• Ifosfamide forms DNA interstrand and intrastrand bonds that interfere with protein synthesis. (medscape.com)
  • They interfere with DNA synthesis by blocking the methylation of deoxyuridylic acid. (medscape.com)
  • Classic antimetabolite anticancer drug with chemical structure similar to endogenous intermediates or building blocks of DNA or RNA synthesis. (medscape.com)
  • This step interferes with DNA and to a lesser degree with RNA synthesis. (medscape.com)
  • It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs , in the treatment of or in remission maintenance programs for leukemia . (online-medical-dictionary.org)
  • Alkylating antineoplastic agents elicit their effects through the formation of covalent bonds with DNA, which disturbs protein synthesis and cellular division. (medscape.com)
  • It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid. (ucdenver.edu)
  • In this manner, fluorouracil interferes with the synthesis of deoxyribonucleic acid (DNA) and to a lesser extent inhibits the formation of ribonucleic acid (RNA). (nih.gov)
  • Hydroxyurea, an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. (targetmol.com)
  • An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. (targetmol.com)
  • It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in. (targetmol.com)
  • Antimetabolites are drugs that interfere with one or more enzymes or their reactions that are necessary for DNA synthesis. (longdom.org)
  • They affect DNA synthesis by acting as a substitute to the actual metabolites that would be used in the normal metabolism (for example antifolates interfere with the use of folic acid). (longdom.org)
  • Cytarabine, which also has antiviral properties, interferes with dihydrofolate reductase, which is necessary for the synthesis of tetrahydrofolate and subsequently for the synthesis of the folic acid needed for DNA formation. (longdom.org)
  • Fluorouracil is a pyrimidine antimetabolite. (medscape.com)
  • Fluorouracil interferes with genetic material (DNA and RNA), which is necessary for the growth and reproduction of cancer cells. (rxhealthmed.ca)
  • Fluorouracil Cream USP is topical preparations containing the fluorinated pyrimidine 5-fluorouracil, an antineoplastic antimetabolite. (nih.gov)
  • A pyrimidine analog that is an antineoplastic antimetabolite. (ucdenver.edu)
  • Intro Cytarabine (cytosine arabinoside, arabinofuranosyl cytidine) is usually ICAM4 a chemotherapeutic medication utilized only or in mixture with additional antineoplastic brokers to deal with different forms of leukemia. (ampkpathway.com)
  • As an analog of deoxycytidine, this antimetabolite medication includes into human being DNA and as a result gets rid of leukemic cells by interfering with DNA and RNA activity [1]. (ampkpathway.com)
  • Most of the parents of cancer kids have been told not to give folic acid supplements during chemo since it interferes with the action of the methotrexate. (pfeist.net)
  • 4. Pharmaceuticals used to destroy cancer cells are called anticancer, chemotherapeutic, antineoplastic, or cytotoxic 5. (studylib.net)
  • When applied as directed, Efudex Cream works as a cytotoxic antimetabolite. (discountdrugsfromcanada.com)
  • Traditional chemotherapeutic agents are cytotoxic by means of interfering with cell division (mitosis) but cancer cells vary widely in their susceptibility to these agents. (worldsbest.rehab)
  • Drugs that exert their influence during a specific phase(s) of the cell cycle are called Cell cycle -specific (CCS) drugs and include antimetabolites, some alkylating agents and vinca alkaloids. (studylib.net)
  • DNA-damaging agents (antineoplastics) and alkylating agents react with DNA to change it chemically and keep it from allowing cell growth. (lls.org)
  • Mercaptopurine is in the thiopurine and antimetabolite family of medications. (wikipedia.org)
  • The cellular kinetics of particular cancers is an important consideration in the design of antineoplastic drug regimens and may influence the dosing schedules and timing intervals of treatment. (msdmanuals.com)
  • As well as interfering with the genetic material DNA of cancer cells, fludarabine can interfere with some of your normal cells. (pharmachoice.com)
  • Drugs used to manage connective tissue disease (CTD) associated with interstitial lung disease (ILD) (CTD-ILD) include nintedanib, corticosteroids, and antineoplastic agents. (medscape.com)
  • Antineoplastic agents interfere with cell reproduction. (medscape.com)
  • Cellular apoptosis (ie, programmed cell death) is another potential mechanism of many antineoplastic agents. (medscape.com)
  • Hypomethylating (demethylating) agents interfere with cancer cell duplication by slowing or reversing hypermethylation. (lls.org)
  • Fludarabine causes the death of cancer cells by interfering with their growth and reproduction. (pharmachoice.com)
  • Antimetabolites mimic the building blocks of DNA or RNA that cancer cells need to survive and grow. (lls.org)
  • By interfering with the cancer cells in this way, their growth is unstable and the cells die. (discountdrugsfromcanada.com)
  • Blocking mTOR creates a starvation-like effect in cancer cells by interfering with cell growth, division, metabolism, and angiogenesis. (adooq.com)
  • Luvica is an antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia. (acteropharma.com)
  • That chronic pain interfered with daily life. (lbbc.org)
  • Sulfanilamides, for example, are antimetabolites that disrupt bacterial, but not human, metabolism and are used to eradicate bacterial infections in humans. (longdom.org)
  • Pemetrexed is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesotheli. (targetmol.com)
  • This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (blogspot.com)
  • This agent also exhibits antiproliferative activity in endometrial tissue and may exhibit chemopreventive and antineoplastic activities in endometrial carcinoma. (medindex.am)
  • In popular usage, it usually refers to antineoplastic drugs used to treat cancer or the combination of these drugs into a standardized treatment regimen . (wikidoc.org)
  • Cisplatin is a platinum-containing compound that exerts an antineoplastic effect by covalently binding to DNA, with preferential binding to N-7 position of guanine and adenosine. (medscape.com)
  • An antineoplastic compound which also has antimetabolite action. (lookformedical.com)
  • Oncozar belongs to a class of drugs called Antineoplastics, Antimetabolite. (acteropharma.com)
  • A factor that reduces or interferes with the mutagenic actions or effects of a substance. (theodora.com)
  • Monoclonal antibodies are laboratory-produced proteins that target specific antigens on the cancer cell's surface to interfere with the cell's function and destroy it. (lls.org)
  • Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (lookformedical.com)
  • When the cancer cell uses an antimetabolite instead of the natural substances, it can't produce normal DNA or RNA and the cell dies. (lls.org)
  • It is thought to work by changing the way the cell turns genes on and off and also by interfering with the production of new RNA and DNA. (europa.eu)