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  • melanoma
  • Intralesional IL-2 is commonly used to treat in-transit melanoma metastases and has a high complete response rate. (wikipedia.org)
  • In this phase II trial, the previously described IL-2 schedule (daily IL-2 for 5 days (per week) every 3 weeks) will be tested in a larger cohort of patients with melanoma to attempt to determine the response rate, median duration of response, and median survival. (clinicaltrials.gov)
  • cDNA
  • Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells. (ebi.ac.uk)
  • Experimental
  • Therefore, I advise caution in deciding to substitute experimental or other drug treatments for IL-2 unless there are already very promising results. (cancerguide.org)
  • Experimental treatments are appropriate if IL-2 has been tried without success, or if you are ineligible for IL-2 treatment for some reason. (cancerguide.org)
  • tyrosine
  • Activation by IL-2 led to tyrosine phosphorylation-dependent interactions between Jak3 and p52ShcA only at lower concentrations. (wikipedia.org)
  • phosphorylation
  • Higher concentrations of IL-2 decreased the phosphorylation of Jak3, disrupted its interactions with p52ShcA, redistributed Jak3 to the nucleus, and induced apoptosis in IEC. (wikipedia.org)
  • expression
  • After costimulation from CD28 the optimal activation of expression of IL-2 and these pathways is induced. (wikipedia.org)
  • Tonsillar biopsy: Examination of tonsil tissue may provide information on the effects of IL-2 on the immune system and the expression of HIV. (clinicaltrials.gov)
  • gamma
  • Kasahara T, Hooks JJ, Dougherty SF, Oppenheim JJ (1983) Interleukin-2 mediated immune interferon (IFN-gamma) production by human T-cells in T-cell subsets. (springer.com)
  • Under viral attack CD-4+ T-cells fail to mature, fail to produce IL-2 and gamma interferon, and consequently fail to coordinate CD-8 responses to viruses. (wikipedia.org)
  • determine
  • Thus, the investigators propose a proof of principal clinical trial to treat WAS subjects with IL-2 to determine safety and efficacy of IL-2 in this population and if NK cell function is restored ex vivo. (knowcancer.com)
  • homeostasis
  • Thus IL-2-induced mucosal homeostasis through posttranslational and transcriptional regulation of Jak3. (wikipedia.org)
  • systemic
  • These data suggest that repeated systemic rIL-2 infusion results in altered vasomotor responsiveness within the cerebral microcirculation. (aacrjournals.org)
  • therapeutic
  • IL-2 has a narrow therapeutic window, and the level of dosing usually determines the severity of the side effects. (wikipedia.org)
  • response
  • Radiographic studies to evaluate for response were done after every 2 cycles (6 weeks) until disease progression or death from any cause up to 2 years. (clinicaltrials.gov)
  • Duration of response is calculated as the time (months) from the date at which response is first observed (per standard Response Evaluation Criteria In Solid Tumors [RECIST] to the date of first observed disease progression or date of death from any cause, whichever came first, assessed up to 2 years. (clinicaltrials.gov)
  • In this experiment, several genes including GADD45G were noted for being induced by IL-2, and they were identified as immediate early response genes in T lymphocytes. (wikipedia.org)