Interferon gamma on melanoma cells. Medical search. Frequent questions

The main issue with these triplet trials is on the one hand that the comparator arm of BRAF/MEK inhibition is not the recommended first-line therapy for unresectable metastatic melanoma in major guidelines. (springermedizin.at)
Background Anti-programmed cell death protein 1 (PD-1) antibodies are now routinely administered for metastatic melanoma and for increasing numbers of other cancers, but still only a fraction of patients respond. (bmj.com)
Here, we investigated whether such reactive T cells can also be informative for clinical outcomes in metastatic melanoma under PD-1 immune-checkpoint blockade (ICB). (bmj.com)
When intravenously injected into mice with metastatic melanoma , it was able to deliver signaling molecules, called cyclic dinucleotides, across the cell membranes of their liver macrophages, where they stimulated the production of immune-related proteins called type 1 interferons via a stimulator of an interferon gene (STING) pathway. (news-medical.net)
Cell tradition and reagents We acquired three metastatic melanoma cell lines, A375, SB2, and WM1727A, from your American Type Tradition Collection (Manassas, VA). Normal human pDCs were from MatTek Corporation (Ashland, MA) and cultured in the manufacturers Corticotropin-releasing factor (CRF) DC-MM growth medium according to their instructions. (techieindex.net)
Subclinical aortitis after starting nivolumab in a patient with metastatic melanoma. (unican.es)

In addition, ITI-3000 induced changes in the tumor microenvironment, including increased numbers of CD4 and CD8 T cells, reduced frequency of myeloid cells, and enhanced pro-inflammatory cytokine production. (biospace.com)
These were characterized using intracellular cytokine staining for interferon gamma (IFN-γ), tumor negrosis factor (TNF) and CD107a. (bmj.com)
Interleukin-2 is a cytokine, and it’s basically a growth factor for a lot of immune cells, mostly T lymphocytes. (targetedonc.com)
Regulatory T cells seem to benefit the most from the regular interleukin-2 cytokine, and they expand most when they see or are exposed to these cytokines. (targetedonc.com)
When the infected tissue or cancer tissue gets exposed to active immune cells, the active immune cells secrete another cytokine known as interferon gamma. (targetedonc.com)
IFNγ signals through Janus Kinase 1/2 (JAK1/2) heterodimer complex and mediates signal transducer and activator of transcription 1 (STAT1) phosphorylation, leading to type I cytokine expression, upregulation of antigen presentation, and tumor cell recognition by cytolytic T lymphocytes (CTL). (biomedcentral.com)
Activated γδ T cells exhibit strong cytotoxic activity and cytokine secretion functions and are effective antitumor lymphocytes with simple and direct recognition modes and rapid responses. (explorationpub.com)
First, γδ T cells exposed to complicated cytokine networks are potentially affected by multiple inhibitory mechanisms. (explorationpub.com)
In addition, alpha-1 thymosin stimulates cytokine production in the immune system, which helps coordinate cells. (direct-sarms.com)
The PD-L1 binding to PD-1 causes immunosuppressive results and enables the tumor in order to avoid immune system devastation by inhibiting the proliferation and success of cytotoxic T cells and reducing cytokine creation (generally interleukin-2) [4,5]. (eprf.ca)
Complete ELISpot kits are highly sensitive, microplate-based assays for the detection of cytokine secreting cells. (rndsystems.com)
IFN-gamma (Interferon-gamma) is the prototype proinflammatory cytokine and is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells. (rndsystems.com)
Interleukin (IL)-2 is a cytokine that enhances the production of cytotoxic lymphocytes capable of lysing tumor cells while leaving benign cells unharmed -- IL-2 activated lymphocytes are known as "lymphocyte-activated killer" or LAK cells [8,9]. (blogspot.com)

This was accompanied by fewer tumor-infiltrating CD8 + T cells, and STZ-mice had fewer tumor-infiltrating CD11c + dendritic cells (DCs) than normoglycemic mice. (nature.com)
Upon successful treatment with IL-12TD cells, we observed the selective elimination of tumor-infiltrating CD11b+ F4/80+ macrophages, CD11b+/ClassII+/CD11c+ dendritic cells and CD11b+/Ly6C+/Ly6G- but not CD11b+/Ly6C+/Ly6G+ myeloid-derived suppressor cells within regressing lesions. (gsea-msigdb.org)
Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. (nwbio.com)
Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. (nwbio.com)
Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. (nwbio.com)
Phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma. (nwbio.com)
Large-scale immunomagnetic selection of CD14+ monocytes to generate dendritic cells for cancer immunotherapy: a phase I study. (nwbio.com)
Babatz J, Röllig C, Löbel B, Folprecht G, Haack M, Günther H, Köhne CH, Ehninger G, Schmitz M, Bornhäuser M. Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. (nwbio.com)
Banchereau J, Ueno H, Dhodapkar M, Connolly J, Finholt JP, Klechevsky E, Blanck JP, Johnston DA, Palucka AK, Fay J. Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon. (nwbio.com)
Maturation and trafficking of monocyte-derived dendritic cells in monkeys: implications for dendritic cell-based vaccines. (nwbio.com)
Vaccination of prostatectomized prostate cancer patients in biochemical relapse, with autologous dendritic cells pulsed with recombinant human PSA. (nwbio.com)
Bleumer I, Tiemessen DM, Oosterwijk-Wakka JC, Völler MC, De Weijer K, Mulders PF, Oosterwijk E. Preliminary analysis of patients with progressive renal cell carcinoma vaccinated with CA9-peptide-pulsed mature dendritic cells. (nwbio.com)
Galectin-9 induces maturation of human monocyte-derived dendritic cells. (unige.ch)
The adenylate cyclase (CyaA) of Bordetella pertussis is able to deliver CD8(+) T cell epitopes into the cytosol of CD11b(+) dendritic cells (DC) following its specific interaction with the alpha(M)beta(2) integrin (CD11b/CD18). (ox.ac.uk)
Myeloid innate immune cells, such as granulocytes, monocytes, macrophages and dendritic cells (DCs), play an important role in cancer-cell recognition, initiation of inflammation and antitumor responses ( 2 ). (frontiersin.org)
Cloning of two members of the SIRP alpha family of protein tyrosine phosphatase binding proteins in cattle that are expressed on monocytes and a subpopulation of dendritic cells and which mediate binding to CD4 T cells. (medecinesciences.org)

