Intercellular adhesion cell adhesion molecules. Medical search. Frequent questions

We show here that the interactions between DV E protein, the sole mannosylated glycoprotein present on DV particles, and the C-type lectin dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) are essential for DV infection of DCs. (unboundmedicine.com)
Antibodies against immune-checkpoint molecules such as PD-1, PD-L1, and CTL connected protein-4 activate CTL against cancers by stopping the inhibitory signal of CD8+ T cells. (translateinthetownships.com)
Both chlordecone and E2 activated splenic B cells and enhanced GC reactions, as shown by upregulated protein expression of GL7, CXCR5, and CXCR4. (nih.gov)
Both treatments increased B-cell bcl-2 and shp-1 gene expression and enhanced ICAM-1 and VCAM-1 protein levels in GC B cells. (nih.gov)
Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)
P-selectin, soluble endothelial protein C receptor, soluble thrombomodulin, plasminogen activator inhibitor 1, ADAMTS-13, von Willebrand factor, tissue factor, soluble intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 were more elevated in LF patients than in controls. (cdc.gov)
Endothelial protein C receptor, thrombomodulin, intercellular adhesion molecule 1, plasminogen activator inhibitor 1, D-dimer, and hepatocyte growth factor were higher in fatal than nonfatal LF cases. (cdc.gov)
We assessed inflammation using levels of high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL-6), fibrinogen, white blood cells, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 (ICAM-1). (nih.gov)
Their regulation may be carried out either through direct binding to DNA as peroxisome proliferator-activated receptors or via modulation in an indirect manner of signaling pathway molecules (e.g., protein kinase C) and other transcription factors (nuclear factor kappa B and sterol regulatory element binding protein). (springer.com)
The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. (mcw.edu)
The protein intercellular adhesion molecule 3 (ICAM-3) functions as a receptor for LFA-1 (leukocyte function-associated antigen-1) and mediates adhesive interactions of leukocyte cell surface adhesion molecules in inflammatory and immune response. (sigmaaldrich.com)
Also known as the S protein, covid jab spike proteins do a whole lot more harm than just bind to the body's ACE (angiotensin-converting enzyme) receptors, allowing the virus to invade cells. (newstarget.com)
The aim of the present study was to identify whether P. gingivalis heat‑shock protein 60 (HSP60) induced the dysfunction of human umbilical vein endothelial cells (HUVECs) in vitro. (spandidos-publications.com)

NF-κB pathways are associated with immunity, inflammation and cell survival. (springer.com)
The present study aimed to investigate the effects of S/V on the expression of metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1), inflammation and apoptosis in human umbilical vein endothelial cells (HUVECs) induced by oxidized low‑density lipoprotein (ox‑LDL) and to elucidate its possible mechanism. (spandidos-publications.com)
Vascular endothelial cells serve a key role in the pathogenesis of atherosclerosis by regulating vascular tension, platelet adhesion, inflammation and fibrinolysis ( 5 ). (spandidos-publications.com)
Effective clearance of inflammatory cells is required for resolution of inflammation. (koreamed.org)
The salivary scavenger and agglutinin (SALSA), also known as gp340 and dmbt1, is an antimicrobial and inflammation-regulating molecule located at the mucosal surfaces. (researchgate.net)
Likewise, dexamethasone can reduce cerebral cell apoptosis and inhibit inflammation [ 10 ,] and deferoxamine (DFX) provides new therapy target [ 11 ]. (karger.com)
As the inflammation continues to destroy more of these bile ducts, it spreads to destroy nearby liver cells (hepatocytes). (emedicinehealth.com)
The combined effects of progressive inflammation, scarring, and toxicity of bile trapped within hepatocytes (liver cells) culminate in cirrhosis. (emedicinehealth.com)
During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. (cdc.gov)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)

These results suggest that, as channel modulators, β subunits play important roles in control of electrical signaling and, as CAMs, β subunits act as critical communication links between extracellular and intracellular signaling molecules. (jneurosci.org)
OBJECTIVE: This study aimed to determine whether simultaneous decreases in the serum levels of cell adhesion molecules (intracellular cell adhesion molecule-1 [ICAM-1], vascular cell adhesion molecule-1 [VCAM-1], and E-selectin) and. (koreamed.org)
Spike proteins also cause cells in the small intestine to stimulate large amounts of L-SIGN (liver / lymph node-specific intracellular adhesion molecules-3 grabbing non-integrin) receptors, which defend against pathogens. (newstarget.com)
multicellular interactions, including intracellular and Addresses intercellular biochemical signaling. (lu.se)

