• Alpha-glucosidase inhibitor which acts within the gastrointestinal tract without being absorbed, reducing intestinal absorption of glucose. (e-lactancia.org)
  • Acarbose is an alpha-glucosidase inhibitor that decreases intestinal absorption of carbohydrates and is used as adjunctive therapy in the management of type 2 diabetes. (verifiedmarketresearch.com)
  • The aqueous leaf extract of V. doniana was the strongest inhibitor of α-amylase with half-maximal inhibitory concentration (IC50) of 3.09 ± 0.22 mg/ml while the ethanol leaf extract was the strongest inhibitor of α-glucosidase with IC50 of 17.12 ±1.42 mg/ml. (academicjournals.org)
  • Acarbose tablets are an oral alpha-glucosidase inhibitor for use in the management of type 2 diabetes mellitus. (drugs-library.com)
  • Voglibose is an alpha-glucosidase inhibitor used for lowering post-prandial blood glucose levels in people with type 2 diabetes mellitus. (genericbucket.com)
  • VOGLIBOSE is a member of the alpha-glucosidase inhibitor class of anti-diabetic drugs used to treat type-2 diabetes mellitus. (lifevisionhealthcare.com)
  • Blood Glucose Control - Voglibose is an alpha-glucosidase inhibitor, which help in slows down the absorption and digestion of carbohydrates in the intestine. (lifevisionhealthcare.com)
  • These medications cause reversible inhibition of pancreatic alpha-amylase and membrane-bound intestinal alpha-glucoside hydrolase enzymes. (medscape.com)
  • The reduction in blood glucose level may be due to the reversible inhibition of alpha-glucosidases present in the brush-border of the small intestinal mucosa, higher rate of glycolysis as envisaged by the higher activity of glucokinase, as one of the key enzymes of glycolysis, and enhanced rate of glycogenesis as evidenced by the higher amount of liver glycogen present after MO administration. (oil-testimonials.com)
  • GAA is one member of the α-glucosidase family of enzymes which break down starch and disaccharides to glucose. (guidetopharmacology.org)
  • Voglibose is metabolized by intestinal enzymes and by the microbial flora. (aboutdrugspdf.com)
  • Posmeal MD (Voglibose) helps reduce blood glucose level by blocking the intestinal alpha-glucosidase, which is one of the hydrolase enzymes and which are involved in breaking down such components of carbohydrates as saccharides, including disaccharides, oligosaccharides, and polysaccharides. (unitedpharmacies-uk.md)
  • These drugs inhibit absorption of intestinal enzymes such as maltase, isomaltase, and sucrase, which leads to reduced carbohydrate absorption and postprandial glycemia. (bioactivesamerica.com)
  • The antihyperglycemic action of acarbose results from a competitive, reversible inhibition of pancreatic alphaamylase and membrane-bound intestinal alpha-glucoside hydrolase enzymes. (drugs-library.com)
  • Acarbose is metabolized exclusively within the gastrointestinal tract, principally by intestinal bacteria, but also by digestive enzymes. (drugs-library.com)
  • Acarbose inhibits enzymes ( glycoside hydrolases ) needed to digest carbohydrates , specifically, alpha-glucosidase enzymes in the brush border of the small intestines and pancreatic alpha-amylase. (curecrowd.com)
  • Reduces plasma glucose (blood sugar levels) via by inhibiting the activity of small-intestinal α-glucosidases (enzymes associated with glucose metabolism) (39). (alphascreed.com)
  • This family includes the following closely related glycosyl hydrolase family 31 (GH31) enzymes: maltase-glucoamylase (MGAM), sucrase-isomaltase (SI), lysosomal acid alpha-glucosidase (GAA), neutral alpha-glucosidase C (GANC), the alpha subunit of neutral alpha-glucosidase AB (GANAB), and alpha-glucosidase II. (umbc.edu)
  • GANC and GANAB are key enzymes in glycogen metabolism that hydrolyze terminal, non-reducing 1,4-linked alpha-D-glucose residues from glycogen in the endoplasmic reticulum. (umbc.edu)
  • The ingredient "Voglibose" in VOGLIBOSE blocks the intestinal enzymes that convert complex sugars into simple sugars like glucose. (lifevisionhealthcare.com)
  • Finally, GLP-2 did not alter other markers of intestinal or pancreatic gene expression, including levels of mRNA transcripts for ornithine decarboxylase, multidrug resistance gene, amylase, proglucagon, proinsulin, and prosomatostatin. (nih.gov)
  • Pancreatic alpha (α)-amylase and intestinal α-glucosidase involved in the enzymatic breakdown of dietary carbohydrates are implicated in postprandial hyperglycemia. (academicjournals.org)
  • Pancreatic alpha-amylase hydrolyzes complex starches to oligosaccharides in the lumen of the small intestine, while the membrane-bound intestinal alpha-glucosidases hydrolyze oligosaccharides, trisaccharides, and disaccharides to glucose and other monosaccharides in the brush border of the small intestine. (drugs-library.com)
