AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceHealth Care
Sequence Homology, Amino AcidMolecular Sequence DataAmino Acid SequenceSequence Homology, Nucleic AcidBase SequenceCloning, Molecularsrc Homology DomainsSequence HomologyStructural Homology, ProteinSequence AlignmentModels, BiologicalModels, MolecularProtein Structure, TertiaryProtein BindingBinding SitesDNA, ComplementaryDNAEscherichia coliSequence Analysis, DNAProteinsMutationSpecies SpecificityCell LinePhylogenyGenes, BacterialAlgorithmsNucleic Acid HybridizationProtein ConformationRestriction MappingGenesRNA, MessengerBacterial ProteinsPlasmidsRecombinant ProteinsSoftwareDNA, BacterialComputational BiologyBiological EvolutionData Interpretation, StatisticalBiological ProductsStructure-Activity RelationshipTranscription, GeneticSignal TransductionOpen Reading FramesCarrier ProteinsRecombinant Fusion ProteinsChromosome MappingKineticsDNA Restriction EnzymesPolymerase Chain ReactionMultigene FamilyGene LibraryConserved SequenceBiological AssayReproducibility of ResultsDNA PrimersComputer SimulationMolecular WeightGene Expression ProfilingMembrane ProteinsTime FactorsProtein Structure, SecondarySaccharomyces cerevisiaeSubstrate SpecificityGene ExpressionBiological TherapyDNA-Binding ProteinsGene Expression RegulationTransfectionPeptidesPhenotypePeptide FragmentsCattlePhosphoproteinsSequence Analysis, ProteinMutagenesis, Site-DirectedTranscription FactorsBlotting, SouthernBiological MarkersElectrophoresis, Polyacrylamide GelBlood ProteinsAmino Acid MotifsCells, CulturedModels, GeneticSensitivity and SpecificityCOS CellsEvolution, MolecularPhosphorylationCrystallography, X-RayRepetitive Sequences, Nucleic AcidMolecular StructureAdaptor Proteins, Signal TransducingOligonucleotide Array Sequence AnalysisLigandsPromoter Regions, GeneticGenetic Complementation TestCell MembraneSequence AnalysisCluster AnalysisBiological Warfare
SpeciesStructuresSequenceMechanisticCrystallographyHigh-throughputExperimentalEvolutionary BiologyHomologousSciencesVariantsPredictionEvolutionGenesArgueFunctionalSubsequentPhenomenonDataConservationFunctionsOrganismsStronglyMechanismsResearchersIssueClinicalDiseasesAccurateCentralStudiesFactResearchProcessHistoryGroupsReviewsAuthorsScienceProvidePatients
Species6
  • To inform each other and human, model organism studies require a complete map of functionally-equivalent genes and processes across species, in order to facilitate mapping of biological and experimental findings across species, but such maps are extremely difficult to obtain experimentally. (biorxiv.org)
  • Homology is a central concept of comparative and evolutionary biology, referring to the presence of the same bodily parts (e.g., morphological structures) in different species. (asu.edu)
  • The existence of homologies is explained by common ancestry, and according to modern definitions of homology, two structures in different species are homologous if they are derived from the same structure in the common ancestor. (asu.edu)
  • Fluorescence-labeled DNA probes constructed from three whole house mouse (Mus domesticus) chromosomes were hybridized to metaphase spreads from deer mouse (Peromyscus maniculatus) to identify homologies between the species. (tamu.edu)
  • Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide with noted sequence homology among species, specifically in the region required for biologic activity (amino-terminal region), and is a major secretagogue of pituitary corticotropin. (medscape.com)
  • 11] Because of homology among species, human and ovine sequences are both used to stimulate pituitary production and adrenal cortisol production. (medscape.com)
Structures8
  • Leanchoilia guts and the interpretation of three-dimensional structures in Burgess Shale-type fossils. (palass.org)
  • Comparative or homology modeling, which uses experimentally elucidated structures of related protein family members as templates, is currently the most accurate and reliable approach to model the structure of the protein of interest. (unibas.ch)
  • QMEANBrane further extends the approach to membrane protein structures, which play crucial roles in many biological processes and are important drug targets. (unibas.ch)
  • Applicants to this FOA should propose work to solve a substantial biological problem for which the determination of many protein structures is necessary. (nih.gov)
