• In this thesis I present compelling in vitro and in vivo evidence that a subpopulation of OLM interneurons (defined by the Chrna2-cre line) distinctively enriched in the CA1 region of the ventral hippocampus is implicated in LTP function (paper I,II), information control (paper V) and the induction of theta activity that is under cholinergic control (paper IV). (diva-portal.org)
  • 1 . Minneci F, Janahmadi M, Migliore M, Dragicevic N, Avossa D, Cherubini E (2007) Signaling properties of stratum oriens interneurons in the hippocampus of transgenic mice expressing EGFP in a subset of somatostatin-containing cells. (yale.edu)
  • Some interneurons of the hippocampus exhibit NMDA receptor-independent long-term potentiation (LTP) that is induced by presynaptic glutamate release when the postsynaptic membrane potential is hyperpolarized. (ox.ac.uk)
  • Haas, H. L. / Activation of interneurons at the stratum oriens/alveus border suppresses excitatory transmission to apical dendrites in the CA1 area of the mouse hippocampus . (elsevier.com)
  • GABA interneurons mediate maturation of the prefrontal cortex (PFC) and hippocampus during adolescence. (lakeforest.edu)
  • Recent findings indicate that these drugs disrupt GABA interneurons in the maturing PFC, but effects on hippocampus are unknown. (lakeforest.edu)
  • Transplantation of GABAergic interneurons (INs) can provide long-term functional benefits in animal models of epilepsy and other neurological disorders. (nih.gov)
  • Fast-spiking (FS) cells are a prominent subtype of GABA-releasing (GABAergic) interneurons ( 12 ), exerting powerful inhibitory control of both excitatory and inhibitory cortical cells ( 13-17 ). (sciencemag.org)
  • Here we demonstrate that individual GABAergic interneurons can effectively phase spontaneous firing and subthreshold oscillations in hippocampal pyramidal cells at 0 frequencies (4-7 Hz). (nih.gov)
  • Inhibitory GABAergic interneurons of the mouse neocortex are a highly heterogeneous population of neurons that originate from the ventral telencephalon and migrate tangentially up into the developing cortical plate. (semanticscholar.org)
  • The two major goals of this project is to 1) provide the research community and public domain for the first time with a comprehensive genome-wide atlas of the histone methylation landscape in selected subpopulations of cortical GABAergic interneurons and other cells residing in mouse cerebral cortex;and 2) To gain first insights into chromatin remodeling mechanisms of GABAergic neurons during the transition from juvenile to mature age. (grantome.com)
  • Dysregulated gene expression in GABAergic interneurons is considered a hallmark of the molecular pathophysiology and a major factor for the synchronization deficits in neural networks that affect widespread areas of the cerebral cortex in subjects on the psychosis or autism spectrum. (grantome.com)
  • Therefore, in the context of this proposal, we plan to generate 4 isogenic lines of BAC (bacterial artificial chromosome) transgenic mice to express green fluorescent protein (GFP)-tagged histone H2B in GABAergic interneurons overall, and in 3 specific subpopulations defined by differential expression of calcium buffering proteins Parvalbumin (PARV) or Calbindin (CALB) or Calretinin (CALR). (grantome.com)
  • In the pilocarpine model of chronic limbic seizures, vulnerability of GABAergic interneurons to excitotoxic damage has been reported in the hippocampal CA1 region. (elsevier.com)
  • Our data demonstrate that the decrease in the number of GAD mRNA-containing neurons in the stratum oriens of CA1 in pilocarpine-treated rats involved two subpopulations of GABAergic interneurons: interneurons labeled for somatostatin only (O-LM and bistratified cells) and interneurons labeled for parvalbumin only (basket and axo-axonic cells). (elsevier.com)
  • Cortical GABAergic interneurons originate from ganglionic eminences and tangentially migrate into the cortical plate at early developmental stages. (duhnnae.com)
  • To elucidate the characteristics of this migration of GABAergic interneurons in living animals, we established an experimental design specialized for in vivo time-lapse imaging of the neocortex of neonate mice with two-photon laser-scanning microscopy. (duhnnae.com)
  • In vesicular GABA-glycine transporter VGAT-Venus transgenic mice from birth P0 through P3, we observed multidirectional tangential migration of genetically-defined GABAergic interneurons in the neocortical marginal zone. (duhnnae.com)
