Interferon protein. Medical search. Frequent questions

It is located with a cluster of interferon inducible genes but is itself not interferon inducible. (wikipedia.org)
Cells expressing the 3a proteins showed ER stress based on activation of genes for the ER chaperones GRP78 and GRP94. (nih.gov)
The cyclic GMP-AMP synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway is a critical defender to sense various pathogens and trigger innate immunity of mammalian cells. (frontiersin.org)
they boost the immune system response and reduce the growth of cancer cells by regulating the action of several genes that control the secretion of numerous cellular proteins that affect growth. (medicinenet.com)
These genes areÂ associated with the interferon response pathway. (elsevierpure.com)
Within this group of upregulated genes with putative membrane -localized proteins , we identified several interferon -induced transmembrane protein (IFITM) genes , including several previously uncharacterized Ptm IFITM3-related genes . (bvsalud.org)
The promoter regions of many interferon-inducible genes share a short DNA sequence motif, termed the interferon consensus sequence (ICS) to which several regulatory proteins bind. (johnshopkins.edu)
The finding has, however, prompted the team to look for other mutations in interferon-related genes, in children who have had severe flu. (newscientist.com)
Certainly other genes involved with interferon affect how badly flu hits us. (newscientist.com)
Knowing how the genes work might also help us tailor anti-flu defences to affected people, for example, by giving them the IFITM3 protein or extra interferon. (newscientist.com)
Interferons (IFNs) are secreted cytokines with the ability to activate expression of IFN stimulated genes that increase resistance of cells to virus infections. (lu.se)

Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. (nih.gov)
Here we outline the current status of the viral evasion mechanism underlying the regulation of the cGAS-STING pathway, focusing on how post-transcriptional modifications, viral proteins, and non-coding RNAs involve innate immunity during viral infection, attempting to inspire new targets discovery and uncover potential clinical antiviral treatments. (frontiersin.org)
Interferon α 2A human has been used to check its antiviral action against chikungunya virus. (sigmaaldrich.com)
Type I interferons (IFNs) are essential mediators of antiviral responses. (figshare.com)
Interferons are naturally produced proteins with antiviral, antitumor, and immunomodulatory actions. (medscape.com)
Value of IFNL3 genetic polymorphism in the prediction of HCV treatment response to direct-acting antiviral drugs versus interferon therapy. (cdc.gov)

Tissue damage at the site of injection occurs with all of the interferons but more commonly with interferon beta-1b and pegylated interferon alfa-2b. (medicinenet.com)
interferon beta 1b, axicabtagene ciloleucel. (medscape.com)
interferon beta 1b, brexucabtagene autoleucel. (medscape.com)
interferon beta 1b, idecabtagene vicleucel. (medscape.com)
interferon beta 1b, lisocabtagene maraleucel. (medscape.com)
interferon beta 1b and pexidartinib both increase inhibition of GI absorption. (medscape.com)

Interferon-induced transmembrane protein 5 is a gene that encodes a membrane protein thought to play a role in bone mineralization. (wikipedia.org)
Expression of IFN-induced transmembrane protein 1 in glomerular endothelial cells. (nih.gov)
Interferon-induced transmembrane protein 1 (IFITM1) is essential for progression of laryngeal squamous cell carcinoma in an Osteopontin/NF-κB-dependent manner. (nih.gov)
Those agents inhibit Smoothened (SMO), a transmembrane protein involved in Hedgehog pathway signal transduction. (medscape.com)

We have previously shown that Interferon-γ inducible protein 16 (IFI16), a host nuclear innate immune DNA sensor, plays an important role in the maintenance of KSHV latency [J Virol. (technologynetworks.com)

