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  • interferon
  • Similarly, TGF-alpha, interferon-gamma (IFN-gamma), IL-6, and tumour necrosis factor-alpha (TNF-alpha) substantially increased HaCAT cell IL-1 alpha, but had no effect on the IL-1Ra, with a concomitant reduction in the icIL-1Ra:IL-1 alpha ratio. (ox.ac.uk)
  • markedly
  • Thus, regulation of the IL-1 cytokine network in keratinocytes involves modulation of icIL-1 alpha rather than of icIL-1Ra levels, and is markedly different from that noted in monocytes. (ox.ac.uk)
  • human
  • The IL-1 cytokine network in epidermal cells was studied in vitro, using the spontaneously transformed HaCAT human keratinocyte line. (ox.ac.uk)
  • ratio
  • Confluent cultures of HaCAT cells were shown to provide optimal conditions for the study, since confluence increased the icIL-1Ra:IL-1 alpha ratio to a level as seen in vivo, which was independent of Ca2+ concentration in the culture medium. (ox.ac.uk)
  • Transforming growth factor-beta (TGF-beta 1) stimulated a dose-dependent increase in HaCAT cell IL-1 alpha without changing IL-1Ra concentration, with a resultant reduction in the icIL-1Ra: IL-1 alpha ratio from 320:1 to 100:1. (ox.ac.uk)
  • In contrast to their effects on monocytes, IL-4 and IL-10 at biologically active levels had no effect on IL-1 alpha, IL-1Ra or the icIL-1Ra: IL-1 alpha ratio in confluent HaCAT cells. (ox.ac.uk)
  • biologic
  • Each of these therapies uses biologic samples (e.g., cells or platelets) taken from a sick or injured horse and processes them to behave in a certain way (e.g., concentrate them, stimulate them to become a certain cell type, or produce a certain protein). (ridingmagazine.com)
  • nuclear proteins
  • Electromobility gel shift assays confirmed the presence of NF-kappaB and C/EBP binding sites within the sIL-1Ra promoter, and indicated a significant increase in the binding activities of nuclear proteins from HepG2 cells treated with IL-1beta and IL-6. (mysciencework.com)
  • inhibition
  • Anti-IL-1 activity was demonstrated by inhibition of lymphocyte and thymocyte proliferation and by decreased TNFalpha expression and ADAMTS-4 and MMP-3 transcription by fibrochondrocytes. (duke.edu)
  • fusion protein
  • The purpose of this study was to develop an injectable drug depot composed of IL-1Ra and ELP domains and to evaluate the properties and bioactivity of the recombinant ELP-IL-1Ra fusion protein. (duke.edu)
  • CONCLUSION: The ELP-IL-1Ra fusion protein proved to retain the characteristic ELP inverse phase-transitioning behavior as well as the bioactivity of the IL-1Ra domain. (duke.edu)
  • PD1-CD28 fusion protein enables CD4+ T cell help for adoptive T cell therapy in models of pancreatic cancer and non-Hodgkin-lymphoma. (uni-muenchen.de)
  • cartilage
  • Joint pathology was evaluated by histology, radiology and serum cartilage oligomeric matrix protein (COMP). (nih.gov)
  • Of great interest is that, although 1 microgram/day IL-4 had only a moderate effect on the inflammatory component of the disease activity, it strongly reduced cartilage pathology, as determined by histological examination (Fig. 1). (nih.gov)
  • cancer
  • Denosumab is designed to block the activity of a protein, which may prevent bone complications in cancer that has spread to the bone. (clinicaltrials.gov)
  • therapy
  • The aim of the Anti-Interleukin-1 in Diabetes Action trial (AIDA) study is to test the feasibility, safety/tolerability and potential efficacy of anti-IL-1 therapy in maintaining or enhancing beta-cell function in people with new onset Type 1 diabetes. (clinicaltrials.gov)
  • pathology
  • We reasoned that necroptosis, a recently described form of necrosis mediated by receptor-interacting protein kinase 3 (RIP3), may contribute to AAA pathology through the induction of SMC death and the significant production of inflammatory cytokines. (ahajournals.org)
  • histological
  • In addition, both histological and radiological analysis showed that bone destruction was prevented (Fig. 1). (nih.gov)
  • Genetic
  • Spontaneous genetic mutations in the NACHT domain of CIAS1, a gene located on chromosome 1 have been recently identified in about half of the patients with NOMID/CINCA syndrome. (clinicaltrials.gov)
  • Joint
  • Such administration of proteins may have limited utility because of their rapid clearance and short half-life in the joint. (duke.edu)
  • disease
  • The BDRQOL is a standardized assessment form in Behcet's disease composed of 30 items (answered true or not true) and each item is scored 0 or 1 (scoring range from 0 to 30). (clinicaltrials.gov)
  • dose
  • If patients do not fulfill improvement criteria at 1 month, the dose will be escalated between 0.5 and 1 mg/kg/day increments to obtain inflammatory remission. (clinicaltrials.gov)
  • Placebo
  • A randomized, placebo controlled, double masked, parallel group, multicentre trial of IL-1 antagonism in subjects with newly-diagnosed Type 1 diabetes. (clinicaltrials.gov)
  • levels
  • Surfactant protein D in newborn infants: factors influencing surfactant protein D levels in umbilica. (biomedsearch.com)
  • These data indicate that an attempt to increased circulating levels of IL-1 inhibitors occurs at different extent in the course of HCV infection as well as in its progression to NHL and/or MC. (unict.it)
  • form
  • The overall goal of this particular grant application is to examine the short-term effects of the administration of the recombinant form of IL-1ra on 1) chronic inflammatory state and 2) protein homeostasis in chronically inflamed CHD patients. (clinicaltrials.gov)
  • [ 1 ] HAPE is a noncardiogenic form of pulmonary edema resulting from a leak in the alveolar capillary membrane. (medscape.com)
  • Most of the children responded quickly to a synthetic form of the protein that's abnormal or missing in the condition. (nih.gov)
  • tissue
  • Tissue distribution of 35S-labelled perfluorobutanesulfonic acid in adult mice following dietary exposure for 1-5 days. (nih.gov)
  • It contains protein growth factors that initiate wound healing which enhance the access of healthy inflammatory cells to areas of injured tissue. (bayhillequine.com)