Loading...
  • subpopulation
  • In this thesis I present compelling in vitro and in vivo evidence that a subpopulation of OLM interneurons (defined by the Chrna2-cre line) distinctively enriched in the CA1 region of the ventral hippocampus is implicated in LTP function (paper I,II), information control (paper V) and the induction of theta activity that is under cholinergic control (paper IV). (diva-portal.org)
  • Antibodies against Kv4.3 and KChIP1 represent an important new tool for identifying a subpopulation of hippocampal interneurons with a unique dendritic A-type channel complement and ability to control BAPs. (nih.gov)
  • morphologically
  • It is the fantastically complex network of interneurons and their specialization into morphologically distinct areas within the brain and other parts of the central nervous system, such as the cerebrum , the thalamus , the cerebellum , the brainstem and various nerve plexuses around the body that allow for truly complex and intelligent behavior . (everything2.com)
  • In summary, the work presented in this thesis elucidates the role of a morphologically and electrophysiologially identified cell population, OLMα2 interneurons, first on the cellular, then on the circuit and ultimately on the behavioral level. (diva-portal.org)
  • embryonic
  • Scientists in China are reporting that by transplanting mouse embryonic interneurons into the brains of mice and combining that procedure with training to lessen fear, they can help to reduce the fear response. (eurekalert.org)
  • subtype
  • We also need to determine the exact subtype of transplanted interneurons and the exact subregion in the amygdala that are responsible for these behavioral effects. (eurekalert.org)
  • mice
  • To determine the contribution that transplanting immature interneurons into the amygdala--a brain structure known to be involved in processing of fear and other emotions--could have on fear extinction training, they inserted medial ganglionic eminence (MGE) cells taken from embryos into the amygdala regions of mature mice. (eurekalert.org)
  • brain
  • Researchers from the MRC Centre for Developmental Neurobiology (MRC CDN) at King´s College London, led by Prof. Oscar Marín, have identified the mechanisms guiding interneurons to the striatum, a major brain centre involved in the coordination of body movement and motivation. (innovations-report.com)
  • putative
  • Hb9 interneurons (Hb9 INs) are putative components of the mouse spinal locomotor central pattern generator (CPG) and candidates for the rhythm-generating kernel. (jneurosci.org)
  • ganglionic
  • Hepatocyte growth factor/scatter factor (HGF/SF) has been identified as an important molecular cue that may guide the movement of interneurons from their birthplace in the ganglionic eminences (GE) to their final resting place in the neocortex. (nih.gov)
  • spontaneous
  • We have extracellularly recorded the spontaneous activity of vestibulocerebellar interneurons in ketamine/xylazine-anesthetized rats and subsequently labeled them with Neurobiotin using the juxtacellular technique. (jneurosci.org)
  • The spontaneous activity of interneurons examined in the ketamine/xylazine rabbit fit within this general pattern. (jneurosci.org)
  • We set out to record the spontaneous activity of interneurons in the vestibulocerebellum of anesthetized rats and then to label them using the juxtacellular technique described by Pinault (1996) . (jneurosci.org)
  • We show that different classes of interneurons can be identified on the basis of statistical measures that characterize their spontaneous firing patterns. (jneurosci.org)
  • Motor
  • bodies, unmyelinated motor-neuron fibres, and interneurons connecting the two sides of the cord. (britannica.com)
  • Having eliminated one source of motor neuron excitotoxicity, the researchers turned to interneuron input. (alzforum.org)
  • We developed a computer-automated system that detects rhythmically active interneurons via two-photon calcium imaging, stores their physical locations in memory, and then laser ablates the targets sequentially, while electrophysiologically monitoring the motor output of the circuit. (pnas.org)
  • The cumulative deletion of preBötC interneurons diminished the amplitude of respiratory motor output and caused an increase in the cycle period that led inexorably to rhythm cessation. (pnas.org)
  • formation
  • We found that although the transplanted interneurons did not alter the formation of fear memories, they reduced recovery and renewal of fear after extinction training," Yu says. (eurekalert.org)
  • activity
  • Rhythmic activity within the heartbeat pattern generator of the medicinal leech is based on the alternating bursting of mutually inhibitory pairs of oscillator heart interneurons (half-center oscillators). (jneurosci.org)
  • cells
  • This study describes the generation of V2a interneurons from human pluripotent stem cells, using developmentally relevant morphogenic signaling pathways. (pnas.org)
  • show
  • Using extracellular recording techniques, we show here that oscillator and premotor heart interneurons continue to burst when pharmacologically isolated with bicuculline, although the bursting is not robust in some preparations. (jneurosci.org)
  • single
  • A two-parameter bifurcation diagram ( E leak vs g leak ) of a mathematical model of a single heart interneuron shows a narrow stripe of parameter values where bursting occurs, separating large zones of tonic spiking and silence. (jneurosci.org)
  • help
  • We propose that this algorithm can be used to help classify vestibulocerebellar interneurons recorded in awake, behaving animals. (jneurosci.org)