The gene is 1,327 bases in length and encodes a protein of 132 amino acids with a predicted molecular weight of 14378 Daltons. (wikipedia.org)
The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. (nih.gov)
This gene encodes a soluble cytokine that is a member of the type II interferon class. (origene.com)
Only the PERK pathway was found to be activated in 3a-expressing cells based on (1) increased phosphorylation of eukaryotic initiation factor 2 alpha (eIF2alpha) and inhibitory effects of a dominant-negative form of eIF2alpha on GRP78 promoter activity, (2) increased translation of activating transcription factor 4 (ATF4) mRNA, and (3) ATF4-dependent activation of the C/EBP homologous protein (CHOP) gene promoter. (nih.gov)
The IFNA2 (interferon alpha 2) gene is mapped to human chromosome 9p21.3. (sigmaaldrich.com)
IFNα protein correlated well with functional activity and IFN-stimulated gene expression. (figshare.com)
Interferon gamma receptor 1 ( IFNGR1 ) also known as CD119 ( C luster of D ifferentiation 119 ), is a protein that in humans is encoded by the IFNGR1 gene . (wikidoc.org)
The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages . (wikidoc.org)
The ADAR gene provides instructions for making a protein called RNA-specific adenosine deaminase 1 (ADAR1). (medlineplus.gov)
The ADAR gene mutations that cause dyschromatosis symmetrica hereditaria result in less functional ADAR1 protein. (medlineplus.gov)
In this experiment, we observed cytokine gene expression changes in Gallus gallus embryo after challenge with Delta SARS-CoV-2 RBD spike protein antigen, from a concentration of 10 µg/mL to a series of highly diluted forms in ethanol, along with controls. (openaccesspub.org)
Protein engineering refers to the process in which a researcher transforms a protein sequence through insertion, substitution, or deletion of nucleotides in the encoding gene, aiming to obtain a modified protein that is more appropriate for a particular application or purpose than an unmodified protein. (globenewswire.com)
Each of her parents had a different mutation in one of their copies of the gene that codes for a protein called IRF7. (newscientist.com)
Each parent was able to produce interferon because their other copy of the gene was normal. (newscientist.com)
The gene codes for a protein that normally helps fight off flu - activated by interferon. (newscientist.com)

The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. (origene.com)
The 3a protein was found to induce serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and to increase IFNAR1 ubiquitination. (nih.gov)
Interferon gamma receptor 1 has been shown to interact with Interferon-gamma . (wikidoc.org)
The human interferon-gamma receptor. (wikidoc.org)
In addition, the ADAR1 protein controls the function of certain chemical messengers called neurotransmitters at particular sites in the body by modifying the RNA blueprint for receptor proteins that interact with the neurotransmitters. (medlineplus.gov)
The crucial step of receptor binding depends on the closed and open conformations of the S-Protein ectodomain trimer 10 , 11 . (openaccesspub.org)
After 48 hours of intervention under different experimental conditions, flow cytometry was used to measure the apoptosis of MPC5 cells, and quantitative real-time PCR and Western blot were used to measure the mRNA and protein expression of slit diaphragm-related proteins (nephrin, CD2AP, and synaptopodin) and the cytoskeleton-related protein transient receptor potential cation channel 6 (TRPC6). (zgddek.com)
Type I interferon and pattern recognition receptor signaling following particulate matter inhalation. (cdc.gov)

Prediction of sofosbuvir response using interleukin-6 serum level and single nucleotide polymorphism of interferon lambda- 4. (cdc.gov)

Further, we found that the cytokine interferon-β (IFN-β) can induce miR-1 expression in mammalian cells, reducing TBC1D15 levels, and safeguarding against proteotoxic challenges. (elifesciences.org)
Interferon-β (IFN-β) is a pleiotropic cytokine secreted in response to various pathological conditions and is clinically used for therapy of multiple sclerosis. (usf.edu)
Recently, we reported that IFN-β activity is affected by interactions with S100A1, S100A4, S100A6, and S100P proteins, which are members of the S100 protein family of multifunctional Ca2+-binding proteins possessing cytokine-like activities (Int J Mol Sci. (usf.edu)
Interferon Gamma is a cytokine produced by T helper cells as part of the immune response to various stimuli. (loinc.org)

IFN-α 2A enhances the expression of MHC proteins by increasing the presentation of antigen peptides and activates cytotoxic T cells. (sigmaaldrich.com)
According to the European Medicines Agency guideline on environmental risk assessments for pharmaceuticals (EMA/CHMP/SWP/4447/00) vitamins, electrolytes, amino acids, peptides, proteins, carbohydrates, lipids proteins, vaccines and herbal medicinal products are exempted because they are unlikely to result in significant risk to the environment. (janusinfo.se)
Expression of TAP1 is down-regulated by human Epstein-Barr virus vil-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. (lu.se)

Commercially available interferons are human interferons manufactured using recombinant DNA technology. (medicinenet.com)
Protein product manufactured by recombinant DNA technology. (medscape.com)

