• ULK1/2 kinase complex (e.g. (fn-test.com)
  • ULK1/2 kinase complex may play a role in the extension of phagocyte. (fn-test.com)
  • The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. (bioss.com.cn)
  • Macroautophagy is regulated by numerous cellular factors, including the Class III PI3K (phosphoinositide 3-kinase) Vps34 (vacuolar protein sorting 34). (nih.gov)
  • The expression of HMGB1, c-Jun N-terminal kinase (JNK), extracellular-signal-regulated kinase (ERK), and p38 mitogen-activated protein kinase (p38 MAPK) was assessed with immunofluorescence and western blot analysis. (molvis.org)
  • In addition, they play important roles in gene transcription (via activation of mitogen activated protein (MAP) kinase pathways and, in higher eukaryotes, the transcription factor NFκB), generation of reactive oxygen species, apoptosis, and cell-cycle progression. (biomedcentral.com)
  • An example of highly conserved signaling pathways in eukaryotes are the mitogen-activated protein kinase (MAPK) pathways. (ku.edu)
  • It interacts directly with MTOR to enhance its kinase activity and stabilizes the MTOR-RPTOR PROTEIN interaction in nutrient-poor conditions, favoring RPTOR inhibition of MTOR activity. (bvsalud.org)
  • The signaling complex which is composed of a transmembrane receptor, histidine protein kinase CheA and adaptor protein CheW plays an important role in chemotaxis signaling pathway. (ucsb.edu)
  • Previously, research showed that CheA interacts with a transmembrane receptor, but how CheA and receptor interact with each other and activate kinase activity are unknown. (ucsb.edu)
  • Neks, mammalian orthologs of the fungal protein kinase never-in-mitosis A, have been implicated in the pathogenesis of polycystic kidney disease. (biomedcentral.com)
  • These VIPs, including transmembrane serine protease 2 (TMPRSS2), receptor-interacting serine/threonine-protein kinase 1 (RIPK1), FYVE and coiled-coil domain autophagy adaptor 1 (FYCO1), zinc finger protein 318 (ZNF318), and the prim-pol primase complex, most likely contributed to SARS-CoV pathogenicity in different mammalian hosts. (trendfool.com)
  • The ArfGAP paxillin kinase linker (PKL)/G protein-coupled receptor kinase-interacting protein (GIT)2 continues to be implicated in regulating cell spreading and motility through its transient recruitment of the p21-activated kinase (PAK) to focal adhesions. (healthyguide.info)
  • In the present study we identify the focal adhesion-associated proteins p130Cas, Pyk2, and paxillin as novel members of the tyrosine kinase signaling pathway downstream of CD36 and show that assembly of this complex is essential for microglial migration. (neuroprobe.com)
  • Fyn, a Src kinase known to interact with CD36, co-precipitates with p130Cas and is an essential upstream intermediate in the signaling pathways leading to phosphorylation of the p130Cas substrate domain. (neuroprobe.com)
  • Furthermore, the p130Cas-interacting kinase Pyk2 and the cytoskeletal adapter protein paxillin also demonstrate CD36-dependent phosphorylation, identifying these focal adhesion molecules as additional members of this β-amyloid signaling cascade. (neuroprobe.com)
  • Disruption of this p130Cas complex by small interfering RNA silencing inhibits p44/42 mitogen-activated protein kinase phosphorylation and microglial migration, illustrating the importance of this pathway in microglial activation and recruitment. (neuroprobe.com)
  • AP2A2 has direct interactions with proteins and molecules. (creativebiomart.net)
  • We selected proteins and molecules interacted with AP2A2 here. (creativebiomart.net)
  • Like its counterparts in Drosophila, TLRs signal through adaptor molecules. (novusbio.com)
  • Glycation, the result of a protein or lipid molecule bonding with sugar molecules, is a consequence of the aging process. (molvis.org)
  • Rho GTPase effectors are a large group of proteins and include actin nucleation promoting molecules, adaptors, as well as kinases. (biomedcentral.com)
  • I joined the department of Molecular Biology as Scientist in 1989, and my lab helped establish a technology to fuse biologically important proteins to antibody molecules. (gene.com)
  • MW) chemicals interact with host cells and molecules and In our daily life, we are confronted with a plethora of natural influence biologic processes such as signal transduction. (cdc.gov)
  • Interestingly, it also acts as an adaptor in complexes that mediate autophagy of aggregated proteins. (unil.ch)
