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  • rhIL-11
  • RhIL-11 treatment normalized Th1/Th2 and T-bet/GATA-3 imbalance in in human immune thrombocytopenic purpura (ITP). (nih.gov)
  • The treatment of the gastric cell lines AGS and MKN45 with rhIL-11 resulted in a significant increase in the expression of V0 and V1. (ijbs.com)
  • Recombinant human interleukin-11 (rhIL-11) has been approved by the Food and Drug Administration as treatment for adults with solid tumours and lymphomas with severe chemotherapy-induced thrombocytopenia. (duke.edu)
  • We conducted a phase I/II trial of rhIL-11 following ifosfamide, carboplatin and etoposide (ICE) chemotherapy in children with solid tumours or lymphomas. (duke.edu)
  • Patients received ifosfamide 1800 mg/m(2)/d for 5 d, carboplatin 400 mg/m(2)/d for 2 d and etoposide 100 mg/m(2)/d for 5 d with rhIL-11 subcutaneous (s.c.) at 25-125 microg/kg/d on days 6-33. (duke.edu)
  • Clinically important adverse events to rhIL-11 were papilloedema and periosteal bone formation. (duke.edu)
  • proteins
  • IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia , induce acute phase proteins , modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation IL-11 causes bone-resorption. (wikidoc.org)
  • Strict calcium dependence of this interaction suggests a possibility of IL-11 interaction with other calcium sensor proteins. (abo.fi)
  • Here we probed specificity of IL-11 to calcium-binding proteins of various types: calcium sensors of the EF-hand family (calmodulin, S100B and neuronal calcium sensors: recoverin, NCS-1, GCAP-1, GCAP-2), calcium buffers of the EF-hand family (S100G, oncomodulin), and a non-EF-hand calcium buffer (α-lactalbumin). (abo.fi)
  • A specific subset of the calcium sensor proteins (calmodulin, S100B, NCS-1, GCAP-1/2) exhibits metal-dependent binding of IL-11 with dissociation constants of 1-19 μM. (abo.fi)
  • Secondary structure and accessibility of the hinge region of the EF-hand proteins studied are predicted to control specificity and selectivity of their binding to IL-11. (abo.fi)
  • The IL-11 interaction with the EF-hand proteins is expected to occur under numerous pathological conditions, accompanied by disintegration of plasma membrane and efflux of cellular components into the extracellular milieu. (abo.fi)
  • Detects 11 Bovine Interleukin proteins. (insightbio.com)
  • gp130
  • IL-11 is a member of the IL-6 -type cytokine family, distinguished based on their use of the common co-receptor gp130 . (wikidoc.org)
  • Signal transduction is initiated upon binding of IL-11 to IL-11Ralpha and gp130, facilitating the homodimerization of gp130 molecules. (wikidoc.org)
  • Die Kolonkarzinomzelllinie HT-29 und isolierte primäre humane Kolonepithelzellen (CEC) exprimierten auf Transkriptions- und Translationsebene die a-Kette des Rezeptors für den spezifischen Liganden IL-11 und das Glykoprotein gp130. (uni-regensburg.de)
  • Osteoclastogenesis induced by IL-6 and IL-11 was inhibited by the addition of an anti-gp130 antibody but not by osteoprotegerin. (ox.ac.uk)
  • humans
  • A number of studies reported IL-11 as a possible cancer progression marker suggesting that therapeutic targeting of IL-11 or IL11RA in humans may be beneficial, however as of 2017 clinically relevant IL-11 signalling antagonists were still under development. (wikidoc.org)
  • expression
  • The results indicate that miR-23b regulates IL-11 and IL-11Ralpha expression, and it might act as an anti-oncogenic agent in the progression of Hepatocellular Carcinoma by directly downregulating IL-11 expression. (nih.gov)
  • It has been concluded that the renal cell carcinoma risk allele at 12p12.1 maps to rs7132434, a functional variant in an enhancer that upregulates BHLHE41 expression which, in turn, induces IL-11, a member of the IL-6 cytokine family. (nih.gov)
  • Mechanically wounded cells were used as a model of gut injury and restitution where immunoblotting was used to examine IL-11 dependent effects on phospho-p65Ser536 and COX-2 expression. (queensu.ca)
  • Exogenous IL-11 increased migration in AGS and MKN45 cells, whereas these effects were reversed when the expression of V0 and V1 were abolished by siRNA targeting versican V0/V1. (ijbs.com)
  • Inflammation
