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Usual interstitIdiopathic interstitPneumoniasHypersensitivityAcuteRenalInflammation and fibrosisTypes of interstitial lung diSarcoidosisCystic FibrosisDiagnosisLungsILDsDiffusePneumonitisAlveolarNSIPDiseasesDiagnosed with idiopathicCauses of interstitialTubularPrevalenceEmphysemaPathologyPathogenesisBiopsyClinicalNational Jewish HealthAbnormalitiesTissueOften used interchangeablyProgressionPatchyHeterogeneous groupFibroblast activationInfiltratesExtracellular matrix2023Systemic
Usual interstit8
  • determine if findings indicate a pattern of (1) usual interstitial pneumonia (UIP), (2) probable UIP, (3) indeterminate of UIP, or (4) alternate diagnosis. (medscape.com)
  • A non-usual interstitial pneumonia pattern was associated with improved survival, as was the presence of the clinical domain. (medscape.com)
  • Usual interstitial pneumonia-pattern fibrosis in surgical lung biopsies. (elsevierpure.com)
  • Dive into the research topics of 'Usual interstitial pneumonia-pattern fibrosis in surgical lung biopsies. (elsevierpure.com)
  • Acute exacerbations are histologically characterised as diffuse alveolar damage (DAD) superimposed on underlying usual interstitial pneumonia (UIP) [ 3 , 4 ]. (ersjournals.com)
  • Usual interstitial pneumonia (UIP) refers to a morphologic entity defined by a combination of (1) patchy interstitial fibrosis with alternating areas of normal lung, (2) temporal heterogeneity of fibrosis characterized by scattered fibroblastic foci in the background of dense acellular collagen, and (3) architectural alteration due to chronic scarring or honeycomb change. (medscape.com)
  • Usual interstitial pneumonia (UIP) is more common in men than in women. (medscape.com)
  • The cause of usual interstitial pneumonia (UIP) in patients with idiopathic pulmonary fibrosis (IPF) is unknown by definition (ie, IPF is defined as idiopathic UIP). (medscape.com)
Idiopathic interstit6
  • In 2015, the European Respiratory Society and American Thoracic Society released a joint consensus statement proposing the term interstitial pneumonia with autoimmune features (IPAF) be used for idiopathic interstitial pneumonia (IIP) with clinical features that suggest an underlying autoimmune process. (medscape.com)
  • When these proposed criteria were applied to 422 patients previously diagnosed with idiopathic interstitial pneumonia (IIP) or undifferentiated CTD-ILD (UCTD), 144 (34%) met IPAF criteria. (medscape.com)
  • These types of PF are called idiopathic interstitial pneumonia (IIP). (henryford.com)
  • Idiopathic interstitial pneumonia (e.g. (nationaljewish.org)
  • These images are a random sampling from a Bing search on the term "Idiopathic Interstitial Pneumonia. (fpnotebook.com)
  • Idiopathic interstitial pneumonia should be suspected in any patient with unexplained interstitial lung disease. (msdmanuals.com)
Pneumonias4
  • Other major histopathologic forms of idiopathic interstitial pneumonias include the following: desquamative interstitial pneumonia (DIP), respiratory bronchiolitis interstitial lung disease (RBILD), acute interstitial pneumonitis (AIP), also known as Hamman-Rich syndrome, nonspecific interstitial pneumonia (NSIP), cryptogenic organizing pneumonia (COP) (see Imaging in Bronchiolitis Obliterans Organizing Pneumonia ), and lymphocytic interstitial pneumonia (LIP) (see Lymphocytic Interstitial Pneumonia ). (medscape.com)
  • American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. (nih.gov)
  • Firstly, there are the Idiopathic Interstitial Pneumonias (IIPs) including Idiopathic Pulmonary Fibrosis (IPF), the most common IIP, along with idiopathic non-specific idiopathic pneumonia (iNSIP), acute interstitial pneumonia (AIP) and respiratory bronchiolitis-associated ILD (RB-ILD), to name a few. (springer.com)
  • General reference Idiopathic interstitial pneumonias (IIPs) are interstitial lung diseases of unknown etiology that share similar clinical and radiologic features and are distinguished primarily by the histopathologic. (msdmanuals.com)
Hypersensitivity5
  • Most important among these are the rheumatic interstitial lung diseases (RILD) and chronic hypersensitivity pneumonitis (CHrHP). (elsevierpure.com)
  • To retrospectively assess the accuracy of thin-section computed tomography (CT) in distinguishing chronic hypersensitivity pneumonitis (HP) from idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP), with histologic results as the reference standard. (rsna.org)
  • Can CT distinguish hypersensitivity pneumonitis from idiopathic pulmonary fibrosis? (rsna.org)
  • If we're at a loss to give the patient a precise label - whether it's IPF or nonspecific interstitial pneumonitis or hypersensitivity pneumonitis - we at least now know that if they've got fibrosis that's getting worse, we can come up with treatment options for them. (medscape.com)
