• Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. (thermofisher.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Interleukin 6 Receptor (IL6R) in samples from serum, plasma, urine, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (pharmas-eu.org)
  • Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 6 Receptor (IL6R) in samples from serum, plasma, tissue homogenates or other biological fluids. (pharmas-eu.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Interleukin 6 Receptor (IL6R) in serum, plasma, tissue homogenates and other biological fluids. (pharmas-eu.org)
  • It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. (wikipedia.org)
  • Gp130 serves as the signal transducing receptor subunit for the IL-6-type cytokines consisting of interleukin (IL)-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), new neurotrophin factor-1 (NNT-1), IL-27, cardiotrophin-1 (CT-1), and cardiotrophin like cytokine (CLC) (2 - 5). (rndsystems.com)
  • The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. (thermofisher.com)
  • Its biological activities are shared by IL-6-family of cytokines such as leukemia inhibitory factor and oncostatin M. IL-6 exerts its biological activities through interaction with specific receptors expressed on the surface of target cells. (sbhsciences.com)
  • also known as IL-6 signal transducer, IL-6 receptor beta, oncostatin-M alpha subunit) is a ubiquitously expressed, 130 kDa type I transmembrane glycoprotein and member of the type II subfamily, type I cytokine receptor family. (rndsystems.com)
  • The complement system, interacting with its regulatory molecules and cellular receptors, plays a central role in the induction and regulation of immunity. (medscape.com)
  • So far, the soluble IL-6 receptor is unique in acting as an agonist together with its ligand. (thermofisher.com)
  • IL-6 exerts its action via a cell surface receptor which consists of two subunits, an 80 kDa ligand binding subunit (gp80) of 468 amino acids and a 130 kDa signal transducing protein (gp130) of 896 amino acid residues. (thermofisher.com)
  • The remainder of the extracellular domain however is essential for low affinity ligand binding, which consecutively triggers the association of the receptor and gp130 thus forming a high affinity binding site for IL-6. (thermofisher.com)
  • Upon binding of IL-6 to the receptor (alpha subunit), gp130 is homodimerized and is subsequently involved in down-stream signal processes binding tyrosine kinases and activating STAT1 and STAT3 transcriptional factors. (sbhsciences.com)
  • The soluble form of IL-6R can bind its ligand and induce cellular responses by association with gp130, thus acting as an IL-6 agonist. (sbhsciences.com)
  • Interestingly, the association of IL-6 with the soluble form of IL-6R alpha is capable of eliciting a biological response in cells that express only the membrane gp130. (sbhsciences.com)
  • Binding affinity is increased by the ligand-induced association of LIF R alpha with the signal transducing subunit gp130 (6, 7). (rndsystems.com)
  • The LIF R alpha /gp130 receptor complex also transduces Oncostatin M signals, although LIF R alpha alone does not interact with Oncostatin M (6). (rndsystems.com)
  • gp130 associates with different ligand-specific receptors to form signaling receptor complexes for the other IL-6 family ligands (1). (rndsystems.com)
  • The CNTF receptor is a ternary complex that contains CNTF R alpha and gp130 as well as LIF R alpha (8, 9). (rndsystems.com)
  • LIF R alpha binds the pleiotropic cytokine LIF with low affinity, and the soluble isoform retains LIF-binding activity (5). (rndsystems.com)
  • The CR1 receptor preferentially binds C3b that is covalently attached to immune complexes, and it has a weaker affinity for bound C4b and iC3b. (medscape.com)
  • A low affinity interleukin-5 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high affinity receptor for INTERLEUKIN-5. (harvard.edu)
  • C-C motif chemokine receptor like 2 [So. (gsea-msigdb.org)
  • C-X3-C motif chemokine receptor. (gsea-msigdb.org)
  • Supplementary MaterialsCorrelation network analysis reveals relationships between microRNAs, transcription factor and deregulated cytokine/chemokine-receptor network in pulmonary sarcoidosis 121378. (thebiotechdictionary.com)
  • and human chorionic gonadotropin beta subunit, ≤ 0.1 ng/mL. (springeropen.com)
  • Leukemia Inhibitory Factor Receptor alpha (LIF R alpha ), also known as LIFR beta (due to its participation in signal transduction) and CD118, is a 190 kDa type I transmembrane protein in the Interleukin-6 receptor family. (rndsystems.com)
