Interleukin 2 receptor beta subunit. Medical search. Frequent questions

Il-2R exist in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta chain), and a low affinity monomer (alpha chain). (lu.se)
The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. (cancer-genetics.org)
Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. (cancer-genetics.org)
A low affinity interleukin-5 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high affinity receptor for INTERLEUKIN-5. (harvard.edu)
Rafts may promote rapid formation of a high affinity IL-2R complex, even at low levels of IL-2 stimulus, and may also form a platform for the regulation of IL-2 induced signals by GPI-proteins (e.g. (unideb.hu)
Co-internalization of the p55 and p70 subunits of the high-affinity human interleukin 2 receptor. (silverchair.com)
Low and high affinity cellular receptors for interleukin 2. (silverchair.com)
Description: IL-15RA Antibody: Interleukin 15 (IL-15RA) is a cytokine receptor that specifically binds IL-15 with high affinity. (influenza-x.org)
The IL-15 and IL-2 receptors share two subunits, IL-2R beta and IL-2R gamma, and IL-15RA is structurally related to IL-2RA, an additional IL-2-specific alpha subunit necessary for high affinity IL-2 binding. (influenza-x.org)
Unlike IL-2RA, IL-15RA is capable of binding IL-15 with high affinity independent of the other subunits. (influenza-x.org)
The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. (novusbio.com)

The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. (cancer-genetics.org)
IL-2R has a high binding affinity to IL-2 and is expressed by antigen-activated T lymphocytes (T cells). (transcriptionfactor.org)
Although IL-2 R gamma by itself does not bind IL-2 with any appreciable affinity, it is required for IL-2 receptor signaling. (novusbio.com)
The CR1 receptor preferentially binds C3b that is covalently attached to immune complexes, and it has a weaker affinity for bound C4b and iC3b. (medscape.com)

CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. (thermofisher.com)
or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
A family of receptors that modulate the activation of T-LYMPHOCYTES by the T-CELL ANTIGEN RECEPTOR. (edu.au)
Recent studies using cloned antigen-specific T lymphocytes and monoclonal antibodies directed at their various surface glycoprotein components have led to identification of the human T cell antigen receptor as a surface complex comprised of a clonotypic 90 kDa Ti heterodimer and the invariant 20 and 25 kDa T3 molecules. (ox.ac.uk)

The β and γ chains of the IL-2R are members of the type I cytokine receptor family. (transcriptionfactor.org)
also known as IL-6 signal transducer, IL-6 receptor beta, oncostatin-M alpha subunit) is a ubiquitously expressed, 130 kDa type I transmembrane glycoprotein and member of the type II subfamily, type I cytokine receptor family. (rndsystems.com)

IL-2 Rα is also known as CD25, p55, and Tac (activated T cell) antigen. (transcriptionfactor.org)
In addition to the beta and gamma(c) chains constitutively expressed in detergent-resistant membrane fractions (DRMs) of T cells, IL-2Ralpha (CD25) was also found in DRMs, independently of its ligand-occupation. (unideb.hu)
Depletion of membrane cholesterol using methyl-beta-cyclodextrin substantially reduced co-clustering of CD25 with CD48 and HLA-DR, as well as the IL-2 stimulated tyrosine-phosphorylation of STATs (signal transducer and activator of transcription). (unideb.hu)
These data indicate a GPI-microdomain (raft)-assisted recruitment of CD25 to the vicinity of the signaling beta and gamma(c) chains. (unideb.hu)
90 Y-Basiliximab is a chimeric, mouse-human monoclonal antibody directed against the Alpha subunit of interleukin-2 receptor (IL-2R Alpha , CD25 or Tac antigen), and labeled with Yttrium-90, with potential antineoplastic activity. (oncidiumfoundation.org)