Healthy humans develop spontaneous CD8+ T cell responses to melanoma associated antigens (MA) expressed by normal melanocytes. (mdpi.com)
Immunochemical analysis of the modulation of human melanoma-associated antigens by DNA recombinant immune interferon. (aai.org)
Tumor Antigens Many tumor cells produce antigens, which may be released in the bloodstream or remain on the cell surface. (msdmanuals.com)
Concomitant use of interferon enhances the expression of major histocompatibility complex (MHC) antigens and TAAs on tumor cells, thereby augmenting the killing of tumor cells by the infused effector cells. (msdmanuals.com)
Licensed recognition of these antigens by effector T cells may in turn trigger the collapse of the tumor stroma and aid in the regression of large vascularized lesions. (gsea-msigdb.org)
Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
Sixty percent of cases express 1 or more T-cell antigens (CD3 + , CD43, or CD45RO). (medscape.com)

Recombinant expression enables cells to process precursor Interleukin 1 Beta to the mature form of the enzyme. (wikipedia.org)
Mammalian cell lines are most commonly used for recombinant antibody production, although cell lines of bacterial, yeast, or insect origin are also suitable. (cellsignal.com)
Where polyclonal antibodies are purified directly from the serum of the immunized host, and monoclonals are purified from either hybridoma-derived tissue culture supernatant or ascites, recombinant antibodies are instead purified from the tissue culture supernatants of transfected host cell lines. (cellsignal.com)
By utilizing the human melanoma cell line Colo 38, a panel of monoclonal antibodies, and a combination of serologic and immunochemical assays, the effect of recombinant immune interferon (IFN-gamma) on the synthesis, expression, and shedding of a cytoplasmic melanoma-associated antigen (MAA) and of the membrane-bound high m.w. (aai.org)
Recombinant adenylate cyclase toxin of Bordetella pertussis induces cytotoxic T lymphocyte responses against HLA*0201-restricted melanoma epitopes. (ox.ac.uk)
With a view to elaborating cancer immunotherapy in humans using CyaA, we constructed two recombinant CyaA carrying HLA*0201-restricted melanoma epitopes. (ox.ac.uk)
Here we show that these recombinant CyaA induce strong anti-melanoma CTL responses in HLA*0201 transgenic mice, even after a single i.v. immunization without adjuvant. (ox.ac.uk)
Finally, human DC treated with the recombinant CyaA were shown to process and present efficiently the melanoma epitopes to human CTL clones. (ox.ac.uk)

ERK/NRF2 cell success signaling pathway, which might be the underlying system by which overexpressing SRXN1 result in security of hCPCs against oxidative stress-induced apoptosis. (biotech2012.org)
Constitutive appearance of PD-L1 in tumor cells is normally induced by dysregulation of oncogenic or tumor suppressor gene signaling pathways (i.e., through the RAS-MEK signaling pathway), by activation of unusual transcription elements (i actually.e., the oncogenic transcription aspect MYC), or by genomic aberrations or gene amplifications (we.e. (eprf.ca)

These factors, which include interleukin 2 (IL2), are secreted by lectin- or antigen-stimulated T cells, and have various physiological effects. (wikipedia.org)
The combination of Cytotoxic T-Lymphozyte Antigen-4 (CTLA‑4) and Programmed death-1 (PD‑1) antibodies and the combination of BRAF and MEK inhibitors are the current clinical standards for combination immune and targeted therapy for melanoma, respectively. (springermedizin.at)
These posters to be presented at the AACR Meeting focus on the investigational nucleic acid platform, UNITE™ (UNiversal Intracellular Targeted Expression) for two vaccines, ITI-3000 for Merkel cell carcinoma (targeting the large T antigen of the Merkel cell polyomavirus) and Her2/Neu-LAMP DNA vaccine, both of which fuse a tumor associated antigen with lysosomal associated membrane protein 1 (LAMP-1). (biospace.com)
This proprietary lysosomal targeting technology results in enhanced antigen presentation and a balanced T cell response. (biospace.com)
This presentation reports results of pre-clinical mouse studies of a cancer vaccine that promotes potent, antigen-specific CD4 T cell responses to MCPγV-LT. The majority of Merkel cell carcinomas (MCC), a rare and highly aggressive type of neuroendocrine skin cancer, are associated with Merkel cell polyomavirus (MCPyV) infection. (biospace.com)
MCPyV integrates into the host genome, resulting in expression of a truncated form of the viral large T antigen (LT) in infected cells, and makes LT an attractive target for therapeutic cancer vaccines. (biospace.com)
To activate antigen-specific CD4 T cells in vivo, the investigators utilized the nucleic acid vaccine platform, UNITE (UNiversal Intracellular Targeted Expression), which fuses a tumor-associated antigen with lysosomal-associated membrane protein 1 (LAMP1). (biospace.com)
Vaccination with LTS220A-UNITE (ITI-3000) induced antigen-specific CD4 Th1 cells that was associated with delayed tumor growth and enhanced survival in treated mice in both the prophylactic and therapeutic settings. (biospace.com)
CD154) is a transmembrane protein expressed on the surface of activated T cells, particularly on CD4 T cells, which stimulates CD40-dependent activation of antigen-presenting cells (APCs), resulting in enhancement of T cell and antibody responses. (biospace.com)
Chimeric antigen receptors (CAR) recognize specific proteins on the surface of tumor cells. (msdmanuals.com)
Direct presentation of antigen by tumor was not necessary, but MHC class I expression on endogenous cells was essential for IL-12 mediated anti-tumor enhancements. (gsea-msigdb.org)
These results are consistent with a model whereby IL-12 triggers the maturation of myeloid-derived cells into competent antigen cross-presenting cells. (gsea-msigdb.org)
Possible explanations for negative effects on CD8 responses include modulation of homing receptor expression or induction of antigen-specific regulatory T cells. (druglib.com)
It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, upregulation of antigen presentation molecules, and immunoglobulin class switching in B cells. (rndsystems.com)
Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)

