the recovered intestine is permanently altered even after inflammation has resolved. (bmj.com)
In the intestinal mucosa, several adaptations of TLR signalling have evolved to avoid chronic inflammatory responses to the presence of commensal microbes. (biomedcentral.com)
The small intestinal mucosa is maintained by a balance between cell proliferation and cell death by apoptosis. (usuhs.edu)
The results demonstrate that binding of rTsCTL to SDC-1 on Caco-2 cells activated the STAT3 pathway, decreased gut tight junction expression, damaged the integrity of the gut epithelial barrier , and mediated T. spiralis invasion of the gut mucosa . (bvsalud.org)
A major adverse effect of chemotherapy drugs is their impact on the intestinal mucosa. (biomedcentral.com)

Intestinal epithelial cells (IECs) play a key role in the inflammatory response to colonizing or invading microorganisms via the secretion of interleukin-8 (IL-8). (biomedcentral.com)
Intestinal epithelial cells (IECs) have evolved to build a complex physiological barrier that separates the intestinal lumen from the underlying mucosal tissue. (nature.com)
Increased expression of specific heat shock proteins (HSPs) in CD patients protects intestinal epithelial cells (IECs) from death. (dal.ca)
A tightly regulated balance of proliferation and cell death of intestinal epithelial cells (IECs) is essential for maintenance of gut homeostasis. (uea.ac.uk)
Genetic loss of Survivin in IECs resulted in destruction of intestinal integrity, mucosal inflammation, and death of the animals. (uea.ac.uk)
Moreover, Survivin-deficient animals showed induced phosphorylation of p53 and H2AX and increased levels of cell-intrinsic apoptosis in IECs. (uea.ac.uk)
Intestinal epithelial cells (IECs) form a critical barrier against pathogen invasion. (elsevierpure.com)

In this study, the protective effect of a fermented wheat germ extract (FWGE) against LPS-induced inflammation and oxidative stress in IPEC-J2 porcine intestinal epithelial cells was studied. (hindawi.com)
Gut health and intestinal barrier integrity could be improved and maintained with proper selection of feed additives which prevent pathogen invasion and inflammation, furthermore stimulating growth of useful microorganisms. (hindawi.com)
The findings described here improve our understanding of NF-κB functions in stem cell biology which, when deregulated, also have an impact on intestinal inflammation and tumorigenesis. (hu-berlin.de)
Examination of tissue from IEC SOCS3 knockout mice, three days post infection, showed little difference in crypt depth or inflammation but suggested an increase in cell turnover, i.e. proliferation. (lancs.ac.uk)
The exact role of DNMT3A in the context of intestinal inflammation has not been investigated so far. (nature.com)
Glutamine (Gln) promotes intestinal growth and maintains gut structure and function, especially in situations of injury and during inflammation. (hal.science)
In conclusion, T. spiralis infection and TsKaSPI can promote cell apoptosis by activating the ERS response in intestinal epithelial cells and activate the NF-κB signalling pathway to promote the occurrence and development of inflammation. (biomedcentral.com)
Inflammatory bowel diseases (IBD) are characterized by wasting and chronic intestinal inflammation triggered by various cytokine-mediated pathways. (mdpi.com)
The study is the first to show the drug, tofacitinib , also called Xeljanz, has a direct effect on cells lining the gut by correcting defects that occur in inflammation. (scienceblog.com)
McCole explained that increased intestinal permeability - or leakiness - is a feature of ulcerative colitis and plays a critical role in promoting inflammation. (scienceblog.com)
His team tested tofacitinib in human intestinal epithelial cell lines, as well as in organoids, or colonoids, that were derived from primary human colonic stem cells isolated from human subjects - primarily patients undergoing elective colonoscopy for colon cancer screening - and found tofacitinib repaired inflammation-induced permeability defects in both. (scienceblog.com)
Inflammation-induced M cells arising in response to inflammatory conditions may provide microbial access to tissues without normal M cell-associated immune surveillance tissue. (bvsalud.org)

We show that DNMT3A plays a critical role in maintaining intestinal homeostasis and gut barrier function. (nature.com)

Each small circular profile under the protozoan represents the rounded tip of a single microvillous, and it is estimated that 2000 to 3000 microvilli cover the surface of a single intestinal epithelial cell. (cdc.gov)

Then they infected laboratory mice with the self-destructing Salmonella bacteria and found that replication in the cytosol of mouse intestinal epithelial cells is important for colonization of the GI tract and fuels fecal shedding. (sciencedaily.com)

