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  • INFLAMMATION
  • A number of studies suggest that IL-10 plays a role in controlling inflammation, autoimmunity, and angiogenesis. (labcorp.com)
  • Cell type-specific regulation of IL-10 expression In inflammation and disease. (labcorp.com)
  • Interleukin-10 intervene immunostimulatory that helps to eradicate infectious and noninfectious materials with limited inflammation. (biology-online.org)
  • The importance of IL-10 in the orchestration of the immune response, and the strong evidence for its posttranscriptional regulation, makes it an attractive candidate for miRNA mediated regulation of inflammation. (pnas.org)
  • IL-10 preserves vascular function, including endothelium-dependent relaxation, during acute inflammation produced by endotoxin ( 4 , 5 ). (diabetesjournals.org)
  • Bovine IL-10 present in dairy products may thus potentially contribute to the prevention of necrotizing enterocolitis and allergy, enhance mucosal tolerance induction and decrease intestinal inflammation and may therefore be applicable in infant foods and in immunomodulatory diets. (wur.nl)
  • Infection and inflammation induce the acute phase response (APR), leading to multiple alternations in lipid and lipoprotein metabolism, mediated by changed cytokine production, especially tumor necrosis factor (TNF)-a, interleukin (IL)-1 and IL-6. (uio.no)
  • antigen
  • IL-10 is secreted by some types of T-lymphocyte, B-lymphocytes and macrophages late after antigen activation. (ebi.ac.uk)
  • IL-10 acts as an immunosuppressor of antigen presenting cells (APC). (labcorp.com)
  • IL-10 isto tako manifestuje potentnu sposobnost da supresuje antigen prezentacionu sposobnost antigen prezentirajućih ćelija . (wikipedia.org)
  • This reputation is due to the experimental observation that IL-10 decreases the function of antigen presenting cells and T helper 1 type immune responses. (ebooks.com)
  • Accordingly, whereas polyclonal activation via triggering of surface immunoglobulins or CD40 antigen induced highly purified normal human B lymphocytes to produce only low (0.3-0.4 ng/ml) but significant amounts of hIL-10, EBV infection induced them to secrete high amounts of hIL-10 (4-9 ng/ml). (rupress.org)
  • Serum
  • Maternal serum interleukin-10 , interleukin-2 and interleukin-6 in preeclampsia and eclampsia. (thefreedictionary.com)
  • Using a specific enzyme-linked immunosorbent assay, IL-10 concentrations were measured in serum from 62 patients with ulcerative colitis (UC), 43 with Crohn's disease (CD), 25 with other colitides, and 44 normal control subjects. (hindawi.com)
  • Serum IL-10 concentrations were increased in patients with active UC but not in those with active CD when compared with normal control subjects. (hindawi.com)
  • Notably, serum IL-10 concentrations increased during the phase of disease resolution and declined thereafter regardless of the treatment modality. (hindawi.com)
  • secrete
  • Using a wide panel of EBV positive and EBV negative cell lines, it has been shown that EBV positive B cell lines derived from patients with AIDS and Burkitt's lymphoma (AABCL) secrete large quantities of B cell IL-10, compared with EBV-positive B cell lines obtained from patients with undifferentiated lymphomas of Burkitt's and non-Burkitt's types. (nih.gov)
  • EBV exerts direct effect on the production of B cell IL-10, and purified tonsillar B cells infected with EBV were triggered to secrete IL-10. (nih.gov)
  • Using two mouse models, we show that the therapeutic dose of IL-10 can be reduced by localized delivery of a bacterium genetically engineered to secrete the cytokine. (sciencemag.org)
  • Interleukin 10 (IL-10) is a pleiotropic factor that enhances proliferation of activated human B lymphocytes and induces them to secrete high amounts of immunoglobulins. (rupress.org)
  • Here we show that several human B cell lines were able to constitutively secrete human (h)IL-10. (rupress.org)
  • deficiency
  • However a deficiency of IL-10 has been considered to show some patho-physiological relevance in inflammatory disorder typify by type 1 cytokine like psoriasis . (biology-online.org)
  • Both IL-10 and IL10R deficiency cause severe early-onset enterocolitis and can be successfully treated by hematopoietic stem cell transplantation (HSCT). (springer.com)
  • Most recent study on IL-10/IL10R deficiency and curative therapy using HSCT. (springer.com)
  • monocytes
  • Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on most hemopoietic cell types. (nih.gov)
  • Therefore, the aim of this study was to evaluate whether bovine IL-10 has immunomodulatory activities on human monocytes and dendritic cells. (wur.nl)
  • IL-10 is an immunoregulatory protein produced by a number of cell lineages, including TH2 cells, B-cells and activated monocytes. (biovendor.com)
  • lymphokine
  • Interleukin 10 (IL-10) is a novel lymphokine which exhibits strong DNA and amino acid sequence homology to BCRF1, an open reading frame in the Epstein-Barr virus genome. (nih.gov)
  • immune responses
