• Furthermore, these findings contribute to the understanding of oral keratinocyte behavior and pave the way for future investigations into the complex interplay between different signaling pathways in oral keratinocytes. (news-medical.net)
  • This clinical picture is actually driven by a complex interplay of inflammatory cells, and their secreted products known as cytokines, that lead to a hyperproliferation of skin keratinocytes. (moddermatology.com)
  • In the complex interplay between the skin and its microbial inhabitants, the ubiquitous C. acnes is emerging as an important player. (inverse.com)
  • Ganguly U, Bir A, Chakrabarti S (2022) Cytotoxicity of mitochondrial Complex I inhibitor rotenone: a complex interplay of cell death pathways. (mitophysiology.org)
  • Although seemingly basic in concept, advances in molecular science have allowed modern medicine to gain a true appreciation of the complex interplay between the cells involved in the phases of wound healing. (medscape.com)
  • Psoriasis is characterized by keratinocyte proliferation and immune cell accumulation in epidermis/dermis [ 1 ]. (thno.org)
  • Psoriasis lesions are characterized by hyper-proliferation of epidermal keratinocytes associated with inflammatory cellular infiltrate in both dermis and epidermis. (springer.com)
  • Due to its role in proliferation and maturation of keratinocytes, vitamin D has become an important local therapeutic option in the treatment of psoriasis. (springer.com)
  • Psoriasis is the result of uncontrolled keratinocyte proliferation, and its pathogenesis involves the dysregulation of the immune system. (encyclopedia.pub)
  • The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury. (omicsdi.org)
  • Epithelial keratinocyte proliferation is an essential element of wound repair, and abnormal epithelial proliferation is an intrinsic element in the skin disorder psoriasis. (omicsdi.org)
  • The expression of REG3A by keratinocytes is induced by interleukin-17 (IL-17) via activation of keratinocyte-encoded IL-17 receptor A (IL-17RA) and feeds back on keratinocytes to inhibit terminal differentiation and increase cell proliferation by binding to exostosin-like 3 (EXTL3) followed by activation of phosphatidylinositol 3 kinase (PI3K) and the kinase AKT. (omicsdi.org)
  • These findings reveal that REG3A, a secreted intestinal antimicrobial protein, can promote skin keratinocyte proliferation and can be induced by IL-17. (omicsdi.org)
  • Psoriasis is a chronic inflammatory skin disease with a clear genetic contribution, characterized by keratinocyte proliferation and immune cell infiltration. (omicsdi.org)
  • Keratinocyte activation in turn results in cell proliferation and chemokine expression, the latter of which fuels the inflammatory process through further immune cell recruitment. (omicsdi.org)
  • This is supported by reduced proliferation of human dermal papilla and predominantly epithelial keratinocytes after incubation with AICAR, the agonist for AMPK signaling which activates PPARGC1a and serves as co-activator of PPARĪ³. (nature.com)
  • It was shown to inhibit keratinocyte proliferation and promotes terminal differentiation 17 . (nature.com)
  • Oral keratinocytes, which play a crucial role in the formation of the oral mucosa epithelial cell sheet, have long been enigmatic in terms of their signaling regulation. (news-medical.net)
  • This is because oral mucosa epithelial cell sheets (oral keratinocytes) have been clinically applied to treat diseases and reconstruct tissue defects in cornea, esophagus and urethra. (news-medical.net)
  • This breakthrough research opens up new avenues for the efficient isolation, expansion, and sheet formation of cultured oral keratinocytes, which are essential for the successful clinical translation of epithelial cell sheets. (news-medical.net)
  • Among the receptor tyrosine kinases deregulated by 16E5 expression, the key paracrine mediator of epithelial homeostasis keratinocyte growth factor receptor (KGFR/FGFR2b) is altered in its signaling and endocytic traffic in undifferentiated keratinocytes expressing 16E5 and it would represent a major target of the viral protein in differentiated cells. (oncotarget.com)
  • With the aim to specifically address the possible interplay of 16E5 with KGFR/FGFR2b in cells already committed to differentiation, we took advantage of an in vitro model for forced overexpression or depletion of KGFR in E5 expressing human keratinocytes under synchronous waves of differentiation. (oncotarget.com)
  • Interleukin (IL)-17/IL-36 axis participates to the crosstalk between endothelial cells and keratinocytes during inflammatory skin responses. (omicsdi.org)
  • Histologically, the dermatosis is characterized by hyperproliferation of keratinocytes, impaired epidermal barrier function at the sites of skin lesions, and skin infiltration by activated inflammatory cells [ 5 ]. (springer.com)
  • During puberty, surges in androgens stimulate sebum production and hyperproliferation of keratinocytes. (msdmanuals.com)
  • Different genetic approaches, including tissue-specific gene deletion and the use of various inflammatory triggers, reveal that Tnip1 controls not only immune cells, but also keratinocyte biology. (omicsdi.org)
  • Various closely interacting cell types, including innate immune cells, T cells, and keratinocytes, are known to contribute to inflammation. (omicsdi.org)
  • The innate immune system induces the activation of the adaptive immune response, and both enter a reciprocal interplay 1 . (pocketdentistry.com)