Genome-wide transcriptome analyses of injected tumor lesions were consistent with a marked upregulation of the type-I interferon pathway. (polyplus-sartorius.com)

Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that are expressed and secreted by white blood cells (leukocytes) as well as some other body cells. (wikipedia.org)
The cytokines tumor necrosis factor, interleukin-1, and gamma interferon, which have been implicated in the pathogenesis of cerebral malaria and are known to promote intercellular adhesion in other systems, did not enhance the cytoadherence of P. falciparum isolates to C32 melanoma cells. (tropmedres.ac)
Then the T cells lose their ability to proliferate, secrete cytokines, and eventually kill the target. (targetedonc.com)
IFN-, via Atg5CAtg12/Atg16L1, inhibited the formation of the membranous cytoplasmic murine norovirus (MNV) replication complex, where Atg16L1 localized.75 Recently, a paradigm has emerged in which Th1 cytokines induce autophagy, while Th2 cytokines inhibit autophagy.76 Tumour necrosis factor (TNF)-upregulates autophagy in cells lacking NF-B activation. (biotech2012.org)
The innate immune response by myeloid cells occurs as a succession of events starting at signaling through cytosolic or surface PRRs, followed by effector responses including the release of cytokines, reactive oxygen species (ROS), reactive nitrogen species (RNS), antibacterial peptides and degranulation ( Figure 1 ). (frontiersin.org)
Pathogen clearance is mediated by mechanisms such as phagocytosis, respiratory burst with the production of ROS and RNS and release of bacteriostatic peptides, but also through the cell-extrinsic initiation of inflammation via the release of proinflammatory cytokines and chemokines ( 24 ). (frontiersin.org)
Interferons belong to a class of proteins called glycoproteins and are cytokines. (canceractive.com)
We used a Cr 51 -release assay to measure the activity of NK/Tc cell and ELISA to evaluate the production of cytokines. (biomedcentral.com)
The activated macrophage can not only recognize and kill tumor cells non-specifically, they removing foreign debris, and produce essential cytokines that are able to stimulate the immune system in general and boost bone marrow production. (digitalnaturopath.com)

Interferon is used as a treatment for certain cancers like malignant melanoma, multiple myeloma and kidney cancers. (canceractive.com)
Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)

The majority of interleukins are synthesized by CD4 helper T-lymphocytes, as well as through monocytes, macrophages, and endothelial cells. (wikipedia.org)
They promote the development and differentiation of T and B lymphocytes, and hematopoietic cells. (wikipedia.org)
T lymphocytes regulate the growth and differentiation of T cells and certain B cells through the release of secreted protein factors. (wikipedia.org)
Therapeutic Candidate or Device OSSM007: cryopreserved, interferon-gamma-primed bone marrow mesenchymal stem cells (BM-MSC) Indication acute Graft versus host disease (aGVHD) resulting from hematopoietic cell transplantation Therapeutic Mechanism Immunomodulation of host-reactive T cells to induce operational tolerance of donor HSC-derived lymphocytes through direct cell-to-cell contact and secreted paracrine factors. (ca.gov)
This includes the subsets of the T-cell lymphocytes CD4 and CD8, as well as natural killers. (targetedonc.com)
Tumor-infiltrating lymphocytes (TILs) may have greater tumoricidal activity than LAK cells. (msdmanuals.com)
Surprisingly, IL-12-dependent enhancement of CD8+ T-cell anti-tumor function did not occur through direct ligation of receptors on lymphocytes or NK cells. (gsea-msigdb.org)
Poly I:C is a powerful immune adjuvant as a result of its agonist activities on TLR-3, MDA5 and RIG-I. BO-112 is a nanoplexed formulation of Poly I:C complexed with polyethylenimine that causes tumor cell apoptosis showing immunogenic cell death features and which upon intratumoral release results in more prominent tumor infiltration by T lymphocytes. (polyplus-sartorius.com)
Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)

Our study aimed to determine the role of neuronal nitric oxide synthase (nNOS)-mediated signaling in IFN-Î³-stimulated melanoma progression and the anti-melanoma effects of novel nNOS inhibitors. (bvsalud.org)