Establishing 3D organoid culture from the small intestine and using different mouse lines, we prove in the second part of the thesis that NF-kB plays an important function in cell differentiation and stem cell maintenance in vivo and in ex-vivo. (hu-berlin.de)
In summary, our results revealed a novel IEC-intrinsic role of NF-κB in cell fate decisions and differentiation which occur via regulation of Wnt signaling and Sox9 expression downstream of NF-κB. (hu-berlin.de)
Physiological shear stress enhances differentiation and mucus-formation of intestinal epithelial cells in vitro. (authorea.com)
Differentiation of a confluent monolayer of human mucus-producing epithelial HT29-MTX cells was monitored under dynamic and static culture conditions. (authorea.com)
We demonstrated the impact of culture conditions on the differentiation of HT29-MTX cells, revealing outstanding in vivo like reorganization of cells and the production of thick adherent mucus networks when cultured under physiological shear stress using our newly designed culture chamber. (authorea.com)
It was however, associated with highly proliferative cells, such as those found in the developing crypts in fetal intestine, as well as in HIEC and Caco-215 cells where, in the latter, [alpha]9[bêta]1 expression was down-regulated as the cells stopped proliferating and undertook their differentiation. (usherbrooke.ca)
This pattern of expression was reproduced in Caco-2/15 cells where [alpha]7B protein levels peaked between confluence and five days post-confluence coinciding almost perfectly with laminin-1 deposition, which was shown to be critical for triggering terminal differentiation in these cells. (usherbrooke.ca)
TET1 plays a critical role in intestinal epithelial differentiation and development, and this is also correlated with increased hydroxymethylation in terminally differentiated epithelial cells. (intechopen.com)
At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)
that regulate the differentiation and activation of these cells. (cdc.gov)

Over-expression of SOCS3 in vitro leads to decreased proliferation and reciprocally, lack of epithelial SOCS3 promotes proliferation and tumour growth in intestinal injury and cancer models. (lancs.ac.uk)
In vitro characterization revealed that the strains tolerate gastric and bile challenges and display a great adhesion capacity to human intestinal cells. (frontiersin.org)
In this article, we demonstrate that dietary fiber and short chain fatty acids (SCFAs) induced the expression of the vitamin A-converting enzyme RALDH1 in intestinal epithelial cells in vivo and in vitro, respectively. (aai.org)
In vitro intestinal toxicity of commercially available spray disinfectant products advertised to contain colloidal silver 1 - 1 of 1 Bibliographic entries All record(s) shown. (cdc.gov)
Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)

12 ] found that ferroptosis is involved in intestinal epithelial cell death in ulcerative colitis and suggested it as a potential therapeutic target for that disease. (biomedcentral.com)
In ulcerative colitis, this epithelial permeability becomes leaky, allowing bacterial products to cross into the gut and nutrients and water to leak out. (scienceblog.com)
Specifically, it fixes intestinal epithelial permeability defects caused by 'interferon-gamma,' an inflammatory cytokine involved in autoimmune diseases such as ulcerative colitis and rheumatoid arthritis. (scienceblog.com)

Mice with and without IEC SOCS3 conditional knockdown were infected with T. muris and intestinal tissue examined at 3, 14, 21 and 35 days after infection. (lancs.ac.uk)
However, it is not known if CXCR1 is expressed on the apical or basolateral poles in polarized Caco-2 BBE cells or human intestinal tissue or whether the direction of TLR signalling influences the direction of IL-8 secretion. (biomedcentral.com)
Additionally, we determined the localization of the CXCR1 receptor in Caco-2 BBE cells and human intestinal tissue samples and investigated the role of IL-8 autocrine signalling using transcriptomics. (biomedcentral.com)
These data demonstrate a critical role for DNMT3A in orchestrating intestinal epithelial homeostasis and response to tissue damage and suggest an involvement of impaired epithelial DNMT3A function in the etiology of IBD. (nature.com)
We prepared a total of n = 40 bisulfite sequencing libraries from individual tissue samples following laser capture microdissection of intestinal epithelial cells in each case. (biomedcentral.com)
In summary, Survivin is a key regulator of gut tissue integrity by regulating epithelial homeostasis in the stem cell niche. (uea.ac.uk)
The parasite is transmitted by environmentally hardy cysts (oocysts) that, once ingested, exist in the small intestine and result in an infection of intestinal epithelial tissue. (wikipedia.org)
First, in the T. spiralis infection model, H&E staining was used to analyse the damage to jejunum tissue, a TUNEL assay was used to examine cell apoptosis, and the expression of ERS-related and apoptosis-related molecules was also measured. (biomedcentral.com)
Using cryopreserved Mouse Intestinal Organoids enables establishment of intestinal organoid cultures without the need to isolate intestinal crypts from primary tissue, eliminating the need for access to fresh mouse tissue and making it easy to standardize experimental starting materials. (stemcell.com)
It is described as a housekeeping enzyme, being responsible for cell-to-cell signaling, tissue homeostasis, and cytoprotection. (medscape.com)
A distinct lineage of epithelial cells, present in MUCOSAL TISSUE, that is responsible for the immune sensing and capture of luminal bacteria and other microparticles. (bvsalud.org)
Niches are special microenvironments in tissue where stem cells are located. (bvsalud.org)
Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
Likewise, these cells give rise to progenitor cells committed to a particular cell lineage, and play a crucial role in tissue repair and homeostasis. (bvsalud.org)

