AdditiveInhibitionDrugsOverdoseMedicationsDosageProteinsHeart'sAntagonismCentersWarfarinAnother substanceImmuneAnginaFrequentSignificantConsequencesSideRecognizeGenesToxicologyPotentialMolecularMechanismsEffectsProfilesGeneticDiarrheaFundamentalIncreaseHumanOnsetEngageCommonlyDirectResultSiteImportantDoctorSimilarPeopleDisease
Additive3
- Drug interactions also may occur when two drugs that have similar (additive) effects or opposite (canceling) effects on the body are administered together. (rxlist.com)
- Drug interactions can be additive (the result is what you expect when you add together the effect of each drug taken independently), synergistic (combining the drugs leads to a larger effect than expected), or antagonistic (combining the drugs leads to a smaller effect than expected). (wikipedia.org)
- On some occasions, it is difficult to distinguish between synergistic or additive interactions, since the individual effects of each drug may vary from patient to patient. (wikipedia.org)
Inhibition3
- 1 A case reporting a threefold increase in tacrolimus levels following the addition of cannabidiol shows that CYP3A4/5 inhibition can also occur. (cmaj.ca)
- Drug interactions with antiretrovirals are commonly caused by the inhibition or induction of hepatic drug metabolism. (medscape.com)
- In occurs through the inhibition of DNA binding of cognate cis- hematopoiesis there exist several lineage branch points with regulatory motif while in the other case DNA binding is unaffected identified key transcription factors and external signals [3-5]. (lu.se)
Drugs13
- Whenever two or more drugs are being taken, there is a chance that there will be an interaction among the drugs. (rxlist.com)
- The interaction may increase or decrease the effectiveness of the drugs or the side effects of the drugs. (rxlist.com)
- The likelihood of drug interactions increases as the number of drugs being taken increases. (rxlist.com)
- Therefore, people who take several drugs are at the greatest risk for interactions. (rxlist.com)
- This definition applies to interactions of drugs with other drugs (drug-drug interactions), as well as drugs with food (drug-food interactions) and other substances. (rxlist.com)
- Drug interactions occur when a drug's mechanism of action is affected by the concomitant administration of substances such as foods, beverages, or other drugs. (wikipedia.org)
- The risk of a drug-drug interaction (DDI) increases with the number of drugs used. (wikipedia.org)
- Drug interaction predictors enable risk assessment of multiple drugs simultaneously with visualizations of risk per therapeutic class, to indicate a spectrum from no risk to high risk. (wikipedia.org)
- Direct interactions between drugs are also possible and may occur when two drugs are mixed before intravenous injection. (wikipedia.org)
- 1 , 3 Interactions with other drugs metabolized by CYP2C19 (Appendix 1, available at www.cmaj.ca/lookup/suppl/doi:10.1503/cmaj.191097/-/DC1 ) should be anticipated. (cmaj.ca)
- Protease inhibitors in combination with other drugs may require dose adjustments or should be avoided because of these potential drug interactions. (medscape.com)
- Goldenseal affects how the liver processes some drugs, which may result in other important drug interactions. (merckmanuals.com)
- Routinely used medications have many potential interactions with drugs used during surgery, but few situations prohibit concurrent administration. (medscape.com)
Overdose1
- A synergistic interaction may be beneficial for patients, but may also increase the risk of overdose. (wikipedia.org)
Medications3
- Over a third (36%) of the elderly in the U.S. regularly use five or more medications or supplements, and 15% are at risk of a significant drug-drug interaction. (wikipedia.org)
- Drug interactions may change how your medications work or increase your risk for serious side effects. (webmd.com)
- The potential for benefit as well as the interaction with other seizure medications and possible side effects require careful review with your doctor. (epilepsy.com)
Dosage1
- Increased angina or myocardial infarction with calcium channel blockers may occur upon dosage initiation or increase ( 5.3 ). (nih.gov)
Proteins6
- Although an interaction site that confers survival functionality has been defined for anti-apoptotic proteins, an activation site has not been identified for BAX, rendering its explicit trigger mechanism unknown. (nature.com)
- Here we demonstrate by NMR analysis that BIM SAHB binds BAX at an interaction site that is distinct from the canonical binding groove characterized for anti-apoptotic proteins. (nature.com)
- Macromolecular interactions, such as those between proteins, form the basis of all biological activity. (europa.eu)
- Here, we propose to map the interactions between 800 proteins involved in early embryonic development of the nematode Caenorhabditis elegans. (europa.eu)
- Finally, the domain interaction map will be integrated with existing phenotypic characterizations and expression profiles to be able to better predict the biological functions of the proteins in the network. (europa.eu)
- Because of the conserved nature of the proteins involved, the interaction network and future results derived from it will be valuable not only to C. elegans researchers but to researchers in other fields as well. (europa.eu)
Heart's2
- The dull, tight chest pain of angina occurs when the heart's muscular wall is not getting enough oxygen. (encyclopedia.com)
- Dentists also use clindamycin as a preventive treatment for endocarditis, which is an infection of the heart's lining that can occur after a dental procedure in people who are at risk. (medicalnewstoday.com)
Antagonism2
- Both synergy and antagonism can occur during different phases of the interaction between a drug and an organism. (wikipedia.org)
- Dynamical models based upon known interactions between these master genes, such as mutual antagonism and autoregulation, fail to make the system bistable, a desired feature for robust lineage determination. (lu.se)
Centers1
- To explore work on gene-environment interaction (GxE) at the Centers for Disease Control and Prevention (CDC) and the Agency for Toxic Substances and Disease Registry (ATSDR), we examined the CDC-Authored Genomics and Precision Health Publications Database (CDC-Authored GPHPD) , which includes articles published by CDC/ATSDR authors since 2011. (cdc.gov)
