IL6RCytokinesSignal transducerImmunitySoluble IL-6 receptGp130Binds2023AffinityChemokine receptorBETA SUBUNITLeukemia inhibiGene encodesMolecularGlycoproteinComplexesMultifunctional cytokineSpecificityTyrosineProteinsExtracellular domainIL7RFlow Cytometry2020RecombinantAgonistBiologicalInsulin receptorCluster of DifferentiatInterferonLigandSuperfamilyKinaseMonoclonalMonocytesType A receptorMiceHeterodimericACE2EpidermalProtein-coupledPleiotropicGenesIncreasesDiseasesFibronectinChain
IL6R4
- Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. (thermofisher.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Interleukin 6 Receptor (IL6R) in samples from serum, plasma, urine, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (pharmas-eu.org)
- Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 6 Receptor (IL6R) in samples from serum, plasma, tissue homogenates or other biological fluids. (pharmas-eu.org)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Interleukin 6 Receptor (IL6R) in serum, plasma, tissue homogenates and other biological fluids. (pharmas-eu.org)
Cytokines4
- It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. (wikipedia.org)
- Gp130 serves as the signal transducing receptor subunit for the IL-6-type cytokines consisting of interleukin (IL)-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), new neurotrophin factor-1 (NNT-1), IL-27, cardiotrophin-1 (CT-1), and cardiotrophin like cytokine (CLC) (2 - 5). (rndsystems.com)
- The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. (thermofisher.com)
- Its biological activities are shared by IL-6-family of cytokines such as leukemia inhibitory factor and oncostatin M. IL-6 exerts its biological activities through interaction with specific receptors expressed on the surface of target cells. (sbhsciences.com)
Signal transducer1
- also known as IL-6 signal transducer, IL-6 receptor beta, oncostatin-M alpha subunit) is a ubiquitously expressed, 130 kDa type I transmembrane glycoprotein and member of the type II subfamily, type I cytokine receptor family. (rndsystems.com)
Immunity1
- The complement system, interacting with its regulatory molecules and cellular receptors, plays a central role in the induction and regulation of immunity. (medscape.com)
Soluble IL-6 recept1
- So far, the soluble IL-6 receptor is unique in acting as an agonist together with its ligand. (thermofisher.com)
Gp1309
- IL-6 exerts its action via a cell surface receptor which consists of two subunits, an 80 kDa ligand binding subunit (gp80) of 468 amino acids and a 130 kDa signal transducing protein (gp130) of 896 amino acid residues. (thermofisher.com)
- The remainder of the extracellular domain however is essential for low affinity ligand binding, which consecutively triggers the association of the receptor and gp130 thus forming a high affinity binding site for IL-6. (thermofisher.com)
- Upon binding of IL-6 to the receptor (alpha subunit), gp130 is homodimerized and is subsequently involved in down-stream signal processes binding tyrosine kinases and activating STAT1 and STAT3 transcriptional factors. (sbhsciences.com)
- The soluble form of IL-6R can bind its ligand and induce cellular responses by association with gp130, thus acting as an IL-6 agonist. (sbhsciences.com)
- Interestingly, the association of IL-6 with the soluble form of IL-6R alpha is capable of eliciting a biological response in cells that express only the membrane gp130. (sbhsciences.com)
- Binding affinity is increased by the ligand-induced association of LIF R alpha with the signal transducing subunit gp130 (6, 7). (rndsystems.com)
- The LIF R alpha /gp130 receptor complex also transduces Oncostatin M signals, although LIF R alpha alone does not interact with Oncostatin M (6). (rndsystems.com)
- gp130 associates with different ligand-specific receptors to form signaling receptor complexes for the other IL-6 family ligands (1). (rndsystems.com)
- The CNTF receptor is a ternary complex that contains CNTF R alpha and gp130 as well as LIF R alpha (8, 9). (rndsystems.com)
Binds2
- LIF R alpha binds the pleiotropic cytokine LIF with low affinity, and the soluble isoform retains LIF-binding activity (5). (rndsystems.com)
- The CR1 receptor preferentially binds C3b that is covalently attached to immune complexes, and it has a weaker affinity for bound C4b and iC3b. (medscape.com)
20231
- 2023;6(2):93-98. (bvsalud.org)
Affinity1
- A low affinity interleukin-5 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high affinity receptor for INTERLEUKIN-5. (harvard.edu)
Chemokine receptor3
- C-C motif chemokine receptor like 2 [So. (gsea-msigdb.org)
- C-X3-C motif chemokine receptor. (gsea-msigdb.org)
- Supplementary MaterialsCorrelation network analysis reveals relationships between microRNAs, transcription factor and deregulated cytokine/chemokine-receptor network in pulmonary sarcoidosis 121378. (thebiotechdictionary.com)
BETA SUBUNIT1
- and human chorionic gonadotropin beta subunit, ≤ 0.1 ng/mL. (springeropen.com)
Leukemia inhibi2