  • The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding. (ox.ac.uk)
  • This gene encodes a member of the type II cytokine receptor family. (nih.gov)
  • This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. (thermofisher.com)
  • He stayed at Sheffield and undertook research into the molecular basis of Immunoglobulin E (IgE) receptor interactions with a focus on therapeutic intervention in allergy graduating with a PhD in 1997. (nottingham.ac.uk)
  • Fibronectin is a dimeric glycoprotein composed of disulfide-linked subunits with a molecular weight of 220-250kDa each. (embl.de)
  • This subunit is the molecular target of the investigational monoclonal antibody dupilumab, that is in clinical trial as a therapy for atopic allergic conditions and nasal polyposis. (guidetomalariapharmacology.org)
  • IL-6 Receptor (IL-6R, gp80) is 80 kDa alpha subunit, transmembrane glycoprotein that is 449 aa long. (sbhsciences.com)
  • In this study we aimed to investigate the effect of ITGA2B (integrin alpha 2b, platelet glycoprotein IIb of IIb/IIIa complex) gene polymorphism on the magnitude of inflammatory response after CPB. (peertechzpublications.com)
  • This type of activation, called "trans-signalling", renders virtually all cells capable of responding to IL-6/sIL-6R alpha complexes, making for a large new spectrum of IL-6 activities, ranging from the control of the immune response to involvement in pathological states. (sbhsciences.com)
  • Complement and complement receptors play a critical role in immune defense by initiating the rapid destruction of invading microorganisms, amplifying the innate and adaptive immune responses, and mediating solubilization and clearance of immune complexes. (medscape.com)
  • IL-6 is a multifunctional cytokine involved in the regulation of the immune response, hematopoiesis and acute phase response. (thermofisher.com)
  • Interleukin-6 (IL-6) is a multifunctional cytokine that regulates pleiotropic roles in immune regulation, inflammation, hematopoiesis, and oncogenesis. (sbhsciences.com)
  • Analysis of the biological function and receptor specificity of a series of human-mouse LIF chimeras implicate two regions of receptor interaction that are located in the fourth helix and the preceding loop. (ox.ac.uk)
  • I have attempted to list the enzymes/receptor proteins below in the sequential order in which they are impacted, subsequent to the docking of the COVID-19 virus onto ACE2 receptors. (mthfrsupport.com)
  • In some cases however, the enzymes/receptor proteins are working in parallel with the immune system. (mthfrsupport.com)
  • Effector proteins interacting with the Fc portion of immunoglobulin M (IgM) include complement and complement receptors. (medscape.com)
  • Partial or complete deficiencies of the components of the complement system, including its receptors and regulatory proteins, are now described in humans and may be of a genetic or familial origin or acquired. (medscape.com)
  • Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)
  • Heterotrimeric guanine nucleotide-binding proteins (G proteins) mediate extracellular signals from transmembrane G protein-coupled receptors (GPCRs) to activate intracellular effector molecules, triggering signaling pathways that lead to a variety of cellular responses [ 1 , 2 ]. (biomedcentral.com)
  • G proteins consist of two functional units, a guanine nucleotide-binding α subunit and a βγ subunit dimer, and are classified according to their α-subunit into four subfamilies: Gs, Gi, Gq, and G12 [ 2 ]. (biomedcentral.com)
  • Mature mouse LIF R alpha consists of a 785 amino acid (aa) extracellular domain (ECD) with two cytokine receptor homology domains, one WSxWS motif, and three fibronectin type III repeats, followed by a 25 aa transmembrane segment and a 239 aa cytoplasmic domain (2, 3). (rndsystems.com)
  • Interleukin-7 receptor (IL7R) ,is a hematopoietin receptor superfamily member. (prospecbio.com)
  • Detection of LIF R alpha in D3 Mouse Cell Line by Flow Cytometry. (rndsystems.com)
  • METHODS: Non-adherent non-T cells (NANT) were separated from heparinized bone marrow blood from 6 asthmatics and 3 normal subjects, loaded with CD34+ and IL-5R alpha monoclonal antibodies conjugated with immunofluorescence and then analyzed by flow cytometry. (tmu.edu.tw)
  • This national cohort study based on the Swedish Intensive Care Registry (SIR) included all patients admitted to a Swedish ICU due to COVID-19 from 6 March 2020 to 9 November 2021. (bvsalud.org)
  • In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-2 R, rhIL-4 R, or rhIL-6 R is observed. (rndsystems.com)