  • In an in vitro neocortical slice preparation, we confirmed that GABA induced a NKCC sensitive depolarization of GABAergic interneurons in VGAT-Venus mice at P0-P3. (duhnnae.com)
  • Thus, activation of GABAAR by ambient GABA depolarizes GABAergic interneurons, leading to an acceleration of their multidirectional motility in vivo. (duhnnae.com)
  • Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo. (ox.ac.uk)
  • Long-term potentiation (LTP) and -depression (LTD) have also been reported in glutamatergic connections to hippocampal GABAergic interneurons expressing parvalbumin (PV+) or nitric oxide synthase (NOS+) in brain slices, but plasticity in these cells has not been tested in vivo. (ox.ac.uk)
  • We used immunocytochemical methods to define the location of the group III receptor mGluR7a in glutamatergic and GABAergic terminals innervating GABAergic interneurons and pyramidal cells. (ox.ac.uk)
  • DLX1 and/or DLX2 activated the transcription of both Gad genes, and defects in Dlx function disrupted the differentiation of GABAergic interneurons with global reduction in GABA levels in the forebrains of the Dlx1/Dlx2 double knock-out mouse in vivo . (fourthventricle.com)
  • it extends our understanding of Dlx gene function in the developing forebrain beyond the regulation of tangential interneuron migration to the differentiation of GABAergic interneurons arising from the basal telencephalon, and may help to unravel the pathogenesis of several developmental brain disorders. (fourthventricle.com)
  • Previous studies have attributed this effect to the activation of HT-5 3 receptors located on GABAergic interneurons. (aspetjournals.org)
  • We interpret these results to indicate that 5-HT 2 receptors activate GABAergic interneurons in the slice, leading to an increase in GABAergic synaptic activity onto pyramidal cells of the CA1 region. (aspetjournals.org)
  • Less is known however about the effects of 5-HT on GABAergic interneurons. (aspetjournals.org)
  • A quantal analysis of the increased synaptic activity indicates that 5-HT 3 receptors elicit this effect by activating GABAergic interneurons ( Ropert and Guy, 1991 ). (aspetjournals.org)
  • Direct evidence for the depolarization and activation of GABAergic interneurons by 5-HT 3 receptors has been obtained recently in the dentate gyrus ( Kawa, 1994 ). (aspetjournals.org)
  • We now present evidence that in addition to 5-HT 3 receptors, 5-HT can act on receptors of the 5-HT 2 subtype family to depolarize and excite GABAergic interneurons of the CA1 region. (aspetjournals.org)
  • The motor and learning functions of the striatum are critically dependent on synaptic transmission from midbrain dopamine neurons and striatal cholinergic interneurons (CINs). (jneurosci.org)
  • In the cerebral cortex, excitation and inhibition are mediated by two cell types born in distinct areas of the embryo: excitatory projection neurons, which are generated in the developing cortex, and inhibitory interneurons, which are produced outside the cortex in the ventral forebrain. (sciencemag.org)
  • The embryologic programs that guide interneuron migration, survival, and circuit integration are also executed by these young neurons after their transplantation into the juvenile and adult nervous systems. (sciencemag.org)
  • Striatal fast spiking (FS) interneurons provide inhibition to each other as well as to medium spiny projection (SP) neurons. (diva-portal.org)
  • In order to characterize these interneurons, we performed quantitative analyses of the different populations of GABAergic neurons labeled for their peptide or calcium-binding protein content. (elsevier.com)
  • These results indicate that the loss of somatostatin-containing neurons corresponds preferentially to the degeneration of interneurons with an axon projecting to stratum lacunosum-moleculare (O-LM cells) and suggest that the death of these neurons is mainly responsible for the deficit of dendritic inhibition reported in this region. (elsevier.com)
  • Vasoactive intestinal polypeptide- (0.1 μM in the bath) excited neurons with response and firing properties characteristic for interneurons at the oriens/alveus border. (elsevier.com)
  • Networks of hippocampal interneurons, with pyramidal neurons pharmacologically disconnected, can generate gamma-frequency (20 Hz and above) oscillations. (ox.ac.uk)
  • Neocortical choline acetyltransferase (ChAT)-expressing interneurons are a subclass of vasoactive intestinal peptide (ChAT-VIP) neurons of which circuit and behavioural function are unknown. (meta.org)
