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  • induces
  • Moreover interferon induces the activity of 2, 3 indoloamine dioxygenase, the enzyme which converts tryptophan into kynurenine, leads to a reduced level of tryptophan, and thus to a reduced level of central serotonin and to an increased level of neurotoxic kynurenine metabolites. (prohealth.com)
  • depressive symptoms
  • Evidence suggests that increased kynurenine production may precipitate depressive symptoms associated with interferon treatment for hepatitis C. Cognitive deficits in schizophrenia are associated with imbalances in the enzymes that break down kynurenine. (wikipedia.org)
  • molecule
  • Superantigens bind first to the MHC Class II and then coordinate to the variable alpha or beta chain of T-cell Receptors (TCR) SAgs show preference for the HLA-DQ form of the molecule. (wikipedia.org)
  • symptoms
  • The most common adverse events associated with IFN- alpha therapy are flu-like symptoms, fatigue, anorexia, and central nervous system and psychiatric reactions. (prohealth.com)
  • Neuropsychiatric symptoms are commonly related to interferon alpha treatment. (prohealth.com)
  • Serotonin selective reuptake inhibitors (SSRI), other antidepressants i.e. nortriptyline, benzodiazepines, naltrexone, and neuroleptics (for maniac and psychotic states) are used to treat interferon associated psychiatric symptoms. (prohealth.com)