  • In direct ELISAs, no cross-reactivity with recombinant human LIF R alpha is observed. (rndsystems.com)
  • Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. (nih.gov)
  • This 55 kDa protein representing the extracellular portion of gp80 is generated by shedding, a process that seems to be controlled by protein kinase C. It is still functional, indicating that soluble gp80 plays a biological role in promoting IL-6 activity. (thermofisher.com)
  • Description: A sandwich ELISA kit for detection of Interleukin 6 Receptor from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (pharmas-eu.org)
  • This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. (wikipedia.org)
  • We studied the expression of the IL-5 receptor alpha-subunit (IL-5R alpha) on bone marrow-derived cluster of differentiation molecule 34 positive (CD34+) progenitor cells in asthmatics to prove the ability of progenitor cells to respond to IL-5 more readily. (tmu.edu.tw)
  • This protein is structurally related to interferon receptors. (wikipedia.org)
  • Characterisation of the extracellular portion of the 80 kDa IL-6 receptor revealed the existence of a single immunoglobulin-like domain in the NH2-terminal of the extracellular region, which does not contribute to ligand binding. (thermofisher.com)
  • A model for receptor binding based on the structure of the GH ligand-receptor complex requires additional, novel features to account for these data. (ox.ac.uk)
  • IL4R is the common ligand binding subunit shared by the IL-4 receptors type I (receptor for IL-4) and type II (receptor for IL-4 and IL-13). (guidetomalariapharmacology.org)
  • Interleukin 10 receptor, alpha subunit has been shown to interact with: Interleukin 10 and Janus kinase 1. (wikipedia.org)
  • Cells known to express IL-6 R include CD4+ and CD8+ T cells, hepatocytes, CD34+ stem cells neurons, neutrophils, monocytes and osteoblasts. (sbhsciences.com)
  • It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action. (lookformedical.com)
  • The density of CR1 receptors on cell surfaces varies with the cell type and with the activation of the cell for neutrophils and monocytes. (medscape.com)
  • Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2. (ouhsc.edu)
  • Mice with C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells. (medscape.com)
  • The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. (nih.gov)
  • Some of the research I have cited pertains to original SAR outbreak in 2002-2003 (called SARS-CoV), but some of the same principles apply to the immune system domino effect upon SARS-CoV-2 first docking with ACE2 receptors. (mthfrsupport.com)
  • Following docking of SARS-CoV-2 onto ACE2 receptors (mostly in lungs and GI), and virus-cell membrane fusion via TMPRSS2 and FURIN , a cascade of enzymatic steps and subsequent immune system mobilization occurs. (mthfrsupport.com)
  • The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. (nih.gov)
  • Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. (thermofisher.com)
  • it inhibits transcription for genes that encode IL-3, IL-4, IL-5, GM-CSF, and TNF-alpha (all involved in early T-cell activation). (medscape.com)
  • MATERIALS AND METHODS: Genotype data on 6 MS risk genes in 591 MS patients and 600 controls were used to investigate the predictive value of combining risk alleles. (ox.ac.uk)
  • Genes encoding for Mda5, Tlr3, and Tlr9 receptors that sign to IFNs had been upregulated. (acancerjourney.info)
  • We also discovered upregulation of inflammatory pathways including elevated manifestation of genes for Tnf and IL-6 (interleukin 6). (acancerjourney.info)
  • Koray Ak, Ergun S, Altınoz H, Uyguner ZO, Tetik S (2016) GG Polymorphism of Platelet ITGA2B Gene Increases the Magnitude of Interleukin-6 Release after Cardiopulmonary Bypass. (peertechzpublications.com)
  • Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. (thermofisher.com)
  • Initial clinical studies indicate the levels of sIL-6R, the alpha subunit, in the serum of patients with various diseases as summarized in table1. (sbhsciences.com)
  • The ECD also contains an N terminal immunoglobulin (Ig)-like C2-type domain, followed by the cytokine receptor homology region (CHR) which is made up of two fibronectin type III-like domains and a WSXWS motif, and three additional fibronectin type III-like domains (2). (rndsystems.com)
  • ITGA2B is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin and functions in platelet activation (5). (peertechzpublications.com)
  • The main chain fold conforms to the four alpha-helix bundle topology previously observed for several members of the hematopoietic cytokine family. (ox.ac.uk)