A nitric oxide (NO) detection kit was used to determine the concentration of NO. Western blotting analysis was performed to determine the levels of intercellular cell adhesion molecule (ICAM)‑1, vascular cell adhesion molecule (VCAM)‑1, endothelin‑1, caspase‑3, Bax, Bcl‑2, Toll‑like receptor 4 (TLR4), p65 and p‑p65. (spandidos-publications.com)
The expression of CSF-1R, a receptor important for myeloid cell migration, differentiation and survival, and the effect of its therapeutic blockade in the context of GVAX in PDAC has not been investigated. (bmj.com)

Certain studies show that P. gingivalis lipopolysaccharide (LPS) could induce the expression of intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 in human umbilical vein endothelial cells (HUVECs) ( 13 , 14 ), which significantly enhances trans-endothelial migration of inflammatory cells. (spandidos-publications.com)

MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)
The AF form of SALSA had a more intact structure and contained peptides from the zona pellucida domain, which is involved in cell differentiation and oligomerization. (researchgate.net)
Such information is mediated immunity, secreting the cytokine crucial to determine the optimal approach interferon-gamma (IFN) that inhibits Th2 to improve the immune response of DN cell differentiation. (who.int)
As representative JAK inhibitors, tofacitinib or ruxolitinib were added during Tck cell differentiation. (bvsalud.org)
Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)

The genesis of an inappropriate oxidative burst by the neutrophil upon exposure to endothelial chemoattractants and adhesion molecules was also measured. (bl.uk)
When neutrophils were exposed to both hypoxic/reoxygenated endothelial cells and the soluble factor (s) released by them a large oxidative burst was elicited. (bl.uk)
Oxidative stress biomarkers and cellular adhesion molecules might be particularly useful as these are elevated in OSA patients and in patients with CVD. (ubc.ca)
Evaluate the association between cellular adhesion molecules, oxidative stress markers and OSA (Chapters 3-4).3. (ubc.ca)
Evaluate whether levels of cellular adhesion molecules and oxidative stress markers predict incident CV events in an OSA-cohort (Chapter 5-6).4. (ubc.ca)

The HVJ-E stimulates dendritic cells to generate cytokines and chemokines such as b-interferon, interleukin-6, chemokine (C-C motif) ligand five, and chemokine (C-X-C motif) ligand 10, which activate each CD8+ T cells and organic killer (NK) cells and Coccidia Formulation recruit them to the tumor microenvironment. (translateinthetownships.com)
Active b-catenin signaling in melanoma prevents chemokine CCL4 production, which final results in the inhibition of dendritic cell infiltration and su. (translateinthetownships.com)

Other trophic factors, such as IL-2, TNF-α, and granulocyte-macrophage stimulating factor, cause activated T cells to produce interferon-γ, TNF-α, and TNF-β, leading to stimulation of macrophages and further up-regulation of leukocyte adhesion molecules. (medscape.com)
Leukocyte adhesion deficiency type I is caused by a mutation in the common chain of the β2 integrin family CD18. (lu.se)

Mammalian intercellular adhesion molecules include: ICAM-1 ICAM2 ICAM3 ICAM4 ICAM5 Gahmberg CG, Tolvanen M, Kotovuori P (April 1997). (wikipedia.org)
Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm. (springer.com)

In this study, we discovered that HVJ-E induced the production of intercellular adhesion molecule-1 (ICAM-1, CD54), a ligand of lymphocyte functionassociated antigen 1, in a number of cancer cell lines via the activation of nuclear factor-jB downstream of retinoic acid-inducible gene I as well as the mitochondrial antiviral signaling pathway. (translateinthetownships.com)

The expression of biomarkers can be detected intracellularly or on the cell membrane of melanoma cells or noncancer cells in association with the melanoma. (hindawi.com)
The purpose of this review is to provide a latest summary of biomarkers associated with endothelial cell activation in COVID-19 and offer mechanistic insights into the molecular basis of endothelial activation/dysfunction in macro- and micro-vasculature of COVID-19 patients. (nature.com)
The studies focus on the effects of omega-3 on levels of inflammatory biomarkers that are involved in damage to cells called soluble adhesion molecules, particularly soluble intercellular adhesion molecule-1 (sICAM-1). (nutraingredients.com)

