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  • Antibody
  • Pretreatment of cells with IL-6R antibody reduced IL-6-mediated VEGF production. (mendeley.com)
  • Preliminary clinical evidence has shown that antibody targeted IL-6 therapy was well tolerated in cancer patients. (nih.gov)
  • In this review, we detail the progress of the current understanding of IL-6 signaling pathway in cancer as well as an antibody targeted IL-6 therapy for human cancer. (nih.gov)
  • The Senescence Marker Antibody Sampler Kit provides a collection of antibodies to commonly used biomarkers of senescence-associated cell cycle arrest (p16 INK4A, p21 Waf1/Cip1), senescence-associated DNA damage (gamma-Histone H2A.X), and the SASP (HMGB1, IL-6, TNF-alpha, MMP3). (cellsignal.com)
  • IL-6 in standards and samples binds to the antibody binding sites on a microtitre plate. (salimetrics.com)
  • We also demonstrate that interleukin 6 (IL-6), shown to be increased in NMO, enhanced the survival of PB as well as their AQP4-Ab secretion, whereas the blockade of IL-6 receptor (IL-6R) signaling by anti-IL-6R antibody reduced the survival of PB in vitro. (pnas.org)
  • Effect of in situ expression of human interleukin-6 on antibody responses against Salmonella typhimurium antigens. (acris-antibodies.com)
  • BSF2
  • Translation of Summary document of Proceedings of the Japanese Society for Immunology, B2-66 Attempt to Prepare Monoclonal Antibodies to human BSF2/IL-6 Receptor (Dec. 6, 1988). (freepatentsonline.com)
  • expression
  • IL-6 expression increased in all groups compared to control. (nih.gov)
  • Cloning and Expression of the Human Interleukin-6 (BSF-2/IFN.beta.2) Receptor", Science, 241:825-828 1988, Aug. 12). (freepatentsonline.com)
  • However, the relationship between IL-6 and vascular endothelial growth factor (VEGF) expression in human osteosarcoma is mostly unknown. (mendeley.com)
  • The apoptosis signal-regulating kinase 1 (ASK1)/p38/AP-1 pathway was activated after IL-6 treatment, and IL-6-induced VEGF expression was abolished by the specific inhibitor and siRNA of ASK1, p38, and AP-1 cascades. (mendeley.com)
  • Importantly, knockdown IL-6 reduced VEGF expression and abolished osteosarcoma conditional medium-mediated angiogenesis. (mendeley.com)
  • Taken together, these results indicate that IL-6 occurs through ASK1 and p38, which in turn activates AP-1, resulting in the activations of VEGF expression and contributing the angiogenesis of human osteosarcoma cells. (mendeley.com)
  • Aging or IL-6 deficiency did not affected the percentage of F 4 / 80 + macrophages, or the surface expression of Toll-like receptor 4 (TLR4) and components of the IL-6 receptor. (hindawi.com)
  • Delayed wound healing in IL-6 KO mice was reversed with a single dose of recombinant murine IL6 or intradermal injection of an expression plasmid containing the full length murine IL6 cDNA. (cdc.gov)
  • In situ hybridization of wound tissue from wild type mice revealed IL-6 mRNA expression primarily in the epidermis at the leading edge of the wound. (cdc.gov)
  • The expression of IL-6 is most prominently identified in neurons in the peri-ischemic regions, and LIF expression shows a similar pattern. (nih.gov)
  • Regulation of expression of interleukin-6. (biovendor.com)
  • Roles of circulating soluble interleukin (IL)-6 receptor and IL-6 receptor expression on CD4 + T cells in patients with chronic hepatitis B. Int J Infect Dis IJID Off Publ Int Soc Infect Dis. (springer.com)
  • In the CNS lesions of NMO, reduced expression of AQP4 on astrocytes is evident even during the early stage ( 6 ), which is followed by the occurrence of vasculocentric destruction of astrocytes associated with perivascular deposition of complement and IgG ( 7 ). (pnas.org)
  • biology
  • In this review, we briefly review the biology of IL-6 and critically evaluate the role(s) of the IL-6 system in the pathogeneses of type 1 and type 2 diabetes (but not in obesity without type 2 diabetes) and suggest directions for future investigations of IL-6 in pathogenetic processes leading to the two diseases. (diabetesjournals.org)
  • cortisol
  • The serum concentration of fully glycosylated cortisol binding globulin (another marker of IL-6 action), suggested by concanavalin A adsorption, was lower in C/C subjects than in G/G individuals (32.6+/-2.9 vs. 37.6+/-4.6 mg/l, P = 0.03). (diabetesjournals.org)
