In conjunction with other β common chain cytokines GM-CSF and IL-5, IL-3 works to regulate the inflammatory response in order to clear pathogens by changing the abundance of various cell populations via binding at the interleukin-3 receptor. (wikipedia.org)
Angiopoietin‑like protein 7 (Angptl7) is one of the main paracrine cytokines in cord blood stem cells, and is capable of stimulating human hematopoietic stem and progenitor cell expansion. (spandidos-publications.com)
The mRNA expression levels and protein concentrations of inflammatory cytokines in the lung tissue and mouse serum were measured using reverse transcription‑quantitative PCR and ELISA, respectively. (spandidos-publications.com)
The anti-inflammatory effects of the isolated compounds were evaluated based on the mRNA levels of proinflammatory cytokines in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophage cells. (bvsalud.org)
Furthermore, HLA-G expression could not be detected in cultured patient TFCs under basal conditions or after stimulation with the proinflammatory cytokines-interleukin 1α, interferon γ, and tumour necrosis factor α. (bmj.com)
Pretreatment with GSP before LPS treatment significantly suppressed the mRNA expression of pro-inflammatory cytokines such as IL-1β, IL-6 and IL-8. (spandidos-publications.com)
Background and Aims Diabetes pathogenesis is driven by a complex network of pro-inflammatory cells and cytokines, of which interleukin-6 (IL-6) plays a key role in the chronic inflammation associated with type 2 diabetes. (ac.ir)
Synchronized endometrial receptivity and blastocyst competence is vital for implantation and it is achieved with a controlled network of paracrine and autocrine elements, including cytokines [7]. (cancerhugs.com)
In the periphery, we have identified a process we call inflamm-aging, where the cytokines interferon-γ, interleukin (IL)-10, and IL-17 play a predominant role. (medscape.com)
Consistent with M1 polarization, the MWCNTs induced the production and secretion of proinflammatory cytokines tumor necrosis factor- and interleukin-1, and proinflammatory LMs leukotriene B4 (LTB4) and prostaglandin E2 (PGE2). (cdc.gov)
Cytokine9
Interleukin 3 is an interleukin, a type of biological signal (cytokine) that can improve the body's natural response to disease as part of the immune system. (wikipedia.org)
The cytokine was originally discovered via the observation that it induced the synthesis of 20alpha-hydroxysteroid dehydrogenase in hematopoietic cells and termed it interleukin-3 (IL-3). (wikipedia.org)
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. (nih.gov)
Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. (nih.gov)
Examination of the bone marrow of the BM-SCID-hu mice for human cytokine mRNA gene expression demonstrated human leukemia inhibitory factor mRNA and interleukin 7 mRNA in nine of nine BM-SCID-hu mice and macrophage-colony-stimulating factor mRNA in seven of eight BM-SCID-hu mice. (elsevierpure.com)
Since interleukin-7 is a crucial cytokine for proliferation and differentiation of T cells in the thymus, the present study indicates that interleukin-7 may contribute to the disturbance of immune regulatory T cells in ulcerative colitis. (elsevierpure.com)
The inflammatory cytokine interleukin-6 (IL-6) is a powerful inducer of the hepatic acute-phase response, and it has been proposed to be a central mediator in the pathogenesis of coronary heart disease through a combination of autocrine, paracrine, and endocrine mechanisms ( 8 ). (ispub.com)
Leukemia inhibitory element (LIF), an interleukin (IL) 6-type cytokine, is among the few substances obligatory for fertility in mice [8]. (cancerhugs.com)
Receptor9
The signal transmission is ensured by high affinity between cell surface interleukin-3 receptor and IL-3. (wikipedia.org)
The main genetic determinant of soluble interleukin 6 receptor (sIL-6R) levels is the missense variant rs2228145 that maps to the cleavage site of IL-6R. (edu.au)
B29), and the -subunit of the E-mail: [email protected] interleukin (IL)-7 receptor [5, 6]. (lu.se)
Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene localized on chromosome 5q31.1. (wikipedia.org)
Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein. (curehunter.com)
Angiopoietin-like protein 7 (Angptl7) is a glycoprotein that shares sequence homology with angiopoietins, important modulators of angiogenesis ( 13 , 14 ). (spandidos-publications.com)
On days 0, 7, 14 and 28 following surgery, the changes in the post-limb mechanical claw threshold, the phospholipase A2 (PLA2), interleukin (IL)-6 and tumor necrosis factor (TNF)-α mRNA expression levels, the secretory PLA2 (sPLA2) expression, the IL-6 and TNF-α content, the nuclear factor (NF)-κBp65 protein expression level in the nucleus pulposus, and the apoptotic rate of the nucleus pulposus cells were detected. (iasp-pain.org)
The results demonstrated that, in the model group, the threshold of hind paw withdrawal was decreased, and that the sPLA2 expression, IL-6 and TNF-α content, PLA2, IL-6 and TNF-α mRNA and NF-κBp65 protein expression levels in the nucleus pulposus were increased. (iasp-pain.org)
In the exercise intervention group, the hind paw withdrawal threshold increased and the TNF-α and IL-6 content, sPLA2 expression and PLA2, IL-6 and TNF-α mRNA and NF-κBp65 protein expression levels were decreased from day 14 following surgery, and the apoptotic nucleus pulposus cells were decreased from day 7 following surgery, as compared with the model group. (iasp-pain.org)
By contrast, for every copy of 358Ala inherited, mean concentration of IL6R increased by 34·3% (95% CI 30·4-38·2) and of interleukin 6 by 14·6% (10·7-18·4), and mean concentration of C-reactive protein was reduced by 7·5% (5·9-9·1) and of fibrinogen by 1·0% (0·7-1·3). (ox.ac.uk)
Treatment of murine macrophages (J774A.1) with Mitsui-7 MWCNTsincreased the expression of Alox5 mRNA and protein in a concentration- and time-dependent manner. (cdc.gov)
Interleukin 3 stimulates the differentiation of multipotent hematopoietic stem cells into myeloid progenitor cells or, with the addition of IL-7, into lymphoid progenitor cells. (wikipedia.org)
This effect was observed at both 24 hours and 7 days' time points, suggesting an early blockage in the cellular differentiation process, which requires further evaluation. (cdc.gov)
Stimulation3
To gain insight into possible mechanisms, we assessed Asp358Ala in relation to localised gene expression and to postlipopolysaccharide stimulation of interleukin 6. (ox.ac.uk)
The purpose of this study was to determine whether there is a stimulation of production of uPA, PAI-1 and interleukin-6 before and after operation in plasma patients with gynecological diseases, and whether vitamin E could inhibit this process. (ispub.com)
These results suggest that IL-6 stimulated PA activity through an enhancement of tPA gene expression and may be involved in extracellular matrix degradation through the stimulation of the PA-plasmin system of human dental pulp (HDP) cells ( 7 ). (ispub.com)
Macrophages1
Taken together, these findings demonstrate the polarization of M1 macrophages by Mitsui-7 MWCNTs invitro and that induction of Alox5 is an important mechanism by which the MWCNTs promote proinflammatory responses by boosting M1 polarization and production of proinflammatory LMs. (cdc.gov)
Antibody3
Mouse anti Ovine Interleukin-6 antibody, clone 4B6 ( MCA1659 ) used as a capture antibody in a sandwich ELISA for the evaluation of IL-6 expression in response to LPS treatment using Rabbit anti Ovine IL-6 antibody ( AHP424 ) as a detection reagent. (bio-rad-antibodies.com)
Mouse anti Sheep interleukin 6 antibody, clone 4B6 ( MCA1659 ) used as a capture reagent for the measurement of interleukin 6 in an ELISA with Rabbit anti Sheep polyclonal antibody ( AHP424 ) as a detection reagent using lamb sera samples. (bio-rad-antibodies.com)
Interleukin 1β was detected with Mouse anti Sheep IL-1β antibody ( MCA1658 ) as a capture reagent and Rabbit anti IL-1β polyclonal antibody ( AHP423 ) as a detection reagent. (bio-rad-antibodies.com)
Concentration1
Enzyme immunoassay demonstrated that the serum interleukin-7 concentration was significantly increased in the patients. (elsevierpure.com)