  • The term UIP is often used interchangeably with idiopathic pulmonary fibrosis (IPF), but other clinical conditions are associated with UIP, although less commonly, including collagen vascular disease, drug toxicity, chronic hypersensitivity pneumonitis, asbestosis, familial IPF, and Hermansky-Pudlak syndrome. (medscape.com)
Acute7
  • It is thought to begin with acute injury to the pulmonary parenchyma, leading to chronic interstitial inflammation, then to fibroblast activation and proliferation, and finally progressing to the common endpoint of pulmonary fibrosis and tissue destruction. (medscape.com)
  • There is acute damage to capillary and alveolar epithelial cells leading to interstitial edema. (med2date.com)
  • This stage may either resolve completely or progress to acute interstitial pneumonia. (med2date.com)
  • This study aims to test a new combination treatment for acute exacerbations, a life-threatening complication of idiopathic pulmonary fibrosis (IPF) that has no approved treatment. (nih.gov)
  • The aim of this study was to evaluate the risk factors for and outcomes of acute exacerbations in patients with advanced idiopathic pulmonary fibrosis (IPF), and to examine the relationship between disease severity and neovascularisation in explanted IPF lung tissue. (ersjournals.com)
  • Some patients present with a more acute onset of respiratory symptoms that may mimic the clinical presentation of acute interstitial pneumonia (AIP). (medscape.com)
  • This syndrome has been termed acute exacerbation of idiopathic pulmonary fibrosis (IPF) or accelerated UIP and occurs in as many as 14% of untreated patients observed for 2 years. (medscape.com)
Renal6
  • In our previous study, we demonstrated that norcantharidin (NCTD) is a potential therapeutic agent for renal interstitial fibrosis (RIF). (ijbs.com)
  • Renal interstitial fibrosis (RIF) is a common pathological feature of progressive injury in CKD and predominantly includes renal tubular epithelial cell atrophy, inflammatory cell infiltration, and the excessive deposition of extracellular matrix (ECM) [ 2 , 3 ]. (ijbs.com)
  • Progressive fibrosis is the major pathological feature of CKD, which leads to end-stage renal disease (ESRD). (nature.com)
  • In conclusion, this study demonstrated that Plk1 plays a pathogenic role in renal tubulointerstitial fibrosis by regulating autophagy/lysosome axis. (nature.com)
  • In this study, we explored the role of Plk1 in the classical kidney fibrosis model, UUO, and cultured fibroblast and renal tubular epithelial cells by using specific Plk1 inhibitors, genetic silencing, and heterozygous global knockout mice. (nature.com)
  • The cause of late renal allograft loss, once known as chronic allograft nephropathy, has been renamed "interstitial fibrosis and tubular atrophy" (IF/TA) to reflect the histologic pattern seen on biopsy. (biomedcentral.com)
Inflammation and fibrosis4
  • Systemic sclerosis (SSc) is a heterogeneous autoimmune disease, characterised by vascular damage, inflammation and fibrosis of skin and various visceral organs. (bmj.com)
  • Literature was reviewed on animal models in which in vivo imaging was used to detect and assess lung lesions that resembled pathological changes found in DIILD, such as inflammation and fibrosis. (lu.se)
  • Pathologies resembling DIILD, such as inflammation and fibrosis, were described in many papers, but only a few explicitly addressed drug-induced toxicity experiments. (lu.se)
  • Classified into 8 histologic subtypes, all are characterized by varying degrees of inflammation and fibrosis and all cause dyspnea. (msdmanuals.com)
Types of interstitial lung di2
Sarcoidosis1
  • Rarely, there has also been evidence of interstitial lung disease, such as sarcoidosis, pulmonary fibrosis, and bronchiolitis obliterans. (cdc.gov)
Cystic Fibrosis1
  • COPD, asthma, and cystic fibrosis (CF) together affect a large number of individuals and no curative treatments are available. (lu.se)
Diagnosis2
  • This registry will collect data on the strategies used to achieve a diagnosis of Idiopathic Pulmonary Fibrosis (IPF) and Chronic Fibrosing Interstitial Lung Disease with Progressive Phenotype (ILD) and the treatment and management efforts applied throughout study follow-up, clinical outcome events and patient reported outcome data. (stanford.edu)
  • Speak to us about why you think it's so important for us to make the diagnosis of fibrosing interstitial lung disease early. (medscape.com)
Lungs8
  • Smoking-related interstitial fibrosis (SRIF) is an abnormality in the lungs characterized by excessive collagen deposition within the walls of the air sacs (interstitial fibrosis). (wikipedia.org)
  • It is described by scarring (fibrosis) of the lungs. (nationaljewish.org)