So when the activated T cells invade the tumor microenvironment and start secreting interferon gamma, they turn that mechanism on. (targetedonc.com)
γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
Therefore, an in-depth understanding of γδ T cells that play conflicting roles in the tumor microenvironment is necessary. (explorationpub.com)
10 Based on these details, we hypothesized that NO produced by iNOS is definitely a key molecule in the melanoma inflammatory tumor microenvironment and a predictor of poor end result. (techieindex.net)
To gain further insight into the part of NO and iNOS in the melanoma inflammatory tumor microenvironment, we performed an inflammatory and autoimmunity gene polymerase chain reaction (PCR) array on a Corticotropin-releasing factor (CRF) series of stage III melanoma lymph node metastasis samples to compare the gene manifestation profile directly between iNOS-positive and iNOS-negative tumor samples. (techieindex.net)
The tradition supernatants of NO-scavenged iNOS-expressing cells advertised the migration of pDCs, mainly because of the manifestation of CXCL10, suggesting that scavenging NO may alter the inflammatory tumor microenvironment of melanoma. (techieindex.net)

We have recently found that engineering tumor-specific CD8+ T cells to secrete IL-12 (IL-12TD) can lead to striking improvements in T-cell activity against established melanomas in murine models. (gsea-msigdb.org)

In melanoma, i have focused in acral lentiginous melanoma for which we described KIT mutation and protein expression status in a large series of cases and described TERT amplification in progression to metastasis. (mdanderson.org)
2021) STING agonist loaded lipid nanoparticles overcome anti-PD-1 resistance in melanoma lung metastasis via NK cell activation. (news-medical.net)
Tumour cell hybridization and metastasis revisited. (medecinesciences.org)

Simple Summary Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer, which predominantly occurs on the head and neck. (unav.edu)
Cutaneous basal cell or squamous cell carcinoma treated with curative therapy. (who.int)

Dr. Martin Algarra areas main of interest have been the therapeutic development of immunotherapy and targeted therapies in Oncology, mainly in melanoma, sarcoma, and rare tumors. (unav.edu)
To investigate the effect of hyperglycemia on anti-tumor function induced by anti-PD-1 antibody treatment, we treated STZ-induced diabetic mice with subcutaneous MC38 colon carcinoma tumors with anti-PD-1 antibody, and examined changes in tumor growth, the number of tumor-infiltrating immune cells, and the expression of chemokines and chemokine receptors. (nature.com)
My research interests comprise cutaneous tumors with emphasis in lymphomas and melanoma. (mdanderson.org)
In lymphomas I have conducted studies in rare aggressive primary cutaneous tumors such as gamma/delta T cell lymphoma (expanding the description of the epidermotropic variant) as well as more indolent entities such as lymphomatoid papulosis (type D) and CD4-positive small to medium size T cell lymphoproliferative disorders. (mdanderson.org)
RESULTS: A total of 137 patients (60 with non-small-cell lung cancer [NSCLC], 55 with colorectal cancer, and 22 with other solid tumors) received divarasib. (bvsalud.org)
Immune cells abundantly infiltrate tumors, creating a complex environment mediated by repetitive cycles of antitumor responses and immune evasion ( 1 ). (frontiersin.org)
In addition to TAMs, solid tumors are also infiltrated by immunosuppressive, immature myeloid progenitor cells, commonly referred to as monocytic or polymorphonuclear myeloid-derived suppressor cells (M/PMN-MDSC) ( 11 - 13 ). (frontiersin.org)
whereas iNOS, as its name indicates, is definitely inducible.7 NO is involved in neurotransmission, vasodilation, inflammation, and immunity8 and is also believed to play tasks in multiple phases of various cancers.9 In fact, a recent study showed that increased iNOS expression is definitely a signature of inferior survival, in estrogen receptor Cnegative breast tumors and exposure of estrogen receptorCnegative cells to NO enhanced cell motility and invasion. (techieindex.net)
Intratumoral treatment with BO-112 of subcutaneous tumors derived from MC38, 4 T1 and B16-F10 leads to remarkable local disease control dependent on type-1 interferon and gamma-interferon. (polyplus-sartorius.com)
Switchable targeting of solid tumors by BsCAR T cells. (yale.edu)

IL2 is a lymphokine that induces the proliferation of responsive T cells. (wikipedia.org)
Programmed death ligand 1 (PD-L1) is an immunosuppressive molecule expressed by many cancer types, including a large proportion of head and neck cancers (HNC), and ligation of its receptor, programmed death 1 (PD-1), induces exhaustion of effector T cells. (biomedcentral.com)
It has been shown that interferon gamma (IFNγ) induces PD-L1 expression in many cancer types including glioblastoma, melanoma, lung and kidney cancer. (biomedcentral.com)
Fusion cell vaccination of patients with metastatic breast and renal cancer induces immunological and clinical responses. (nwbio.com)
Knockdown of KDM1B inhibits cell proliferation and induces apoptosis of pancreatic cancer cells. (cancerindex.org)