In addition, the signaling beta and gamma chains are shared by other cytokines (e.g. (unideb.hu)
While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. (lookformedical.com)
Gp130 serves as the signal transducing receptor subunit for the IL-6-type cytokines consisting of interleukin (IL)-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), new neurotrophin factor-1 (NNT-1), IL-27, cardiotrophin-1 (CT-1), and cardiotrophin like cytokine (CLC) (2 - 5). (rndsystems.com)
These cytokines are involved in a variety of functions including the modulation of inflammatory and immune responses, heart development, fertility, and many other activities (2). (rndsystems.com)
Interleukin-12 (IL-12) and interleukin-23 (IL-23), which belong to the IL-12 family of cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in the pathogenesis of inflammatory bowel disease. (nature.com)

The key targets in the Bone Marrow Transplant Rejection pipeline drugs market are Tyrosine Protein Kinase JAK1, Tyrosine Protein Kinase JAK2, Tyrosine Protein Kinase BTK, Interleukin 2 Receptor, Programmed Cell Death Protein 1, Alpha 1 Antitrypsin, Cells Expressing B Lymphocyte Antigen CD20, Interleukin 2 Receptor Subunit Beta, Macrophage Colony Stimulating Factor 1 Receptor, and Tyrosine Protein Kinase ITK/TSK among others. (globaldata.com)
The key mechanisms of action in the Bone Marrow Transplant Rejection pipeline drugs market are Tyrosine Protein Kinase JAK1 Inhibitor, Tyrosine Protein Kinase JAK2 Inhibitor, Tyrosine Protein Kinase BTK Inhibitor, Interleukin 2 Receptor Agonist, Alpha 1 Antitrypsin Replacement, Cytotoxic To Cells Expressing B Lymphocyte Antigen CD20 , Interleukin 2 Receptor Subunit Beta Antagonist, Programmed Cell Death Protein 1 Agonist, Tyrosine Protein Kinase ITK/TSK Inhibitor, and CD40 Ligand Inhibitor among others. (globaldata.com)
Interleukin 35 (IL35) may presumably signal via a complex that includes Tyrosine protein kinase JAK1 (JAK1) and JAK2 associated with Interleukin 6 receptor beta subunit (IL6ST) and Interleukin 12 receptor beta 2 subunit (IL12RB2) (Collison et al. (reactome.org)

Triggering of the T3-Ti receptor complex induces a rapid increase in free cytoplasmic Ca2+ and gives rise to specific antigen-induced proliferation through an autocrine pathway involving endogenous interleukin-2 production, release and subsequent binding to interleukin-2 receptors. (ox.ac.uk)
IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232 residue extracellular domain, a 29 residue transmembrane domain and an 86 residue cytoplasmic domain. (novusbio.com)

Non covalent dimer of an alpha and a beta chains. (lu.se)
Interleukin-5 Receptor alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Several isoforms of the interleukin-5 receptor alpha subunit exist due to multiple ALTERNATIVE SPLICING. (harvard.edu)
This graph shows the total number of publications written about "Interleukin-5 Receptor alpha Subunit" by people in Harvard Catalyst Profiles by year, and whether "Interleukin-5 Receptor alpha Subunit" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Interleukin-5 Receptor alpha Subunit" by people in Profiles. (harvard.edu)
The IL-2R is made up of 3 subunits - alpha (α), beta (β) and gamma (γ). (transcriptionfactor.org)
Subunits (alpha, beta and gamma) of the interleukin-2 receptor complex (IL-2R) are involved in both proliferative and activation-induced cell death (AICD) signaling of T cells. (unideb.hu)
CD8 subunit alpha [Source:HGNC Symbol;A. (gsea-msigdb.org)
The top five most associated protein-coding genes were Interferon Alpha and Beta Receptor Subunit 2 (IFNAR2), 2'-5'-Oligoadenylate Synthetase 3 (OAS3), mucin 1 (MUC1), Interleukin 10 Receptor Subunit Beta (IL10RB), and Napsin A Aspartic Peptidase (NAPSA). (cdc.gov)
The alpha and beta subunits of Ti bear no precursor-product relationship to one another and are encoded by separate germline V, D, J and C segments which rearrange during intrathymic differentiation to form an active gene set. (ox.ac.uk)
Description: Recombinant Human Interleukin-15 Receptor Alpha & Interleukin-15 Fusion Protein is produced by our Mammalian expression system and the target gene encoding Ile31-Asp96&Asn49-Ser162(Asn120Asp) is expressed with a Fc tag at the C-terminus. (influenza-x.org)
Fc alpha receptor [Source:HGNC Symbol;A. (gsea-msigdb.org)
In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse IL-2 R gamma is observed, less than 10% cross-reactivity with recombinant human (rh) IL-2 R beta is observed, and less than 2% cross-reactivity with rhIL-2 R alpha is observed. (novusbio.com)
The dominant variants in the United States and much of the world are Alpha, Beta, Delta, and Omicron. (msdmanuals.com)

Interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to the cytokine IL-2. (transcriptionfactor.org)
This antibody recognizes and binds binding site II of human interleukin-6 which interacts with gp130 (IL-6 receptor subunit beta). (absoluteantibody.com)

While the IL12Rβ1 subunit is constitutively expressed, the expression of the IL12RB2 gene is up-regulated by interferon gamma. (wikipedia.org)
The potential causal genes were enriched in biological processes related to type I interferons, interferon gamma inducible protein 10 production, and chemokine (C-X-C motif) ligand 2 production. (cdc.gov)
Seder, R. A., Gazzinelli, R., Sher, A. & Paul, W. E. Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. (nature.com)
Fc gamma receptor and transporter [Sour. (gsea-msigdb.org)
G protein subunit gamma transducin 1 [S. (gsea-msigdb.org)
Detects human Common gamma Chain/IL‑2 R gamma in direct ELISAs and Western blots. (novusbio.com)
Besides IL-2, the gamma chain has been shown to be a component of the functional receptor complexes for IL-4, IL-7, IL-9 and IL-15. (novusbio.com)
It has been proposed that IL-2 R gamma be designated the common gamma chain ( gamma c ). (novusbio.com)

CD122, also known as the Interleukin-2 receptor beta subunit, is a key signaling receptor that is known to increase proliferation of these effector T cells. (prohostbiotech.com)
Bempegaldesleukin, Nektar's lead immuno-oncology candidate, is an investigational CD122-preferential IL-2 pathway agonist designed to provide activation and proliferation of cancer-killing immune cells, known as CD8+ effector T cells and natural killer (NK) cells. (nektar.com)
Bempegaldesleukin is designed to stimulate cancer-killing immune cells in the body by targeting CD122 receptors found on the surface of these immune cells. (nektar.com)

This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. (creativebiomart.net)
This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. (antibodies-online.com)

The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. (wikipedia.org)
The protein encoded by this gene belongs to the cytokine receptor family. (creativebiomart.net)
The protein encoded by this gene represents the beta subunit and is a type I membrane protein. (cancer-genetics.org)
This gene encodes a member of the type II cytokine receptor family. (nih.gov)
This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. (nih.gov)

Here we show, in four cell lines of human adult T cell lymphoma/leukemia origin, that the three IL-2R subunits are compartmented together with HLA glycoproteins and CD48 molecules in the plasma membrane, by means of fluorescence resonance energy transfer (FRET), confocal microscopy and immuno-biochemical techniques. (unideb.hu)
Normal neuromuscular junction showing a presynaptic terminal with a motor nerve ending in an enlargement (bouton terminale): Synaptic cleft and postsynaptic membrane with multiple folds and embedded with several acetylcholine receptors. (medscape.com)

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. (thermofisher.com)
Included under this heading are signaling receptors, non-signaling receptors and accessory proteins required for receptor signaling. (edu.au)
Effector proteins interacting with the Fc portion of immunoglobulin M (IgM) include complement and complement receptors. (medscape.com)
Partial or complete deficiencies of the components of the complement system, including its receptors and regulatory proteins, are now described in humans and may be of a genetic or familial origin or acquired. (medscape.com)
Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)

The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). (antibodies-online.com)

