• N -(4-[ 18 F]Fluorobenzoyl)interleukin-2 ([ 18 F]FB-IL2) specifically binds to interleukin-2 receptors (IL-2R) and thus may be used to detect inflammation processes using positron emission tomography (PET). (springer.com)
  • High levels of interleukin-2 receptors (IL-2R) can be found mainly on the surface of activated T lymphocytes (both CD4+ and CD8+, mainly Th1 lymphocytes) [ 1 - 3 ] after endogenous stimulation. (springer.com)
  • IL4R is the common ligand binding subunit shared by the IL-4 receptors type I (receptor for IL-4) and type II (receptor for IL-4 and IL-13). (guidetomalariapharmacology.org)
  • ABSTRACT: Multisubunit cytokine receptors such as the heterotrimeric receptor for interleukin-2 (IL-2) are ubiquitous in hematopoeitic cell types of importance in biotechnology and are crucial regulators of cell proliferation and differentiation behavior. (physiomeproject.org)
  • Nasal insufflation of IL-11 causes AHR in wild-type mice while lung inflammation induced by antigen sensitization and challenge, which mimics features of atopic asthma in humans, is attenuated in mice genetically deficient in IL-11 receptor subunit alpha-1 (IL-11Ra1-deficient mice), a transmembrane receptor that is required along with glycoprotein 130 to transduce IL-11 intracellular signaling. (cdc.gov)
  • IL-2R has a high binding affinity to IL-2 and is expressed by antigen-activated T lymphocytes (T cells). (transcriptionfactor.org)
  • IL-2 Rα is also known as CD25, p55, and Tac (activated T cell) antigen. (transcriptionfactor.org)
  • A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. (ontobee.org)
  • 90 Y-Basiliximab is a chimeric, mouse-human monoclonal antibody directed against the Alpha subunit of interleukin-2 receptor (IL-2R Alpha , CD25 or Tac antigen), and labeled with Yttrium-90, with potential antineoplastic activity. (oncidiumfoundation.org)
  • A high correlation between ex vivo tracer uptake (standardized uptake value) in the xenograft and the number of inoculated CD25-positive cells was observed ( R 2 = 0.90). (springer.com)
  • The IL-2R consists of three subunits (α, β and γ chains, called CD25, CD122 and CD132, respectively). (springer.com)
  • CD25 contains the main binding site for IL-2 and can be present as a transmembrane or soluble receptor. (springer.com)
  • Thr bonds, and it can also cleave the alpha subunit of the interleukin-2 (IL-2) receptor (CD25). (expasy.org)
  • The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. (nih.gov)
  • The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. (nih.gov)
  • Interleukin 22 binding protein (IL-22BP), also known as CRF2-10, CRF2-X, and IL-22 RA2, is a 35-45 kDa secreted glycoprotein in the type II cytokine receptor family (CRF). (rndsystems.com)
  • Interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to the cytokine IL-2. (transcriptionfactor.org)
  • The protein encoded by this gene represents the beta subunit and is a type I membrane protein. (cancer-genetics.org)
  • Further, CP-1158 attenuated LPS-induced syntheses of tumor necrosis factor (TNF)-alpha, IL-1beta, interferon-inducible protein (IP)-10 and macrophage inflammatory protein (MIP)-1beta transcripts. (wikigenes.org)
  • GxxxA design at the correct position in TM1 of 1 imparts a new function to the 1 subunit that's perhaps not seen in the wild type protein. (plasignaling.com)
  • The top five most associated protein-coding genes were Interferon Alpha and Beta Receptor Subunit 2 (IFNAR2), 2'-5'-Oligoadenylate Synthetase 3 (OAS3), mucin 1 (MUC1), Interleukin 10 Receptor Subunit Beta (IL10RB), and Napsin A Aspartic Peptidase (NAPSA). (cdc.gov)
  • The potential causal genes were enriched in biological processes related to type I interferons, interferon gamma inducible protein 10 production, and chemokine (C-X-C motif) ligand 2 production. (cdc.gov)