  • To examine the mechanisms for increased monocyte/macrophage recruitment in IPF and nonIPF interstitial lung diseases (nonIPF) the localization of monocyte chemoattractant protein-1 (MCP-1) was investigated in 14 cases of IPF, seven cases of nonIPF, and seven normal control lungs (CTRL) by immunohistochemistry using a specific anti-MCP-1 monoclonal antibody, F9. (elsevierpure.com)
  • It can also affect other organs, such as the lungs, causing severe breathing problems that health experts call pulmonary fibrosis. (medicalnewstoday.com)
  • Scarring in the lungs is referred to as pulmonary fibrosis (PF) or Interstitial Pneumonia(IP). (henryford.com)
  • Interstitial lung disease is the name for a large group of diseases that inflame or scar the lungs. (medlineplus.gov)
  • Interstitial lung disease (ILD) is a broad category of lung diseases that includes more than 130 disorders characterized by scarring (i.e. "fibrosis") and / or inflammation of the lungs. (nationaljewish.org)
  • According to the 2002 American Thoracic Society (ATS)/European Respiratory Society (ERS) consensus statement, IPF is defined as a distinctive type of chronic fibrosing interstitial pneumonia of unknown cause limited to the lungs and with histologic features of UIP on surgical lung biopsy or certain clinical, radiologic, and pulmonary function test findings in the absence of surgical lung biopsy. (medscape.com)
ILDs3
  • For serum biomarker measurements, measuring serum matrix metalloproteinase 7, chemokine ligand 18, Krebs von den Lungen-6, or surfactant protein D is not recommended solely to distinguish idiopathic pulmonary fibrosis from other ILDs, owing to high false-positive and false-negative results. (medscape.com)
  • We've invited a person whose impressive portfolio of clinical and translational research includes among other things, studies of novel compounds for IPF and other interstitial lung diseases (ILDs). (medscape.com)
  • The interstitial lung diseases (ILDs) are a diverse group of chronic lung conditions characterised by dyspnoea on exertion and poor health related quality of life. (bmj.com)
Diffuse5
  • As a group, diffuse interstitial diseases of the lung are uncommon. (medscape.com)
  • As a precursor to overt heart failure, diabetics experience a unique alteration in myocardial architecture marked by diffuse interstitial fibrosis. (biomedcentral.com)
  • Well-controlled diabetics with normal ventricular structure, function, and no prior cardiac disease have diffuse interstitial myocardial fibrosis by CMR. (biomedcentral.com)
  • Diffuse fibrosis is associated with LAVI, a marker of diastolic function, but not with other markers of clinical or cardio-metabolic risk. (biomedcentral.com)
  • Fibrosis and diffuse interstitial lung disease. (who.int)
Pneumonitis4
  • The underlying histopathology of IPF is usual interstitial pneumonitis (UIP). (medscape.com)
  • The diseases cause inflammation or scarring of the lung tissue (interstitial lung disease) or result in filling of the air spaces with exudate and debris (pneumonitis). (medscape.com)
  • dNonspecific interstitial pneumonitis. (medscape.com)
  • Pneumonitis that progresses to pulmonary fibrosis is the most severe toxicity reported. (medscape.com)
Alveolar2
  • The mnemonic "PAINT" has been used to divide the causes of restrictive lung disease into pleural, alveolar, interstitial, neuromuscular, and thoracic cage abnormalities. (medscape.com)
  • Overview of Interstitial Lung Disease Interstitial lung diseases are a heterogeneous group of disorders characterized by alveolar septal thickening, fibroblast proliferation, collagen deposition, and, if the process remains unchecked. (msdmanuals.com)
NSIP1
Diseases4
Diagnosed with idiopathic1
  • The purpose of this study is to compare the effect of n-acetylcysteine (NAC) plus standard care with matched placebo plus standard of care in patients diagnosed with idiopathic pulmonary fibrosis (IPF) who have the TOLLIP rs3750920 TT genotype. (stanford.edu)
Causes of interstitial1
  • Obtain a detailed history for possible environmental exposures or medication use to exclude potential causes of interstitial lung disease (ILD). (medscape.com)
Tubular5
  • The common pathological feature of CKD is the loss of tubular cells and progressive interstitial fibrosis. (nature.com)
  • However, the role of Plk1 in kidney tubular interstitial fibrosis has not been reported. (nature.com)
  • Interstitial fibrosis and tubular atrophy (IF/TA) describes the histologic characteristics of allograft destruction over time. (biomedcentral.com)
  • CNI can cause microvascular and glomerular damage, arteriolar hyaline deposition, tubular atrophy, and striped interstitial fibrosis. (biomedcentral.com)
  • Reliable, digital, automated detection of interstitial fibrosis and tubular atrophy (IFTA) has not yet been developed. (ufl.edu)
Prevalence1
  • The reported overall prevalence of interstitial lung disease in New Mexico is 80.9 per 100,000 males and 67.2 per 100,000 females, corresponding with annual incidence rates of 31.5 per 100,000 per year in males and 26.1 per 100,000 per year in females. (medscape.com)