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. (cancer-genetics.org)
Programmed death ligand 1 (PD-L1), a mediator of the PD-1 receptor, plays an inhibitory role in cancer immune responses. (cancer-genetics.org)
It is a novel mechanism of action in immunotherapy, which is what is attracting us to the drug, knowing in fact that existing IL-2 therapy activates both immunosuppressive as well as immune-stimulatory receptors, which has limited its utility in clinical settings before the surfacing of NKTR-214. (prohostbiotech.com)
Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (T h 1)-specific immune responses and inhibits the development of IL-4-producing Th cells. (nature.com)
Complement and complement receptors play a critical role in immune defense by initiating the rapid destruction of invading microorganisms, amplifying the innate and adaptive immune responses, and mediating solubilization and clearance of immune complexes. (medscape.com)
CR1 and CR2 have been shown to influence the immune environment in a B-cell receptor-independent manner. (medscape.com)

The receptors are responsive to one or more B7 ANTIGENS found on ANTIGEN-PRESENTING CELLS and, depending upon the specific ligand-receptor combination, modulate a variety of T-cell functions such as the rate of clonal expansion, CELL SURVIVAL and cytokine production. (edu.au)

It is an inhibiting antibody interacting with the gp130 (IL-6 receptor subunit beta) binding site II. (absoluteantibody.com)

Such treatment was associated with upregulation of invasion- and inflammation-promoting soluble factors, such as matrix metalloproteinase 2 (MMP2), its activator MMP14, tissue inhibitors of matrix metalloproteinase 2 (TIMP2), chemokine ligand 2 (CCL2), and urokinase-type plasminogen activator (uPA), the latter two being linked to the recruitment of the monocytic cells. (biomedcentral.com)
Description: A competitive ELISA for quantitative measurement of Rabbit Soluble IL 1 Receptor 4/ST2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (influenza-x.org)

Nasal insufflation of IL-11 causes AHR in wild-type mice while lung inflammation induced by antigen sensitization and challenge, which mimics features of atopic asthma in humans, is attenuated in mice genetically deficient in IL-11 receptor subunit a-1 (IL-11Ra1-deficient mice), a transmembrane receptor that is required conjointly with glycoprotein 130 to transduce IL-11 signaling. (cdc.gov)

A family of structurally-related cell-surface receptors that signal through an intrinsic PROTEIN-TYROSINE KINASE. (edu.au)

IL-15RA is thought to enhance cell proliferation and expression of apoptosis inhibitor Bcl-xL and Bcl-2. (influenza-x.org)

We selected most pathways IL10RB participated on our site, such as Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Jak-STAT signaling pathway, which may be useful for your reference. (creativebiomart.net)

Receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. (edu.au)

Determined by its ability to increase the proliferation effect of IL-2 in murine CTLL-2 cells. (transcriptionfactor.org)
Recombinant Human IL‑2 (Catalog # 202-IL) stimulates proliferation in the MO7e human megakaryocytic leukemic cell line in a dose-dependent manner (orange line). (novusbio.com)

Synthetic peptide derived from the central portion of the ZO-2 protein. (thermofisher.com)

1994). "Expression cloning of a human IL-12 receptor component. (wikipedia.org)
and human chorionic gonadotropin beta subunit, ≤ 0.1 ng/mL. (springeropen.com)
In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-2 R, rhIL-4 R, or rhIL-6 R is observed. (rndsystems.com)
Cellular receptors that bind the human immunodeficiency virus that causes AIDS. (edu.au)
The ontogeny, structure and function of the human T lymphocyte receptor for antigen and major histocompatibility complex. (ox.ac.uk)
We previously demonstrated the critical involvement of SRC-2 in murine embryo implantation as well as in human endometrial stromal cell (HESC) decidualization, a cellular transformation process required for trophoblast invasion and ultimately placentation. (frontiersin.org)
We show here that, like SRC-2, SRC-3 is expressed in the epithelial and stromal cellular compartments of the human endometrium during the proliferative and secretory phase of the menstrual cycle as well as in cultured HESCs. (frontiersin.org)

It is an accessory chain essential for the active interleukin 10 receptor complex. (creativebiomart.net)
The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ-chain, along with the β subunit. (transcriptionfactor.org)