  • IL20RA, along with the IL-20 receptor, beta subunit, form the heterodimeric interleukin-20 receptor, which binds the cytokines IL-19, IL-20 and IL-24. (wikipedia.org)
  • While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. (lookformedical.com)
  • In a tumour setting, NK T cells activated by alpha-galactosylceramide (alpha-GalCer) execute anti-tumour activity by secreting cytokines. (ox.ac.uk)
  • Since IL-2 is the natural ligand of the IL-2R, this glycoprotein was selected as a potential radiopharmaceutical for imaging activated T lymphocytes [ 16 ]. (springer.com)
  • Computational results from this model predict that IL-2 depletion can be reduced by decreasing its binding affinity for the IL-2R betagamma subunit relative to the alpha subunit at endosomal pH, as a result of enhanced ligand sorting to recycling vis-a-vis degradation, and that an IL-2 analogue with such altered binding properties should exhibit increased potency for stimulating the T cell proliferation response. (physiomeproject.org)
  • Computational Model for Effects of Ligand/Receptor Binding Properties on Interleukin-2 Trafficking Dynamics and T Cell Proliferation Response, Eric M. Fallon and Douglas A. Lauffenburger, 2000, Biotechnology Progress , 16, 905-916. (physiomeproject.org)
  • Increased serum level of soluble interleukin-2 receptor is associated with a worse response of metastatic clear cell renal cell carcinoma to interferon alpha and sequential VEGF-targeting therapy. (cusabio.com)
  • A low affinity interleukin-5 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high affinity receptor for INTERLEUKIN-5. (harvard.edu)
  • Il-2R exist in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta chain), and a low affinity monomer (alpha chain). (lu.se)
  • The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. (cancer-genetics.org)
  • The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. (cancer-genetics.org)
  • Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. (cancer-genetics.org)
  • Interleukin-23 ( IL-23 ) is a heterodimeric cytokine composed of an IL12B ( IL-12p40 ) subunit (that is shared with IL12 ) and the IL23A ( IL-23p19 ) subunit. (wikidoc.org)
  • IL20RA also forms a complex with the IL-10 receptor, beta subunit, which binds the cytokine IL-26. (wikipedia.org)
  • In this pathway, after a cytokine binds IL20RA and the beta subunit, JAKs linked to intracellular domains of IL20R activate and phosphorylate tyrosine residues found in the longer alpha chains of IL20RA. (wikipedia.org)
  • The labelled IL-2 derivatives showed good results in terms of localization of the inflammation within the limitations of gamma camera imaging. (springer.com)
  • It acts by targeting interleukin 2 receptor subunit alpha and gamma.It was also under development for the treatment of ulcerative colitis and systemic lupus erythematosus (SLE). (globaldata.com)
  • The IL-2R is made up of 3 subunits - alpha (α), beta (β) and gamma (γ). (transcriptionfactor.org)
  • Sharing the beta and gamma receptor subunits results in several common functions: e.g. the promotion of T cell proliferation. (unideb.hu)
  • Interleukin (IL)-15, a major cytokine involved in cross-talk between accessory cells (dendritic cells and macrophages) and NK cells, is produced by epithelial renal cells. (nih.gov)
  • This subunit is the molecular target of the investigational monoclonal antibody dupilumab, that is in clinical trial as a therapy for atopic allergic conditions and nasal polyposis. (guidetomalariapharmacology.org)
  • Data show that interleukin-2 receptor alpha, tumor necrosis factor receptor 1, serum STimulation-2 (IL1RL1 gene product), and regenerating islet-derived 3-alpha were significantly associated with non-relapse mortality. (cusabio.com)
  • The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. (cancer-genetics.org)
  • On the other hand, due to their distinct alpha receptor subunits, they also play opposing roles in immune processes such as activation induced cell death and immunological memory. (unideb.hu)