  • Here, we find that in the medial prefrontal cortex (mPFC), ChAT-VIP neurons directly excite interneurons in layers (L)1-3 as well as pyramidal neurons in L2/3 and L6 by fast cholinergic transmission. (meta.org)
  • Dual recordings of presynaptic ChAT-VIP neurons and postsynaptic L1 interneurons show fast nicotinic receptor currents strictly time-locked to single presynaptic action potentials. (meta.org)
  • A fraction (10-20%) of postsynaptic neurons that received cholinergic input from ChAT-VIP interneurons also received GABAergic input from these neurons. (meta.org)
  • In contrast to regular VIP interneurons, ChAT-VIP neurons did not disinhibit pyramidal neurons, but instead depolarized fast spiking and low threshold spiking interneurons. (meta.org)
  • Glutamate transmission to gamma-aminobutyric acid (GABA)ergic interneurons and to principal neurons differs in various important respects. (gu.se)
  • In marked contrast to AMPA silencing in principal neurons, AMPA silencing in interneurons was not developmentally restricted, but was observed to the same extent after the first postnatal month as in the second postnatal week. (gu.se)
  • These results highlight a diversity of glutamate signaling to CA1 stratum radiatum interneurons, and they indicate that the glutamate synapses onto pyramidal neurons and to interneurons can mature differentially. (gu.se)
  • To better understand this diversity, we have performed a detailed anatomical and physiological characterization of 3 subtypes of visual cortex interneurons, isolated from transgenic mice which express green fluorescent protein in somatostatin, parvalburnin, and neuropeptide Y positive neurons. (cshl.edu)
  • The frequency of strongly mGluR7a positive terminals innervating the soma and dendrites of mGluR1 alpha/somatostatin-expressing interneurons was very high relative to other neurons. (ox.ac.uk)
  • Furthermore, selective suppression of PV interneurons in the mPFC using hM4Di, a DREADD (designer receptor exclusively activated by designer drug), promoted helplessness, indicating that activation of these neurons during stress promotes the establishment of resilient behavior. (cshl.edu)
  • Thus, GABAergic synaptic activity in CA1 pyramidal neurons is maintained, in part, by tonically active α7 nAChRs located on the preterminal region of axons and/or the somatodendritic region of interneurons that synapse onto the neurons under study. (aspetjournals.org)
  • We reveal Dmrt3 neurons comprise a population of glycinergic inhibitory, spike-frequency adapting commissural interneurons active during locomotion. (diva-portal.org)
  • Transporter-dependent potentiation of mGluR1 EPSCs led to a dramatic increase in interneuron firing and enhanced inhibition of CA1 pyramidal neurons, suggesting that acute or prolonged disruption of transporter activity could lead to changes in network activity as a result of enhanced interneuron excitability. (bergleslab.com)
  • These GABA related gene expression deficits include distinct cell types such as the class of fast spiking interneurons commonly recognized by expression of the calcium binding protein, Parvalbumin. (grantome.com)
  • Theta-burst stimulation (TBS) generated LTP of the synaptically-evoked spike probability in pyramidal cells, and in a bistratified cell and two unidentified fast-spiking interneurons. (ox.ac.uk)
  • For the fast-spiking interneurons, as a group, no correlation was found between plasticity and local field potential oscillations (1-3 or 3-6 Hz components) recorded immediately prior to TBS. (ox.ac.uk)
  • Dynamics of action potential firing in electrically connected striatal fast-spiking interneurons. (neuroelectro.org)
  • Vurdering af den relative bidrag af hver komponent er en kompliceret opgave, som er særligt vanskeligt med hensyn til udviklingen af γ-aminosmørsyre (GABA) erge kortikale interneuroner (CIs). (jove.com)
  • Thus, stratum oriens/alveus interneurons have a profound inhibitory effect on signal transmission in the apical dendritic area of CA1, which is, at least in part, mediated by GABA(B) receptors. (elsevier.com)
  • It appears that the GABA(B) receptor-mediated effect in stratum lacunosum-moleculare is produced by vasoactive intestinal polypeptide-sensitive interneurons. (elsevier.com)
  • Some GABA (gamma-aminobutyric acid)-containing interneurons fire phase-locked to theta oscillations (4-8 Hz) or to sharp-wave-associated ripple oscillations (120-200 Hz), which represent different behavioural states. (ox.ac.uk)