  • If there are no means to know or identify the structures, then the antibody's properties, biological functions and/or manufacturing methods may be used to define the antibodies. (chinapatentstrategy.com)
  • This virtual approach offers the possibility to connect with certainty all the external foramina to the blood and nerve canals and the central structures, and thus identify accurate homologies without destroying the specimen. (plos.org)
  • The explosion in the use of this technique has largely been driven by the increasing desire to characterize biomolecular structures in solution and the availability of easy-to-use software for the analysis and interpretation of small-angle scattering (SAS) data. (iucr.org)
  • In order to evaluate the interpretation of SAS data, information concerning sample quality, data acquisition and experimental validation are essential, especially when detailed three-dimensional structures are presented. (iucr.org)
Sequence3
  • In this talk, I will present methods to identify massive numbers of prokaryotic sequence annotation errors in public databases and demonstrate that homology and pattern matching techniques can be deployed to solve them. (tcgcrest.org)
  • AAP) has been structurally analyzed to date and its structure was shown to be considerably similar to SGAP, despite the low sequence homology between the two enzymes. (huji.ac.il)
  • This includes exploration of the protein family space, multiple sequence alignments, discovery of deterministic motifs, combined with fold recognition, homology modeling, 3D structure representation and analysis. (imp.ac.at)
Mechanistic3
  • The 1.75 Å crystallographic structure of native SGAP has been previously reported, but did not allow critical mechanistic interpretations owing to inconclusive structural regions around the active site. (huji.ac.il)
  • What has been called the new mechanistic philosophy conceives of mechanisms as the main providers of biological explanation. (philpapers.org)
  • We draw on the characterization of the p53 gene in molecular oncology, to show that explaining a biological phenomenon implies instead a dynamic interaction between the mechanistic level-rendered at the appropriate degree of ontological resolution-and far more general explanatory tools that perform a fundamental epistemic role in the provision of biological explanations. (philpapers.org)
Crystallography1
  • Acta Crystallographica Section D: Biological Crystallography , 56 (5), 551-558. (huji.ac.il)
High-throughput2
  • We investigate large functional genomics and high-throughput biological datasets. (imp.ac.at)
  • This FOA encourages applications to establish partnerships between researchers interested in a biological problem of significant scope and researchers providing high-throughput structure determination capabilities through the NIGMS PSI:Biology network. (nih.gov)
Experimental1
  • Throughout his career, his aim has been to combine experimental, theoretical and data analysis methods to obtain holistic understanding of biological and medical problems. (lu.se)
Evolutionary Biology2
  • Phylogenetics and Evolutionary Biology are the fields that deals with the study of evolutionary relations among the groups of organisms and the computational simulation techniques for the study of biological, behavioral, and social systems. (hilarispublisher.com)
  • The journal promotes studies and reporting of articles that address emerging challenges in interpretation of biological transformations and depicts the recent trends of research activities in evolutionary biology. (hilarispublisher.com)
Homologous1
  • A pair of genes from the same gene family is said to be homologous to each other, and the assumption is that homologous genes are likely to have similar biological functions. (biorxiv.org)
Sciences4
  • Proceedings of the Royal Society B: Biological Sciences. (wikipedia.org)
  • 2014)". Proceedings of the Royal Society B: Biological Sciences. (wikipedia.org)
  • Alessandro Blasimme , Paolo Maugeri & Pierre-Luc Germain - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (3):374-384. (philpapers.org)
  • Journal of Biological Sciences, 7: 614-619. (scialert.net)
Variants2
  • From the resulting scores, we generate a model to predict the capacities of full-length BRCA1 variants to support homology-directed DNA repair, the essential role of BRCA1 in tumor suppression, and show that it outperforms widely used biological-effect prediction algorithms. (protabank.org)