  • AN2728-loaded antibody-conjugated nanocarriers inhibited cytokine/chemokine overexpression in activated keratinocytes without affecting cell viability. (thno.org)
  • Karavyraki M, Gnaiger E, Porter RK (2022) Bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells. (mitophysiology.org)
  • The incidence of keratinocyte cancer (basal cell and squamous cell carcinomas of the skin) is 17-fold lower in Singapore than the UK, despite Singapore receiving 2-3 times more ultraviolet (UV) radiation. (cdc.gov)
  • Interestingly, the study also revealed that the STAT3 and ERK1/2 pathways, previously thought to be major contributors to oral keratinocyte behavior, showed only minor effects. (news-medical.net)
  • Arsenic exposure of human HaCaT keratinocytes induced nuclear accumulation of PRMT1 and PRMT4, histone H4R3 and H3R17 methylation proximal to the ARE, but not to the non-ARE regions of ferritin genes. (embl.de)
  • IL-23 mediates expansion of T helper 17 (Th17) cells, whose effector functions, including IL-17A, activate keratinocytes. (omicsdi.org)
  • Some studies propose that KP is not primarily a disorder of the skin cells (keratinocytes) but rather a problem with the hair shafts. (yourdoctors.online)
  • To determine the role that bacteria play in lipid production, we exposed keratinocytes, the cells that make up the epidermis , to different bacteria naturally present on the skin and analyzed changes in lipid composition. (inverse.com)
  • By activating the EGF/EGFR signaling pathway and downstream cascades, such as Src/PI3K/Akt/mTOR, it may be possible to enhance the motility and proliferative capacity of oral keratinocytes during ex vivo cell expansion. (news-medical.net)
  • By applying in vivo imaging, we demonstrate that Hai1-deficient keratinocytes acquire mesenchymal-like characteristics, lose contact with each other, and become mobile and more susceptible to apoptosis. (biologists.com)
  • We hypothesized that differences in keratinocyte cancer incidence may be reflected in the normal skin mutational landscape. (cdc.gov)
  • Keratinocytes demonstrate a critical capacity to initiate psoriatic inflammation by activating the onset of the pathogenic event and sustaining the prolonged phase [ 3 ]. (thno.org)
  • However, this study, conducted by a team of researchers based at the Division of Biomimetics, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Japan, highlights the significant involvement of the epidermal growth factor/epidermal growth factor receptor (EGF/EGFR) axis and its downstream signaling cascade, particularly Src/PI3K/Akt/mTOR, in the modulation of oral keratinocyte cell motility and proliferative capacity. (news-medical.net)
  • This interaction between Src and EGFR suggests a potential upstream signal transduction from Src to the EGF/EGFR axis in oral keratinocytes. (news-medical.net)
  • Scientists have made significant progress in understanding the signals involved in regulating oral keratinocyte cell motility and proliferative capacity, offering new insights into potential pharmacological manipulation for regenerative medicine. (news-medical.net)
  • A recent study, published in FEBS Open Bio , elucidated the role of the epidermal growth factor (EGF) and its downstream signaling cascade in controlling the behavior of oral keratinocytes. (news-medical.net)
  • Professor Kenji Izumi and his team examined the impact of growth supplements on oral keratinocyte behavior. (news-medical.net)
  • Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1. (embl.de)
  • Kennedy G. Borges L, et al, A protective role for keratinocyte growth factor in a murine model of chemotherapy and radiotherapy-induced mucositis, International Journal of 4, Radiation Oncology Biology Physics 66 1pp. (ceas-mana.ro)
  • This finding indicates the crucial role of EGF in regulating the behavior and quality of oral keratinocytes. (news-medical.net)
  • The findings of this study provide a foundation for potential pharmacological manipulation of oral keratinocytes for regenerative medicine. (news-medical.net)
  • Our results provide a clue on pharmacological manipulation of oral keratinocytes for use in regenerative medicine ', added Prof. Izumi. (news-medical.net)
  • SLURP-1 and -2 in normal, immortalized and malignant oral keratinocytes. (famri.org)
  • Receptor-mediated tobacco toxicity: alterations of the NF-kappaB expression and activity downstream of alpha7 nicotinic receptor in oral keratinocytes. (famri.org)
  • Our results define an exquisite level of precision in the reader-writer interplay that governs the biological outcome of E2F-1 activity. (embl.de)
  • The targeted nanohybrids also suppressed neutrophil migration by reducing CXCL1 and CXCL2 release from keratinocytes. (thno.org)
  • The initiation phase is mediated by keratinocyte response to injury through the release of AMPs [ 1 ] . (encyclopedia.pub)
  • Contact allergen-induced innate immunity contrast to irritant contact dermatitis (ICD), which evolves emollients may help reduce irritancy and stabilize the barrier as a consequence of direct toxic effects of physical or chemi- function of the skin avoiding the penetration of contact aller- cal agents resulting in keratinocyte damage and local inflam- gens. (cdc.gov)
  • Flow cytometry and confocal microscopy showed a 9-fold increase in keratinocyte uptake of targeted nanohybrids relative to non-targeted nanoparticles. (thno.org)