Cells10
Continuous interleukin-6 application in vivo via macroencapsulation of interleukin-6-expressing COS-7 cells induces massive gliosis. (uni-bielefeld.de)
6 With respect to activity, HLA-G molecules can inhibit natural killer cell mediated and antigen specific CD8 + T cell mediated cytolysis, 7 induce apoptosis of activated CD8 + T cells, 8 suppress the proliferation of allogeneic CD4 + T cells, 9 and inhibit the transendothelial migration of natural killer cells. (bmj.com)
The apoptotic rate of the nucleus pulposus cells was increased from day 7 following surgery, as compared with the sham operation group. (iasp-pain.org)
In the glioma cells, EIF5B promotes cell survival by enhancing the translation of several IRES-containing mRNAs including those encoding anti-apoptotic proteins such as XIAP and Bcl-xL [ 4 ]. (techscience.com)
Furthermore, cancer cells undergoing EMT phenotypic changes also acquire drug resistance [ 7 ]. (techscience.com)
Several studies have shown that adipocytes highly express CD1d, which presents lipid antigens to invariant natural killer T (iNKT) cells and stimulates the activation of iNKT cells ( 5 - 7 ). (frontiersin.org)
Cells were harvested at 24 hours or 7 days post exposure, to investigate changes in (a) inflammation, (b) oxidative stress-related, and (c) cell-type specific markers using qPCR and/or IF staining. (cdc.gov)
Exposure to high dose of nZnO induced a significant decrease in expression of club (SCGB1A1), goblet (MUC5AC) and ciliated cells (FoxJ1) markers at mRNA levels. (cdc.gov)
Katagiri K, Itami S, Hatano Y, Yamaguchi T, Takayasu S. In vivo expression of IL-4, IL-5, IL-13 and IFN-gamma mRNAs in peripheral blood mononuclear cells and effect of cyclosporin A in a patient with Kimura's disease. (medscape.com)
uPA, PAI-1 and interleukin-6 were determined by enzyme linked immunosorbent assay (ELISA) in non oncological diseases (n=34) and in healthy individuals (n=20) and correlated with vitamin E treatment after operations. (ispub.com)
Induce1
Here we examined the molecular mechanism by which multi-walled CNTs (MWCNTs, Mitsui-7) induce M1 polarization invitro. (cdc.gov)
Levels5
Transgene-encoded IL-6 mRNA levels were similar in the brain of GFAP-IL6 and GFAP-IL6/sgp130 mice. (jneurosci.org)
Circadian rhythmicity, variability and correlation of interleukin-6 levels in plasma and cerebrospinal fluid of healthy men. (uni-bielefeld.de)
Compounds 1, 2, 6, and 7 inhibited the increase in interleukin (IL)-1ß and IL-6 mRNA levels stimulated by LPS. (bvsalud.org)
Analysis of mRNA levels in two cohorts did not identify significant associations between rs12083537 and IL6R transcription levels. (edu.au)
In vitro fibroblasts from involved fascia produce increased levels of mRNA for collagen types I, III, and IV compared with adjacent dermal fibroblasts. (medscape.com)
Objective To observe the effects of oxymatrine on the expression of interleukin-6（IL-6）, interleukin- 1β（IL-1β）mRNA of human periodontal ligament cell（PDLC） stimulated by lipopolysaccharides（LPS）, and to discuss oxymatrine's inhibition mechanism on periodontal inflammation stimulated by LPS. (hxkqyxzz.net)
7 Accumulated data indicate that COX-2 and iNOS are involved in many inflammatory processes and are induced in various carcinomas, suggesting that COX-2 and iNOS play a key role in inflammation and tumorigenesis. (asahq.org)
Tissues1
PCR and Southern blot hybridization demonstrated that interleukin- 7 mRNA expression was increased in the thymus tissues from patients but decreased in the colonic mucosa. (elsevierpure.com)
Human2
Conclusion Oxymatrine can restrain the expression of IL-6 and IL-1β mRNA of human PDLC stimulated by LPS. (hxkqyxzz.net)
The effects of oxymatrine on expression of interleukin-6 and interleukin-1β mRNA of human periodontal ligament cell stimulated by lipopolysaccharides[J]. West China Journal of Stomatology, doi: 10.3969/j.issn.1000-1182.2010.06.022 . (hxkqyxzz.net)
Endometrial1
4 ) found that uPA mRNA seems to be up-regulated in endometriotic glands and endometrial stroma as well as PAI-1 mRNA in endometriotic and endometrial stroma from women with endometriosis. (ispub.com)