  • Rab21 has been reported to localize in the ER in human intestinal epithelial cells, with partial colocalization with alpha-glucosidase, a late endosomal/lysosomal marker. (umbc.edu)
  • MGAM and SI are anchored to small-intestinal brush-border epithelial cells. (umbc.edu)
  • The inhibitory potentials of the extracts on α-amylase were assayed through the method of starch-iodine colour change while α-glucosidase inhibition was assessed by measuring the release of 4-nitrophenol by p-nitrophenyl-α-D-glucopyranoside (pNPG). (academicjournals.org)
  • 2000) In vitro inhibition and intracellular enhancement of lysosomal alpha-galactosidase A activity in Fabry lymphoblasts by 1-deoxygalactonojirimycin and its derivatives. (guidetopharmacology.org)
  • Hence, in this present study, crude saponins of PP were isolated, characterized and in-vitro enzyme inhibition against alpha-amylase and Alpha-glucosidase was determined. (ijpsr.com)
  • It reduces hepatic glucose output, may decrease intestinal absorption of glucose, and may increase glucose uptake in peripheral tissues. (medscape.com)
  • Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. (genericbucket.com)
  • Anti-microbial: S. boulardii adheres to pathogens, which decreases their adhesion to the intestinal wall and decreases invasion of enterocytes into the body. (arogga.com)
  • Maltase-glucoamylase is a membrane-bound enzyme located in the intestinal walls. (wikipedia.org)
  • It is caused by deficiency of functional lysosomal acid alpha-glucosidase (GAA) which leads to accummulation of glucose in muscle cells, that causes irreversible cell damage. (guidetopharmacology.org)
  • Isolated from intestinal mucosa as a single polypeptide chain also CC displaying activity toward isomaltose (EC 3.2.1.10). (expasy.org)
  • In the small intestine, this enzyme works in synergy with sucrase-isomaltase and alpha-amylase to digest the full range of dietary starches. (wikipedia.org)
  • Enzymatic activity: In healthy adults, S. boulardii increases the enzymatic activities (lactase, alpha glucosidase, alkaline phosphatase). (arogga.com)
  • It is a starch blocker and inhibits alpha-glucosidase, an intestinal enzyme that releases glucose from larger carbohydrates. (verifiedmarketresearch.com)
  • SI is implicated in the digestion of dietary starch and major disaccharides such as sucrose and isomaltose, while GAA degrades glycogen in the lysosome, cleaving both alpha-1,4 and alpha-1,6 glucosidic linkages. (umbc.edu)
  • In many patients, use of alpha-glucosidase inhibitors (acarbose and miglitol) may help. (medscape.com)
  • Compounds that inhibit ALPHA-GLUCOSIDASE. (bvsalud.org)
  • This study was therefore designed to investigate the ability of the leaf extracts of Vitex doniana to inhibit α-amylase and α-glucosidase as well as the in-vivo antidiabetic potential of the ethanol leaf extract. (academicjournals.org)
  • The delayed absorption of acarbose-related radioactivity reflects the absorption of metabolites that may be formed by either intestinal bacteria or intestinal enzymatic hydrolysis. (drugs-library.com)
  • This occurs thanks to alpha-glucosidase, a component that prevents the intestinal absorption of sugars. (nutritionandmac.com)
  • This intestinal enzyme breaks apart complex sugars and enhances their absorption into the bloodstream. (betterhealthinternational.net)
  • After oral administration, metformin dextrin, and disaccharides by inhibiting the action of α-glucosidase in the intestinal brush absorption is saturable and incomplete. (aboutdrugspdf.com)
  • Maltase-glucoamylase, intestinal is an enzyme that in humans is encoded by the MGAM gene. (wikipedia.org)
  • Maltase-glucoamylase is an alpha-glucosidase digestive enzyme. (wikipedia.org)
  • An alternative name for Maltase-Glucoamylase is glucan 1,4-alpha-glycosidase. (wikipedia.org)
  • Human small intestinal maltase-glucoamylase cDNA cloning. (wikipedia.org)
  • Recombinant alpha glucosidase agents are used as enzyme replacement therapies to treat Pompe disease. (guidetopharmacology.org)
  • GLP-2 treatment may be a promising therapy to enhance intestinal adaptation and improve digestive function in preterm infants with jejunostomy following intestinal resection. (unboundmedicine.com)
  • TY - JOUR T1 - Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates. (unboundmedicine.com)
  • α-glucosidase inhibitors do not stimulate insulin release and therefore do of absorption and slightly delays absorption. (aboutdrugspdf.com)