  • Among these features are deficits of working memory and decreased levels of glutamic acid decarboxylase 67, one of the enzyme isoforms that catalyzes the synthesis of GABA, and parvalbumin, a Ca 2+ -binding protein expressed by interneurons, primarily in the stratum pyramidale. (aspetjournals.org)
  • We have found that quantal release of GABA from interneurons elicits GABA(A) receptor currents with rapid rise times in hippocampal OPCs. (bergleslab.com)
  • These currents did not exhibit properties of spillover transmission or release by transporters, and immunofluorescence and electron microscopy suggest that interneuronal terminals are in direct contact with OPCs, indicating that these GABA currents are generated at direct interneuron-OPC synapses. (bergleslab.com)
  • GABAergic interneuron, pyramidal neuron, single CA3-CA1 glutamatergic synapse, and astrocytes, we found that interneuron-astrocyte signaling dynamically affected excitatory neurotransmission in an activity- and time-dependent manner, and determined the sign (inhibition vs potentiation) of the GABA-mediated effects. (bergleslab.com)
  • For my thesis, I investigated three such drugs for effects on hippocampal GABA interneurons in adolescent rats. (lakeforest.edu)
  • I found developmental disregulation of GABA interneurons to cocaine and a glutamate agonist, but not to a marijuana-mimic. (lakeforest.edu)
  • Neocortical interneurons display great morphological and physiological variability and are ideally positioned to control circuit dynamics, although their exact role is still poorly understood. (cshl.edu)
  • K(+) channel expression distinguishes subpopulations of parvalbumin- and somatostatin-containing neocortical interneurons. (jax.org)
  • Stratum oriens interneurons labeled for somatostatin/calbindin or somatostatin/parvalbumin were preserved. (elsevier.com)
  • Because interneuron diversity potentially conceals simple rules underlying different forms of plasticity, we focus on glutamatergic synapses onto a subset of interneurons with dendrites in stratum oriens and a main ascending axon that projects to stratum lacunosum moleculare, the oriens-lacunosum moleculare (O-LM) cells. (ox.ac.uk)
  • The consequences of activation or inactivation of interneurons at the CA1 stratum oriens/alveus border for signal transmission at the apical dendritic region of pyramidal cells were investigated in slices from mice submerged in a perfusion chamber. (elsevier.com)
  • Stimulation in stratum oriens reliably elicited a slow mGluR1-mediated current in O-LM interneurons if they were briefly depolarized to allow Ca2+ entry before stimulation. (bergleslab.com)
  • MicrocircuitDB: CA1 oriens alveus interneurons: signaling properties (Minneci et al. (yale.edu)
  • Origins of cortical interneuron subtypes. (semanticscholar.org)
  • Our goal is to determine how synaptic interactions of local interneurons with different M/T cells subtypes in the external plexiform layer (EPL) could make this possible. (grantome.com)
  • The spontaneous activity and evoked responses of the interneurons are consistent with anatomical studies suggesting they are excited by and inhibit different M/T cell subtypes within different EPL sublaminae. (grantome.com)
  • Aim 1 will test the hypothesis that EPL interneurons include several electrophysiologically and morphologically distinct subtypes or, alternatively, neurochemically distinct subtypes that have different distributions within the three EPL sublaminae. (grantome.com)
  • Aim 2 will test the hypothesis that the excitatory synaptic inputs of EPL interneurons located in the superficial EPL are correlated with spike bursts of superficial tufted cells, whereas the excitatory synaptic inputs of interneurons located in deeper sublaminae are correlated with spike bursts of multiple M/T cell subtypes. (grantome.com)
  • The results will reveal if different EPL interneuron subtypes and M/T cell subtypes together define spatial domains for sensory encoding, which allow the M/T cells to act in parallel to transmit information about odors that activate clusters of glomeruli having overlapping odor sensitivities. (grantome.com)
  • A characteristic subpopulation of interneurons with a horizontal dendritic tree in this region, which sends a GABAergic projection to the apical dendrites of CA1 pyramidal cells is strongly excited by metabotropic glutamate receptor activation and receives GABAergic input from vasoactive intestinal polypeptide-containing interneurons. (elsevier.com)