  • Due to paucity of information on the mechanisms underlying inflammation -induced CRP dynamics, our model was developed by systematically evaluating several models for their ability to retrieve variable CRP profiles observed in IL-11-treated breast cancer patients. (curehunter.com)
  • Consistent with this, model simulations suggest that periodic IL-11 therapy may result in prolonged low-grade (chronic) inflammation post treatment. (curehunter.com)
  • Bovine lactoferricin-induced anti-inflammation is, in part, via up-regulation of interleukin-11 by secondary activation of STAT3 in human articular cartilage. (semanticscholar.org)
  • Interleukin-1 and tumor necrosis factors, whose actions are almost identical to those of IL-1, are involved in fever production and other systemic effects of inflammation. (thefreedictionary.com)
  • STAT3
  • Reduced IL-11 production and STAT3 phosphorylation may contribute to unexplained infertility in some women. (sigmaaldrich.com)
  • intestinal
  • A potential protective or anti-inflammatory effect of interleukin-11 (IL-11) for the intestinal mucosa has been postulated from several animal models of inflammatory bowel disease (IBD) and mucosal damage. (uni-regensburg.de)
  • transcription
  • Evidence from the Ropeleski Lab supports IL-11 dependent activation of the transcription factor Nuclear Factor кB (NFкB), without the degradation of the inhibitor кB (IкB), which deviates from the classical mechanism involving proteolytic processing of IкB. (queensu.ca)
  • hepatic
  • Case 1 was a 46-year-old man with recurrence of hepatic carcinoma who was treated with IL-11 (3 mg per day). (curehunter.com)
  • Primary
  • In the present study we investigated downstream effects of IL-11 induced signaling in human colonic epithelial cells (HT-29 and primary human colonic epithelial cells, CEC). (uni-regensburg.de)
  • factor
  • IL-11 mRNA was induced in chondrocytes in response to transforming growth factor (TGF)-beta 1 and IL-1 beta. (semanticscholar.org)
  • In order to determine whether IL-6 and IL-11 could independently support human osteoclast formation, these factors were added to cultures of human peripheral blood mononuclear cells of the monocyte (CD14(+)) fraction in the presence of macrophage colony-stimulating factor (M-CSF). (ox.ac.uk)
  • glycosylation
  • First, most of the muteins displayed enhanced cell-stimulatory properties (super-agonist behavior) in a glycosylation-dependent manner, suggesting that the non-core region is biologically designed to limit the cell-proliferative potential of hIL-11. (jimmunol.org)
  • alpha
  • From a structural point of view hIL-11 belongs to the long-helix cytokine superfamily, which is characterized by a conserved core motif consisting of four alpha-helices. (jimmunol.org)
  • severe
  • The detection of IL-11-induced CLS supports the hypothesis that CLS could be a severe side effect of IL-11 treatment in some patients. (curehunter.com)
  • epithelial cells
  • The known beneficial effects of IL-11 therapy are likely to be mediated by epithelial cells via activation of the Akt-survival pathway, mediating anti-apoptotic effects to ensure mucosal integrity. (uni-regensburg.de)
  • residues
  • Replacements of the respective S100P residues by alanine drastically decrease its affinity to IL-11, suggesting their involvement into the association process. (abo.fi)
  • suggests
  • This suggests IL-11 and pSTAT3 may be involved in the secretory transformation of glandular epithelium during receptivity. (sigmaaldrich.com)
  • motif
  • There was no increased binding of p65 to the кB binding motif on DNA after IL-11 treatment. (queensu.ca)
  • biological
  • These findings have unveiled new and unexpected elements modulating the biological activity of hIL-11, which may be exploited to develop more versatile medications based on this important cytokine. (jimmunol.org)
  • Phase I/II dose escalation study of recombinant human interleukin-11 following ifosfamide, carboplatin and etoposide in children, adolescents and young adults with solid tumours or lymphoma: a clinical, haematological and biological study. (duke.edu)
  • phosphorylation
  • Inhibition of IL-11 signaling was carried out using various pharmacological inhibitors in order to determine their effect on p65 phosphorylation. (queensu.ca)