Loading...
  • STAT6
  • Većina IL-13 bioloških efekata, poput IL-4 efekata, su vezane za jedan transkripcioni faktor , pretvarač signala i aktivator transkripcije 6 ( STAT6 ). (wikipedia.org)
  • Studies of STAT6 transgenic mice suggest the interesting possibility that IL-13 signaling occurring only through the airway epithelium is required for most of these effects. (wikidoc.org)
  • serum levels
  • Hasegawa M, Fujimoto M, Kikuchi K, Takehara K (1997) Elevated serum levels of interleukin-4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis. (springer.com)
  • However, IL-13 serum levels have not been assessed in subjects with insulin resistance, and associations of IL-13 with parameters of low-grade systemic inflammation are still unknown. (hindawi.com)
  • This study demonstrates that IL-13 serum levels are elevated in patients with insulin resistance without showing correlation with parameters of low-grade systemic inflammation. (hindawi.com)
  • airway
  • Although IL-13 is associated primarily with the induction of airway disease, it also has anti-inflammatory properties. (wikidoc.org)
  • immune
  • In this immune dysregulated context, marked by the recruitment of aberrantly large numbers of Th2 cells, IL-13 inhibits the ability of host immune cells to destroy intracellular pathogens . (wikidoc.org)
  • Interleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. (reactome.org)
  • interferon
  • Our data clearly indicate that prolonged survival of IL13-expressing allogeneic MSC grafts in muscle tissue coincided with the induction of an alternatively activated M2a macrophage phenotype in vivo and a reduced number of alloantigen-reactive interferon gamma (IFNγ)- and/or interleukin-2 (IL2)-producing CD8 + T cells compared to non-modified allografts. (uantwerpen.be)
  • regulation
  • However, the regulation of the IL-13/IL-13R axis is not understood completely and it is not clear whether IL-13 receptors are functional in GBM. (nih.gov)
  • genes
  • Glomerular transcriptional profile of IL-13 -overexpressed rats showed characteristic features of podocyte injury with 87% of podocyte related genes being significantly down-regulated. (clinsci.org)
  • tumor
  • IL-13 and IL-13Ralpha1 are overexpressed in extranodal natural killer/T cell lymphoma and mediate tumor cell proliferation. (nih.gov)
  • In previous studies, we described a "counter-immunosurveillance" mechanism initiated by tumor-activated, interleukin-13 (IL-13)-producing natural killer T cells that signal Gr-1 + cells to produce transforming growth factor-β 1 (TGF-β 1 ), a cytokine that suppresses the activity of tumor-inhibiting cytolytic CD8 + T cells. (aacrjournals.org)
  • In the present study, we determined whether TGF-β 1 production arising from IL-13 signaling via IL-13Rα 2 as described above applies to counter-immunosurveillance in the syngeneic CT-26 colon cancer and 15-12RM fibrosarcoma regressor experimental tumor models. (aacrjournals.org)
  • Both type 1 and type 2 IL-13R are shown to be expressed on various tumor cell types ( 11 , 13 , 15 -17 , 23 -25 ). (aacrjournals.org)
  • lung
  • The eggs of the parasite Schistosoma mansoni may lodge in a variety of organs including the gut wall, liver, lung and even central nervous system, inducing the formation of granulomas under the control of IL-13. (wikidoc.org)
  • Doucet C, BroutyBoye D, PottinClemenceau C, Canonica GW, Jasmin C, Azzarone B (1998a) Interleukin (IL) 4 and IL-13 act on human lung fibroblasts. (springer.com)
  • systemic
  • To determine whether IL-13Rα2 chain can render sensitivity of breast cancer to IL-13 cytotoxin, we injected IL-13Rα2 plasmid in s.c. established tumors by i.t. route, followed by systemic or i.t. (aacrjournals.org)