  • Here we use network simulations to investigate how pyramidal cells, connected to the interneurons and to each other through AMPA-type and/or NMDA-type glutamate receptors, might modify the interneuron network oscillation. (ox.ac.uk)
  • In the present study, we examined whether this developmental difference in AMPA signaling is also true for glutamate transmission to CA1 stratum radiatum interneurons. (gu.se)
  • In addition, we found that glutamate synapses onto these interneurons can also be N-methyl-d-aspartate (NMDA)-silent, that is, only AMPA-signaling. (gu.se)
  • The enrichment of mGluR7a in the main GABAergic, as well as in the glutamatergic, innervation of mGluR1 alpha/somatostatin-expressing interneurons suggests that their activation is under unique regulation by extracellular glutamate. (ox.ac.uk)
  • Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. (bergleslab.com)
  • To determine which glutamate transporters are essential for removing glutamate at these excitatory synapses, we recorded mGluR1-mediated EPSCs from oriens-lacunosum moleculare (O-LM) interneurons in acute hippocampal slices. (bergleslab.com)
  • A comparison of responses recorded from wild-type and transporter knock-out mice revealed that the astroglial glutamate transporters GLT-1 and GLAST, but not the neuronal transporter EAAC1, restrict activation of mGluRs in O-LM interneurons. (bergleslab.com)
  • Perisoma-inhibiting interneurons (PIIs) control fundamental aspects of cortical network function by means of their GABAergic output synapses. (jneurosci.org)
  • The properties of excitatory synapses at FS cells ( 13 , 18 ), as well as their voltage-dependent conductances ( 19-21 ), suggest that these cells may be particularly sensitive to the timing of their inputs, as has been shown for hippocampal interneurons ( 22 , 23 ). (sciencemag.org)
  • Silent synapses onto interneurons in the rat CA1 stratum radiatum. (gu.se)
  • We found that AMPA silent synapses onto these interneurons also exist, and that they can be generated by test pulse stimulation. (gu.se)
  • After test pulse stimulation, the AMPA-silent, the NMDA-silent and the AMPA/NMDA-signaling synapses onto the developing interneurons were estimated to be about equally frequent. (gu.se)
  • These data suggests that similar activation points are required for stimulation-induced DLL as for LTD at excitatory striatal synapses, and that cholinergic interneurons are key modulators of stimulation-induced eCB signaling in the striatum. (gu.se)
  • Oriens-lacunosum moleculare (OLM) cells are hippocampal inhibitory interneurons that have been implicated in regulation of information flow and synaptic plasticity in the CA1 circuit. (meta.org)
  • Developmental expression of potassium-channel subunit Kv3.2 within subpopulations of mouse hippocampal inhibitory interneurons. (jax.org)
  • Subgroups of parvalbumin-expressing interneurons in layers 2/3 of the visual cortex. (semanticscholar.org)
  • Experiments and models have shown how the network frequency depends on excitation of the interneurons, and on the parameters of GABAA-mediated IPSCs between the interneurons (conductance and time course). (ox.ac.uk)
  • With or without AMPA-receptor mediated excitation of the interneurons, the pyramidal cells and interneurons fired in phase during the gamma oscillation. (ox.ac.uk)
  • Synaptic excitation of the interneurons by pyramidal cells caused them to fire spike doublets or short bursts at gamma frequencies, thereby slowing the population rhythm. (ox.ac.uk)
  • The results demonstrate activity-induced long-term plasticity in synaptic excitation of hippocampal PV+ and NOS+ interneurons in vivo. (ox.ac.uk)
  • Modulation of endocannabinoid-mediated long-lasting disinhibition of striatal output by cholinergic interneurons. (gu.se)
  • We postulate that inhibition provided by the interneurons increases coherence of M/T cell spike output from glomerular clusters, which could signal the odor category and improve detection of weak odors within the category. (grantome.com)
  • We show that anti-Hebbian LTP in O-LM interneurons has consistent induction and expression properties, and is prevented by selective inhibition of AMPA receptors. (ox.ac.uk)
  • Scopolamine (10 μM) restored DLL in strychnine-treated slices, suggesting that inhibition of glycine receptors on cholinergic interneurons could modulate eCB signaling by enhancing muscarinic receptor activation and reducing the opening of L-type calcium channels in response to depolarization. (gu.se)