Chlordecone reduced total B cell and GC B-cell apoptosis without affecting proliferation, another feature shared by E2 treatment. (nih.gov)
Similarities in the effects of chlordecone and E2 on specific immune functions, such as diminished apoptosis in GC B cells, may provide valuable clues regarding key events in the acceleration of autoimmunity by E2, chlordecone, and other agents. (nih.gov)
Animal experiments demonstrated that fingolimod could reduce edema, cell apoptosis and cerebra atrophy and show neuroprotective function in ICH rats [ 8 ]. (karger.com)

In the natural infection, DV is introduced into human skin by an infected mosquito vector where it is believed to target immature dendritic cells (DCs) and Langerhans cells (LCs). (unboundmedicine.com)
Dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) and Langerin are C-type lectins of dendritic cells (DCs) that share a specificity for mannose and are involved in pathogen recognition. (uea.ac.uk)
Dendritic cells (DC), present in the skin, are the first target cells of dengue virus (DENV). (unboundmedicine.com)
0.05), but not mature dendritic cells ( p = 0.132). (bmj.com)

In addition, HVJ-E suppressed tumor development in MDA-MB-231 tumor-bearing SCID mice, and also the HVJ-E antitumor impact was impaired when NK cells were depleted by treatment with all the anti-asialo GM1 antibody. (translateinthetownships.com)
The term pemphigus refers to a group of autoimmune blistering diseases of the skin and mucous membranes characterized histologically by intraepidermal blister and immunopathologically by the finding of in vivo bound and circulating immunoglobulin G (IgG) antibody directed against the cell surface of keratinocytes. (medscape.com)

Pathogen-associated molecular patterns released by infecting organisms not only bind immune receptors on inflammatory cells but also bind receptors on cells in the heart ( 8 ). (frontiersin.org)
These conserved families of secreted morphogens/signals, such as Fibroblast Growth Factor (FGF), Hedgehog (Hh), Wingless (Wg)/Wnt, Epidermal Growth Factor (EGF), and Decapentaplegic (Dpp - a BMP homolog), act away from their sources and, upon binding to receptors, activate gene regulatory pathways to induce functions in recipient cells 1 , 2 . (biorxiv.org)
A 2021 paper published in the bioRxiv preprint repository found that spike proteins cause the Type 1 catalytic receptors in the kidneys to increase in kidney cell tissue, making the kidneys more susceptible to the Fauci Flu. (newstarget.com)
Similarly, spike proteins trigger an increase in DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) receptors in the lungs, which can trigger inflammatory symptoms in the lungs. (newstarget.com)

ROS generation in turn caused the release of a soluble factor (s) which induced a conformational change on the neutrophil surface allowing it to bind to the intercellular adhesion molecule 1 (ICAM-1) on the endothelial cell. (bl.uk)
Neutrophils are unable to aggregate and do not bind to intercellular adhesion molecules on endhothelial cells. (lu.se)
It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. (bvsalud.org)

Intercellular adhesion molecule 1 (ICAM-1), interleukin (IL)-8, and IL-6 levels in the supernatant of VSMCs were measured with enzyme-linked immunosorbent assay 0 and 24 h after grouping. (geneticsmr.com)

The bile ducts carry bile, a fluid that is produced by the liver cells (hepatocytes) and modified by the biliary lining (epithelial) cells as it flows through the ducts to the small intestine. (emedicinehealth.com)

Flow cytometry was conducted to detect the apoptotic rate of cells. (spandidos-publications.com)
Flow cytometry analysis of tumor infiltrating T-cells in a murine model of PDAC was performed to investigate the therapeutic effects and mechanism of anti-CSF-1R/anti-PD-1/GVAX combination immunotherapy. (bmj.com)
Flow cytometry was utilized to analyze the composition of immune cells of mouse BALF samples on day 5 after infection. (bvsalud.org)