DNMT3A expression is downregulated in intestinal epithelial cells from IBD patients and upon tumor necrosis factor treatment in murine intestinal organoids. (nature.com)
Experiments with IEC organoids demonstrated that IEC expulsion did not require other cell types. (elsevierpure.com)
Cryopreserved Mouse Intestinal Organoids provide a convenient way to establish or standardize intestinal organoid cultures in your laboratory. (stemcell.com)
Each vial contains 200 mouse intestinal organoids derived from the small intestine of C57BL/6 mice that were cultured in IntestiCult™ Organoid Growth Medium (Mouse) and cryopreserved in CryoStor® CS10. (stemcell.com)

abstract = "Ethnopharmacology relevanceMaytenus ilicifolia is a Celastracea plant used in traditional medicine to alleviate digestive tract inflammatory disorders.Aim of the studyWe investigated anti-inflammatory properties of M. ilicifolia crude extract towards Caco-2 cell line, as a model of Toll-like Receptor 2 (TLR-2) inflammatory pathway.Materials and MethodsToxicity was assessed following culture of Caco-2 with M. ilicifolia, using apparent cell permeability and trans-epithelial electric resistance. (aber.ac.uk)

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. (nature.com)
however, only scarce data exist regarding the role of commensal fungi in maintaining intestinal homeostasis and triggering IBD. (leibniz-hki.de)
When the genetic information containing the "blueprint" for these substances is disrupted, cell homeostasis is disrupted, resulting in a wide-range of immediate and/or delayed toxicological effects. (cdc.gov)

The immune system's attempt to eliminate Salmonella bacteria from the gastrointestinal (GI) tract instead facilitates colonization of the intestinal tract and fecal shedding, according to scientists. (sciencedaily.com)
Given the strong link between the regulation of some of these genes and the growth and dissemination of gastrointestinal cancers, we believe their aberrant expression in UC may provide a mechanism for epithelial hyper-proliferation and, in the context of malignant transformation, for tumour growth. (bmj.com)
The gastrointestinal tract is continuously exposed to many environmental factors that influence intestinal epithelial cells and the underlying mucosal immune system. (aai.org)
Cryptosporidium, sometimes called crypto, is an apicomplexan genus of alveolates which are parasites that can cause a respiratory and gastrointestinal illness (cryptosporidiosis) that primarily involves watery diarrhea (intestinal cryptosporidiosis), sometimes with a persistent cough (respiratory cryptosporidiosis). (wikipedia.org)
Gastric cancer is the fourth commonest ently reported that H. pylori eradication were subjected to routine history and malignant disorder and the second com- can lead to a regression of acute gastritis clinical examination, fol owed by an monest cause of cancer-related death and intestinal metaplasia, and that such upper gastrointestinal endoscopic ex- worldwide [1]. (who.int)
After Cryptosporidium oocysts are ingested, they excyst in the gastrointestinal tract and release sporozoites, which parasitize gastrointestinal epithelial cells. (msdmanuals.com)