  • Interleukin-10 (IL-10) is an important suppressor of immune responses. (labcorp.com)
  • IL-10 plays a key role in differentiation and function of a newly appreciated type of T cell, the T regulatory cell, which may figure prominently in control of immune responses and tolerance in vivo. (nih.gov)
  • regulates
  • In this study, using a combination of bioinformatics and molecular approaches, we report that microRNA (hsa-miR-106a) regulates IL-10 expression. (pnas.org)
  • Here, we report the identification of a miRNA, hsa-miR-106a, that regulates IL-10 expression. (pnas.org)
  • innate
  • Finally, human observations demonstrate that systemic administration of IL-10 to normal volunteers is associated with very little toxicity and pro-inflammatory properties mediated through activation of effector cells of the innate immune response. (ebooks.com)
  • In this book, I tried to cover not only the molecular biology of IL-10 but also asked to summarize in general terms its postulated role in controlling adoptive and innate immunity. (ebooks.com)
  • upregulation
  • IL-10 amplified the upregulation of PPARa, CPT1a, CPT2 and ABCA1 gene expressions mediated by IL-6 and ADRP gene expressions induced by TNF-a. (uio.no)
  • pathophysiology
  • B cell IL-10 may function as autocrine growth factor for B cell lymphomas, and both IL-10 and BCRF1 seem to be involved in the pathophysiology of non-Hodgkin's lymphomas. (nih.gov)
  • Factor
  • The expression of IL-10 is nominal on unmotivated tissues that require stimulating factor by commensal micro-flora where it strongly regulated by transcriptional and post-transcriptional point. (biology-online.org)
  • transgenic
  • Surprisingly, however, IL-10 has potent anti-cancer effects since most experimental models demonstrate immune-mediated anti-tumor effects whether IL-10 is locally (tumor transfectant models) or systemically (transgenic models, administration of soluble cytokine) provided. (ebooks.com)
  • regulation
  • Although the importance of posttranscriptional regulation of IL-10 has been previously shown, understanding the underlying mechanisms is still in its infancy. (pnas.org)
  • Also, the involvement of transcription factors, Sp1 and Egr1, in the regulation of hsa-miR-106a expression and concomitant decrease in the IL-10 expression, has also been demonstrated. (pnas.org)
  • Regulation of IL-10 expression has been studied at the transcriptional and posttranscriptional levels. (pnas.org)
  • A growing class of noncoding RNAs called microRNAs (miRNAs) is involved in posttranscriptional regulation of genes ( 10 ). (pnas.org)
  • role of IL-10
  • Last but not least a chapter was commissioned on the role of IL-10 in cancer since this is probably one of the most controversial areas. (ebooks.com)
  • These results demonstrate, for the first time, direct evidence for the role of IL-10 in ROS-dependent NF-B activation. (cdc.gov)
  • ELISA
  • In contrast, EBV-negative B cell lines do not express IL-10 by Northern blot analysis, ELISA or even PCR. (nih.gov)
  • exerts
  • What is not known, however, is the mechanism by which IL-10 exerts its effect on IB- degradation. (cdc.gov)
  • Thus
  • Thus, the role that interleukin-10 plays in vivo in physiological or pathological conditions remains controversial. (ebooks.com)
  • We also find that Sp1 and Egr1 have an important role in hsa-miR-106a transcription and, thus, indirectly regulate the expression of IL-10 posttranscriptionally. (pnas.org)
  • Thus, diabetes produces greater impairment of relaxation to acetylcholine in IL-10 −/− mice than in IL-10 +/ + mice. (diabetesjournals.org)
  • express IL-10
  • Also, using miRex, we found that 5 miRNAs (namely hsa-miR-106a, miR-106b, miR-20a, miR-20b, and miR-93) were expressed in cells of lymphoid and myeloid origin, which are known to express IL-10. (pnas.org)
  • Human
  • Human B cell interleukin 10. (nih.gov)
  • Moreover, 24 of these 25 hIL-10-producing B cell lines contained the Epstein-Barr virus (EBV) genome, suggesting a relationship between hIL-10 production by human B cell lines and EBV expression. (rupress.org)
  • regulate
  • To predict the miRNA that may regulate IL-10, we used a consensus approach by employing 3 different miRNA target prediction software, as described in Materials and Methods . (pnas.org)
  • stimulation
  • The ED 50 as determined by the dose-dependent co-stimulation (with murine IL-4) of MC/9 cells was found to be less than 2.0ng/ml, corresponding to a specific activity of 5.0×10 5 IU/mg. (prospecbio.com)
  • Addition of IL-10 inhibited both IB- degradation and generation of OH radicals in response to LPS stimulation. (cdc.gov)
  • inhibition
  • The mechanism of IL-10 induced inhibition appears to involve a reduction in the abundance of the macrophage surface molecules that directly stimulate T-cells and natural killer cells. (ebi.ac.uk)
  • Interleukin-10-mediated Inhibition of free radical generation in macrophages. (cdc.gov)
  • The present study investigates the possible role of reactive oxygen species (ROS) and their inhibition by IL-10 in NF-B activation and IB- degradation in macrophages. (cdc.gov)