Eosinophilic2
[ 1 ] described 7 cases of a condition they termed "eosinophilic hyperplastic lymphogranuloma. (medscape.com)
Further research into eosinophilic fasciitis has shown elevations of transforming growth factor-beta and interleukin 5, which normalize with corticosteroid therapy. (medscape.com)
Correlation1
The structures of compounds 1-7 were elucidated by extensive 1D and 2D NMR spectroscopic analyses, including 1D total correlation spectroscopy (TOCSY), HSQC, HMBC, double quantum-filtered (DQF)-COSY, heteronuclear two-bond correlation (H2BC), and HSQC-TOCSY experiments, as well as high-resolution electrospray ionization HRESIMS analysis, and quantum chemical electronic CD calculations. (bvsalud.org)
Stability1
IGF2BP3 increased the stability of the EIF5B mRNA in an m6A-dependent manner. (techscience.com)
Kimura1
A retrospective review of 21 histopathologic specimens diagnosed as Kimura disease at the US Armed Forces Institute of Pathology found the following racial distribution: 7 whites, 6 African Americans, 6 Asians, 1 Hispanic, and 1 Arab. (medscape.com)
In the present study, we investigated how an eight-week KD alters mRNA expression during fatty acid mobilization, FAO and ketolysis. (elsevierpure.com)
Significantly higher2
Our results show that uPA, PAI 1, and interleukin-6 values were significantly higher in non oncological gynecological cases in comparison with healthy individuals (8.3 times, 3.8 times, and 9.8 times, respectively, P≤ 0.0001). (ispub.com)
uPA, PAI-1, and interleukin-6 were significantly higher after abdominal gyneocological operation than before operation in the group of patients who were not treated with vitamin E after operation (P≤ 0.0001). (ispub.com)
Genes2
ANALYSES: Skeletal muscle mRNA expression of 223 genes underwent hierarchal clustering for targeted analysis and validation. (edu.au)
EIF5B (Eukaryotic Translation Initiation Factor 5B) is a conserved eukaryotic translation factor that mediates association of the 40S and 60S ribosomal subunits during eukaryotic translation initiation, and modulates the cell cycle progression by regulating the translation of upstream open reading frames (uORF)-containing mRNAs such as p27 and p21 [ 3 ]. (techscience.com)
CAF EVs promoted SACC cell invasion and EMT by delivering interleukin (IL)-6 and activating JAK2/STAT3 signaling pathway. (researchsquare.com)
Humans1
Interleukin 3 was originally discovered in mice and later isolated from humans. (wikipedia.org)
Clinical1
In addition, fascial fibroblasts express transforming growth factor-beta I and connective-tissue growth factor mRNA, which may account for the clinical fibrosis. (medscape.com)
Mouse1
Effects of astrocyte-targeted production of interleukin-6 in the mouse on the host response to nerve injury. (uni-bielefeld.de)
Effects1
7 , 8 Alternatively, cisplatin (cis-Diamminedichloro-platinum(II))-based therapeutic strategy has a relatively low response rate, significant side effects, and acquired or intrinsic chemoresistance. (dovepress.com)
Journal1
Also despite the fact that the big pharma mRNA vaccines have published no peer reviewed results, AstraZeneca report that they have sent a peer reviewed study of their complete test results thus far, to the Lancet and they expect these to be published in the next edition of the journal - likely within the next few days. (moonofalabama.org)
Acid1
In this study, three new sulfur-containing spiroketals - breynin J (1), epibreynin J (2), and probreynogenin (3) - along with four known compounds - probreynin I (4), phyllaemblic acid (5), breynin B (6), and epibreynin B (7) - were isolated from the roots of Breynia disticha. (bvsalud.org)
Patients1
uPA and interleukin-6 decreased significantly after abdominal gyneocological operation in the patients treated with vitamin E in comparison with the group of patients without such treatment (P≤ 0.0001). (ispub.com)
Response1
Within the lung, Mtb is initially contained by granuloma formation, the characteristic host immune response to the pathogen [ 7 ]. (ersjournals.com)