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  • genes
  • Interferons act through common receptor that activates Jak/Stat pathway of signal transduction molecules, which, in turn, lead to activation of interferon-responsive genes. (medscape.com)
  • The Human Interferons & Receptors RT² Profiler PCR Array profiles the expression of 84 genes whose expression is controlled by or involved in cell signaling mediated by interferon ligands and. (qiagen.com)
  • The Human Type I Interferon Response RT² Profiler PCR Array profiles the expression of genes involved in the interferon-a and interferonimmune responses. (qiagen.com)
  • This brief chapter, drawn largely from the author's own experiences, relates how progress was achieved in some key areas of interferon research in the 1960s and 1970s despite the lack of analytical tools that had become available only after the successful cloning of interferon genes. (springer.com)
  • The subsequent transcriptional response is mediated via the Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway, which controls transcription of a range of interferon-stimulated genes (ISGs). (sciencemag.org)
  • viral infection
  • The early host response to viral infection is regulated by the type I interferons (IFNα/β), which are induced after detection of virus-specific products. (sciencemag.org)
  • Interferons are produced by a wide variety of cells in response to the presence of double-stranded RNA , a key indicator of viral infection. (wikidoc.org)
  • Interferons assist the immune response by inhibiting viral replication within host cells, activating natural killer cells, increasing antigen presentation to lymphocytes, and inducing the resistance of host cells to viral infection. (wikidoc.org)
  • Signaling
  • Interferons bind to their receptors, initiating JAK-STAT signaling and ultimately increasing interferon responsive gene (ISG) transcription. (qiagen.com)
  • QIAGEN provides a broad range of assay technologies for interferon signaling research that enables analysis of gene expression and regulation, epigenetic modification, genotyping, and signal transduction pathway activation. (qiagen.com)
  • receptor
  • Sphingosine 1-phosphate receptor agonists suppress immunopathology by targeting the type I interferon receptor for degradation. (sciencemag.org)
  • The dsRNA acts like a trigger for the production of interferon (via Toll Like Receptor 3 ( TLR 3 ) a pattern recognition receptor of the innate immune system which leads to activation of the transcription factor IRF3 and late phase NF kappa Beta). (wikidoc.org)
  • synthesis
  • One of the topics discussed concerns the evolution of the idea that interferon synthesis is controlled both at transcriptional and posttranscriptional levels. (springer.com)
  • pathogens
  • Interferons were originally discovered as antiviral factors, but later studies showed they are secreted in response to many different pathogens, including bacteria and fungi. (qiagen.com)
  • Furthermore
  • Furthermore, interferon leads to upregulation of MHC I and therefore to increased presentation of viral peptides to cytotoxic CD8 T cells, as well as to a change in the proteasome (exchange of some beta subunits by b1i, b2i, b5i - then known as the immunoproteasome) which leads to increased production of MHC I compatible peptides. (wikidoc.org)
  • immune cells
  • Interferon beta may decrease expression of B7-1 (a proinflammatory molecule) on surface of immune cells and increase levels of TGF-beta (anti-inflammatory) in circulation of MS patients. (medscape.com)