• We examined their interaction with L-α-dipalmitoyl phosphatidylcholine (DPPC) membranes using fluorescence anisotropy, transmission electron microscopy (TEM), and differential scanning calorimetry (DSC). (iisc.ac.in)
  • Importantly, these cholesteryl amphiphiles behave less like cholesterol in that their incorporation in DPPC not only abolishes the phase transition but also depresses the phase transition temperature. (iisc.ac.in)
  • We have reconstituted TNAP in liposomes of dipalmitoylphosphatidylcholine (DPPC) or dioleoylphosphatidylcholine (DOPC) combined with Chol or its derivatives Cholestenone (Achol) and Ergosterol (Ergo). (bvsalud.org)
  • Phase-separation was observed in the form of domains made of dipalmitoylphosphatidylcholine (DPPC), sphingomyelin (SM), or SM/cholesterol (SM/Chl) surrounded by a fluid matrix of dioleoylphosphatidylcholine (DOPC). (ac.be)
  • Experiments on bilayers and monolayers containing lipids such as dipalmitoylphosphatidylcholine (DPPC) provide the essential target data for this project. (nih.gov)
  • By combining dipalmitoylphosphatidylcholine (DPPC) lipids, cholesterol and the water-soluble polymer PEG2000, the researchers incorporated baicalein into liposomes (nanoscale drug-delivery capsules). (sciencenews.dk)
  • This work investigates how docosahexaenoic acid (DHA) modifies the effect of Cholesterol (Chol) on the structural and dynamical properties of dipalmitoylphosphatidylcholine (DPPC) membrane. (nutrition-evidence.com)
  • It occurs in many lipid mixtures combining cholesterol with a phospholipid and/or sphingolipids e.g. sphingomyelin. (wikipedia.org)
  • Careful analyses of DSC and fluorescence anisotropy data suggest that the nature of perturbation induced by each of these cationic cholesterol derivatives is dependent on the details of their molecular structure and provides significant information on the nature of interaction of these derivatives with phospholipid molecules. (iisc.ac.in)
  • One aspect of the present invention provides a peptide-liposome complex composed of a lipid bilayer including (a) a first phospholipid, (b) a second phospholipid containing PEG, (c) cholesterol, and (d) a lipid conjugate consisting of the second phospholipid and a peptide having the amino acid sequence set forth in SEQ ID NO: 1. (justia.com)
  • These include bilayers with complex lipids (e.g., gangliosides and phosphoinositides), other components including cholesterol, sugars such as trehalose, viral fusion peptides, and bacterial toxins. (nih.gov)
  • Surfactant recovered by alveolar wash from most mammals contains 70-80% phospholipids, 8-10% protein, and 10% neutral lipids, primarily cholesterol. (medscape.com)
  • Compared to the plasma membrane, MVs are rich in Cholesterol (Chol) (â ¼32%) and TNAP, but how Chol influences TNAP activity remains unclear. (bvsalud.org)
  • Real-time imaging of drug-membrane interactions by atomic force microscopy. (ac.be)
  • We suggest that the higher membrane stability of SM-containing domains results from stronger intermolecular interactions between SM molecules. (ac.be)
  • In spite of the relevance of lipid-protein interactions, the phase behaviour of the lipid components of the cell membrane is believed to be of major importance to uncover some underlying principles behind the membrane function. (hindawi.com)
  • Organisms usually contain large numbers of sphingolipid subspecies (for a pathway based compilation, see www.sphingomap.org) and knowledge about the types and amounts is imperative because they influence membrane structure, interactions with the extracellular matrix and neighboring cells, vesicular traffic and the formation of specialized structures such as phagosomes and autophagosomes, as well as participate in intracellular and extracellular signaling. (sphingolipidclub.com)
  • In particular, the impact of α-spinasterol on the structure and organization of lipid membranes was investigated and compared with those of cholesterol. (mdpi.com)
  • Simulations of Anionic Lipid Membranes: Development of Interaction-Specific Ion Parameters and Validation using NMR Data," R. M. Venable, Y. Luo, K. Gawrisch, B. Roux and R. W. Pastor, Journal of Physical Chemistry B , 117 pp. 10183-10192 (2013). (nih.gov)
  • Disruption of such inter-lipid interactions can result in changes in lipid bilayer phase behavior, which is related to the degree of lipid ordering and bilayer viscosity. (biomedcentral.com)
  • As a matter of fact, the number of studies on the influence of domain partitioning on interactions with peptides and nucleic acids has increased significantly in recent years [ 4 - 7 ]. (hindawi.com)
  • FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
  • 1987. Phase equilibria in the phosphatidylcholine-cholesterol system. (wikipedia.org)
  • These results suggest that lipid bilayers can distort to accommodate large hydrophobic nanoparticles, relative to the thickness of the bilayer, and may provide insight into nanoparticle/biomembrane interactions and the design of multifunctional liposomal carriers. (biomedcentral.com)
  • Particularly, a considerable number of drugs with high therapeutic efficacy are currently used in clinical applications as monoclonal antibodies that selectively bind to immune checkpoints, specifically programmed death-ligand 1 (PD-L1), programmed death-receptor (PD-1), and cytotoxic T lymphocyte associated protein 4 (CTLA-4), which are involved in the interaction between cancer cells and T cells. (justia.com)
  • Understanding drug-biomembrane interactions at high resolution is a key issue in current biophysical and pharmaceutical research. (ac.be)
  • 1993. "A C-13 and H-2 Nuclear-Magnetic-Resonance Study of Phosphatidylcholine Cholesterol Interactions - Characterization of Liquid-Gel Phases. (wikipedia.org)
  • Fortunately, this undesirable interaction can be suppressed or completely eliminated," explains co-author Farhang Aliakbari, who has been a visiting scientist at iNANO, Aarhus University and has done much of the current work at the National Institute of Genetic Engineering and Biotechnology in Tehran, Iran, co-supervised by Dina Morshedi. (sciencenews.dk)
  • These include bilayers with complex lipids (e.g., gangliosides and phosphoinositides), other components including cholesterol, sugars such as trehalose, viral fusion peptides, and bacterial toxins. (nih.gov)
  • 1] Gallova J, Klacsova M, Devinsky F, Balgavy P. Partial volumes of cholesterol and monounsaturated diacylphosphatidylcholines in mixed bilayers. (sciendo.com)
  • Interactions among structural and cytoplasmic cell components and their response to external signals make up transport processes responsible for the membrane selectivity exhibited within and among cell types. (justia.com)
  • Density measurement and molecular interactions. (sciendo.com)
  • By adsorbing to the air-water interface of alveoli with the hydrophilic headgroups in the water and the hydrophobic tails facing towards the air, the main lipid component of surfactant, dipalmitoylphosphatidylcholine , reduces surface tension . (wikidoc.org)
  • Application to a bilayer/cholesterol system at various concentrations shows the typical cholesterol condensation effect similar to that observed in all atom representations. (typeset.io)
  • To reproduce the free energies of these chemical building blocks, the number of possible interaction levels of the coarse-grained sites has increased compared to those of the previous model. (typeset.io)
  • However, this reduction was only significant for liposomes containing the derivative dipalmitoylphosphatidylcholine. (medscape.com)