  • Researchers at University of Texas at Dallas may have revolutionized diabetes management thanks to a remarkable new wrist-worn sensor that is able to continuously and accurately monitor glucose, cortisol, and interleukin-6 in perspired sweat for up to a week. (medgadget.com)
  • These days, blood has to be drawn and levels of cortisol and interleukin-6 can only be measured once in a while and not continuously. (medgadget.com)
  • human
  • A vast number of epidemiological, genetic, rodent, and human in vivo and in vitro studies have investigated the putative role of action/lack of action of IL-6 in the pathogeneses underlying obesity, insulin resistance, β-cell destruction, type 1 diabetes, and type 2 diabetes. (diabetesjournals.org)
  • Antibodies, polyclonal and monoclonal, which are capable of specifically binding to a human interleukin-6 receptor. (freepatentsonline.com)
  • Also included are monoclonal antibodies which competitively and non-competitively inhibit human interleukin-6, and a method of producing hybridomas of the said monoclonal antibodies capable of specifically binding to a human interleukin-6 receptor. (freepatentsonline.com)
  • Lust JA, Donovan KA, Kline MP, Greipp PR, Kyle RA, Maihle NJ (1992) Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor. (springer.com)
  • To further delineate the role of IL-6 in epidermal regeneration, we demonstrate that IL-6 mRNA is expressed and immunoreactive IL-6 is released from normal human epidermal keratinocytes (NHEKs) following in vitro wounding. (cdc.gov)
  • Biotin conjugated to goat antibodies to human IL-6 are added and attach to the bound IL-6. (salimetrics.com)
  • IL-6 is present in the positive control sample (human serum) and absent from the negative control sample (mouse brain). (antibodies-online.com)
  • Possible role of human interleukin-6 and soluble interleukin-6 receptor in hepatitis B virus infection. (springer.com)
  • Psoriasis patient skin has elevated IL-6 and IL-6 receptor is present in human coronary atheroma, supporting a link between skin and distant vessel disease in patient tissue. (jci.org)
  • Recombinant human interleukin-6 infusion during low-intensity exercise does not enhance whole body lipolysis or fat oxidation in humans. (acris-antibodies.com)
  • Kaposi's sarcoma-associated herpesvirus-encoded viral interleukin-6 is secreted and modified differently than human interleukin-6: evidence for a unique autocrine signaling mechanism. (acris-antibodies.com)
  • Contributes
  • Here we argue that IL-6 action-in part regulated by variance in the IL-6 and IL-6α receptor genes-contributes to, but is probably neither necessary nor sufficient for, the development of both type 1 and type 2 diabetes. (diabetesjournals.org)
  • differentiation
  • IL-6 is involved in the host immune defense mechanism as well as the modulation of growth and differentiation in various malignancies. (nih.gov)
  • biological
  • Hirano T, Akira S, Taga T, Kishimoto T. Biological and clinical aspects of interleukin 6. (biovendor.com)
  • These latter findings appear to contrast with the antiinflammatory properties assigned by some to IL-6 (( 9 ), ( 10 )), and suggest that the sIL-6R/IL-6 complex not only potentiates IL-6 signaling, but may also modify its biological activities. (rupress.org)
  • serum
  • The serum measurement of IL-6 and IL-10 was performed in a subgroup (54 cases and 54 controls) by enzyme-linked immunosorbent assay (ELISA). (hindawi.com)
  • IL-6 genotypes had no influence on IL-6 serum levels. (hindawi.com)
  • glucose
  • IL-6 has in addition to its immunoregulatory actions been proposed to affect glucose homeostasis and metabolism directly and indirectly by action on skeletal muscle cells, adipocytes, hepatocytes, pancreatic β-cells, and neuroendocrine cells. (diabetesjournals.org)
  • genotype
  • To avoid this, we now have collected the mortality data of our cohort of 285 nonagenarians (representing mortality between 90 and 95 years of age) and correlated these to the IL-6 genotype. (nih.gov)
  • mainly
  • Interleukin-6 is made mainly by some T lymphocytes. (cancer.gov)
  • The major IL-6 downstream signaling pathway is JAK-STAT, and Stat3 activation occurs mainly in neurons during postischemic reperfusion. (nih.gov)