  • ULK1, ULK2, ATG13 and RB1CC1) is required for autophagy initiation as well, and also positively regulates Beclin 1 complex by promoting the release of Beclin 1 complex from microtubules. (fn-test.com)
  • During mitochondrial autophagy, LC3-II binds with mitochondrion by BNIP3L adaptor protein. (fn-test.com)
  • Thus NRBF2 plays a critical role in the induction of starvation-induced autophagy as a specific member of Vps34 Complex I. (nih.gov)
  • This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. (utsouthwestern.edu)
  • The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. (utsouthwestern.edu)
  • The protein is thought to be involved in clathrin-mediated endocytosis. (utsouthwestern.edu)
  • Estrogen Effects on Actin Cytoskeletal and Endocytic Proteins Associated With Tubulobulbar Complex Disruption in Rat Testes. (creativebiomart.net)
  • A thesis is proposed here, based on rational argument that depletion of the cytoskeletal organizer protein shank3 may result in defective nNOS membrane localization, resulting in defective nitric oxide synthesis. (frontiersin.org)
  • Interactions between adaptor proteins such as ankyrins and cytoskeletal proteins such as obscurin play a pivotal role in organizing these functional domains in cardiomyocytes. (tmc.edu)
  • In mammalian cells, as many as twenty types of protein have been reported to bind to activated Cdc42 [ 2 ]. (biomedcentral.com)
  • 25208} 4EGI-1 prevents the expression of oncogenic proteins in mammalian cancer cells, leading to apoptosis. (bertin-bioreagent.com)
  • In fact, few SNARE proteins are known to interact with ion channels, notably mammalian Syntaxin 1A, which binds several different Ca2+ and K+ channels in nerves. (unisalento.it)
  • mATG9 mainly exits in Golgi network as a transmembrane protein and briefly interacts with phagocyte in a ulk1 dependent manner. (fn-test.com)
  • The Toll-like receptor (TLR) family in mammals comprises a set of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain, and in the IL-1 receptor motif in the cytoplasmic domain. (novusbio.com)
  • For membrane proteins, a third mechanism, based on the interaction of their transmembrane domain (TMD) with lipid microdomains, must also be considered. (biologists.com)
  • A PPI network provides crucial information on how biological pathways are structured and coordinated from individual protein functions. (nature.com)
  • PPIs are essential for individual protein functions, forming various cellular pathways, and are also involved in the development of diseases. (nature.com)
  • an adapter protein coupling the receptor to downstream signaling pathways. (bioss.com.cn)
  • In order for eukaryotes to efficiently detect and respond to environmental stimuli, a myriad of protein signaling pathways are utilized. (ku.edu)
  • The AAA-ATPase (ATPases associated with diverse cellular activities) valosin-containing protein (VCP), is essential for many cellular pathways including but not limited to endoplasmic reticulum-associated degradation (ERAD), DNA damage responses, and cell cycle regulation. (portlandpress.com)
  • VCP primarily identifies ubiquitylated proteins in these pathways and mediates their unfolding and degradation by the 26S proteasome. (portlandpress.com)
  • Valosin-containing protein (VCP, also p97, or Cdc48p in yeast) is an evolutionarily conserved, homo-hexameric, ubiquitin-selective, AAA-ATPase that functions in numerous ubiquitin-dependent protein quality control pathways. (portlandpress.com)
  • The encoded protein belongs to the adaptor complexes medium subunits family. (wikipedia.org)
  • The activity of CDKs is controlled by their binding to coactivator subunits termed Cyclins, as well as by CDK inhibitory proteins termed CKIs. (intechopen.com)
  • SCF ligases have four subunits: SKP1, CUL1, RBX1, and an F-box protein for substrate recognition. (1library.net)
  • The substrate recognition subunits of the SCF are the adaptor SKP1-like protein (ASK1 in plants) and a substrate binding F-box protein (reviewed in Cardozoand Pagano 2004). (1library.net)
  • In eukaryotes, a set of initiation factors (eIFs) interact with ribosomal subunits to initiate mRNA translation. (bertin-bioreagent.com)
  • Generation of the subunits requires association with the death-inducing signaling complex (disc), whereas additional processing is likely due to the autocatalytic activity of the activated protease. (lu.se)
  • The coat on the budding vesicle comprises two layers, an inner layer of adaptor proteins (gray ovals) and an outer layer that forms a polyhedral cage. (biologists.com)