Since ER stress can cause differential modulation of the unfolded protein response (UPR), which includes the inositol-requiring enzyme 1 (IRE-1), activating transcription factor 6 (ATF6) and PKR-like ER kinase (PERK) pathways, these were individually tested in 3a-expressing cells. (nih.gov)
The levels and subcellular distribution of the interferon-inducible double-stranded RNA-dependent protein kinase PKR have been measured in human Daudi cells and stably transfected mouse NIH 3T3 cells expressing the human protein kinase. (pasteur.fr)
in response to interferon treatment the protein kinase is induced severalfold in the cytoplasm whereas the level in the nucleus does not increase significantly. (pasteur.fr)
Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity. (ox.ac.uk)
However, other cytoplasmic RNA sensors, including the double-stranded RNA-binding protein kinase R (PKR), have been implicated in IFN-alpha/beta production, although their relative contribution and mechanism have been unclear. (ox.ac.uk)
Using cells expressing nonfunctional PKR or reduced levels of kinase, we show that PKR is required for production of IFN-alpha/beta proteins in response to a subset of RNA viruses including encephalomyocarditis, Theiler's murine encephalomyelitis, and Semliki Forest virus, but not influenza or Sendai virus. (ox.ac.uk)

The aim of this study in Egypt was to estimate the usefulness of an interferon-gamma release assay (IFN-γ) assay for the detection of latent TB infection in contacts of active TB cases. (who.int)

For instance, due to their genetic flexibility, viruses have developed various viral proteins and non-coding RNAs to interrupt several checkpoints of cGAS-STING. (frontiersin.org)

The encoded protein contains 165 amino acid. (sigmaaldrich.com)
The protein engineering market is growing speedily and creating numerous growth opportunities due to the increasing number of engineered proteins and amino acids worldwide. (globenewswire.com)
The derived sequence of H-ICSBP reveals restricted homology within the first 120 amino acids to three other interferon regulatory factors, IRF-1, IRF-2, and ISGF3γ. (johnshopkins.edu)

Abstract Objective To investigate the effect and molecular mechanism of interferon-α (INF-α) on the apoptosis of the mouse podocyte cell line MPC5 induced by hepatitis B virus X (HBx) protein. (zgddek.com)

As the second messenger, cGAMP activates STING and induces the following cascade to produce type I interferon (IFN-I) to protect against infections. (frontiersin.org)
Interferon Beta 1a, specifically, activates macrophages that engulf antigens and natural killer cells (NK cells), a type of immune T-Cell. (medicinenet.com)

Recombinant human interferon protein (IFN-y) is a bioactive protein primarily used for cell culture applications in many diagnostic laboratories. (clickpress.com)
Recombinant human interferon proteins are not just limited to the process of discharging of reactive oxygen species. (clickpress.com)
Recombinant human interferon protein is one of the recombinant proteins available currently, the only difference is that it is sourced from CHO-cell line. (clickpress.com)
The status of recombinant human interferon protein is strictly regulated as it require strict temperature control, which is around -70°C or below for retaining full action activity. (clickpress.com)
Recombinant human interferon protein is mostly available in beta and alpha form, though other forms have started emerging in the market. (clickpress.com)
Recombinant human interferon protein is principally studied on the protein production, it is probably going to strike the intensive research and development sector. (clickpress.com)
The adoption of recombinant human interferon protein started with the advancement in the field of molecular biology. (clickpress.com)
Though the effectiveness of recombinant human interferon proteins is still debatable with other species induced, recombinant proteins are being used in general applications. (clickpress.com)
Tentatively, the global recombinant human interferon protein market can be segmented on the basis of type, end user and geography. (clickpress.com)
The global market for recombinant human interferon protein is expected to witness steady growth over the forecast period due to rise of molecular biology in most of the disease applications. (clickpress.com)
Geographically, the global recombinant human interferon protein market is segmented into North America, Latin America, Europe, CIS & Russia, Asia-Pacific excluding Japan (APEJ), Japan and the Middle East and Africa (MEA). (clickpress.com)
North America is expected to be the dominant regional market for recombinant human interferon protein owing to increasing number of research activities in the region. (clickpress.com)
The recombinant human interferon protein market in Asia Pacific excluding Japan is expected to grow at a significant CAGR due to product development and expansion by key players. (clickpress.com)
Europe is expected to hold a large share in the global recombinant human interferon protein market throughout the forecast period due to its quality healthcare facilities and modern outlook for recombinant human Interferon protein. (clickpress.com)
The global market for recombinant human interferon protein is highly fragmented. (clickpress.com)
Examples of some of the key players operating in the global recombinant human interferon protein market are Merck KGaA, Abcam plc, R&D Systems, Thermo Fisher Scientific, BioLegend, Invitrogen, OriGene, and Biorbyt, among others. (clickpress.com)
Subsequently, we screened all known human H3K9-MTase and identified two proteins that interact with IFI16 and is recruited by IFI16 at KSHV promoters. (technologynetworks.com)
The ADAR1 protein is also thought to inhibit the replication and spread of certain viruses, such as human immunodeficiency virus (HIV) and hepatitis C, by modifying their RNA. (medlineplus.gov)