  • Saccharomyces boulardii strain survives stomach acid to colonize in the intestinal tract while acting as a temporary flora to protect the beneficial organisms of the intestine. (arogga.com)
  • Another means by which chlorogenic acid supports healthy after-meal glucose levels is by targeting the alpha-glucosidase enzyme. (betterhealthinternational.net)
  • Acute intestinal infarction or obstruction: search for better laboratory tests in an animal model. (elsevierpure.com)
  • Mesenteric vascular occlusion and intestinal obstruction are difficult-to-diagnose medical emergencies. (elsevierpure.com)
  • We evaluated a large panel of biochemical markers as diagnostic and prognostic indicators in a rat model of intestinal infarction and partial, complete, and strangulated intestinal obstruction. (elsevierpure.com)
  • After intestinal infarction and obstruction, laboratory data are distinctly abnormal. (elsevierpure.com)
  • Serum maltase activity increased from abnormally low values after surgery to abnormally high values in the six animals that recovered from partial intestinal obstruction. (elsevierpure.com)
  • Dive into the research topics of 'Acute intestinal infarction or obstruction: search for better laboratory tests in an animal model. (elsevierpure.com)
  • Contraindications include inflammatory bowel disease, colon ulcerations, and intestinal obstruction. (conduent.com)
  • tell your doctor if you have or have ever had ketoacidosis, cirrhosis, or intestinal disease such as inflammatory bowel disease or bowel obstruction. (elispot.biz)
  • CA Hydrolysis of sucrose and maltose by an alpha-D-glucosidase-type action. (expasy.org)
  • Once the activity of alpha-glucosidase is reduced, the complex carbohydrates breakdown and glucose absorption are slowed down as well - it leads to the reduction of postprandial blood glucose level, also known as postprandial hyperglycemia. (unitedpharmacies-uk.md)
  • A new study published in Science shows how intestinal worms aided healthy levels of good bacteria in the gut which reduce the likelihood of intestinal bowel disease (IBD) by lowering inflammation. (diabetesdaily.com)
  • Alpha-glucosidase II is a GH31 enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. (umbc.edu)
  • In this present study, the objective was to extract crude saponins from the root of Phoenix pusilla (PP) and to check its inhibitory potential of α- amylase and α- glucosidase enzyme. (ijpsr.com)
  • Gastrointestinal and liver physiology JO - Am J Physiol Gastrointest Liver Physiol VL - 305 IS - 4 N2 - Short bowel syndrome (SBS) is a frequent complication after intestinal resection in infants suffering from intestinal disease. (unboundmedicine.com)
  • The need to standardize other aspects of intestinal physiology and redefine the energy content of diets containing non-metabolizable substrates in this type of work is also emphasized. (wikigenes.org)
  • α-glucosidase inhibitors are used as adjuncts to help regulate glucose levels in patients with type 2 diabetes mellitus. (guidetopharmacology.org)
  • Activity of α-amylase and α-glucosidase was inhibited by extracts of all S. spinosum organs. (biomedcentral.com)
  • At the same time, the medication does not affect beta-glucosidase activity in any way. (unitedpharmacies-uk.md)
  • One metabolite (formed by cleavage of a glucose molecule from acarbose) also has alpha-glucosidase inhibitory activity. (drugs-library.com)
  • 4. Lesur B, Ducep J-B, Lalloz M-N, Ehrhard A, Danzin C. (1997) New deoxynojirimycin derivatives as potent inhibitors of intestinal α-glucohydrolases. (guidetopharmacology.org)
  • Thus induction of intestinal growth by GLP-2 in wild-type mice results in a normal-to-increased capacity for nutrient digestion and absorption in vivo. (nih.gov)
  • We tested whether treatment with the intestinotrophic hormone glucagon-like peptide-2 (GLP-2) increases intestinal volume and function in the period immediately following intestinal resection in preterm pigs. (unboundmedicine.com)
  • Short bowel syndrome (SBS) is a frequent complication after intestinal resection in infants suffering from intestinal disease. (unboundmedicine.com)
  • Glucagon-like peptide-2 (GLP-2) stimulates small intestinal growth through induction of intestinal epithelial proliferation. (nih.gov)
  • Intestinal resection was associated with markedly reduced endogenous GLP-2 levels. (unboundmedicine.com)
  • Researchers note that in presence of healthy intestinal function there is less B vulgatus and more Clostridia and in people with IBD, there is more B vulgatus and less Clostridia, this is seen even in children tested in North America. (diabetesdaily.com)