However, when mice with this genetic deletion have wild-type neural precursor cells injected into their hippocampus and these cells are allowed to mature into astrocytes containing the interleukin-1 receptors, the mice exhibit normal hippocampal-dependent memory function, and partial restoration of long-term potentiation. (wikipedia.org)
We analyzed the effect of PD-1-Ab on tumor growth in streptozotocin-induced diabetic mice (STZ-mice) subcutaneously inoculated with MC38 (a colon carcinoma cell line). (nature.com)
Furthermore, we assessed the expression of chemokines by polymerase chain reaction (PCR) array in tumor-draining lymph nodes (dLNs) of these mice and MC38 cells cultured in different glucose concentrations. (nature.com)
mRNA expression levels of CXCL9, a chemokine recruiting CD8 + T cells, were lower in dLNs of STZ-mice than in normoglycemic mice after PD-1-Ab treatment, and its protein was expressed in DCs. (nature.com)
To induce hyperglycemia, mice were intraperitoneally injected with STZ, which can damage pancreatic β cells resulting in the development of insulin dependent diabetes, a model of type 1 diabetes mellitus (T1DM). (nature.com)
Mice were intraperitoneally injected with STZ or sodium citrate buffer (CB) 7 days before subcutaneous inoculation with MC38 cells in the right flank on day 0 (Fig. 1 A). Then, the mice were treated with anti-PD-1 antibody or normal rat IgG on days 5, 8, and 11. (nature.com)
In this study, we examined the possibility of HemoHIM both to enhance anticancer effect with cisplatin and to reduce the side effects of cisplatin in melanoma-bearing mice. (biomedcentral.com)
Anticancer effects of HemoHIM with cisplatin were evaluated in melanoma-bearing mice. (biomedcentral.com)
However HemoHIM administration enhanced both NK cell and Tc cell activity in mice. (biomedcentral.com)
In melanoma-bearing mice treated with cisplatin, HemoHIM administration also increased the activity of NK cells and Tc cells and the IL-2 and IFN-γ secretion from splenocytes, which seemed to contribute to the enhanced efficacy of cisplatin by HemoHIM. (biomedcentral.com)
B16-F10 and B16-OVA melanoma, MC38 colon carcinoma or 4 T1 breast carcinoma cells were injected subcutaneously (5 × 105-106) into the right flank of 8- to 10-week-old female C57BL/6 or BALB/c (6-11 mice/group) on day 0. (polyplus-sartorius.com)
Some degree of control of non-injected tumor lesions following BO-112 intratumoral treatment was found in mice bearing bilateral B16-OVA melanomas, an activity which was enhanced with co-treatment with systemic anti-CD137 and anti-PD-L1 mAbs. (polyplus-sartorius.com)

Two types of IL-1 receptor, each with three extracellular immunoglobulin (Ig)-like domains, limited sequence similarity (28%) and different pharmacological characteristics have been cloned from mouse and human cell lines: these have been termed type I and type II receptors. (wikipedia.org)
In addition, it acts on some B cells, via receptor-specific binding, as a growth factor and antibody production stimulant. (wikipedia.org)
γδ T cells express unique T cell receptor (TCR) γ and TCR δ chains, with structural and functional heterogeneity. (explorationpub.com)
ROCKVILLE, Md., US, 09 November 2022) Immunocore Holdings plc (Nasdaq: IMCR) ("Immunocore" or the "Company"), a commercial-stage biotechnology company pioneering the development of a novel class of T cell receptor (TCR) bispecific immunotherapies designed to treat a broad range of diseases, including cancer, autoimmune and infectious diseases, today announced its financial results for the third quarter ended September 30, 2022 and provided a business update. (theeveningleader.com)
Programmed cell loss of life proteins 1 (PD-1) can be an immune system checkpoint receptor portrayed on the top of turned on T cells, B cells, and macrophages. (eprf.ca)
IFN-gamma dimers signal through a receptor complex of two IFN-gamma R1 and two IFN-gamma R2 subunits. (rndsystems.com)

Although antilymphocyte serum was used in the treatment of chronic lymphocytic leukemia and in T-cell and B-cell lymphomas, resulting in temporary decreases in lymphocyte counts or lymph node size, newer humoral immunotherapeutic modalities have been developed. (msdmanuals.com)
Two courses of four weekly infusions of rituximab with or without interferon-2a: final results from a randomized phase III study in symptomatic indolent B-cell lymphomas. (cancercentrum.se)

T-cell responses were assessed by an ex vivo interferon gamma ELISpot assay. (druglib.com)

Now, scientists at Hokkaido University and Aichi Institute of Technology have found a way around this by developing a specially designed lipid nanoparticle that can carry immunity-triggering molecules into immune cells in the liver called macrophages. (news-medical.net)
However, these immunotherapeutic approaches are hampered by the tumor-promoting nature of myeloid cells, including monocytes, macrophages, and neutrophils. (frontiersin.org)
It is able to protect blood macrophages from free radical attack during and after the radiation allowing these cells to continue to carry their important functions in the irradiated body and release factors important to the restoration of normal bone marrow production. (digitalnaturopath.com)

Domaica, C.I. Human Natural Killer Cell Maturation Defect Supports In Vivo CD56bright to CD56dim Lineage Development. (uba.ar)
Zwirner, N.W. 'Human Natural Killer Cell Maturation Defect Supports In Vivo CD56bright to CD56dim Lineage Development' (2012) PLoS ONE. (uba.ar)

After cloning the antibody genes into an expression vector, this is then transfected into an appropriate host cell line for antibody expression. (cellsignal.com)
however, it remains unknown whether the anti-tumor effects of anti-programmed cell death-1 antibody (PD-1-Ab) treatment are changed in hyperglycemic conditions. (nature.com)
To demonstrate specificity of staining, binding by the FITC Mouse Anti-Human IFN-γ antibody was blocked by preincubation of fixed/permeabilized cells with excess Purified Mouse Anti-Human IFN-γ antibody (Cat. (bdbiosciences.com)
The B27 antibody is useful for immunofluorescent staining and flow cytometric analysis to identify and enumerate IFN-γ producing cells within mixed cell populations. (bdbiosciences.com)
Interestingly, the most primordial defense responses employed by myeloid cells against pathogens, such as complement activation, antibody-dependent cell cytotoxicity and phagocytosis, actually seem to favor cancer progression. (frontiersin.org)
IFN-α (interferon-alpha) is known to stimulate NK (natural killer ) cells, induce MHC (major histocompatibility complex) class I response, augments the ability of Th1 (T-helper cells) and increase antibody recognition -- all mechanisms that stimulate the immune response in the bladder [2,3]. (blogspot.com)