  • The impaired function of specific organelles indicates that the causative genes encode protein complexes that regulate vesicle trafficking in the endolysosomal system including AP-3, BLOC-1, BLOC-2, and BLOC-3. (medscape.com)
  • HPS-2 is caused by a mutation in the gene encoding the beta-3A subunit of the heterotetrameric AP3 complex ( AP3BA ), which assists in the vesicle formation from the trans-Golgi network or late endosome. (medscape.com)
  • MAIGO5 functions in protein export from Golgi-associated endoplasmic reticulum exit sites in Arabidopsis . (bio-protocol.org)
  • Secretory proteins exit the endoplasmic reticulum (ER) in coat protein complex II (COPII)-coated vesicles and then progress through the Golgi complex before delivery to their final destination. (biologists.com)
  • Isoform 9 interacts at the endoplasmic reticulum with a complex containing bcap31, bap29, bcl2 and/or bcl2l1. (lu.se)
  • These proteins are involved in signal transduction from ectoderm to mesenchyme during development of the fetus and are indispensable for the differentiation of ectoderm-derived structures such as eccrine sweat glands, teeth, hair, skin, and/or nails. (springer.com)
  • Within the last 10 years significant progress has been made in understanding the pathogenesis of HED and this is mainly due to the discovery of unknown proteins and the elucidation of their function in signal transduction via the TNFα-related pathway. (springer.com)
  • SH2 domain-containing transforming protein C1 (SHC1), also known as SHCA, is a cytoplasmic adaptor protein that is important in the signal transduction from growth factor, cytokine, and lymphocyte antigen receptors. (rndsystems.com)
  • LC3-II binds with substrates to perform autophagic degradation by different adaptor proteins. (fn-test.com)
  • VCP interacts with adaptor proteins to identify ubiquitylated substrates for degradation by the proteasome. (portlandpress.com)
  • Many aspects of plant biology depend on the ubiquitin proteasome system for degradation of regulatory proteins. (1library.net)
  • Here, we report characterization of a mutant isolated from a genetic screen in Arabidopsis thalianadesigned to identify plants defective in degradation of an Aux/IAA fusion protein, Aux/IAA1-luciferase (IAA1-LUC). (1library.net)
  • Thecul1-7mutation affects the C terminus of the protein, results in reduced cul1-7 levels, and interferes with RBX1 interaction.cul1-7seedlings are defective in degradation of an endogenous SCF substrate, Repressor ofga1-3(RGA), and have altered responses to gibberellins.cul1-7seedlings exhibit slower degradation of the light-labile red/far-red photoreceptor phytochrome A and are photomorpho-genic in the dark. (1library.net)
  • Casitas B-lineage lymphoma (Cbl)-interacting protein of 85 kDa (CIN85) is an adaptor protein, originally identified as a Cbl-binding protein, and was suggested to be involved in the internalization and degradation of receptors and kinases. (usm.my)
  • EGFR is a cell surface protein that binds to epidermal growth factor. (bioss.com.cn)
  • Of them, SARS-CoV-2 S protein binds to its cellular receptor, angiotensin-converting enzyme 2 (ACE2) [ 8 , 9 ], to enter the cells. (ijbs.com)
  • Ubiquitin is ultimately transferred to a lysyl residue within a substrate protein or to one or more lysyl residues of a previously attached ubiquitin, forming a polyubiquitin chain. (1library.net)
  • NO regulates the function of many proteins by e.g. interacting with tyrosine and cysteine residues, thus inducing post-translational modifications. (helsinki.fi)
  • Typically Rho proteins are 190-250 residues long and consist only of the GTPase domain and short terminal C-terminal extensions. (biomedcentral.com)
  • This suggests that endocytosis and trafficking of membrane proteins may be involved, generating new insights into possible mechanisms of resistance. (gla.ac.uk)
  • For example, shank proteins are located further away from the membrane in the cytosolic faces of the PSDs, facing the actin cytoskeleton. (frontiersin.org)
  • The rationale of this organization may be related to important roles of these proteins as "exchange hubs" for the signaling proteins for their migration from the subcortical cytosol to the membrane. (frontiersin.org)
  • In this review, the hypothesis is forwarded that nNOS delivered to subcortical cytoskeleton requires interactions with scaffolding proteins prior to docking at the membrane. (frontiersin.org)
  • CONTINUOUS VASCULAR RING (COV1) is a trans-Golgi network-localized membrane protein required for Golgi morphology and vacuolar protein sorting. (bio-protocol.org)