  • Its activity is controlled by glutamatergic afferents from cortex and thalamus, by dopaminergic inputs from the ventral midbrain, and by local interneurons. (jneurosci.org)
  • Here we show that glutamatergic synaptic transmission to inhibitory interneurons in the basolateral amygdala is mediated solely by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. (semanticscholar.org)
  • Magoh is highly expressed in the ganglionic eminences during interneuron neurogenesis, and conditional Magoh depletion in interneuron progenitors (but not in post-mitotic migrating interneurons) reduces cortical interneuron number in a dose-dependent manner. (biologists.org)
  • But while deletion of p53 in Magoh haploinsufficient progenitors completely rescues cortical interneuron number, it does not in Magoh homozygous progenitors, which still show delayed mitosis. (biologists.org)
  • The early differentiating MATH1-expressing cells in the dorsal neural tube co-express TAG-1, DCC-1 and LH2, markers of dorsal commissural interneurons. (biologists.org)
  • Expression of the MATH1/lacZ transgene persists in differentiated dorsal commissural interneurons. (biologists.org)
  • Taken together, we demonstrate MATH1 expression in a differentiating population of neuronal precursors in the dorsal neural tube that appear to give rise specifically to dorsal commissural interneurons. (biologists.org)
  • Here we report that three distinct interneuron types--basket, axo-axonic and oriens-lacunosum-moleculare cells--visualized and defined by synaptic connectivity as well as by neurochemical markers, contribute differentially to theta and ripple oscillations in anaesthetized rats. (ox.ac.uk)
  • A blueprint for the spatiotemporal origins of mouse hippocampal interneuron diversity. (semanticscholar.org)
  • Yasaka, T. , Tiong, S.Y.X. , Hughes, D.I. , Riddell, J.S. and Todd, A.J. (2010) Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach. (gla.ac.uk)
  • Our results demonstrate that certain distinctive populations of inhibitory and excitatory interneuron can be recognised in lamina II. (gla.ac.uk)
  • We expect that the various interneuron subpopulations, which differ in terms of function and developmental history, will show cell type specific chromatin signatures in many portions of the genome. (grantome.com)
  • Precursors of inhibitory interneurons transplanted from the medial ganglionic eminence of the ventral embryonic forebrain into the juvenile or adult rodent cortex migrate from the graft site and become dispersed throughout the recipient tissue (shown as small red dots in the transplanted hemisphere in a cross section of the rodent brain, upper left). (sciencemag.org)
  • Mammalian interneurons are crucial for cortical function, and are formed by progenitors located in the ganglionic eminences. (biologists.org)
  • The majority of cortical interneurons arise from a transient embryonic structure known as the medial ganglionic eminence (MGE), but how the remarkable diversity is specified in this region is not known. (semanticscholar.org)
  • Genetic fate mapping reveals that the caudal ganglionic eminence produces a large and diverse population of superficial cortical interneurons. (semanticscholar.org)
  • Using conditional astrocyte-specific GABAB receptor (Gabbr1) knockout mice, we confirmed the glial source of the interneuron-induced potentiation, and demonstrated the involvement of astrocytes in hippocampal theta and gamma oscillations in vivo. (bergleslab.com)
  • The question raised here is whether spinal interneurons can mediate the cortical command for independent finger movements, like a precision grip between the thumb and index finger in the macaque monkey, or if this function depends exclusively on a direct corticomotoneuronal pathway. (diva-portal.org)
  • One-third of all progenitor daughter cells also undergo apoptosis, and there is a bias towards interneurons at the expense of new progenitors in the surviving daughters. (biologists.org)
  • Using patch recording and biocytin labeling methods, we have found that mouse EPL interneurons exhibit several subsets of electrophysiological and morphological properties and that in two dimensions they bridge EPL space below adjacent glomeruli. (grantome.com)
  • Her præsenterer vi en protokol, der tillader genetisk modifikation af embryonale interneuron-progenitorer ved hjælp af fokal ex vivo-elektroporation. (jove.com)
  • Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo. (ox.ac.uk)
  • The large diversity of interneurons poses the question of whether they have specific roles in shaping distinct network activities in vivo. (ox.ac.uk)
  • Physiological and pathological activity patterns in vivo may generate similar plasticity in these interneurons. (ox.ac.uk)
  • Roles of Molecular Layer Interneurons in Sensory Information Processing in Mouse Cerebellar Cortex Crus II In Vivo - Descarga este documento en PDF. (duhnnae.com)
  • After migrating from their origins across the developing brain, young interneurons reach the cortex and differentiate into various inhibitory neuronal cell types. (sciencemag.org)
  • Her præsenterer vi en protokol, designet til at bruge kemo genetiske værktøjer til at manipulere aktiviteten af kortikale interneuron forfædre transplanteres i cortex af tidlige postnatale mus. (jove.com)
  • Interneuron forfædre isoleret fra embryonale ganglioniske to er i stand til at overleve, sprede og integrere sig i værtsnetværket ved transplantation i cortex 7 , 8 . (jove.com)
  • Cerebellar cortical molecular layer interneurons MLIs play essential roles in sensory information processing by the cerebellar cortex. (duhnnae.com)
  • Enrichment of mGluR7a in the presynaptic active zones of GABAergic and non-GABAergic terminals on interneurons in the rat somatosensory cortex. (ox.ac.uk)
  • We have now isolated one spinal interneuronal system, the C3-C4 propriospinal interneurons with projection to hand and arm motoneurons. (diva-portal.org)
  • Motoneurons and abducens interneurons were both affected in a similar way. (wright.edu)
  • The targets of VIP/mGluR7a-expressing terminals were mainly (88%) mGluR1 alpha-expressing interneurons, which were mostly somatostatin immunopositive. (ox.ac.uk)
  • However, its neuronal circuitry is poorly understood due to the difficulty of identifying functional populations of interneurons. (gla.ac.uk)
  • These respective features are consistent with properties of excitatory and inhibitory interneuron populations in this region of the spinal cord. (gla.ac.uk)
  • Although both AMPA and kainate receptors are expressed in hippocampal interneurons, their relative roles in anti-Hebbian LTP are not known. (ox.ac.uk)
  • In the previous study, the lateral corticospinal tract (CST) was interrupted in C4/C5 (input intact to the C3-C4 propriospinal interneurons), and in this study, the CST was interrupted in C2 (input abolished). (diva-portal.org)
  • We conclude that C3-C4 propriospinal interneurons also can carry the command for precision grip. (diva-portal.org)
  • The role of propriospinal interneurons in recovery from spinal cord injury. (jove.com)
  • Studies in intact animals as well as theoretical work suggest that inhibitory interneurons may coordinate neuronal activity in cortical networks ( 6-11 ). (sciencemag.org)
  • This discovery helps explain how Dlx mutations result in abnormal forebrain development, due to defective differentiation, in addition to the loss of tangential migration of GABAergic inhibitory interneurons to the neocortex. (fourthventricle.com)
  • Studiet af CI udvikling er udfordrende, fordi CIs er genereret i forbigående embryonale strukturer, der er svære at få adgang til, og de følger en lang tangentielle migration, før de når pallium og udvikle deres modne anatomiske og fysiologiske ejendomme 3 . (jove.com)
  • Lamina II contains a large number of interneurons involved in modulation and transmission of somatosensory (including nociceptive) information. (gla.ac.uk)
  • Here, we investigate the role of parvalbumin (PV) interneurons in the medial PFC (mPFC) in shaping behavioral responses to stress induced by the learned helplessness procedure, in which animals are subjected to an unpredictable and inescapable stressor. (cshl.edu)
  • We conclude that the diversity of interneurons, innervating distinct domains of pyramidal cells, emerged to coordinate the activity of pyramidal cells in a temporally distinct and brain-state-dependent manner. (ox.ac.uk)
  • In the recipient, transplanted interneurons follow cell-intrinsic programs that normally regulate their survival and differentiation in the embryo. (sciencemag.org)
  • Sauer and Bartos, 2010 ) and remains shunting throughout postnatal development ( Banke and McBain, 2006 ), one of the most basic questions, namely whether interneurons hyperpolarize or depolarize PCs, is still open. (jneurosci.org)