  • We envision that massively parallel functional assays may facilitate the prospective interpretation of variants observed in clinical sequencing. (protabank.org)
Prediction2
  • 2016). In addition, Vihinen has introduced widely followed guidelines, recommendations and policies, he has founded a new sub-discipline of immunome, and introduced systematics to biological prediction methods and their assessment. (lu.se)
  • Current studies are devoted into analysis of variations and their effects, including prediction method development, and systems biological studies. (lu.se)
Evolution3
Genes3
  • Biological reaction pathways, involving genes, proteins and other molecules, are graphical networks as well. (github.com)
  • The protein expression of key genes in the pathway, including adaptor protein containing a pleckstrin homology (PH) domain, phosphotyrosine-binding (PTB) domain, and leucine zipper motif 1 (Appl1), Sortilin and Syndecan-1, was examined by immunohistochemistry (IHC) in a pilot study of 29 patients with prostate cancer, using monoclonal antibodies designed against unique epitopes. (edu.au)
  • The very premise of using model organisms to inform human biology relies on the fact that many biological processes, and the underlying genomic elements that encode them, are frequently conserved across large evolutionary distances, especially for protein-coding genes. (biorxiv.org)
Argue1
  • In response to both interpretations, we argue that the foundational basis of extrapolations cannot simply be provided by homology and that relevant disanalogies can, thanks to the techniques of molecular biology, be experimentally controlled and exploited to allow useful and reliable extrapolations. (philpapers.org)
Functional1
  • The study of evolutionary relationships (phylogenetic reconstruction, orthology assignments, remote homology detection) provides complementary information for understanding functional conservation and diversity. (imp.ac.at)
Subsequent2
  • It subsequently suggested to be an annelid by other researchers, however subsequent studies rejected this interpretation. (wikipedia.org)
  • Understanding the early changes in response to stress in harvested perishable commodity would provide fundamental knowledge for better interpretation of subsequent changes and designing appropriate control measures. (scialert.net)
Phenomenon1
  • Once perceived as an unimportant occurrence in living organisms, cell degeneration was reconfigured as an important biological phenomenon in development, aging, health, and diseases in the twentieth century. (asu.edu)
Data3
  • We provide access to a number of complete data analysis workflows with extensive result reporting to aid the biological interpretation of NGS data (RNA-seq, ChIP-seq, smRNA-seq). (imp.ac.at)
  • The data also are useful in interpretation of chromosomal evolutionary history in myomorphic rodents. (tamu.edu)
  • As such, it is important to establish guidelines for publication that will ensure that there is adequate reporting of the data and its treatment so that reviewers and readers can independently assess the quality of the data and the basis for any interpretations presented. (iucr.org)
Conservation1
  • well, if you suggest to assist what magnifies Aging in the solution, you discuss a anything, are some minutes and understand magnetostrophic interpretation of conservation. (mooreamusicpele.com)
Functions4
  • Analysis of biological sequences is done with respect to the corresponding interpretation of biological functions that begin with annotation. (tcgcrest.org)
  • Interestingly, these chemosensory GPCRs (csGPCRs) are expressed in several tissues of the body where they are supposed to play a role in biological functions other than chemosensation. (mdpi.com)
  • We observed alteration in biological functions related to extracellular matrix function and organization, cellular adhesion, muscle growth, lipid metabolism and proteolysis. (biomedcentral.com)
  • Transcription factors and regulatory mechanisms are proposed for these altered biological functions. (biomedcentral.com)
Organisms1
  • Model organisms can serve the biological and medical community by enabling the study of conserved gene families and pathways in experimentally-tractable systems. (biorxiv.org)