  • Protein crowding induces membrane curvatures through an entropic mechanism. (portlandpress.com)
  • Crowding of asymmetric proteins results in an asymmetric lateral pressure across the membrane which can be used by cells in a number of biological processes involving membrane remodeling. (portlandpress.com)
  • In this Commentary, I review evidence in favor of the idea that partitioning of TMDs into bilayer domains that are endowed with distinct physico-chemical properties plays a pivotal role in the transport of membrane proteins within the early secretory pathway. (biologists.com)
  • The combination of such self-organizational phenomena with canonical intermolecular interactions is most likely to control the release of membrane proteins from the ER into the secretory pathway. (biologists.com)
  • This process depends on the general physico-chemical features of the cargo membrane protein and on the interactions of these features with the collective properties of the bilayer, instead of the one-to-one intermolecular interactions that exist between discrete signals and their receptors. (biologists.com)
  • Via hetero-oligomeric interactions, these proteins form highly stable protein-protein interactions, the so called SNARE-complex, that allow membrane fusion. (unisalento.it)
  • Stoichiometry of these proteins reveals that they are more abundant than required for membrane traffic. (unisalento.it)
  • 4) provided direct evidence that SYP121 is part of a scaffold of proteins associated, by direct interaction with channel KAT1, with the membrane transport of K+. (unisalento.it)
  • SARS-CoV-2 genome consists of 14 functional open reading frames (ORFs), including two regions (ORF1a and ORF1b) for 16 non-structural proteins (Nsp1-Nsp16), nine regions for nine putative accessory proteins, and other regions for four structural proteins, spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins [ 5 - 7 ]. (ijbs.com)
  • In primary microglia and macrophages exposed to β-amyloid, the scaffolding protein p130Cas is rapidly tyrosine-phosphorylated and co-localizes with CD36 to membrane ruffles contemporaneous with F-actin polymerization. (neuroprobe.com)
  • PI(3)P is produced by catalytic subunit hVps34 of Beclin 1 complex and required for recruitment of downstream autophagic components(e.g. (fn-test.com)
  • The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. (bioss.com.cn)
  • Although dozens of proteins act downstream of these GTPases, a comparison of effector proteins from evolutionarily diverse organisms suggests that six groups of proteins serve as the core machinery for signaling from Cdc42 and Rac. (biomedcentral.com)
  • RESULTS Identification of a 95-kDa Tyrosine Phosphorylated Nck-binding Protein The SH3-SH3-SH3-SH2 adaptor protein Nck is a major downstream mediator of extracellular matrix and growth element receptor signaling to the cytoskeleton through its ability to associate with receptor tyrosine kinases PAK and the WASP/WAVE complex (Buday and indicated like a Box-and-Whiskers Storyline (Number 10B). (healthyguide.info)
  • This locus, however, also encodes a protein from an alternative reading frame, designated p19ARF. (medscape.com)
  • Recent advances in understanding the molecular events underlying hypohidrotic ectodermal dysplasia (HED) caused by mutations of the genes encoding proteins of the tumor necrosis factor α (TNFα)-related signaling pathway have been presented. (springer.com)
  • Novel data were reviewed and discussed on the structure and functions of the components of TNFα-related signaling pathway, the consequences of mutations of the genes encoding these proteins, and the prospect for further investigations, which might elucidate the origin of HED. (springer.com)
  • Mutations of these genes are responsible for systemic tooth agenesis, in addition to the defects of other ectodermal structures, and this review is limited to description of the function of their protein products. (springer.com)
  • Functional analyses reveal that YAP1 positively regulates numerous genes related to cancer stemness and lipid metabolism and interacts with COUP-TFII to form a transcriptional complex. (nih.gov)
  • Activation of Shc1 by phosphorylation at Ser239, Ser240, and Tyr317 enables SHC1 to interact with the GRB2/SOS complex, leading to the transcription of genes involved in mitogenesis and apoptosis. (rndsystems.com)