- Leukemia Inhibitory Factor Receptor alpha (LIF R alpha ), also known as LIFR beta (due to its participation in signal transduction) and CD118, is a 190 kDa type I transmembrane protein in the Interleukin-6 receptor family. (rndsystems.com)
- The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding. (ox.ac.uk)
Gene encodes2
- This gene encodes a member of the type II cytokine receptor family. (nih.gov)
- This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. (thermofisher.com)
Molecular3
- He stayed at Sheffield and undertook research into the molecular basis of Immunoglobulin E (IgE) receptor interactions with a focus on therapeutic intervention in allergy graduating with a PhD in 1997. (nottingham.ac.uk)
- Fibronectin is a dimeric glycoprotein composed of disulfide-linked subunits with a molecular weight of 220-250kDa each. (embl.de)
- This subunit is the molecular target of the investigational monoclonal antibody dupilumab, that is in clinical trial as a therapy for atopic allergic conditions and nasal polyposis. (guidetomalariapharmacology.org)
Glycoprotein2
- IL-6 Receptor (IL-6R, gp80) is 80 kDa alpha subunit, transmembrane glycoprotein that is 449 aa long. (sbhsciences.com)
- In this study we aimed to investigate the effect of ITGA2B (integrin alpha 2b, platelet glycoprotein IIb of IIb/IIIa complex) gene polymorphism on the magnitude of inflammatory response after CPB. (peertechzpublications.com)
Complexes2
- This type of activation, called "trans-signalling", renders virtually all cells capable of responding to IL-6/sIL-6R alpha complexes, making for a large new spectrum of IL-6 activities, ranging from the control of the immune response to involvement in pathological states. (sbhsciences.com)
- Complement and complement receptors play a critical role in immune defense by initiating the rapid destruction of invading microorganisms, amplifying the innate and adaptive immune responses, and mediating solubilization and clearance of immune complexes. (medscape.com)
Multifunctional cytokine2
- IL-6 is a multifunctional cytokine involved in the regulation of the immune response, hematopoiesis and acute phase response. (thermofisher.com)
- Interleukin-6 (IL-6) is a multifunctional cytokine that regulates pleiotropic roles in immune regulation, inflammation, hematopoiesis, and oncogenesis. (sbhsciences.com)
Specificity1
- Analysis of the biological function and receptor specificity of a series of human-mouse LIF chimeras implicate two regions of receptor interaction that are located in the fourth helix and the preceding loop. (ox.ac.uk)
Tyrosine1
- Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. (wikipedia.org)
Proteins7
- I have attempted to list the enzymes/receptor proteins below in the sequential order in which they are impacted, subsequent to the docking of the COVID-19 virus onto ACE2 receptors. (mthfrsupport.com)
- In some cases however, the enzymes/receptor proteins are working in parallel with the immune system. (mthfrsupport.com)
- Effector proteins interacting with the Fc portion of immunoglobulin M (IgM) include complement and complement receptors. (medscape.com)
- Partial or complete deficiencies of the components of the complement system, including its receptors and regulatory proteins, are now described in humans and may be of a genetic or familial origin or acquired. (medscape.com)
- Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)
- Heterotrimeric guanine nucleotide-binding proteins (G proteins) mediate extracellular signals from transmembrane G protein-coupled receptors (GPCRs) to activate intracellular effector molecules, triggering signaling pathways that lead to a variety of cellular responses [ 1 , 2 ]. (biomedcentral.com)
- G proteins consist of two functional units, a guanine nucleotide-binding α subunit and a βγ subunit dimer, and are classified according to their α-subunit into four subfamilies: Gs, Gi, Gq, and G12 [ 2 ]. (biomedcentral.com)
Extracellular domain1
- Mature mouse LIF R alpha consists of a 785 amino acid (aa) extracellular domain (ECD) with two cytokine receptor homology domains, one WSxWS motif, and three fibronectin type III repeats, followed by a 25 aa transmembrane segment and a 239 aa cytoplasmic domain (2, 3). (rndsystems.com)
IL7R1
- Interleukin-7 receptor (IL7R) ,is a hematopoietin receptor superfamily member. (prospecbio.com)
Flow Cytometry2
- Detection of LIF R alpha in D3 Mouse Cell Line by Flow Cytometry. (rndsystems.com)
- METHODS: Non-adherent non-T cells (NANT) were separated from heparinized bone marrow blood from 6 asthmatics and 3 normal subjects, loaded with CD34+ and IL-5R alpha monoclonal antibodies conjugated with immunofluorescence and then analyzed by flow cytometry. (tmu.edu.tw)
20201
- This national cohort study based on the Swedish Intensive Care Registry (SIR) included all patients admitted to a Swedish ICU due to COVID-19 from 6 March 2020 to 9 November 2021. (bvsalud.org)
Recombinant2
- In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-2 R, rhIL-4 R, or rhIL-6 R is observed. (rndsystems.com)
- In direct ELISAs, no cross-reactivity with recombinant human LIF R alpha is observed. (rndsystems.com)