Strongly1
  • As of now, a group of pharma companies including Bristol Myers Squibb and UCB Biopharma has submitted an Amicus Brief to the Supreme Court strongly arguing why the Federal Circuit's interpretation is overly restrictive, will hurt innovation and progress in the field, and should be overturned. (chinapatentstrategy.com)
Mechanisms2
  • on the other hand, they are called explanatory because, as we show in this paper, their importance in explaining biological phenomena is not secondary with respect to mechanisms. (philpapers.org)
  • We illustrate how explanatory frameworks establish selective and local criteria of causal relevance that drive the search for, characterisation and usage of biological mechanisms. (philpapers.org)
Researchers1
  • It is expected that these awards will lead to new collaborations between researchers emphasizing biological function and researchers emphasizing biological structure. (nih.gov)
Issue2
  • This study addresses a key issue in the field of prostate cancer pathology by presenting a novel combination of three biomarkers and has the potential to transform clinical pathology practice by standardising the interpretation of the tissue morphology. (edu.au)
  • We take into account two common views on the issue, the homology view and the disanalogy view. (philpapers.org)
Clinical1
  • However, morphology does not necessarily reflect the complex biological changes occurring in prostate cancer disease progression, and current biomarkers have demonstrated limited clinical utility in patient assessment. (edu.au)
Diseases1
  • He has published numerous original ideas and reports, established standards and guidelines for variations and variation databases and developed tools and performed analyses for the interpretation of variations in several diseases. (lu.se)
Accurate2
  • Diagnosis and assessment of patients with prostate cancer is dependent on accurate interpretation and grading of histopathology. (edu.au)
  • This study aimed to develop biomarkers that accurately define prostate cancer biology by distinguishing specific pathological features that enable reliable interpretation of pathology for accurate Gleason grading of patients. (edu.au)
Central1
  • En su alcance, el Hermetismo y la noción de similitud constituyen un papel central, siendo el Hermetismo el nuevo espíritu antropológico, subtítulo de la obra. (bvsalud.org)
Studies1
  • Its interpretation as megacheiran arthropod has been questioned in later studies. (wikipedia.org)
Fact1
  • Although it is likely to be an arthropod, its affinity as megacheiran is still questioned, due to the fact that homology between the cephalic appendages of the two groups is unclear. (wikipedia.org)
Research1
  • Research in bioinformatics is driven to analyze and interpret biological sequences. (tcgcrest.org)
Process1
  • The SWISS-MODEL expert system developed by our group is a fully automated web-based workbench, which greatly facilitates the process of computing of protein structure homology models. (unibas.ch)
History1
  • What is more, that mesh fits - like a tailor made suit - on the extensive body of history of chemical and biological warfare (CBW) and medical experiments against people of color, prisoners, and other unsuspecting citizens. (kersplebedeb.com)
Groups1
  • Three Peromyscus linkage groups were assigned to chromosomes, based on linkage homology with Mus. (tamu.edu)
Reviews2
Authors1
  • Rather, the purpose is to establish the way in which SAS experiments should be presented in order to enable a reviewer and a reader to independently assess the validity of the interpretations made by the authors. (iucr.org)
Science1
  • En Science de l'homme et Tradition [1975], Durand desarrolla una serie de argumentos sobre una nueva organización epistemológica para las ciencias del hombre. (bvsalud.org)
Provide1
  • Here, a panel of biomarkers was assessed to provide insights into the biological relationship between IDCP, HGPIN, and AIP and their relevance to current clinicopathological recommendations. (bvsalud.org)
Patients1
  • To determine the impact of a novel IHC-assisted interpretation (the utility of Appl1, Sortilin, and Syndecan-1 labelling as a panel) of Gleason grading, versus standard haematoxylin and eosin (H&E) Gleason grade assignment, a radical prostatectomy sample cohort comprising 114 patients was assessed. (edu.au)