  • In a recent study posted to the bioRxiv * pre-print server, researchers performed high-throughput evolutionary analyses of genes encoding 334 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral-interacting proteins (VIPs) of modern humans, primates, and bats, followed by comprehensive functional-genetic analyses of seven VIPs of interest. (trendfool.com)
  • Additional genes with mutations associated with pustular psoriasis include caspase-activating recruitment website member 14 (Cards14), adaptor protein complex 1 subunit sigma 3 (AP1S3), TNFAIP3-interacting protein 1 (TNIP1), and serpin family A member 3 (SERPINA 3) [16]. (kinasechem.com)
  • Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
  • The impaired function of specific organelles indicates that the causative genes encode proteins operative in the formation of lysosomes and vesicles. (medscape.com)
  • The cytoplasmic dynein complex is fundamentally important to all eukaryotic cells for transporting a variety of essential cargoes along microtubules within the cell. (ox.ac.uk)
  • Despite the importance of the cytoplasmic dynein complex, we know comparatively little of the roles of each component protein, and in mammals few mutants exist that allow us to explore the effects of defects in dynein-controlled processes in the context of the whole organism. (ox.ac.uk)
  • Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. (joplink.net)
  • Ubiquitin is the highly conserved small molecule globular protein found in cytoplasm, nucleus and eukaryotic cell. (fn-test.com)
  • Contactin/F3, a cell adhesion molecule, has been shown to interact with and enhance surface expression of sodium channels Na v 1.2 and Na v 1.9. (jneurosci.org)
  • Binding to the adapter molecule fadd recruits it to either receptor. (lu.se)
  • This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system. (wikipedia.org)
  • Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. (bioss.com.cn)
  • The related protein GIT1 is definitely tyrosine phosphorylated inside a Src-dependent manner (Bagrodia (http://www.molbiolcell.org/cgi/doi/10.1091/mbc.E05-02-0131) in July. (healthyguide.info)
  • Adaptor proteins play important roles in T cell signaling by creating nodes to recruit signaling proteins and form signal complexes to regulate the direction of signaling. (usm.my)
  • Protein-protein interactions (PPIs) play essential roles in many biological processes. (nature.com)
  • This complex also plays more specialized roles in neurons. (ox.ac.uk)
  • The primary roles of N protein are to assemble with genomic RNA into the viral RNA-protein (vRNP) complex and to localize to the replication transcription complexes (RTCs) to enhance viral replication and transcription. (ijbs.com)
  • BEACH-domain proteins act together in a cascade to mediate vacuolar protein trafficking and disease resistance in Arabidopsis . (bio-protocol.org)
  • Literature search for NOS1 adapting proteins followed by Uniprot data mining indicated CAPON as a potential candidate to mediate NOS1: TRKB interaction. (helsinki.fi)
  • In turn, GTP-bound active GTPases can interact with a plethora of different effectors which mediate the different cellular functions of this family of proteins. (biomedcentral.com)
  • This motif is found in Cdc42/Rac-associated proteins such as the protein kinases Pak, MRCK and Ack, the adaptor proteins Spec and WASP, and, in degenerate form, in the kinases MLK, Mekk4, adaptor Par6, scaffold protein IRSp53, and the Borg proteins. (biomedcentral.com)
  • This signaling cascade consists of the three kinases SteC, MkkB, and MpkB, as well as the SteD adaptor protein and the HamE scaffold. (ku.edu)
  • In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. (joplink.net)
  • We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination. (bertin-bioreagent.com)
  • They are responsible for interact-ing with both the substrate and the E2 carryinteract-ing activated ubiquitin. (1library.net)
  • The F-box protein is the variable subunit of the complex and interacts directly with the substrate. (1library.net)
  • 2007). Substrate specificity appears to be determined in large part by the nature of the F-box protein present. (1library.net)
  • Interestingly, functionally redundant SNIPER1 and SNIPER2 can control the protein levels of diverse sNLRs and the interactions between SNIPER1 and sNLRs appear to be through the common nucleotide-binding (NB) domains of sNLRs. (ubc.ca)
  • Plant intracellular nucleotide binding and leucine-rich repeat proteins (NB-LRR, NLRs) function as immune receptors to detect microbial pathogens directly or indirectly. (ubc.ca)