LFA-1 participates in several processes, such as T cell-mediated killing, T helper and B lymphocyte responses, natural killing, Ab-dependent cellular cytotoxicity by monocytes and granulocytes, and adherence of leukocytes to endothelial cells, fibroblasts, and epithelial cells. (sigmaaldrich.com)
It may also function in lymphocyte activation, as well as in adhesion. (sigmaaldrich.com)
The autoimmune nature of diabetes and inflammatory cytokine IL-10 (as markers the major contribution of lymphocyte T- of inflammatory changes) and the soluble cells are well established. (who.int)

In molecular biology, intercellular adhesion molecules (ICAMs) and vascular cell adhesion molecule-1 (VCAM-1) are part of the immunoglobulin superfamily. (wikipedia.org)

The problem with this is that after a large number of adhesions occur, the small intestine becomes more susceptible to viral infection. (newstarget.com)

The activation state of different PMN preparations was measured by immunofluorescence staining of the adhesion glycoproteins Mac-1 and L-selectin. (aspetjournals.org)

BACKGROUND/AIMS: Nucleotide-binding oligomerization domain 1 (NOD1) is required for primary intestinal epithelial cells (IECs) to respond to natural mucopeptides secreted by gram-negative bacteria. (koreamed.org)

However, the poor sensitivity and specificity of those markers and many other molecules are serious limitations for their routine use in both early (AJCC stage I and II) and advanced stages of melanoma (AJCC stage III and IV). (hindawi.com)
Therefore, we hypothesized that CRC cancer stem cell markers (CRCSC) will identify a group of patients at high risk for progression. (jcancer.org)
Inflammatory markers neopterin and soluble intercellular adhesion molecule (sICAM-1) appeared to be clinically useful for isolated assessments of disease activity. (who.int)
Cellular adhesion molecules such as ICAM-1 and E-selectin were associated with incident CV events and might be promising markers in CV disease prediction in OSA. (ubc.ca)

The aim of this study was to investigate the influence of activated endothelial cells on the proliferation and secretion of vas-cular smooth muscle cells (VSMCs). (geneticsmr.com)
TNF-α-activated endothelial cells promote VSMC proliferation and secretion of ICAM-1 and IL-8 by elevating IL-6 release. (geneticsmr.com)
Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)
Mouse macrophage cell line RAW264.7 was planted and treated by different concentrations of RDN(150, 300, 600 µg·mL~(-1)) for 24 h or 48 h, and cell proliferation was detected by CCK-8 assay. (bvsalud.org)

In the case of melanoma, circulating cells may find a suitable microenvironment in the first draining lymph node, known as the sentinel lymph node, in other lymphnodes or in distant organs, leading to secondary tumor growth (Figure 1 ). (hindawi.com)

The gene ICAM3 (intercellular adhesion molecule 3) encodes type I membrane glycoprotein that belongs to the immunoglobulin (ig) superfamily. (sigmaaldrich.com)

HVJ) envelope (HVJ-E) has numerous anticancer effects, such as induction of cancer-selective cell death and activation of anticancer immunity. (translateinthetownships.com)

In addition, ICAMs may exist in soluble forms in human plasma, due to activation and proteolysis mechanisms at cell surfaces. (wikipedia.org)
It is mediated by circulating autoantibodies directed against keratinocyte cell surfaces. (medscape.com)
Pemphigus vulgaris is an autoimmune, intraepithelial, blistering disease affecting the skin and mucous membranes and is mediated by circulating autoantibodies directed against keratinocyte cell surfaces. (medscape.com)
FGF-source and recipient ASP cells extend cytonemes that present FGF and FGFR on their surfaces and reciprocally recognize each other over distance by contacting through CAM-like FGF-FGFR binding. (biorxiv.org)
molecule located at the mucosal surfaces. (researchgate.net)

Cancer stem cells are thought to be responsible for tumor initiation, dissemination and treatment failure. (jcancer.org)

β1 also recruits ankyrin to the plasma membrane at sites of cell-cell contact in response to homophilic cell adhesion (Malhotra et al. (jneurosci.org)
Subsequent un-anchoring of FGFR-bound-FGF from the source cell membrane dissociates cytoneme contacts and delivers FGF target-specifically to ASP cytonemes for paracrine functions. (biorxiv.org)

BACKGROUND: Endothelial adhesion molecule expression induced by pro-inflammatory cytokine plays an important role in vascular endothelial cell injury, leading to vascular disease. (koreamed.org)
In this study, we investigated the effect of JAK inhibitors on the generation of cytokine-activated T (Tck) cells and the production of cytokines and chemokines induced by Tck cell/macrophage interactions. (bvsalud.org)

