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  • IKCa
  • Similar hyperpolarization was evoked with cyclopiazonic acid (10 microM, an inhibitor of sarcoplasmic endoplasmic reticulum calcium ATPase (SERCA)) while 1-EBIO (300 microM, an IKCa activator) only increased the potential by a few millivolts. (ox.ac.uk)
  • Subunit
  • Examination of transgenic mice, each lacking one of the three SK channel genes expressed in the CNS, reveals that mice without the SK2 subunit completely lack the apamin-sensitive component of the ImAHP in CA1 neurons, whereas the IsAHP is not different in any of the SK transgenic mice. (jneurosci.org)
  • neuronal
  • Electrophysiological results showed that rats with visceral hypersensitivity presented a decrease in the SK channel-mediated afterhyperpolarization current ( I AHP ), and an increase in neuronal firing rates and c -Fos positive staining in the spinal DH. (frontiersin.org)
  • Moreover, intrathecal administration of the SK2 channel activator 1-EBIO or CyPPA alleviated visceral hypersensitivity, reversed the decrease in I AHP and the increase in neuronal firing rates in spinal DH in rats that experienced CRD. (frontiersin.org)
  • receptor
  • Although quiescent at 4 days in vitro (DIV), HN acquired distinctive SCO patterns as they matured to form extensive dendritic networks by 16 DIV. Challenge with kainate, a kainate receptor (KAR) agonist, 4-aminopyridine (4-AP), a K + channel blocker, or pilocarpine, a muscarinic acetylcholine receptor agonist, caused distinct changes in SCO dynamics. (aspetjournals.org)
  • Currents
  • Cellular localization of mitochondria contributes to the regulation of Kv channel currents in the rat pulmonary, but not mesenteric arterial myocytes. (bath.ac.uk)
  • vascular
  • In a rat model of balloon catheter injury (BCI), we investigated whether alterations in expression of Ca 2+ -activated K + channels (K Ca ) contribute to intimal hyperplasia and vascular restenosis. (ahajournals.org)
  • inhibitors
  • Recent evidence from tissue specimens obtained from patients who have received mTOR inhibitors suggests that ERK may be activated in response to mTOR interruption. (jci.org)
  • modulator
  • 1,3-phenylenebis(methylene) bis(3-fluoro-4-hydroxybenzoate) (RA-2) is a negative gating modulator that inhibits K Ca 3.1 with an IC 50 of 17 nM and all three K Ca 2 channels with similar potency. (guidetopharmacology.org)
  • role
  • In contrast, CTX binding affinity to the hIKCa1_H236C channel mutant was increased suggesting that His236 might play a role in the binding of CTX, but has only a weak influence in the binding of MTX to hIKCa1 channels. (ovid.com)
  • Role of voltage-gated K+ channels in pulmonary arteries: The tale of two channels. (bath.ac.uk)
  • localization
  • Cellular localization of mitochondria contributes to Kv channel-mediated regulation of cellular excitability in pulmonary but not mesenteric circulation. (bath.ac.uk)