  • We also found out that AD fluoxetine prevents nitration of TRKB receptors in vivo and antidepressant drugs fluoxetine, phenelzine and imipramine disrupt the interactions of TRKB, NOS1 and NOS1 adaptor protein (CAPON) in co-immunoprecipitation assay. (helsinki.fi)
  • SNAREs (N-ethylmaleimide-sensitive factor adaptor protein receptors) are small polypeptides characterized by a particular domain, the SNARE motif, that can form a coiled-coil structure. (unisalento.it)
  • In separate work, my team identified a set of secreted proteins overexpressed in the tumor microenvironment, and developed antibodies to block their cognate receptors for therapeutic gain. (gene.com)
  • [ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
  • It has been recently reported that motor proteins like myosin Va play important role in transcytosis of nNOS. (frontiersin.org)
  • Evidence has suggested the role of motor proteins like myosin Va in transposition of nNOS within the nerve terminals to the membranes to facilitate nitrergic neurotransmission ( 11 , 12 ). (frontiersin.org)
  • VCP identifies ubiquitylated substrates through numerous dedicated adaptor proteins and unfolds substrates by threading them through a central pore in the hexamer ( Figure 1 ). (portlandpress.com)
  • Most NLRs guard host proteins that are the direct targets of pathogen effectors. (ubc.ca)
  • Many host proteins can also function as cofactors for viral entry, such as heparin sulfate proteoglycans, C-type lectins, neuropilin-1 and furin [ 10 - 13 ]. (ijbs.com)
  • Here we want to investigate the interaction between the CheA and receptor protein by using mutagenesis and phosphorylation assay. (ucsb.edu)
  • CONCLUSION An increased artemisinin-resistant phenotype occurs along with a mutation in a functional element of the AP2 adaptor protein complex. (gla.ac.uk)
  • Perturbation of this interaction, including a single point mutation in talin, which disrupts KANK1 binding but not the talin function in adhesion, abrogates the association of microtubule-stabilizing complexes with focal adhesions. (kent.ac.uk)
  • We find that, surprisingly, an N235Y point mutation in this protein results in altered neuronal development, as shown from in vivo studies in the developing cortex, and analyses of electrophysiological function. (ox.ac.uk)
  • HPS-2 is caused by a mutation in the gene encoding the beta-3A subunit of the heterotetrameric AP3 complex ( ADTB3A ), which resides on chromosome 5. (medscape.com)
  • CusabioAlternative Name(s): Caspase and RIP adapter with death domain RIP-associated protein with a death domainGene. (joplink.net)
  • In innate immune system, N protein inhibits IFN-β production and RNAi pathway for virus survival. (ijbs.com)
  • Additionally, the host serine protease TMPRSS2 is important for priming of the S protein for receptor interactions and entry [ 9 ]. (ijbs.com)
  • The accumulation of both Cyclin and CKI proteins is tightly regulated at the level of transcription. (intechopen.com)
  • these proteins are also important in regulating gene transcription. (biomedcentral.com)
  • This complex has been shown to assemble in the cytoplasm and MpkB enters the nucleus, where it would presumably interact with various transcription factors. (ku.edu)
  • SARS-CoV-2 Nucleocapsid (N) protein plays a critical role in multiple steps of the viral life cycle and participates in viral replication, transcription, and assembly. (ijbs.com)
  • The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
  • SUSA2 encodes an F-box protein Actin-Related Protein 8 (ARP8) and SUSA3 encodes the chaperone protein HSP90.3. (ubc.ca)
  • By regulating filamentous actin, Cdc42 and Rac exert a profound effect on cell shape, polarity, migration, cell:cell and cell:matrix adhesion, protein traffic, and cytokinesis. (biomedcentral.com)
  • Widely used RNA-seq methods start with adapter ligation and cDNA synthesis of biological RNA samples followed by PCR amplification to generate sequencing libraries1. (cdc.gov)
  • Significant obstacles for the sequencing of tRNA include the presence of numerous post-transcriptional modifications and its stable and extensive secondary structure, which interfere with cDNA synthesis and adapter ligation. (cdc.gov)
  • The extension of phagosome requires for mATG9 and ubiquitin-like protein LC3. (fn-test.com)
  • We also show that β1-spectrin, a protein that does not directly interact with obscurin or sAnk1.5, can be recruited to a macromolecular complex via an interaction with AnkG107/130. (tmc.edu)
  • Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. (bioss.com.cn)