Genetic deletion of Dnmt3a in intestinal epithelial cells ( Dnmt3a ΔIEC ) in mice confirms the phenotype of an altered epithelial ultrastructure with shortened apical-junctional complexes, reduced Goblet cell numbers and increased intestinal permeability in the colon in vivo. (nature.com)
Toxicity was assessed following culture of Caco-2 with M. ilicifolia, using apparent cell permeability and trans-epithelial electric resistance. (aber.ac.uk)
What is super interesting is that GBS can normally go through the cell membrane and infiltrate the cell which affects the cell's permeability (the ability for GBS or other substances to cross the cell membrane). (groupbstrepinternational.org)

When bacteria invade these cells, the cells are ejected into the gut lumen -- the hollow portion of the intestines. (sciencedaily.com)
To address this question, the scientists genetically engineered Salmonella bacteria that self-destruct when exposed to the cytosol of epithelial cells but grow normally in other environments, including the lumen of the intestine. (sciencedaily.com)
These results show that IL-8 induces autocrine signalling via an apical CXCR1 in Caco-2 BBE intestinal epithelial cells and that this receptor is also expressed on the apical surface of differentiated human intestinal epithelial cells in vivo , suggesting an autocrine function for IL-8 secreted in the lumen. (biomedcentral.com)
Translocation of bacteria, primarily Gram-negative pathogenic flora, from the intestinal lumen into the circulatory system leads to sepsis. (springer.com)
The infections may originate from a hospital environment or may arise from the translocation of microorganisms from the intestinal lumen to the peripheral blood supply. (springer.com)

Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection. (nature.com)
The results showed that ERS occurred during the intestinal phase of T. spiralis infection, while remission began during the cyclic phase. (biomedcentral.com)
Therefore, we hypothesized that T. spiralis SPI (TsSPI) may be involved in intestinal epithelial cell apoptosis induced by T. spiralis infection, but the specific mechanism remains to be further explored. (biomedcentral.com)
We sought to determine the mechanism(s) responsible for this increase in burden using invitro co-culture and co-infection of human intestinal epithelial cell lines. (groupbstrepinternational.org)
Here, we used a panel of EV-D68 isolates, including a historical pre-2014 isolate and multiple contemporary isolates from AFM outbreak years, to define the dynamics of viral replication and the host response to infection in primary human airway cells and stem cell-derived enteroids. (cdc.gov)
CRTH2: Chemoattractant receptor-homologous molecule expressed includes nonallergic asthma phenotypes, such as asthma on TH2 cells associated with exposure to air pollution, infection, or obesity, ILC: Innate lymphoid cell that require innate rather than adaptive immunity. (cdc.gov)

In Tg murine and normal human colonic enterocytes as well as in colorectal cell lines CD97 was localized preferentially in E-cadherin-based adherens junctions. (nih.gov)
Interestingly, IL-8 has been measured in the colon milieu of healthy volunteers using a dialysis bag inserted in the rectum [ 9 ] suggesting that it might be apically secreted by colonic epithelial cells. (biomedcentral.com)
Using laser capture microdissection, epithelial cell-specific methylation signatures were characterized by whole-genome bisulfite sequencing of ileal and colonic samples at the time of surgery for NEC and after NEC had healed at reanastomosis ( n = 40). (biomedcentral.com)

Twenty-nine of these genes were significantly regulated in UC-in-remission subjects compared with non-IBD controls, including a large number of epithelial cell-expressed genes such as REG4, S100P, SERPINB5, SLC16A1, DEFB1, AQP3 and AQP8, which modulate epithelial cell growth, sensitivity to apoptosis and immune function. (bmj.com)
C-type lectin (CTL) is a protein that binds to saccharides and plays an important role in parasite adhesion, host cell invasion and immune evasion . (bvsalud.org)
This work has demonstrated a novel role of GLYT1 in intestine and shown that intestinal epithelial cells respond directly to oxidative challenge without reliance on extra-epithelial tissues or functions such as neurone, blood-flow or immune responses for antioxidant defence. (ncl.ac.uk)
Thus, a coordinated IEC-intrinsic, Caspase-1 and -8 inflammasome response plays a key role in intestinal immune defense and pathology. (elsevierpure.com)
IgM is the first class of immunoglobulin that is made by immune cells when stimulated by antigen. (cdc.gov)
Our study shows tofacitinib is not just acting on immune cells, as was first thought, but can have a direct effect on the epithelial cells that are the key factor in maintaining gut barrier function. (scienceblog.com)

Cryopreserved human intestinal cells are viable for one year when stored under these conditions. (novabiosis.com)
Cryopreserved primary human intestinal cells are assured to be viable and functional when thawed and maintained properly. (novabiosis.com)