  • In addition, activated T cells can express an inducible co-stimulator (iCOS), a surface receptor that is structurally and functionally similar to CD28 and enhances expression of Th2-related interleukin (IL)-10 rather than immune activating IL-2 [ 8 ] . (encyclopedia.pub)
  • Brinkman et al5 examined whether the presence and foods.1,2 However, much less is known about the poten- severity of AD was predictive of the occurrence and mag- tial influence that skin challenges have on the systemic nitude of early and late asthmatic responses to inhaled immune response, in particular whether sensitization allergens. (cdc.gov)
  • This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. (nih.gov)
  • A second trial (SCIDn2) was carried out to treat SCID-X1 using an improved self-inactivated vector in which the LTR strong enhancer sequences were deleted [ 19 ], and a promoter comprised of the short elongation factor 1 alpha (EF1a) promoter, devoid of enhancer regions, was used to express the therapeutic IL2RG gene. (europeanhealthjournal.com)
  • IL-10 R beta is also a component of the receptor complexes for IL-10, IL-26, IL-28, and IL-29 (1, 2). (rndsystems.com)
  • Non covalent dimer of an alpha and a beta chains. (lu.se)
  • hemoglobin subunit beta [Source:HGNC S. (gsea-msigdb.org)
  • 2) Estimation of T cell population structure by sequencing of the recombined T cell receptor (TCR) beta locus. (europeanhealthjournal.com)
  • and human chorionic gonadotropin beta subunit, ≤ 0.1 ng/mL. (springeropen.com)
  • The dominant variants in the United States and much of the world are Alpha, Beta, Delta, and Omicron. (msdmanuals.com)
  • MbIL-15 on the target did not interfere with resting NK cell activation and target cell cytolysis but rescued NK cells from IL-2 starvation-induced apoptosis through contact-dependent interaction. (nih.gov)
  • it inhibits transcription for genes that encode IL-3, IL-4, IL-5, GM-CSF, and TNF-alpha (all involved in early T-cell activation). (medscape.com)
  • Interleukin-2 and interleukin-15 (IL-2, IL-15) are key participants in T and NK cell activation and function. (unideb.hu)
  • Furthermore, we show that MbIL-15 from renal cell carcinoma cells is functional and involved in rapid nuclear translocation of phosphorylated signal transducers and activators of transcription 3 in IL-2-starved NK cells. (nih.gov)
  • We describe here a computational model for trafficking dynamics of the IL-2 receptor (IL-2R) system, which is able to predict T cell proliferation responses to IL-2. (physiomeproject.org)
  • This model comprises kinetic equations describing binding, internalization, and postendocytic sorting of IL-2 and IL-2R, including an experimentally derived dependence of cell proliferation rate on these properties. (physiomeproject.org)
  • Everyone with type 1 diabetes - except those who have received pancreas or islet-cell transplants - and more than half of people with type 2 diabetes use insulin to manage their diabetes. (sciencegate.app)
  • Our results imply a potential application of combining T(reg) cell depletion with alpha-GalCer to stimulate NK T cells for cancer therapy. (ox.ac.uk)
  • 2 currents andwith cell surfacebiotinylation for theW391Amutation, we performed similar studies following mutation of Y388. (plasignaling.com)
  • They can skin and can extend to the bone marrow, simulate benign skin disorders, making them blood lymphocytes, lymph nodes, and a diagnostic challenge for dermatologists1,2. (bvsalud.org)
  • IL20RA is an alpha-chain with a long intracellular domain. (wikipedia.org)
  • Studies which blocked the function of IL-12p35 did not produce the same results as those targeting IL-12p40 as would have been expected if both subunits formed part of IL-12 only. (wikidoc.org)
  • The interleukin 20 receptor, alpha subunit is also referred to as IL20R1 or IL20RA. (wikipedia.org)