  • NRBF2 directly interacts with Vps15 via the Vps15 WD40 domain as well as other regions of Vps15. (nih.gov)
  • and liprins are recruited to focal adhesions by the adaptor protein KANK1, which directly interacts with the major adhesion component, talin. (kent.ac.uk)
  • To understand the nature of TRKB and NOS1 interaction, we thus examined the protein domains in NOS1 and TRKB using Uniprot database, and we were unable to identify sites that could interact directly. (helsinki.fi)
  • Here we show that AtSYP51 interacts directly with a non-SNARE protein, AtNLM1, probably regulating autophagocytosis processes. (unisalento.it)
  • After being entry, the viral and host membranes can fuse together and then release the positive sense, single-stranded RNA genome of SARS-CoV-2 that directly translates into the structural and nonstructural proteins [ 9 ]. (ijbs.com)
  • Interacts with fadd, cflar and pea15. (lu.se)
  • Ubiquitination refers to the ubiquitin-protein conjugation process. (fn-test.com)
  • ED1 , encoding a ligand-ectodysplasinA-A1 (EDA-A1), EDAR , coding for ectodysplasinA-A1 receptor, EDARADD , programming the structure of EDAR-associated death domain protein and NEMO whose protein product, NFκB essential modulator (NEMO), is necessary for an indirect activation of nuclear factor κB (NFκB). (springer.com)
  • Toll-interacting protein (Tollip) is a modulator of inflammatory cascades. (unil.ch)
  • Alternative splicing of ankyrin yields numerous isoforms that interact with obscurin at various sub-cellular domains. (tmc.edu)
  • Two muscle-specific ankyrin isoforms, sAnk1.5 and AnkG107/130, which do not interact with each other, were used to test if obscurin could serve to bridge these ankyrins. (tmc.edu)
  • Lastly, both ankyrin isoforms localize to the M-line of cardiomyocytes suggesting that obscurin could serve to target two separate ankyrin protein complexes to the same domain (M-line). (tmc.edu)
  • Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. (bioss.com.cn)
  • The complex consists of 11 types of protein that interact with each other and with external adaptors, regulators and cargoes. (ox.ac.uk)
  • SNAREs also interact with several proteins acting as regulators of SNARE-complex formation. (unisalento.it)
  • Likely target for the cowpox virus CRMA death inhibitory protein. (lu.se)
  • This gene encodes a subunit of the heterotetrameric AP-4 complex. (wikipedia.org)
  • Identification of protein-protein interactions (PPIs) is important for understanding how proteins work together in a coordinated fashion in a cell to perform cellular functions. (nature.com)
  • Aruffo A, Melnick MB, Linsley PS, Seed B. The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins. (hcdm.org)
  • SLP-76 7 , T cell-specific adaptor protein 8 , TCR/CD3 complex 9 and Syntenin-1. (hcdm.org)
  • Hem CD, Ekornhol M, Granum S, Sundvold-Gjerstad V, Spurkland A. CD6 and Linker of Activated T Cells are Potential Interaction Partners for T Cell-Specific Adaptor Protein. (hcdm.org)
  • Tissue or cell-specific expression of the Nek1 protein was never reported, since no anti-Nek1 antibodies were available then, and the association of Nek1 with pleiotropic abnormalities including PKD was not made in mice until later [ 4 ]. (biomedcentral.com)
  • Intro Cell attachment distributing Panobinostat and motility are complex processes requiring the integration of varied signaling networks and structural assemblies (Jockusch for 10 min at 4°C supernatants were taken as cell lysates. (healthyguide.info)
  • Therefore abrogation of appropriate temporal-spatial rules of PKL profoundly impairs normal cell adhesion dynamics consistent with a critical part for this protein Panobinostat and its binding partners. (healthyguide.info)
  • This review will focus on the role of Rac and Rho small GTPases in cell motility and in the complex relationship driving the reciprocal control between Rac and Rho granting for the opportunistic motile behaviour of aggressive cancer cells. (biomedcentral.com)
  • Besides the function in viral life cycle, N protein can bind GSDMD to antagonize pyroptosis but promotes cell death via the Smad3-dependent G1 cell cycle arrest mechanism. (ijbs.com)
  • In this review article, we are focusing on the signaling mechanisms of SARS-CoV-2 N protein in viral replication, cell death and inflammation. (ijbs.com)
  • For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
  • The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
  • The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)