The purpose of this study was to determine whether IGF-1 protects intestinal cells from ROS-induced apoptosis. (mcmaster.ca)

The CXCR1 receptor for IL-8 was expressed only on the apical membrane of Caco-2 BBE cells and differentiated epithelial cells in the human small intestine and colon. (biomedcentral.com)
Specifically, we identified DNA methylation differences in intestinal epithelial cell genomic DNA within resected ileum or colon that may provide new insights into the biology and mechanisms of NEC pathogenesis. (biomedcentral.com)
The role of inflammatory lipid mediators on colon cancer initiating cells (CICs). (lu.se)

These specialized cells absorb nutrients and are a critical barrier that prevent pathogens from spreading to deeper tissues. (sciencedaily.com)
Background: Intestinal epithelial cell (IEC) turnover has been implicated in the expulsion of and resistance to intestinal pathogens, including the murine whipworm Trichuris muris. (lancs.ac.uk)
However, little is currently known regarding the interactions between probiotics/pathogens and epithelial cell mucins. (korea.ac.kr)
The most important intestinal protozoan pathogens. (msdmanuals.com)

found that FWGE can promote apoptosis in different types of cancer cell lines such as SNU-5, MKN-45, SNU-620, SNU-1, and SNU-16. (hindawi.com)
FWGE has significant antiproliferative effects and kills tumour cells by the induction of apoptosis via the caspase-poly (ADP-ribose) polymerase pathway [ 9 ]. (hindawi.com)
Among the genes that remain deregulated during remission, we identify several that are expressed by epithelial cells and are involved in epithelial cell proliferation, resistance to apoptosis and response to stress. (bmj.com)
The purpose of this study is to determine whether glutamine deprivation induces apoptosis in rat intestinal epithelial (RIE-1) cells and to compare the effect of glutamine starvation with that of methionine and cysteine (Met/Cys) starvation. (usuhs.edu)
This study provides biochemical and morphologic evidence that glutamine deprivation induces apoptosis in rat intestinal epithelial cells. (usuhs.edu)
In contrast, Met/Cys starvation suppresses cell number without induction of apoptosis: These results suggest that glutamine serves as a specific survival factor in enterocytes. (usuhs.edu)
Unstimulated T cells exhibited increased activation and pro-inflammatory cytokine secretion upon exposure, while there was no effect on apoptosis or proliferation. (leibniz-hki.de)
In contrast, C. albicans-challenged CD3-stimulated T-cells exhibited decreased activation, cytokine secretion, apoptosis, and proliferation, suggesting reciprocal responsiveness to C. albicans. (leibniz-hki.de)
The results showed that TsKaSPI could induce apoptosis in a porcine small intestinal epithelial cell line (IPEC cells) by activating ERS and promote activation of the NF-κB signalling pathway. (biomedcentral.com)
The results confirmed that TsKaSPI could activate ERS and lead to apoptosis in intestinal epithelial cells. (biomedcentral.com)
Thus, the aim of this study was to analyse whether TsSPI regulated the host intestinal inflammatory response by regulating ERS-mediated apoptosis signalling during T. spiralis invasion. (biomedcentral.com)

The scientists hypothesize that, by hijacking the epithelial cell response, Salmonella amplify their ability to invade neighboring cells and seed the intestine for fecal shedding. (sciencedaily.com)
Novabiosis primary human intestinal epithelial cells are specifically critical in the digestion and retention of nutrients and shields the organism from toxins and bacteria found in the intestine. (novabiosis.com)

Treatment with FWGE (1-2%) significantly decreased the level of intracellular ROS compared to LPS-treated cells. (hindawi.com)
Exogenous glycine protected human intestinal Caco-2 and HCT-8 cells against the oxidative agent tert-butylhydroperoxide and reduced the intracellular concentration of reactive oxygen species, when applied prior to but not concomitant with the oxidative challenge. (ncl.ac.uk)
Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport. (gu.se)
Cryptosporidia are obligate, intracellular coccidian protozoa that replicate in small-bowel epithelial cells of a vertebrate host. (msdmanuals.com)

Sigalling and trafficking of the cysteinyl leukotriene receptors in intestinal epithelial cells. (lu.se)