Advances in molecular biology have led to the development of new in vitro assays that measure interferon (IFN)-γ released by sensitised T cells after stimulation with Mycobacterium tuberculosis antigens. (ersjournals.com)
We compared the frequencies of gamma interferon (IFN-gamma)-secreting T cells specific for five region of difference 1 (RD1)-encoded antigens and one DosR-encoded antigen in 205 individuals either with active disease (n = 167), whose immune responses had failed to contain the bacillus, or with remotely acquired latent infection (n = 38), who had successfully achieved immune control, and a further 149 individuals with recently acquired asymptomatic infection. (birmingham.ac.uk)
released from sensitized lymphocytes in whole blood incubated overnight with purified protein derivative (PPD) from M. tuberculosis and control antigens. (cdc.gov)

The SARS-CoV-2 spike protein is a significant type 1 trans-membrane protein with two subunits, S1 and S2. (openaccesspub.org)
Integral membrane protein. (lu.se)

According to background information, disease progression after HIV infection is associated with the decreased presence of plasmacytoid dendritic cells (pDCs), major producers of an immune protein called type 1 interferon. (healthday.com)
Activation of PERK affects innate immunity by suppression of type 1 interferon (IFN) signaling. (nih.gov)
IFNA2 is a type 1 interferon which acts as the first line of defense, and offers protection against pathogenic invasion. (sigmaaldrich.com)
Interferon α 2A (IFN-α 2A) belongs to the type I interferon protein family and is produced by many cell types in response to viral infection. (sigmaaldrich.com)
It is structurally different from type I interferon and its major activity is immunoregulation. (iwai-chem.net)
In contrast to the adapted SHIVs, the unadapted SHIVs have lower replication kinetics in macaque lymphocytes and are sensitive to type-1 interferon (IFN). (bvsalud.org)
By Protein Type, the monoclonal antibody segment accounted for the largest revenue share. (globenewswire.com)
Results: The novel finding was a dominant type I interferon signaling network with the transcription factor Irf7 as a central component maintained through 28 d. (cdc.gov)
Remarkably, these effects showed consistency across all tissues indicating a systemic type I interferon response that was complemented by changes in serum proteins (decreased MMP-9, CRP and increased VCAM1, oncostatin M, IP-10). (cdc.gov)

A murine cDNA which encodes an ICS binding protein has been reported (M-ICSBP). (johnshopkins.edu)

KSHV hijacks multiple cellular proteins and pathways to establish lifelong latency in infected hosts, and latency is associated with KSHV malignancies. (technologynetworks.com)

These results provide further mechanistic details of the pro-apoptotic effects of the SARS-CoV 3a protein, and suggest a potential role for it in attenuating interferon responses and innate immunity. (nih.gov)

Hepatitis B virus X protein modulates apoptosis in primary rat hepatocytes by regulating both NF-kappaB and the mitochondrial permeability transition pore[J]. J Virol, 2009, 83(10):4718-4731. (zgddek.com)

Interferons modulate the response of the immune system to viruses , bacteria, cancer , and other foreign substances that invade the body. (medicinenet.com)
The ADAR1 protein is involved in the control of the innate immune response, which is the immune system's early response to foreign invaders (pathogens). (medlineplus.gov)
However, spike protein conformational masking and glycan shielding are critical ways that coronaviruses evade host immune response. (openaccesspub.org)
Conclusions Our results demonstrate for the first time a chromatin-mediated interferon-related transcriptional response driven by an engineered fusion protein that physically links repressive histone marks with active transcription. (elsevierpure.com)
manufactured by Cellestis Limited, Carnegie, Victoria, Australia) that measures the release of interferon-gamma in whole blood in response to stimulation by purified protein derivative was approved by the Food and Drug Administration. (cdc.gov)
Mechanistically, OGG1 bound to 8-oxoGua in proximity to interferon response elements, which inhibits the IRF3/IRF7 and NF-κB/RelA DNA occupancy, while promoting the suppressor NF-κB1/p50-p50 homodimer binding to the IFN-λ2/3 promoter. (lu.se)

