Loading...
  • Gene
  • The human IL-3 gene is located on chromosome 5, only 9 kilobases from the GM-CSF gene, and its function is quite similar to GM-CSF. (wikipedia.org)
  • Il3 gene expression was highly upregulated at the second tick-feeding site, and adoptive transfer of interleukin-3 (IL-3)-sufficient but not IL-3-deficient CD4 + T cells conferred the basophil infiltration on T-cell-deficient mice, indicating that the CD4 + T-cell-derived IL-3 is essential for the basophil recruitment. (frontiersin.org)
  • To isolate transcription factors important in the regulation of the human interleukin-3 (IL-3) gene, we screened a lambda gt11 cDNA library, constructed from phytohemagglutinin-stimulated human T-cell RNA, with a probe containing regulatory sequences in the upstream region of the IL-3 gene (located from bp -165 to -128 and referred to as the DNase I footprint A region). (asm.org)
  • erythropoietin
  • Lineage-negative, Ly-6A/E+, c-kit+ bone marrow cells from male mice were cultured in suspension in the presence of stem cell factor, IL-6, IL-11, and erythropoietin with or without IL-3 or IL-1. (pnas.org)
  • Tyrosine
  • While we demonstrate that the Gab-2 PH domain can bind PI(3,4,5)P3, it is dispensable for Gab-2 membrane localisation, tyrosine phosphorylation and signalsome formation. (sigmaaldrich.com)
  • Mechanisms
  • We conclude that one component of the survival mechanisms elicited by IL-3 involves the subcellular redistribution of glucose transporters, thus ensuring the supply of a key metabolic substrate. (lancs.ac.uk)
  • survival
  • Interleukin-3-mediated Cell Survival Signals Include Phosphatidylinositol 3-Kinase-dependent Translocation of the Glucose Transporter GLUT1 to the Cell Surface. (lancs.ac.uk)
  • cytokines
  • Because of their known myelopoietic activities, both interleukin (IL)-3 and IL-1 are often used in combination with other cytokines for in vitro (ex vivo) expansion of stem cells. (pnas.org)
  • The results suggest that these cytokines may have a modulatory role on the self-renewal of stem cells and further indicate that the use of IL-3 and IL-1 for in vitro expansion of human stem cells needs to be cautiously evaluated. (pnas.org)
  • Many of the IL-3 activities depend upon co-stimulation with other cytokines. (cellsciences.com)
  • human
  • Isolation and characterization of an expressible cDNA encoding human IL-3. (wikipedia.org)
  • Ticks are blood-feeding ectoparasites that transmit a variety of pathogenic organisms, such as viruses, bacteria, protozoa, and helminths, many of which can cause various infectious disorders in human and animal hosts ( 1 - 3 ). (frontiersin.org)
  • Tick-borne diseases include viral encephalitis, sever fever with thrombocytopenia syndrome, Lyme disease, monocytic human ehrlichiosis, Rocky mountain spotted fever, and babesiosis ( 1 - 3 ). (frontiersin.org)
  • Twenty chemotherapy-naive patients with ovarian carcinoma received 1, 5, 10, or 15 µg/kg/day (five patients per dose step) of recombinant human interleukin 3 (rhIL-3) over 7 days after carboplatin/cyclophosphamide in Cycles 1 and 3. (aacrjournals.org)
  • Clone
  • We isolated a 0.96-kb cDNA that encoded a basic amino acid domain and a leucine zipper domain and used the "rapid amplification and cloning of 3' ends" technique to isolate the 3' half of the cDNA clone, generating a 1.9-kb full-length cDNA clone. (asm.org)
  • erythroid
  • RESULTS: Ten patients were not evaluable for erythroid response because of relevant side effects related to GM-CSF or IL-3 administration. (haematologica.org)
  • chromosome
  • This means there is a translocation between chromosome 9 and chromosome 22, with breaks happening in region (3), band (4), sub-band (1) of the long arm (q) of chromosome 9 and region (1), band (1), sub-band (2) of the long arm (q) of chromosome 22. (wikipedia.org)
  • conclude
  • Since there was also no difference in hematological efficacy between the two routes of rhIL-3 administration, we conclude that the s.c. route of administration appears to have no disadvantages over the i.v. route and may facilitate its clinical application. (aacrjournals.org)
  • Structures
  • As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1MRQ, 1Q13, and 1Q5M. (wikipedia.org)
  • whereas
  • In enzymology, a 20-α-hydroxysteroid dehydrogenase (EC 1.1.1.149) is an enzyme that catalyzes the chemical reaction 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ ⇌ {\displaystyle \rightleftharpoons } 17alpha-hydroxyprogesterone + NAD(P)H + H+ The 3 substrates of this enzyme are 17alpha,20alpha-dihydroxypregn-4-en-3-one, NAD+, and NADP+, whereas its 4 products are 17-alpha-hydroxyprogesterone, NADH, NADPH, and H+. (wikipedia.org)