One of the first lines of defense in the GI tract is the physical barrier provided by a single layer of intestinal epithelial cells. (sciencedaily.com)
The intestinal epithelial cell (IEC) layer of the intestinal tract makes direct contact with a number of microbiota communities, including bacteria known to have deleterious health effects. (korea.ac.kr)
Intestinal tract mucins are principal components of the mucus layer on epithelial surfaces, and perform a protective function against microbial damage. (korea.ac.kr)
Cyclospora and Cryptosporidium are examples of coccidian parasites that infect the epithelial (lining) cells of the intestinal tract. (cdc.gov)
Poor absorption of nutrients by the intestinal tract. (cdc.gov)
We developed a mouse model of GBS and C. albicans co-colonization and noted that the presence of C. albicans is associated with greater GBS burden in the neonatal intestinal tract. (groupbstrepinternational.org)
When you talk about colonization and translocation, are you referring to translocation within the intestinal tract or would this potentially apply other areas of the body such as milk ducts? (groupbstrepinternational.org)
So I am referring to GBS colonization and translocation in the intestinal tract to the bloodstream which is what the gene Lmb (Laminin-binding protein) is significant for. (groupbstrepinternational.org)

Furthermore, our data showed that the expression levels of RALDH1 in small intestinal epithelial cells correlated with the activity of vitamin A-converting enzymes in mesenteric lymph node dendritic cells, along with increased numbers of intestinal regulatory T cells and a higher production of luminal IgA. (aai.org)

COX-1 is expressed constitutively and is isolated throughout most cell lines in almost all mammalian tissues. (medscape.com)
Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)
Tissues and Cells. (lu.se)

Recognized as gut-brain axis disorders by Rome IV criteria, FGIDs etiology is linked to altered gut-brain interaction, intestinal physiology, and microbiota. (frontiersin.org)
Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistance. (nature.com)

Transcriptome analyses revealed that Caco-2 BBE cells respond to stimulation with IL-8 supporting the hypothesis that IL-8 induces G protein-coupled receptor signalling. (biomedcentral.com)

We conclude that LKB1 can induce complete polarity in intestinal epithelial cells. (nih.gov)
Immunization of type VII collagen in athymic nude SJL mice did not induce an autoimmune response, whereas the repletion of T cells from type VII collagen-immunized wild-type mice to the thymic mice showed autoantibody production and resulted in a blistering disease phenotype, supporting the role of T cells in the induction of epidermolysis bullosa acquisita. (medscape.com)

In summary, CD97 increases the structural integrity of enterocytic adherens junctions by increasing and stabilizing junctional beta-catenin, thereby regulating intestinal epithelial strength and attenuating experimental colitis. (nih.gov)
The effect of FWGE on the intestinal barrier integrity was determined by transepithelial electric resistance measurements and using a FD4 fluorescent tracer dye. (hindawi.com)
Furthermore, LPS-triggered partial disruption of epithelial integrity was reduced after FWGE application. (hindawi.com)

Here we investigated whether polarized monolayers of intestinal epithelial cells might regulate inflammatory responses by secreting IL-8 in a vectorial fashion (i.e. apical versus basolateral) depending on the location of the TLR stimulus. (biomedcentral.com)

Although multiple kidney cell lines from monkeys were susceptible to SARS-CoV-2, we found many cell types derived from humans, dogs, minks, cats, mice, and chicken were not. (cdc.gov)

Crosstalk between colorectal cancer cells and tumour-associated macrophages. (lu.se)

Involvement of eicosanoid signalling in epithelial cell migration. (lu.se)

Impaired epithelial barrier function is regarded as a key feature of patients with inflammatory bowel disease (IBD) 3 . (nature.com)
Therefore, the main objective of this study was to elucidate how iron-depleted, iron-saturated, and manganese-saturated forms of lactoferrin regulate intestinal barrier function via interactions with epithelial cells and macrophages. (springer.com)
McCole's research group was the first to identify PTPN2 normally helps to protect the barrier function of the epithelial cells that line the gut. (scienceblog.com)