In addition, pulmonary expression of interferon alpha and beta and Irf7 specific pattern recognition receptors (PRR) and signaling molecules (Ddx58, Ifih1, Dhx58, ISGF3) were induced, an effect that showed specificity when compared to other inflammatory exposures. (cdc.gov)

New York, May 23, 2023 (GLOBE NEWSWIRE) -- The Protein Engineering Market size is projected to surpass around USD 9,329 Million by 2032, and it is poised to reach a CAGR of 13.6% from 2023 to 2032. (globenewswire.com)
By Technology, the rational protein design segment has dominated the market, and it is growing at the highest CAGR over the forecast period 2023 to 2032. (globenewswire.com)

Results MPC5 cells transfected by pEX-HBx had the highest expression of HBx mRNA at 48 hours after transfection (P P P P Conclusions INF-α can inhibit the apoptosis of podocytes induced by HBx, possibly through improving the abnormal expression of slit diaphragm-related proteins (CD2AP, nephrin, and synaptopodin) and cytoskeleton-related protein (TRPC6) induced by HBx. (zgddek.com)

The encoded protein is secreted by cells of both the innate and adaptive immune systems. (origene.com)
Appropriate regulation of autophagy is crucial for clearing toxic proteins from cells. (elifesciences.org)
Here, we report that the microRNA miR-1 regulates the autophagy pathway through conserved targeting of the orthologous T re-2/ B ub2/ C DC16 (TBC) Rab GTPase-activating proteins TBC-7 and TBC1D15 in Caenorhabditis elegans and mammalian cells, respectively. (elifesciences.org)
Fusion of autophagosomes with lysosomes results in degradation of their contents and thereby removes toxic proteins and damaged organelles from cells to maintain homeostasis. (elifesciences.org)
The Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) is reported to cause apoptosis of infected cells and several of its proteins including the 3a accessory protein, are pro-apoptotic. (nih.gov)
Since the 3a protein localizes to the endoplasmic reticulum (ER)-Golgi compartment, its role in causing ER stress was investigated in transiently transfected cells. (nih.gov)
The models of most immune evasion during innate immune responses are conserved, including altering the post-transcriptional modifications (PTMs) of vital proteins to inactivate or degrade these components, eluding DNA sensing from PRRs, decreasing cyclic GMP-AMP (cGAMP) cellular abundance, and modifying metabolism approach in host cells ( Eaglesham and Kranzusch, 2020 ). (frontiersin.org)
Interferons are a family of naturally-occurring proteins that are made and secreted by cells of the immune system (for example, white blood cells, natural killer cells, fibroblasts, and epithelial cells). (medicinenet.com)
The proteasome pathway is an enzyme complex existing in all cells, which degrades ubiquitinated proteins that control the cell cycle and cellular processes and maintains cellular homeostasis. (medscape.com)
While the function of this protein in the skin is unknown, researchers suggest that incorrect RNA editing may result in pigment-producing cells (melanocytes) that are more or less active than normal, resulting in the skin spots that occur in this disorder. (medlineplus.gov)
Interferon is a protein released by the cells of the body when they are under attack from a virus or other invader. (medicalnewstoday.com)
When interferon is released, it sets off a series of reactions in nearby cells to help them defend against the infection. (medicalnewstoday.com)
So neither her immune cells nor her lung cells were able to crank out interferon when exposed to the flu virus. (newscientist.com)

Studies around the world, including a huge WHO study, are looking at different interferons to treat COVID-19 coronavirus, but no existing COVID-19 drug trials in the U.S. included interferons as of April 7, 2020. (medicinenet.com)

Disrupting interferon-alpha and NF-kappaB crosstalk suppresses IFITM1 expression attenuating triple-negative breast cancer progression. (nih.gov)
Protein Expression and Purification. (monash.edu)
Here, we tested the hypothesis that the DNA repair protein OGG1 recognizes 8-oxoguanine (8-oxoGua) in promoters modulating IFN expression. (lu.se)

The S protein generates neutralizing -antibodies, protective immunity, and T-cell responses. (openaccesspub.org)