Similarly removal of ROS by superoxide dismutase or catalase also attenuated adhesion. (bl.uk)
Plasma levels of 8-isoprostane, 8-hydroxydeoxyguanosine (8-OHdG), superoxide dismutase (SOD), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and E-selectin (endothelial selectin) were assessed. (ubc.ca)

Intercellular adhesion molecule 5, which binds to and activates integrins, may be a direct target of perisynaptic MMP proteolysis during LTP. (nature.com)
Here, we show that FGF is Glycosylphosphatidylinositol-anchored to the producing cell surface and that this modification both inhibits free FGF secretion and activates target-specific bidirectional FGF-FGFR signaling through cytonemes. (biorxiv.org)
It activates endothelial cells and stimulates nitric oxide release. (escardio.org)

Knocking out expression of ICAM-1 in MDA-MB-231 cells applying the CRISPR/Cas9 process ACAT1 web considerably decreased the killing impact of NK cells on ICAM-1-depleted MDA-MB-231 cells. (translateinthetownships.com)
Our findings recommend that HVJ-E enhances NK cell sensitivity against cancer cells by escalating ICAM-1 expression on the cancer cell surface.Cancer is a leading cause of death worldwide, and its prevalence is increasing because of aging and life style alterations. (translateinthetownships.com)
Compared with the ox‑LDL group, S/V treatment significantly increased the cell viability, NO concentration and Bcl‑2 expression, decreased the levels of IL‑1β, IL‑6 and TNF‑α and reduced the expressions of MALAT1, ICAM‑1, VCAM‑1, cleaved‑caspase‑3, Bax, TLR4 and p‑p65. (spandidos-publications.com)
Previous studies have shown that the expression of MALAT1 is increased in endothelial cells induced by ox-LDL and its expression level can reflect the damage degree of endothelial cells ( 11 , 12 ). (spandidos-publications.com)
Sodium channel β1 subunits modulate α subunit gating and cell surface expression and participate in cell adhesive interactions in vitro . (jneurosci.org)
β1 subunits affect sodium channel gating and cell surface expression when expressed in heterologous cells in vitro . (jneurosci.org)
However, the effects of β1 are highly dependent on the experimental system in which they are studied, and different effects on the kinetics and voltage dependence of gating of brain sodium channels are observed on expression in Xenopus oocytes, Chinese hamster lung and ovary cells, and human embryonic kidney cells (Isom et al. (jneurosci.org)
These results suggest that effects of β1 on sodium channel gating are dependent on the genetic background and signal transduction pathways present in the cell type used in heterologous expression and emphasize the importance of analyzing the effects of β1 in vivo . (jneurosci.org)

Strikingly, each signal and signaling pathway can generate a wide range of cell types and organizations in diverse contexts 3 . (biorxiv.org)

Analysis of the supernatant from hypoxic/reoxygenated endothelial cell cultures and studies using inhibitors of secretion suggested platelet activating factor (PAF) may be a major component in this overall sequence of events. (bl.uk)

At the onset of atherosclerosis, LDL is deposited on vascular endothelial cells to be oxidized to form ox-LDL, which is then absorbed by macrophages to form foam cells. (spandidos-publications.com)

Diabetic nephropathy (DN) is a leading selectin), and soluble thrombomodulin--are cause of chronic renal failure and is a grow- providing further evidence of the relation- ing concern given the increasing incidence ship between endothelial cell activation and of type 2 diabetes. (who.int)

During development, intercellular communication of morphogens is critical for embryonic cells to determine their positional identity, directionality, and interactions in an organized pattern to sculpt tissue. (biorxiv.org)
Understanding how signals might inform cells of their positional identity, directionality, and interactions and organize these functions in diverse tissue-specific patterns is critical to understanding morphogenesis. (biorxiv.org)
interactions between cells. (lu.se)

Pathologic changes seen on autopsy lack major cell and tissue injury but include signs of pleural effusion, pulmonary edema, ascites, and gastrointestinal mucosa bleeding ( 5 , 6 ), all indications of systemic vascular leakage. (cdc.gov)