Here we show that expression of the EMT master inducer Snail in primary adult Drosophila intestinal tumors leads to the dissemination of tumor cells and formation of macrometastases. (whiterose.ac.uk)
In this work, we analyze expression patterns of DNMT3A in patients with IBD, perform loss of function experiments using Caco-2 cell line and generate a conditional Dnmt3a ΔIEC mouse line. (nature.com)
qPCR and Western blotting revealed that rTsCTL binding to SDC-1 increased the expression of SDC-1 and claudin-2 , and reduced the expression of occludin and claudin-1 in Caco-2 cells incubated with rTsCTL via the STAT3 pathway. (bvsalud.org)
ß-Xyloside (a syndecan-1 synthesis inhibitor) and Stattic (a STAT3 inhibitor) significantly inhibited rTsCTL binding to syndecan-1 in Caco-2 cells and activation of the STAT3 pathway, abrogated the effects of rTsCTL on the expression of gut tight junctions , and impeded larval invasion. (bvsalud.org)
It is also important to note that the expression of MUC2 mucin was increased as the result of the addition of L. acidophilus A4 cell extracts (10.0 mg/ml), which also induced a significant reduction in the degree to which E. coli O157:H7 attached to epithelial cells. (korea.ac.kr)
Anti-inflammatory properties of M. ilicifolia were assessed through IL-8 secretion and TLR-2 associated gene expression of Caco-2 cells with or without an LTA challenge. (aber.ac.uk)
BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)

We investigated anti-inflammatory properties of M. ilicifolia crude extract towards Caco-2 cell line, as a model of Toll-like Receptor 2 (TLR-2) inflammatory pathway. (aber.ac.uk)

The precise disease mechanisms leading to surgical NEC (sNEC) remain ill defined, likely in part because few intestinal samples are available for analysis. (biomedcentral.com)

Here, we show that Survivin is specifically expressed in transit-amplifying cells and Lgr5(+) stem cells. (uea.ac.uk)
Consequently, induced deletion of Survivin in Lgr5(+) stem cells led to cell death. (uea.ac.uk)
Dental pulp stem cells have been isolated from deciduous and permanent teeth and have the potential to self-renew and differentiate. (bvsalud.org)
However, little is known about the exact anatomic location of these cells, and the relationship between stem cells and surrounding cells in dental pulp. (bvsalud.org)
that is, they have the ability to generate other stem cells and perpetuate themselves. (bvsalud.org)

The study, published in Cell Host & Microbe , was conducted by National Institute of Allergy and Infectious Diseases (NIAID) scientists at Rocky Mountain Laboratories in Hamilton, Montana. (sciencedaily.com)
Therefore, this study mainly explored whether Trichinella spiralis Kazal-type serine protease inhibitor (TsKaSPI) contributed to the invasion of intestinal epithelial cells during the infectious stage of T. spiralis by regulating ERS. (biomedcentral.com)
Norovirus is the commonest cause of outbreaks of infectious intestinal disease (IID) with around 50% of all IID outbreaks attributed to this pathogen [ Reference Patel 1 , Reference Yen 2 ]. (cambridge.org)

Dnmt3a ΔIEC mice suffer from increased susceptibility to experimental colitis, characterized by reduced epithelial regeneration. (nature.com)

We demonstrated that while intestinal epithelial cell (IEC) proliferation and death are unaltered in mice with ubiquitous suppression of NF-κB activity, goblet cell numbers increase at the expense of Paneth cells. (hu-berlin.de)

Ultrastructural analysis revealed that overexpression of CD97 strengthened lateral cell-cell contacts between enterocytes, which, in contrast, were weakened in CD97 knockout (Ko) mice. (nih.gov)
In this study, we investigated the role and mechanism of action of TBHQ on 5-fluorouracil-induced (5-FU-induced) human intestinal epithelial cell (HIEC) injury and intestinal mucositis in mice. (biomedcentral.com)

http://dx.doi.org/10.1016/j.jaci.2014.02.015 epithelial cells and airway smooth muscle cells. (cdc.gov)

Anatomy48

Organisms21

Diseases15

Chemicals and Drugs92

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes50

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Epithelium13

Mucosa5

IECs7

Inflammation12

Role in maintainin1

Single intestinal epithelial1

Mouse intestinal epithelial1

Differentiation10

Vitro5

Ulcerative Colitis3

Tissue14

Organoids4

Abstract1

Homeostasis3

Gastrointestinal6

Permeability3

Lumen5

Infection6

Colonic3

Immune6

Human intestinal cells2

Protects intestinal1

Colon3

Pathogens4

Apoptosis11

Intestine2

Intracellular4

Receptors1

Tract8

Dendritic cells1

Tissues3

Microbiota2

Induces1

Induce2

Integrity3

Inflammatory responses1

Humans1

Tumour1

Eicosanoid1

Barrier function3

Expression7

Pathway1

Mechanisms1

Stem Cells5

Infectious3

Experimental colitis1

Goblet cell numbers1

Mice2

10.10161