Clinical trials of LAK cells in humans are ongoing but this approach has not gained widespread use and is generally considered less effective than other cell therapies. (msdmanuals.com)

These are a T-cell subset that are specialized in regulating the immune system, but just like other T cells, effector T cells benefit from interleukin-2. (targetedonc.com)
In passive cellular immunotherapy, specific effector cells are directly infused and are not induced within the patient. (msdmanuals.com)
In passive cellular immunotherapy, specific effector cells. (msdmanuals.com)
PRR on myeloid cells can be triggered by pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs), but also indirectly by secondary mechanisms such as complement activation and circulating antibodies (Abs), resulting in cytolytic and phagocytic effector mechanisms. (frontiersin.org)

Interferon-gamma (IFN-Î³) is shown to stimulate melanoma development and progression. (bvsalud.org)
In this review, we discuss how rudimentary defense mechanisms deployed by myeloid cells can promote tumor progression. (frontiersin.org)

While treatment with carboplatin enriches for CA125-negative cells, co-treatment with carboplatin and birinapant eliminates these cells in HGSCs expressing high levels of the inhibitor of apoptosis protein cIAP in the CA125-negative population. (biotech2012.org)
Possible role of galectin-9 in cell aggregation and apoptosis of human melanoma cell lines and its clinical significance. (unige.ch)
On the other, mistletoe therapy can induce apoptosis (the process of natural cell death) in tumour cells, which results in the inhibition of tumour growth. (integratedmedicine.co)

live CD4-B220+ cells in spleen were determined by flow cytometry. (biotech2012.org)
C, lower panels) Flow cytometry analyzing the frequency of IgG1+ GC B cells among live CD4?B220+GL7+Fas+ cells in the spleen. (biotech2012.org)

Interferon alpha, the usual version used (the others are beta and gamma), is used to stimulate the body's natural immune system in the expectation that this will then overwhelm the cancer. (canceractive.com)
Patients were vaccinated with 12 class I major histocompatibility complex-restricted melanoma peptides (12MP) to stimulate CD8(+) T cells and were randomly assigned to receive a tetanus helper peptide or a mixture of six melanoma-associated helper peptides (6MHP) to stimulate CD4(+) T cells. (druglib.com)
Basic research results indicate that medicinal mistletoe may stimulate the immune system to fight cancer cells. (integratedmedicine.co)

Over the past decade, cancer immunotherapy has been steering immune responses toward cancer cell eradication. (frontiersin.org)
Hence, myeloid cells play a dual role in cancer as they can initiate antitumor responses and communicate with cells of the adaptive immune system, but also promote local inflammation leading to chronic cancer-associated inflammation ( 5 , 6 ). (frontiersin.org)
PURPOSE: This multicenter randomized trial was designed to test whether melanoma-associated helper peptides augment CD8(+) T-cell responses to a melanoma vaccine and whether cyclophosphamide (CY) pretreatment augments CD4(+) or CD8(+) T-cell responses to that vaccine. (druglib.com)
RESULTS: Vaccination with 12MP plus tetanus induced CD8(+) T-cell responses in 78% of patients and CD4(+) T-cell responses to tetanus peptide in 93% of patients. (druglib.com)
CY had no significant effect on T-cell responses. (druglib.com)

The gene expression of infected cells was first normalized with β-actin and further normalized with ORF1b gene. (cdc.gov)
The gene expression of mock-infected cells was presented after normalization with β-actin. (cdc.gov)
Therapeutic Candidate or Device Autologous hematopoietic stem cells transduced with a HexA/HexB expressing lentiviral vector Indication Tay-Sachs disease Therapeutic Mechanism The transplanted gene modified autologous hematopoietic stem cells will engraft in the bone marrow and start producing HexA/HexB expressing immune progeny. (ca.gov)

The Interferon is usually given by subcutaneous injection in the abdomen or thigh and phials should be kept in the refrigerator. (canceractive.com)

Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. (cancerindex.org)
Additionally, IL-2 augments the immune system through a variety of interactions with NK cells, monocytes and Th1 cells [9,10]. (blogspot.com)

These were released into the blood, activating another type of immune cell called natural killer cells in the spleen and lung, which produced interferon-gamma inside the lung metastases. (news-medical.net)
Interestingly, HemoHIM increased the proportion of NK cells in the spleen. (biomedcentral.com)

Potential future uses for temozolamide include the treatment of glioblastomas, melanoma, and sarcoma. (worthingtoncaron.com)

The activation of checkpoint proteins on the surfaces of immune cells help regulate the immune response by preventing them from indiscriminately attacking the body's other cells. (news-medical.net)

Dendritic cell immunotherapy for patients with metastatic renal cell carcinoma: University of Tokyo experience. (nwbio.com)
11 A few studies indicate a possible positive effect on survival 7,12-14 , although no significant survival effects were found for patients with metastatic colorectal cancer 15 , melanoma 16 , or head and neck cancer 17 , and further studies are required to confirm these findings. (integratedmedicine.co)