These macrophages, in addition to smooth muscle cells, activate T cells by presenting antigens, including oxidized LDL. (medscape.com)
Previously validated protocols were used to generate macrophages and Tck cells from monocytes and CD4+ T cells, respectively. (bvsalud.org)
RAW264.7 cells and mouse primary peritoneal macrophages were stimulated with synthetic single stranded RNA(R837), which elicited the inflammatory response by mimicking the infection of single-stranded RNA viruses. (bvsalud.org)

However, chlordecone treatment did not alter the composition of splenic B-cell subsets in marked contrast to the decrease in transitional B cells and increase in marginal zone B cells seen in E2-treated mice. (nih.gov)
T-cells have 2 subsets of betic patients with and without nephropathy. (who.int)
OBJECTIVES: Macrophage subsets, activated by T cells, are increasingly recognised to play a central role in rheumatoid arthritis (RA) pathogenesis. (bvsalud.org)

found evidence and they did not require insulin therapy of endothelial cell injury in renal failure for glucose control. (who.int)

Se localiza en la membrana basal de la lámina lúcida y funciona uniendo las células epiteliales a las membranas basales. (bvsalud.org)
risk of basal and squamous cell skin cancer. (who.int)

PURPOSE: This study aimed to investigate the effect of adipose-derived stem cell (ADSC) transplantation on atherosclerosis (AS) and its underlying mechanisms. (koreamed.org)
peptide 14 or 19 from P. gingivalis HSP60 may have either an anti- or pro-atherogenic role, respectively, in the ApoE(−/-) mouse model of infection-triggered atherosclerosis through distinct mechanisms operating in the polarization of T cells. (spandidos-publications.com)
of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)

These findings bring along a paradox - not only do signals instruct cells and organize discrete cellular patterns, but cells also control the patterns of signal presentation and reception by organizing the distribution of cytonemes and cytoneme contacts 6 , 9 . (biorxiv.org)

Remarkably, the potency of the CBAs against DENV in MDDC cultures was significantly higher (up to 100-fold) than in Raji/DC-SIGN(+) cells. (unboundmedicine.com)
Neutrophil adhesion to ECV304 cells, which had been hypoxic for 4 hours and then reoxygenated for 30 minutes, was significantly increased. (bl.uk)

Glycomimetic molecules targeting DC-SIGN have been reported as promising agents for the inhibition of viral infections and for the modulation of immune responses mediated by DC-SIGN. (uea.ac.uk)

SARS-CoV-2 infection alters the balance of endothelial protective molecules and endothelial damaging molecules, leading to endothelial dysfunction. (nature.com)
Th2 cells produce cy- patients which might reduce the morbidity tokine interleukins IL-4 and IL-10, which and mortality due to infection. (who.int)
What's more, RDN restored the depletion of T cells, which might prevent secondary infection and deteriorative progression of the disease. (bvsalud.org)

They also inhibit the pulmonary cell mitochondria, which is where energy is produced. (newstarget.com)

Background: T-cell activation is associated with an adverse outcome in COVID-19, but whether T-cell activation and exhaustion relate to persistent respiratory dysfunction and death is unknown. (uib.no)
In the brain, they have well-described roles in slowly emerging, but long-lasting pathophysiological processes of cell loss and synaptic dysfunction associated with acute injury, ischaemia, neurodegeneration and demyelination. (nature.com)
Therefore, the study of ox-LDL-mediated endothelial cell dysfunction can further clarify the pathogenesis of atherosclerosis and provide a more theoretical basis for the treatment and prevention of atherosclerosis. (spandidos-publications.com)
A number of viral species, such as dengue, ebola and cytomegalovirus can infect endothelial cells (ECs) and cause endothelial dysfunction [ 5 ]. (nature.com)

Thus, GPI-anchored FGF organizes both source and recipient cells and self-regulates its cytoneme-mediated tissue-specific dispersion and signaling. (biorxiv.org)
The discrete tissue-specific organization of morphogen signaling is known to be dependent on the ability of signal-receiving cells to selectively sense and respond to a specific signal 3 . (biorxiv.org)
It has been hypothesized that this fibrin cuff serves as a barrier to oxygen diffusion, with resulting tissue hypoxia and cell damage. (medscape.com)
Finally to appraise how tissue function might be affected by endothelial cell hypoxia the contractility of vascular smooth muscle was examined. (bl.uk)

Anatomy44

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Phenomena and Processes50

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