Note the image below, as well as the article Pediatric Complement Receptor Deficiency may be helpful. (medscape.com)

The complement system, interacting with its regulatory molecules and cellular receptors, plays a central role in the induction and regulation of immunity. (medscape.com)

The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. (nih.gov)
IL-12 (Interleukin-12) is a heterodimeric cytokine that consists of a p35 and a p40 subunit. (rndsystems.com)

[ 1 , 2 ] Although the chief target of the autoimmune attack in most cases is the skeletal muscle nicotinic acetylcholine receptor (nAChR), other antigenic targets that are components of the neuromuscular junction (NMJ) have also been implicated. (medscape.com)
Because of their high numbers, red blood cells express an average of 90% of the CR1 receptors despite their having a lower number of antigenic sites per cell. (medscape.com)

Fig. 2: Cellular sources, target cells, signalling and downstream effects of IL-23. (nature.com)
Although the lack of estrogen receptor β (ERβ) is a risk factor for the development of inflammatory bowel disease (IBD) and psychiatric disorders, the underlying cellular and molecular mechanisms are not fully understood. (biomedcentral.com)

The following product was used in this experiment: ZO-2 Polyclonal Antibody from Thermo Fisher Scientific, catalog # 71-1400, RRID AB_2533976. (thermofisher.com)
A single dose of NKTR-214 resulted in a 500-fold area under the curve (AUC) exposure within the tumor compared with an equivalent dose of the existing IL-2 therapy, enabling, for the first time, an antibody-like dosing regimen for a cytokine. (prohostbiotech.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Calpain, Small Subunit 1 (CAPNS1) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (resourcerecovery.be)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Calpain, Small Subunit 1 (CAPNS1) in samples from tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (resourcerecovery.be)

NKTR-214 uses Nektar's this technology to enable preferential activation of immunostimulatory IL-2 receptors. (prohostbiotech.com)
Mouse pharmacodynamics data demonstrated that a single dose of NKTR-214 can increase and sustain STAT5 phosphorylation (a marker of IL-2 pathway activation) through one-week post-dose. (prohostbiotech.com)
[ 2 ] T cell-derived complement C3a and CD46 activation is required for Th1 induction. (medscape.com)
The density of CR1 receptors on cell surfaces varies with the cell type and with the activation of the cell for neutrophils and monocytes. (medscape.com)

The domains in the CHR are the structural hallmarks of the hematopoietic cytokine receptor family (2). (rndsystems.com)
also known as NCOA3 or AIB1) is a member of the multifunctional p160/SRC family of coactivators, which also includes SRC-1 and SRC-2. (frontiersin.org)

The IL12Rβ2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules. (wikipedia.org)

COVID-19 Vaccine Initiation and Dose Completion During the SARS-CoV-2 Delta Variant Surge in the United States, December 2020-October 2021. (cdc.gov)
Rag-1 and Rag-2 and initiation of Ig recombination events [7]. (lu.se)

Description: A sandwich ELISA for quantitative measurement of Rat Calpain small subunit 1(CAPNS1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (resourcerecovery.be)
Description: A sandwich ELISA kit for detection of Calpain, Small Subunit 1 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (resourcerecovery.be)

Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. (edu.au)

Anatomy22

Organisms13

Diseases3

Chemicals and Drugs137

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes55

Disciplines and Occupations1

Information Science3

High affinity11

Affinity4

Antigen receptor4

Type I cytokine rece2

CD255

Cytokines5

Jak23

Cytoplasmic2

Alpha14

Binds2

Gamma8

CD1223

Chromosome2

Gene5

Membrane2

Proteins5

Heterodimer1

Immune6

Antigens1

Gp1301

Soluble2

Transmembrane1

Tyrosine1

Inhibitor1

IL10RB1

LYMPHOCYTE ACTIVATION1

Proliferation2

Peptide1

Human7

Chain2

Deficiency1

Regulatory1

Heterodimeric2

Antigenic2

Cellular2

Antibody4

Activation4

Family2

Cell Differentiation1

Initiation2

ELISA2

Signal1