• The protective effects of combination therapy utilizing recombinant human TNF-alpha (rTNF-α) and natural murine interferon-beta (IFN-β) in mice infected with herpes simplex virus type 1 (HSV-1) was investigated. (utmb.edu)
  • This study will examine the safety of the drug interferon beta 1a in patients with acute ischemic stroke to determine the highest dose patients can tolerate without serious side effects and to determine the best way to give the medication. (clinicaltrials.gov)
  • The optimal preparation, dosage, and route of administration of interferon beta for the management of MS has not been determined. (healthcentral.com)
  • Interferon beta-1b injection is used to reduce episodes of symptoms in patients with relapsing-remitting (course of disease where symptoms flare up from time to time) of multiple sclerosis (MS, a disease in which the nerves do not function properly and patients may experience weakness, numbness, loss of muscle coordination and problems with vision, speech, and bladder control). (medlineplus.gov)
  • Interferon beta-1a controls symptoms of MS but does not cure it. (medlineplus.gov)
  • Many patients report influenza-like symptoms hours after taking interferon beta that usually improve within 24 hours, being such symptoms related to the temporary increase of cytokines. (wikipedia.org)
  • Another common transient secondary effect with interferon-beta is a functional deterioration of already existing symptoms of the disease. (wikipedia.org)
  • IFN-alpha production in embryonic fibroblasts from IFN-beta-/- mice could be rescued by 'priming' the cells using exogenous IFN-beta. (nih.gov)
  • Aare (1979) In: Dunnick JK, Galasso GJ (1979) Clinical trials with exogenous interferon: Summary of a meeting. (springer.com)
  • Thus, it is difficult and inappropriate to try to compare the effectiveness of one interferon formulation with another. (healthcentral.com)
  • Just saw this interesting bit of news re: a study they did on the effectiveness of taking Interferon Beta 1b after the initial MS attack as opposed to waiting. (thisisms.com)
  • The IFN-Beta (0.25mg/ml) contains 20mM HEPES (pH6.0), 0.5M NaCl, 10% glycerol. (prospecbio.com)
  • Interferon beta-1a is made from human proteins. (cigna.com)
  • Interferon beta-1b is made from human plasma (part of the blood) which may contain viruses and other infectious agents. (cigna.com)
  • Intracellular bacteria and cytosolic poly (dA-dT) trigger IFN-beta responses in different human cells without requiring human ZBP1. (prospecbio.com)
  • Interferon beta-1b injection comes as a powder to be mixed with liquid and injected subcutaneously (just under the skin). (medlineplus.gov)
  • Use interferon beta-1b injection exactly as directed. (medlineplus.gov)
  • If you become pregnant while receiving interferon beta-1b injection, call your doctor. (medlineplus.gov)
  • ask your doctor about the safe use of alcoholic beverages while receiving interferon beta-1b injection. (medlineplus.gov)
  • What is Interferon beta-1a IM Injection? (patientslikeme.com)
  • Interferon beta-1a is available only in injectable forms, and can cause skin reactions at the injection site that may include cutaneous necrosis. (wikipedia.org)
  • Interferon beta-1a may also be used for purposes not listed in this medication guide. (cigna.com)
  • Please talk with your doctor and ask about his/her recommendations for YOU, specifically, if you are taking or considering using a beta interferon to treat your MS. It is not uncommon that a neurologist may suggest trying a different interferon medication even after one has not worked for you. (healthcentral.com)
  • Alemtuzumab vs. interferon beta-1a in early multiple sclerosis. (nih.gov)
  • In the alemtuzumab group, the lesion burden (as seen on T(2)-weighted magnetic resonance imaging) was reduced, as compared with that in the interferon beta-1a group (P=0.005). (nih.gov)
  • From month 12 to month 36, brain volume (as seen on T(1)-weighted magnetic resonance imaging) increased in the alemtuzumab group but decreased in the interferon beta-1a group (P=0.02). (nih.gov)
  • In patients with early, relapsing-remitting multiple sclerosis, alemtuzumab was more effective than interferon beta-1a but was associated with autoimmunity, most seriously manifesting as immune thrombocytopenic purpura. (nih.gov)
  • We report here that embryonic fibroblasts from such mice produce neither IFN-beta nor IFN-alpha upon Sendal virus infection, whereas the production of IFN-alpha by leukocytes from the same strain of mice is intact. (nih.gov)
  • The body naturally manufactures interferon when the immune system is weak. (wddty.com)
  • 76: 476-80).Surprisingly, even the medical press have been sceptical about the use of this powerful drug, which is similar, but not exactly like, naturally occurring interferon. (wddty.com)
  • A small number of pregnant women have had miscarriages while using interferon beta-1b. (cigna.com)
  • Do not use interferon beta-1b if you are pregnant. (cigna.com)
  • Alcohol can make the side effects from interferon beta-1b worse. (medlineplus.gov)
  • What are the possible side effects of interferon beta-1b? (cigna.com)
  • Participants are randomly assigned to receive either interferon beta 1a or placebo (an inactive substance). (clinicaltrials.gov)
  • Interferon is a substance produced in cells infected with viruses. (wddty.com)
  • Interferon beta on the other hand, acts as an immune suppressor, increasing the activity of suppressor lymphocytes and inhibiting the activation of other immune cells. (news-medical.net)
  • However, it is known that non-responder and responders to interferon beta differ in their genes. (healthcentral.com)
  • Mouse IFN beta is fused to 21 amino acid at N-terminus and purified by proprietary chromatographic techniques. (prospecbio.com)
  • Overall, therapy with interferon beta leads to a reduction of neuron inflammation. (wikipedia.org)
  • Interferon beta-1a may be kept at room temperature for short periods if protected from light. (cigna.com)
  • Store interferon beta-1a in a refrigerator. (cigna.com)
  • After mixing interferon beta-1b, store in the refrigerator and use within 3 hours. (cigna.com)