Emphysema3
  • The defining feature of smoking-related interstitial fibrosis is a distinctive/unique type of fibrosis characterized by "ropey" collagen bundles within the walls of the air sacs (alveoli), almost always in association with other smoking-related abnormalities such as pigmented macrophages and emphysema. (wikipedia.org)
  • These patients generally have no symptoms attributable to fibrosis, although they may have symptoms attributable to emphysema (COPD), which is a common abnormality in smokers with lung cancer. (wikipedia.org)
  • Mineral dust small airways disease, pneumoconiosis (macules and nodules), and pathologic changes consistent with chronic bronchitis, emphysema, and interstitial fibrosis predominated in farm workers compared with nonfarmworkers. (cdc.gov)
Pathology1
  • We evaluated airway and parenchymal pathology using standardized diagnostic criteria and semiquantitative grading schemata, including the grading of small airways for fibrosis and birefringent mineral dust particles. (cdc.gov)
Pathogenesis1
Biopsy3
  • The morphology domain is divided into three sections: interstitial pneumonia patterns suggested by HRCT imaging, histopathologic features identified by surgical lung biopsy, or evidence of additional thoracic compartment involvement as determined by diagnostic imaging, histopathologic findings, right heart catheterization (RHC) or pulmonary function testing. (medscape.com)
  • Corticosteroids are the mainstay of therapy and are indicated when lung biopsy show an active cellular process without extensive fibrosis. (med2date.com)
  • and inflammation, fibrosis, or both on biopsy. (msdmanuals.com)
Clinical3
  • UIP is the expected histopathological pattern in patients with clinical idiopathic pulmonary fibrosis (IPF), but the UIP-pattern can be seen in other conditions on occasion. (elsevierpure.com)
  • He performs health services and outcomes research focused on understanding and improving the lives and care of patients with advanced lung disease and is actively involved in clinical trials to improve outcomes in interstitial lung disease. (stanford.edu)
  • Objectives To identify the predictive clinical characteristics and establish a prediction model for the progression of mild interstitial lung disease (ILD) in patients with systemic sclerosis (SSc). (bmj.com)
National Jewish Health1
  • The National Jewish Health Interstitial Lung Disease Center for Patient Care, Education, Discovery and Innovation is one of the largest interstitial lung disease (ILD) centers in the country. (nationaljewish.org)
Abnormalities1
Tissue4
  • Over time, rheumatoid arthritis (RA) can lead to lung tissue damage, which can result in a condition doctors call pulmonary fibrosis. (medicalnewstoday.com)
  • Idiopathic pulmonary fibrosis (31%) and connective-tissue disease related ILD (21.7%) were the two most common subtypes. (springer.com)
  • Once patients have developed fibrosis, they have irreversibly lost functioning lung tissue, and as it stands, none of the therapies available to us will reverse that fibrosis or physiological loss. (medscape.com)
  • Previous histological studies have shown a heterogeneous pattern of vessel turnover, with the extent of both increased capillary density and vascular regression varying according to the extent of the tissue fibrosis that is present [ 9 ]. (ersjournals.com)
Often used interchangeably1
  • The terms ILD, PF and interstitial pneumonia (IP) are often used interchangeably. (henryford.com)
Progression1
  • Some studies showed that blocking cell cycle progression ameliorated fibrosis. (nature.com)
Patchy2
  • Pulmonary fibrosis in surgical lung biopsies is said to have a 'usual interstitialpneumonia-pattern' (UIP-pattern) of disease when scarring of the parenchyma is present in a patchy, 'temporally heterogeneous' distribution. (elsevierpure.com)
  • Taken in isolation, the UIP-pattern seen in patients with IPF may appear to overlap with that of RILD and CHrHP, at least when using the broadest definition of this term (patchy fibrosis). (elsevierpure.com)
Heterogeneous group1
Fibroblast activation1
  • The results supported that inhibition of Plk1 ameliorated kidney fibrosis by suppressing fibroblast activation and partial EMT. (nature.com)
Infiltrates2
  • Frontal chest radiograph demonstrating bilateral reticular and nodular interstitial infiltrates with upper zone predominance. (medscape.com)
  • However, the chest portion of the upright abdomen is positive for interstitial infiltrates. (hawaii.edu)
Extracellular matrix2
20231
Systemic1
  • Some forms of DPLD are related to occupational, environmental, drug, and/or radiation exposure, as well as systemic illness such as collagen-vascular disease (see Interstitial Lung Disease Associated With Collagen-Vascular Disease ). (medscape.com)