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  • type
  • Objective To establish an easy and practical assay for identifying systemic interferon (IFN) type I bioactivity in patients with primary Sjögren's syndrome (pSS). (bmj.com)
  • The aetiology of pSS is largely unknown, but evidence for a role of interferon (IFN) type I in the pathogenesis of pSS has been emerging. (bmj.com)
  • lymphocytes
  • T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis. (abcam.com)
  • In contrast to interferon alpha and interferon beta which can be expressed by all cells, Interferon gamma is secreted by T lymphocytes and NK cells only. (abcam.com)
  • Mammalian Interferon gamma is mainly produced by T lymphocytes and NK cells. (abcam.com)
  • Interferon-γ (IFN-γ) release assays rely on the fact that T-lymphocytes will release IFN-γ when exposed to specific antigens. (wikipedia.org)
  • Detection
  • This antigen affinity purified antibody, in conjunction with recommended pair as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant mIFN-gamma. (abcam.com)
  • cell
  • Expression of type I and III IFNs can be induced in virtually all cell types upon recognition of viral components, especially nucleic acids, by cytoplasmic and endosomal receptors, whereas type II interferon is induced by cytokines such as IL-12, and its expression is restricted to immune cells such as T cells and NK cells. (wikipedia.org)
  • However, the infected cell can prepare neighboring cells against a potential infection by the virus by releasing interferons. (wikipedia.org)
  • million
  • Total revenue in the second quarter of 2009 primarily consisted of Actimmune(R) (interferon gamma-1b) revenue of $7.1 million, compared with $7.3 million in the same quarter of 2008, a decrease of approximately 2 percent, reflecting lower off-label physician prescriptions of Actimmune for the treatment of idiopathic pulmonary fibrosis (IPF), which InterMune does not promote. (bio-medicine.org)