Interferon-gamma stimulates the expression of galectin-9 in cultured human endothelial cells. (unige.ch)
When these cells are activated, it stimulates a cascade of events which enhances immunity. (digitalnaturopath.com)

Interferons are glycoproteins with a number of anti-viral properties. (blogspot.com)

The in vitro cytotoxicity of BO-112 in mouse and human cell lines was continuously assessed by measuring electric impedance in an xCELLigence machine (ACEA). (polyplus-sartorius.com)

Myeloid-derived cells comprising the tumor stroma represent a heterogeneous population of cells critical to the structure, function and growth of established cancers. (gsea-msigdb.org)
The connections of CTLA-4 with B7 leads to inhibitory signaling, marketing the success of cancers cells. (eprf.ca)
The PD-1/PD-L1 pathway has a crucial function in cancers cells immune system get away through the PD-1 upregulation. (eprf.ca)
Cancers cells cannot affect turned on T cells as well KLRK1 as the immune system response remains energetic. (eprf.ca)
The ability of IFN-α to fight off cancers has been attributed to both an ability to stop cell growth and its immunomodulatory effects. (blogspot.com)

Importantly, the stimuli and mechanism for PD-L1 upregulation in HNC cells are not well characterized. (biomedcentral.com)

Immune checkpoint inhibitors (ICIs), including antibodies against programmed cell death-1 (PD-1) and PD-1 ligand-1 (PD-L1), induce their anti-tumor effects by improving the function of immune cells 11 . (nature.com)
Eventually the tumor tissues that do not express PD-L1, after they’re exposed to the interferon gamma from the attacking T cells, become PD-L1 positive in order to protect themselves from the attacking immune cells. (targetedonc.com)
This review further emphasizes the diversified cross-talk between γδ T cells and other immune cells. (explorationpub.com)
The lipid, called YSK12-C4, has a high affinity for immune cells. (news-medical.net)
Mistletoe therapy acts on many levels: On the one hand, it boosts the immune system by multiplying and activating the immune cells. (integratedmedicine.co)
On the contrary, immune cells and other healthy cells are protected against further injury, e.g. damage caused by cytostatic drugs. (integratedmedicine.co)

The gamma-linolenic acid in evening primrose oil may reduce non-inflammatory and inflammatory acne lesions ( 1 ). (stylecraze.com)

To determine whether isolates of Plasmodium falciparum have intrinsically different cytoadherent properties and whether these differences contribute to the clinical severity of human falciparum malaria, we studied the cytoadherence to C32 melanoma cells in vitro of 59 parasite isolates from patients with naturally acquired infections in Thailand. (tropmedres.ac)
HemoHIM itself did not inhibit melanoma cell growth in vitro , and did not disturb the effects of cisplatin in vitro . (biomedcentral.com)

The name "interleukin" was chosen in 1979, to replace the various different names used by different research groups to designate interleukin 1 (lymphocyte activating factor, mitogenic protein, T-cell replacing factor III, B-cell activating factor, B-cell differentiation factor, and "Heidikine") and interleukin 2 (TSF, etc. (wikipedia.org)

In contrast to TCR T cells, CAR T cells recognize only relatively large proteins on the surface of tumor cells. (msdmanuals.com)
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. (unige.ch)

Inducible appearance identifies the appearance of PD-L1-managed inflammatory Gambogic acid indicators from tumor cells or various other immune system cells. (eprf.ca)
In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation. (rndsystems.com)
Psoriasis is a complex, chronic, multifactorial, inflammatory disease that involves hyperproliferation of the keratinocytes in the epidermis, with an increase in the epidermal cell turnover rate (see the image below). (medscape.com)

The potential implications of the marked changes in the antigenic profile of melanoma cells treated with IFN-gamma are discussed in view of the changes in the immunogenicity of IFN-gamma-treated melanoma cells. (aai.org)
Randomized multicenter trial of the effects of melanoma-associated helper peptides and cyclophosphamide on the immunogenicity of a multipeptide melanoma vaccine. (druglib.com)

T-cell engagers are bispecific antibodies that recruit cytotoxic T cells to kill tumor cells. (msdmanuals.com)

Only age over 60 years, cardiovascular disorders, and diabetes mellitus increased the risk of death due to COVID-19, but not advanced melanoma stage nor melanoma systemic therapies. (unav.edu)
The success of these therapies has stimulated research into novel drug combinations for melanoma, of which a large majority are based on combination with PD‑1 or PD-Ligand 1 (PD-L1) blocking drugs. (springermedizin.at)
Within the last year the landscape for mUC has seismically shifted following the approval of five therapies targeting the programmed cell death protein (PD-1)/programmed cell death ligand 1 (PD-L1) axis. (biomedcentral.com)

Our study shows that IFN-Î³ markedly induced the expression levels of nNOS in melanoma cells associated with increased intracellular nitric oxide (NO) levels. (bvsalud.org)
This delivery results in intracellular processing and presentation by MHC class I molecules of the CD8(+) T cell epitopes inserted into CyaA. (ox.ac.uk)

Moreover, TAK-243 significantly increases the F508del-CFTR short-circuit current induced by elexacaftor/tezacaftor/ivacaftor in differentiated human primary airway epithelial cells, a gold standard for the pre-clinical evaluation of patients' responsiveness to pharmacological treatments. (bvsalud.org)
CAR T cell immunotherapy for human cancer. (msdmanuals.com)
At present, the phenotypic heterogeneity and functional variation of human γδ T cells are increasing. (explorationpub.com)
In this review, we use the Heilig nomenclature to describe human γδ T cells [ 1 ]. (explorationpub.com)
Expression of IFN-γ by stimulated human peripheral blood mononuclear cells (PBMC). (bdbiosciences.com)
Gamma-interferon-inducible lysosomal thiol reductase is upregulated in human melanoma. (harvard.edu)
RT "Low-dose interferon-gamma-producing human neuroblastoma cells show RT reduced proliferation and delayed tumorigenicity. (cellosaurus.org)