The market is growing positively due to the rising utilization of protein drugs over non-protein ones. (globenewswire.com)
Increasing frequencies of chronic diseases would fuel the demand for protein engineering in order to develop effective protein drugs for the treatment of chronic diseases, and this will lead to market growth. (globenewswire.com)
Development and validation of a six-RNA binding proteins prognostic signature and candidate drugs for prostate cancer. (cdc.gov)

interferon naturally occurring in the body is responsible for all flu-like symptoms to begin with, whether you have the coronavirus or a common cold . (medicinenet.com)
As well as occurring naturally in the body, interferon is also used as a treatment for various health disorders, including multiple sclerosis (MS), some types of cancer , and hepatitis C . (medicalnewstoday.com)

This host-specific binding of the spike protein initiates coronavirus infection. (openaccesspub.org)

Our objective was to obtain protein profiles to identify potential general biomarkers of SLE and to determine molecular subgroups within SLE for patient stratification. (nih.gov)
Unsupervised clustering of all investigated proteins identified three molecular subgroups among SLE patients, characterized by (1) high levels of rheumatoid factor-IgM, (2) low IRF5, and (3) high IRF5. (nih.gov)

IFN Gamma is the major interferon produced by mitogenically or antigenically stimulated lymphocytes. (iwai-chem.net)

and Permyakov, Sergei E., "Interferon-β Activity Is Affected by S100B Protein" (2022). (usf.edu)
The global protein engineering market size accounted for USD 2,691 Million in 2022. (globenewswire.com)

Essentially, when confronted with a virus, each cell shoots an emergency flare of interferon to tell the immune system to marshall its defenses. (medicinenet.com)
The theory is, interferon may be able to make the immune system stronger by turning on dormant parts and directing them toward the defense against SARS -nCoV-2's assault. (medicinenet.com)
In this way, the protein helps the immune system avoid inappropriate targeting of the body's own tissues. (medlineplus.gov)
The level of gamma interferon produced provides a measure of sensitization of the cell mediated immune system to the specific stimulus. (loinc.org)
Interferon is, therefore, a critical part of the immune system. (medicalnewstoday.com)

We observed significantly high levels of interferon γ (IFN-γ) and chemokines such as IP-10, monokine induced by IFN-γ (MIG), interleukin 8 (IL-8), monocyte chemotactic protein (MCP)-1, and macrophage inflammatory protein (MIP)-1α in tuberculous pleural effusions. (nirt.res.in)

The mechanism of action of interferon is complex and is not well understood. (medicinenet.com)
Studies suggest that the ADAR1 protein may have other functions that are not well understood. (medlineplus.gov)
The connection between interferon and heart damage is not clearly understood, but it is worth being mindful of when someone is considering treatment. (medicalnewstoday.com)

Macaque interferon-induced transmembrane proteins limit replication of SHIV strains in an Envelope-dependent manner. (bvsalud.org)

Prospective randomized controlled study of interferon-alpha in preventing hepatocellular carcinoma recurrence after medical ablation therapy for primary tumors[J]. Cancer, 2004, 100(2):376-382. (zgddek.com)
The alpha granules contain hemostatic proteins such as fibrinogen, vWf, and growth factors (eg, platelet-derived growth factor and transforming growth factors). (medscape.com)

This protein boosts the production of a virus-fighting molecule called interferon. (newscientist.com)

Besides a higher specificity and an at-least equal sensitivity as the TST, interferon-γ release assays (IGRAs) correlate better with surrogate measures of exposure to M. tuberculosis 4 - 6 and have a higher predictive value for LTBI progression to active TB in close contact in low-incidence settings 7 . (ersjournals.com)

In a set of 15 potential biomarkers differentiating SLE patients and controls, two of the proteins were transcription factors, i.e. (nih.gov)

This term was created for, but is not limited in use to, the submitter's Bovigam Mycobacterium bovis Gamma Interferon Test Kit for Cattle, a blood-based in vitro laboratory test for bovine tuberculosis. (loinc.org)

Can interferons treat COVID-19 coronavirus disease? (medicinenet.com)
Interferon beta-1a, currently in use to treat multiple sclerosis , and interferon alfa-2b are both under investigation as potential treatments for people with COVID-19 coronavirus disease, the deadly respiratory pandemic caused by the SARS -nCoV-2 virus. (medicinenet.com)

Autophagy is a degradation system that involves sequestration of cytoplasmic proteins and organelles by double-layered membranes that form vesicles called autophagosomes. (elifesciences.org)

or= 0.006) and culture filtrate protein 10 (CFP-10) antigen (P = 0.029). (birmingham.ac.uk)

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