AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and Processes
ApomorphineDopamine AgonistsReceptors, DopamineHaloperidolPiribedilEmeticsPenile ErectionPimozideStereotyped BehaviorDopamine AntagonistsStartle ReactionLevodopaAntiparkinson AgentsDopamineReceptors, Dopamine D2CatalepsyTranquilizing AgentsCarbidopaSensory GatingHydroxydopaminesYawningQuinpiroleParkinson DiseaseAdministration, SublingualDopamine AgentsParkinson Disease, SecondaryDomperidone2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineReceptors, Dopamine D1OxidopamineErgolinesBis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfideAmphetamineMotor ActivityHarmineSubstantia NigraCorpus StriatumBehavior, AnimalPenisReceptors, Dopamine D3Infusion PumpsBenzazepinesDyskinesia, Drug-InducedSulpirideSpiperoneErectile DysfunctionLisurideInjections, SubcutaneousFlupenthixolDose-Response Relationship, DrugRats, Sprague-Dawley
SubcutaneousDelivery of apomorphineFormulation of apomorphineParkinson'sErectile dysfunctionLevodopaPatientsTreatmentPainGoodDopamine receptorSublingualParkinson's DiseaseAntagonistsInjectionEpisodes
Subcutaneous5
  • P enile erections were regularly induced by intermittent subcutaneous injections of apomorphine in five patients with Parkinson's disease (PD) complicated by motor fluctuations. (biopsychiatry.com)
  • Apomorphine is the only molecule approved for acute, intermittent treatment of OFF episodes for advanced PD patients, but is currently only approved as a subcutaneous injection in the United States. (traderpower.com)
  • APL-130277 is a "turning ON" medication designed to rapidly, safely and reliably convert a PD patient from the OFF to the ON state while avoiding many of the issues associated with subcutaneous delivery of apomorphine. (traderpower.com)
  • These therapies are in order of increasing invasiveness the subcutaneous apomorphine pump (apomorphine is a dopamine agonist in use for decades), the intrajejunal levodopa gel pump (jejunum is the proximal part of the small intestine) and the deep brain stimulator systems that provide intermittent electrical stimulation in deep brain structures with very good therapeutic results. (nevrologos-sidiropoulos.gr)
  • For example, the subcutaneous apomorphine pump is minimally invasive and easy to use, but it is probably best for younger and healthier, from a cognitive and clinical standpoint, patients, as it can sometimes cause hallucinations, confusion, low blood pressure, nausea and sleepiness. (nevrologos-sidiropoulos.gr)
Delivery of apomorphine1
Formulation of apomorphine2
  • KYNMOBI (apomorphine hydrochloride) sublingual film, a novel formulation of apomorphine, a dopamine agonist, is the first and only sublingual therapy for the fast-acting, on-demand treatment of OFF episodes associated with Parkinson's disease. (pipelinereview.com)
  • The Company successfully completed a Phase 2 clinical trial for its product candidate, APL-130277, a sublingual formulation of apomorphine hydrochloride, or apomorphine. (traderpower.com)
Parkinson's5
  • Apomine Solution for Infusion® and Apomine Intermittent® (apomorphine) for the treatment of Parkinson's disease will be extended, to include access to maintenance treatment through community pharmacy in addition to hospitals. (health.gov.au)
  • MARLBOROUGH, MA, USA I May 21, 2020 I Sunovion Pharmaceuticals Inc. (Sunovion) announced today that the U.S. Food and Drug Administration (FDA) has approved KYNMOBI™ (apomorphine HCI) sublingual film (APL-130277) for the acute, intermittent treatment of OFF episodes in patients with Parkinson's disease (PD). (pipelinereview.com)
  • KYNMOBI TM (apomorphine hydrochloride) sublingual film is a prescription medicine used to treat short-term (acute), intermittent "off" episodes in people with Parkinson's disease (PD). (pipelinereview.com)
  • Acute, intermittent treatment of "off" episodes in Parkinson's disease. (empr.com)
  • INDICATION APOKYN is indicated for the acute, intermittent treatment of hypomobility, "of f " episodes ("end-of-dose wearing-of f " and unpredictable "on-of f " episodes) in patients with advanced Parkinson's disease (PD). (apokynhcp.com)
Erectile dysfunction1
Levodopa2
  • For refractory, disabling symptoms in patients without dementia, stereotactic deep brain stimulation or lesional surgery and levodopa and an apomorphine pump may help. (msdmanuals.com)
  • Inbrija (previously known as CVT-301) is an inhaled powder formulation of levodopa indicated for the intermittent treatment of 'off episodes' in patients with Parkinson's disease currently taking carbidopa/levodopa . (cloudfront.net)
Patients1
  • The benefit of apomorphine on sexual function in some patients suggests a possible role in the treatment of impotence in PD. (biopsychiatry.com)
Treatment1
  • The Foundation supported early clinical development of sublingual apomorphine, and this approval brings an important new treatment option for people with PD who experience OFF. (pipelinereview.com)
Pain1
  • Epidural anaesthesia is the m ost efficient way of relieving the ache of childbirth, and provides com plete relief of contraction pain in 95% of labouring wom en. (dnahelix.com)
Good1
  • Although equally good results intermittent catheterisation of the ejaculatory tactile sensitivity is poor (see the labels associated with clinical stage 1 refers to style and approach tendencies. (ben.edu)
Dopamine receptor1
  • AB - A series of apomorphine congeners has been studied with respect to their ability to mimic the structural requirements of the dopamine pharmacophore in the potent and stereoselective dopamine receptor agonist (R)-apomorphine. (nih.gov)
Sublingual2
  • APL is a sublingual formulation of apomorphine being developed for the acute treatment of all types of intermittent OFF episodes. (mdsabstracts.org)
  • Sunovion Pharmaceuticals submitted a new drug application to the FDA this week for its apomorphine sublingual film designed to treat motor fluctuations experienced by people with Parkinson's disease. (drugdeliverybusiness.com)
Parkinson's Disease3
  • The apomorphine test determines the levodopasensitivity of a parkinsonian syndrome by application of an apomorphine bolus to distinguish between idiopathic Parkinson's disease and atypical parkinsonian syndromes. (nih.gov)
  • Acorda Therapeutics (NSDQ:ACOR) said today that the European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) has recommended approval of its Inbrija device for the intermittent treatment of "off" episodes in people with Parkinson's disease. (drugdeliverybusiness.com)
  • Acorda Therapeutics (NSDQ:ACOR) said this week that the FDA approved its Inbrija device for the intermittent treatment of "off" episodes in people with Parkinson's disease. (drugdeliverybusiness.com)
Antagonists1
  • Profound hypotension and loss of consciousness reported when 5HT3 antagonists are coadministered with apomorphine. (medscape.com)
Injection2
  • These highlights do not include all the information needed to use APOMORPHINE HYDROCHLORIDE INJECTION safely and effectively. (nih.gov)
  • It is important in the intermittent Apomorphine therapy to change the injection site every time you set a new catheter. (d-minecare.com)
Episodes1
  • The frequency of regurgitation varies from intermittent irregular episodes to multiple episodes per day. (canine-megaesophagus.com)