In MC38 cells cultured with 25 mM glucose, mRNA expression of CCL7, a chemokine recruiting DCs, was decreased compared to cells cultured with 5 mM glucose. (nature.com)
These results suggest that the STZ-induced hyperglycemia impairs the effect of PD-1-Ab treatment on MC38 tumor growth, and is accompanied by reduced infiltration of DCs and CD8 + T cells and decreased expression of CCL7 and CXCL9. (nature.com)

The effects of IFN-gamma on the cytoplasmic MAA are similar to those of leukocyte and fibroblast interferons, whereas those on the membrane-bound MAA are significantly different. (aai.org)
cis-Proline mutants of quiescin sulfhydryl oxidase 1 with altered redox properties undermine extracellular matrix integrity and cell adhesion in fibroblast cultures. (harvard.edu)

The exposed tissue to the interferon gamma, over time, starts upregulating a molecule called PD-L1. (targetedonc.com)
The goal of that PD-L1 molecule is to engage on a PD-1 [programmed cell death protein 1] molecule on the activated T cells, which are the same cells that secrete the interferon gamma. (targetedonc.com)
Using CFBE41o- cells expressing F508del-CFTR, we provide mechanistic evidence that targeting the E1 ubiquitin-activating enzyme (UBA1) by TAK-243, a small molecule in clinical trials for other diseases, boosts the rescue of F508del-CFTR induced by CFTR correctors. (bvsalud.org)

In order to find and destroy bacteria and viruses, and tumour cells, Z cells are activated. (direct-sarms.com)
Cytotoxic effects on tumour cells have been observed in animal models 4,5 . (integratedmedicine.co)

Therapeutic Candidate or Device Autologous blood stem cells edited to restore iduronidase expression Indication Severe Mucopolysaccharidosis Type 1 (MPS1/ Hurler's syndrome) Therapeutic Mechanism Autologous blood stem cells undergo genome editing to restore the production of the missing enzyme. (ca.gov)
Therapeutic Candidate or Device Hematopoietic stem and progenitor cells collected from X-CGD patients modified with a highly regulated lentiviral vector Indication X-linked Chronic Granulomatous Disease Therapeutic Mechanism Lentiviral vector (LV) modification of autologous hematopoietic stem and progenitor cells (HSPCs) to restore physiologic gp91phox expression. (ca.gov)
This effect was dependent on the CD4 T cells ability to produce IFNγ (interferon gamma), suggesting the potential mechanism of action of ITI-3000. (biospace.com)
So it’s an adaptive immune protection that normal tissue has, but it’s a mechanism that’s hijacked by the cancer cells and the cancer cells become resistant to the immune system. (targetedonc.com)
We investigated basal PD-L1 expression and the mechanism by which IFNγ signaling upregulates PD-L1 in HNC cells including dependence on JAK/STAT pathway. (biomedcentral.com)
But some cancer cells are able to hijack this mechanism, preventing an immune response against them as well. (news-medical.net)
Vignery A. Osteoclasts and giant cells: macrophage-macrophage fusion mechanism. (medecinesciences.org)

An evaluation of melanoma tissue from selected cases suggested a correlation between tumor-resident NY-ESO-1- and Melan-A-reactive T cells and disease control, supporting the notion of a therapy-associated sequestration of cells from the periphery to the tumor predominantly in those patients benefitting from ICB. (bmj.com)
However, the progenitor cells consist of T cells isolated from resected tumor tissue. (msdmanuals.com)
It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. (unige.ch)

We previously showed that the presence of NY-ESO-1-reactive and/or Melan-A-reactive T cells in the blood correlated with prolonged overall survival (OS) of patients with melanoma with a heterogeneous treatment background. (bmj.com)

While polyclonal antibodies are secreted by many different B cell clones and recognize multiple antigenic epitopes, monoclonals originate from a single B cell clone and are specific for just one epitope. (cellsignal.com)

Anatomy24

Organisms10

Diseases19

Chemicals and Drugs78

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes38

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Health Care2

Metastatic melanoma6

Cytokine13

Dendritic cells16

Antigens7

Recombinant8

Signaling pathway2

Antigen16

Type I interferon1

Cytokines9

Malignant3

Lymphocytes9

Anti-melanoma1

Microenvironment6

Murine1

Metastasis3

Squamous cell carc2

Tumors10

Induces5

Mice12

Receptor6

Lymphomas2

Assay1

Macrophages3

Vivo2

Antibody6

Humans1

Effector4

Progression2

Apoptosis3

Flow Cytometry2

Stimulate3

Responses5

Gene3

Subcutaneous1

Monocytes2

Spleen2

Sarcoma1

Attacking the body's1

Patients with metastatic2

Stimulates2

Glycoproteins1

Cytotoxicity1

CANCERS5

Upregulation1

Immune cells6

Lesions1

Vitro2

Lymphocyte1

Proteins2

Inflammatory3

Immunogenicity2

Cytotoxic T cel1

Therapies3

Intracellular2

Human7

MC382

Fibroblast2

Molecule3

Tumour2

Mechanism7

Tissue3

Heterogeneous1

Antigenic1