Agonist1
- Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. (nih.gov)
Biological2
- This 55 kDa protein representing the extracellular portion of gp80 is generated by shedding, a process that seems to be controlled by protein kinase C. It is still functional, indicating that soluble gp80 plays a biological role in promoting IL-6 activity. (thermofisher.com)
- Description: A sandwich ELISA kit for detection of Interleukin 6 Receptor from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (pharmas-eu.org)
Insulin receptor1
- This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. (wikipedia.org)
Cluster of Differentiat1
- We studied the expression of the IL-5 receptor alpha-subunit (IL-5R alpha) on bone marrow-derived cluster of differentiation molecule 34 positive (CD34+) progenitor cells in asthmatics to prove the ability of progenitor cells to respond to IL-5 more readily. (tmu.edu.tw)
Interferon1
- This protein is structurally related to interferon receptors. (wikipedia.org)
Ligand3
- Characterisation of the extracellular portion of the 80 kDa IL-6 receptor revealed the existence of a single immunoglobulin-like domain in the NH2-terminal of the extracellular region, which does not contribute to ligand binding. (thermofisher.com)
- A model for receptor binding based on the structure of the GH ligand-receptor complex requires additional, novel features to account for these data. (ox.ac.uk)
- IL4R is the common ligand binding subunit shared by the IL-4 receptors type I (receptor for IL-4) and type II (receptor for IL-4 and IL-13). (guidetomalariapharmacology.org)
Superfamily1
- Belongs to the IL-6 superfamily. (gentaur.fr)
Kinase1
- Interleukin 10 receptor, alpha subunit has been shown to interact with: Interleukin 10 and Janus kinase 1. (wikipedia.org)
Monoclonal1
- Sarilumab is a human monoclonal antibody directed against the alpha subunit of the interleukin-6 receptor complex. (stanfordhealthcare.org)
Monocytes3
- Cells known to express IL-6 R include CD4+ and CD8+ T cells, hepatocytes, CD34+ stem cells neurons, neutrophils, monocytes and osteoblasts. (sbhsciences.com)
- It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action. (lookformedical.com)
- The density of CR1 receptors on cell surfaces varies with the cell type and with the activation of the cell for neutrophils and monocytes. (medscape.com)
Type A receptor1
- GABA type A receptor associated. (gsea-msigdb.org)
Mice2
- Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2. (ouhsc.edu)
- Mice with C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells. (medscape.com)
Heterodimeric1
- The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. (nih.gov)
ACE22
- Some of the research I have cited pertains to original SAR outbreak in 2002-2003 (called SARS-CoV), but some of the same principles apply to the immune system domino effect upon SARS-CoV-2 first docking with ACE2 receptors. (mthfrsupport.com)
- Following docking of SARS-CoV-2 onto ACE2 receptors (mostly in lungs and GI), and virus-cell membrane fusion via TMPRSS2 and FURIN , a cascade of enzymatic steps and subsequent immune system mobilization occurs. (mthfrsupport.com)
Epidermal1
- The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. (nih.gov)
Protein-coupled1
- G protein-coupled receptor clas. (gsea-msigdb.org)
Pleiotropic1
- Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. (thermofisher.com)
Genes4
- it inhibits transcription for genes that encode IL-3, IL-4, IL-5, GM-CSF, and TNF-alpha (all involved in early T-cell activation). (medscape.com)
- MATERIALS AND METHODS: Genotype data on 6 MS risk genes in 591 MS patients and 600 controls were used to investigate the predictive value of combining risk alleles. (ox.ac.uk)
- Genes encoding for Mda5, Tlr3, and Tlr9 receptors that sign to IFNs had been upregulated. (acancerjourney.info)
- We also discovered upregulation of inflammatory pathways including elevated manifestation of genes for Tnf and IL-6 (interleukin 6). (acancerjourney.info)
Increases1
- Koray Ak, Ergun S, Altınoz H, Uyguner ZO, Tetik S (2016) GG Polymorphism of Platelet ITGA2B Gene Increases the Magnitude of Interleukin-6 Release after Cardiopulmonary Bypass. (peertechzpublications.com)
Diseases2
- Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. (thermofisher.com)
- Initial clinical studies indicate the levels of sIL-6R, the alpha subunit, in the serum of patients with various diseases as summarized in table1. (sbhsciences.com)
Fibronectin2
- The ECD also contains an N terminal immunoglobulin (Ig)-like C2-type domain, followed by the cytokine receptor homology region (CHR) which is made up of two fibronectin type III-like domains and a WSXWS motif, and three additional fibronectin type III-like domains (2). (rndsystems.com)
- ITGA2B is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin and functions in platelet activation (5). (peertechzpublications.com)
Chain1
- The main chain fold conforms to the four alpha-helix bundle topology previously observed for several members of the hematopoietic cytokine family. (ox.ac.uk)