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  • receptor alpha subunit
  • Clinical trials have shown drugs targeting IL-5 or its receptor alpha subunit (IL-5Ra) to be a promising therapeutic approach to severe asthma, whose characteristics render standard therapy of little use: systemic corticosteroids only partially control the disease and have well-known adverse effects, and omalizumab is used for allergic subtypes. (frontiersin.org)
  • monocyte
  • Predictive value of interleukin-5 and monocyte chemotactic protein-1 for bacteremia in children with febrile neutropenia. (ucdenver.edu)
  • Increasing evidence, however, has suggested that IL-4 contributes to the initiation and progression of atherosclerosis by oxidative stress-mediated up-regulation of pro-inflammatory mediators such as vascular cell adhesion moledule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1), and interleukin-6 (IL-6) in vascular endothelium. (vt.edu)
  • Immune
  • Intestinal microbiota modulates immune system either through pathogen-associated molecular patterns on the surface of microbes, such as lipopolysaccharides and peptidoglycans [ 2 ], or through microbial products, such as short-chain fatty acids, interacting with both immune cells and enterocytes [ 4 , 5 ]. (hindawi.com)
  • Prebiotics may modulate the immune system directly through ligation of carbohydrate or pattern recognition receptors on immune and epithelial cells [ 5 , 9 ]. (hindawi.com)
  • More likely, however, prebiotics affect the immune response indirectly by enhancing intestinal fermentation and growth of certain microbes [ 5 , 9 ]. (hindawi.com)
  • neutrophil
  • Binding studies with a number of other human cell lines, including a B-lymphoma line, and with lymphocyte and neutrophil preparations were also performed, but IL-5 receptors were not detectable on these cells. (edu.au)
  • synthesis
  • Antisense technology has also shown the dependence of IL-5 gene transcription on the de novo synthesis of the transcription factor Fra2.Inhibition of IL-5 reporter constructs by dexamethasone when induced by PMNcAMP, but not PMNCaI, provided a tool for understanding the mechanism. (edu.au)
  • lymphokine
  • This study aimed at understanding the role of conserved lymphokine element 0 (CLEO) in induction and inhibition of IL-5.The conserved proximal CLEO/TATA elements driving a luciferase reporter gene gave higher expression than a 500bp promoter in PER1 17 T-cell line. (edu.au)
  • mast
  • Similarly, ECP IL-5, GATA-3 mRNA expression and IgE-induced release of LTC4/D 4 /E 4 and PGD 2 from mast cells were significantly increased in patients with PER compared to patients with IAR. (wiley.com)
  • mononuclear
  • The levels of interleukin-2 (IL-2) and interferon-γ (IFNγ) for type 1 and interleukin-4, interleukin-5 and interleukin-10 (IL-4, IL-5 and IL-10) for type 2 responses were estimated by ELISA in peripheral blood mononuclear cell (PBMC) culture supernatants. (alliedacademies.org)
  • The proliferation of spontaneous and phytohemagglutinin-stimulated peripheral blood mononuclear cells (PBMCs) and their production of interleukin-4, interleukin-5, transforming growth factor- β 1, and interferon- γ (IFN γ ) were determined in eighteen men at the baseline and during a 2-week period of probiotics (mixture of Lactobacillus rhamnosus GG, Lactobacillus rhamnosus LC705, Propionibacterium freudenreichii ssp. (hindawi.com)
  • vascular
  • Although 5-LOX has been implicated in the development of atherosclerosis, it remains unclear whether 5-LOX-mediated ROS generation is associated with IL-4-induced MCP-1 expression in vascular endothelium. (vt.edu)
  • lymphatic
  • There is an up regulation of IL-4, IL-5 and IL-10 expression in patients with lymphatic filariasis and a simultaneous decrease in levels of the interferon-gamma and IL-2. (alliedacademies.org)
  • MeSH
  • Interleukin-5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
  • factor
  • Interleukin-4 (IL-4), IL-5, IL-10, IL-13, gamma interferon, and transforming growth factor levels were measured in the cultures and in plasma. (aber.ac.uk)
  • Non-inhibition of IL-5 reporter constructs by dexamethasone in a Jurkat cell line, however, showed a possible intermediary factor involved in the inhibition mechanism. (edu.au)
  • Efficacy
  • Data on the comparative efficacy of treatments would be valuable for clinicians making decisions about patients who are potential candidates for IL-5Rα or anti-IL-5 treatments. (ersjournals.com)
  • receptors
  • Expression of hIL-5 receptors on HL-60 cells was upregulated by butyric acid under alkaline conditions, downregulated by hIL-3, virtually eliminated by dimethyl sulfoxide and hIL-5, while hIL-2 had no detectable effect. (edu.au)
  • increases
  • Two and three copies of IL-5 CLEO upstream of the silent IL-4 minimal promoter gave 150-200 fold increases in expression in forward orientation, but little activity in reverse orientation. (edu.au)
  • levels
  • A marked transient increase in plasma IL-5 levels was observed in 75% of the subjects (n 48) by 1 day posttreatment. (aber.ac.uk)
  • 100 pg/ml) displayed reduced IL-5, IL-13, and IL-10 responses to SWA, and in contrast to the rest of the cohort, these high-IL-5 subjects displayed reduced levels of SWA-specific IgE in plasma 21 days posttreatment. (aber.ac.uk)
  • Levels of IL-4, IL-5 and IL-10 were increased in all chronic, microfilaraemic and endemic control cases. (alliedacademies.org)
  • role
  • Recently, the role of interleukin-4 (IL-4) in atherogenesis became controversial and gained attention. (vt.edu)
  • production
  • PD-L2 Regulates B-1 Cell Antibody Production against Phosphorylcholine through an IL-5-Dependent Mechanism. (ucdenver.edu)
  • Antisense oligonucleotides are new compounds that can specifically inhibit IL-5 production. (edu.au)
  • cell
  • A Phase I/II Trial of Combination Therapy With 5-Fluorouracil, Interferon-an Interleukin-2, and Thalidomide for Metastatic, Advanced or Recurrent Renal Cell Carcinoma. (clinicaltrials.gov)