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  • PMID
  • Two types of IL-1 receptor, each with three extracellular immunoglobulin (Ig)-like domains, limited sequence similarity (28%) and different pharmacological characteristics have been cloned from mouse and human cell lines: these have been termed type I and type II receptors [ PMID: 8702856 ]. (ebi.ac.uk)
  • Both IL-1 receptors appear to be well conserved in evolution, and map to the same chromosomal location [ PMID: 1833184 ]. (ebi.ac.uk)
  • This entry represents Interleukin-1 receptor type 1 (IL1R1), the crystal structure of the soluble extracellular part of type-I IL1R complexed with IL1RA has been determined to 2.7A resolution [ PMID: 9062194 ]. (ebi.ac.uk)
  • interleukin-36 alpha, beta and gamma (previously IL-1F6, IL-1F8 and IL-1F9, respectively), which are pro-inflammatory and signal through IL-1Rrp2 and IL-1RAcP [ PMID: 14734551 ]. (ebi.ac.uk)
  • interleukin-36 receptor antagonist (previously IL-1F5), which binds IL-1Rrp2, acting as an antagonist for interleukins signalling via this route [ PMID: 17908936 ]. (ebi.ac.uk)
  • apoptosis
  • IL-1 inhibits the function and induces apoptosis of β-cells ( 9 ) and has been implicated as a mediator of the β-cell destruction leading to type 1 diabetes ( 10 ). (diabetesjournals.org)
  • Although apoptosis is ordinarily considered noninflammatory, these data demonstrate that nonphagocytosed endothelial apoptotic bodies are inflammatory, providing a vehicle for IL-1α and, therefore, constitute a unique mechanism for sterile inflammation. (pnas.org)
  • MP are larger (100 nm to 1 μm), membrane-derived vesicles expressing phosphatidylserine on the outer face of the membrane ( 7 , 9 - 11 ), notably released from endothelial cells during exposure to a proinflammatory challenge such as TNFα ( 12 ), a prothrombotic product such as thrombin ( 13 ), or during cell apoptosis ( 7 , 9 ). (pnas.org)
  • 2017
  • Clin Lab, 2017 Jan 1. (nih.gov)
  • Filipa I. Baptista, Célia A. Aveleira, Áurea F. Castilho, and António F. Ambrósio, "Elevated Glucose and Interleukin-1 β Differentially Affect Retinal Microglial Cell Proliferation," Mediators of Inflammation , vol. 2017, Article ID 4316316, 11 pages, 2017. (hindawi.com)
  • Beta
  • Crystallographic refinement of interleukin 1 beta at 2.0 A resolution. (ebi.ac.uk)
  • Patterns of structure and sequence in the Kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factors. (ebi.ac.uk)
  • C Simon, G N Piquette, A Frances, and M L Polan, "Localization of interleukin-1 type I receptor and interleukin-1 beta in human endometrium throughout the menstrual cycle," The Journal of Clinical Endocrinology & Metabolism , vol. 77, no. 2, pp. 549-555, 1993. (hindawi.com)
  • Interleukin-1 beta regulates human cytotrophoblast metalloproteinase activity and invasion in vitro," The Journal of Biological Chemistry , vol. 269, no. 25, pp. 17125-17131, 1994. (hindawi.com)
  • S W Kauma, "Interleukin-1 beta stimulates colony-stimulating factor-1 production in human term placenta," The Journal of Clinical Endocrinology & Metabolism , vol. 76, no. 3, pp. 701-703, 1993. (hindawi.com)
  • Topological frustration and the folding of interleukin-1 beta. (nih.gov)
  • The il-1 receptor on t-lymphocytes and fibroblasts is composed of a single polypeptide chain that binds both il-1 alpha and il-1 beta . (biology-online.org)
  • The hypothesis is that anti-IL-1 treatment as add-on therapy to conventional insulin therapy will preserve or enhance beta-cell function. (clinicaltrials.gov)
  • The aim of the Anti-Interleukin-1 in Diabetes Action trial (AIDA) study is to test the feasibility, safety/tolerability and potential efficacy of anti-IL-1 therapy in maintaining or enhancing beta-cell function in people with new onset Type 1 diabetes. (clinicaltrials.gov)
  • This collection protocol features general considerations to maximize salivary IL-1 Beta analysis. (salimetrics.com)
  • induce
  • The acute phase response is a systemic, generalized reaction despite the fact that most disease processes which induce circulating IL-1 produced at the site of the disease, for example, the lung in pneumonia. (springer.com)
  • Contrary to present concepts, endothelial microparticles do not contain IL-1α and do not induce neutrophilic chemokines in vitro. (pnas.org)
  • polymorphisms
  • All of the Spanish Caucasian participants were genotyped for four polymorphisms ?IL-1α -889 C/T, IL-1ß +3953 C/T, IL-1RA (86bp)n, and TNFα -308A/G - and assessed at baseline and again at six months for alcohol intake, addiction severity, and biomarkers of alcohol intake. (scienceblog.com)
  • necrosis
  • During myocardial infarction, stroke, or acute renal failure, sterile inflammation occurs in response to cell necrosis ( 1 ). (pnas.org)
  • chronic
  • Although inflammation can be triggered by either bacterial or viral infection, sterile inflammation is the cause of most diseases, both acute and chronic ( 1 ). (pnas.org)
  • stimulation
  • A Nilkaeo, K Green, and S Kauma, "Interleukin-1 (IL-1) stimulation of trophoblast proliferation is mediated by the induction of interleukin-6 (IL-6) production," Journal of the Society for Gynecologic Investigation , vol. 7, no. 1 suppl, p. 162A, 2000. (hindawi.com)
  • IL-1β is released from the granules following α- and β-adrenergic stimulation. (salimetrics.com)
  • contrast
  • In contrast to IL-1, LPS was found to provoke accumbal DA changes. (mcmaster.ca)
  • In contrast, formation of stable native secondary structure, as measured by quenched-flow deuterium-hydrogen exchange experiments, began after only 1 second. (sciencemag.org)
  • 1998
  • phase growth-arresting action of interleukin-1 is independent of p53 and p21/WAF1 function," The Journal of Biological Chemistry , vol. 273, no. 46, pp. 30517-30523, 1998. (hindawi.com)
  • insulin
  • Type 2 diabetes is caused by inability of the functional β-cell mass to compensate for increased insulin needs due to insulin resistance ( 1 ). (diabetesjournals.org)
  • factor
  • A Nilkaeo, P Takacs, and S Kauma, "Leukemia inhibitory factor (LIF) stimulates trophoblast proliferation and is upregulated in trophoblast by IL-1," Journal of the Society for Gynecologic Investigation , vol. 7, no. 1 suppl, p. 210A, 2000. (hindawi.com)
  • Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1. (springer.com)
  • vivo
  • For instance, the increase of in vivo DA release induced by stressors within the nucleus accumbens are not marked in IL-1 treated rats, and in prefrontal cortex the effects of IL-1 are limited at best (although 5-HT alterations are evident and synergisms with airpuff stress do appear). (mcmaster.ca)
  • ratio
  • The complex has approximate dimensions of 97Å×52 Å ×35 Å with one s-IL1R molecule wrapping around the IL-1β molecule with 1:1 ratio. (proteopedia.org)
  • species
  • Purified IL-1, as analyzed by two-dimensional electrophoresis/electrofocusing gels, exhibited a series of charged species with isoelectric points ranging from 6.0 to 4.9, all with a molecular weight of approximately 17,500. (rupress.org)