Warfarin1
- The drug interaction between warfarin (Coumadin) and vitamin K-containing products is a good example of this type of interaction. (rxlist.com)
Another substance2
- A drug interaction can be defined as an interaction between a drug and another substance that prevents the drug from performing as expected. (rxlist.com)
- An interaction can occur because one substance causes another substance to have a different effect than expected. (healthline.com)
Immune1
- This disorder is more likely to occur if you have conditions related to a weakened immune system (such as HIV disease, bone marrow transplant , kidney transplant ). (medicinenet.com)
Angina1
- Postoperative myocardial infarction (MI) and angina have a peak incidence during the first 3 postoperative days but may occur for up to 5 days. (medscape.com)
Frequent2
- Being close together to one another encourages frequent serendipitous interactions. (lostgarden.com)
- An informal needs assessment may occur through frequent conversations and personal interactions with colleagues and clients. (cdc.gov)
Significant1
- About three weeks ago, we began seeing a significant number of cases occurring outside of China that were reflecting local transmission. (cdc.gov)
Consequences2
- Leber, B., Lin, J. & Andrews, D. W. Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes. (nature.com)
- Occasionally, small neuron misfires may occur with little consequences. (hopkinsmedicine.org)
Side4
- Drug interactions contribute to the cost of healthcare because of the costs of medical care that are required to treat problems caused by changes in effectiveness or side effects. (rxlist.com)
- ORAL (Zovirax) side effects, medical uses, and drug interactions. (medicinenet.com)
- Seek immediate medical attention if any of these rare but serious side effects occur: extreme tiredness , slow/fast/irregular heartbeat, easy bruising /bleeding, new fever , bloody/ dark urine , severe stomach/ abdominal pain , yellowing eyes/skin, sudden vision changes, loss of consciousness , seizures .A very serious allergic reaction to this drug is rare. (medicinenet.com)
- This is not a complete list of side effects and others may occur. (everydayhealth.com)
Recognize1
- [ 1 , 2 ] Failure to recognize these interactions may lead to loss of therapeutic effect or excess toxicity. (medscape.com)
Genes1
- Understanding the interactions between our environment and our genes and how they affect health outcomes offers a multitude of potential opportunities in public health. (cdc.gov)
Toxicology1
- The purpose of an Interaction Profile is to evaluate data on the toxicology of the "whole" priority mixture (if available) and on the joint toxic action of the chemicals in the mixture in order to recommend approaches for the exposure-based assessment of the potential hazard to public health. (cdc.gov)
Potential3
- Therefore, the kidney and the liver are very important sites of potential drug interactions. (rxlist.com)
- Potential for drug interactions should be considered when selecting ART for patients with human immunodeficiency virus (HIV) infection. (medscape.com)
- As an application, this leads to uniqueness of steady states in aggregation-diffusion equations with any attractive interaction potential for diffusion power \(m\ge 2\), where the threshold is sharp. (rutgers.edu)
Molecular1
- We found some articles related to environmental interactions with inherited genotype and others on environmental exposures that damage genetic material and initiate molecular pathways of pathogenesis. (cdc.gov)
Mechanisms1
- Therefore, the elucidation of host protective mechanisms against malaria and parasite-host interactions is essential to strategies to control malaria, including vaccine development. (nature.com)
Effects3
- 1 A pharmacokinetic study found that the CYP3A4 inhibitor ketoconazole nearly doubled THC and cannabidiol concentrations, 2 and similar interactions could occur with other CYP3A4 inhibitors, including macrolides and verapamil, augmenting the psychoactive effects of THC and dose-related adverse effects of cannabidiol (e.g., somnolence, transaminase elevation). (cmaj.ca)
- We identify a particular class of conjunctive goal interactions, which cannot be directly inferred from the domain knowledge, as they are not explicitly represented in the preconditions and effects of the domain operators. (aaai.org)
- Dangerous effects could occur. (everydayhealth.com)
Profiles1
- As part of the mixtures program a series of documents, Interaction Profiles, are being developed for certain priority mixtures that are of special concern to ATSDR. (cdc.gov)
Genetic1
- We are using C. elegans as a model system because it is a relatively simple, tractable multicellular organism, and powerful genetic tools are available to study components of interaction networks in vivo. (europa.eu)
Diarrhea1
- Stomach upset and diarrhea may occur. (webmd.com)
Fundamental1
- These concepts have fundamental applications in the pharmacodynamics of these interactions. (wikipedia.org)
Increase1
- Notably, an apparent dysbiosis occurred, characterized by a reduction of Firmicutes and an increase in Proteobacteria. (nature.com)
Human3
- HALLOWELL - A gas leak that forced the evacuation Saturday afternoon of the Camden National Bank Ice Vault may have been caused by "human interaction" and is under investigation, police said Monday. (pressherald.com)
- Natural gas technicians told Owens the damaged line was "physically broken off" because of "human interaction. (pressherald.com)
- The field of computer-mediated communication (CMC) studies communication that occurs between human beings via the instrumentality of computers with the goal to enhance communication by spanning spatial and temporal distances [ 1 ]. (springer.com)
Onset2
- To better understand these interactions, we examined colonization rates of 3 respiratory bacterial pathogens among 320 children when healthy and at onset of acute otitis media (AOM). (cdc.gov)
- Bacterial interactions result in differing pathogen prevalence during periods of health and at onset of AOM. (cdc.gov)
Engage1
- Players must engage in escalating back-and-forth interactions in order to negotiate shared social norms. (lostgarden.com)
Commonly1
- A weight-of-evidence approach is commonly used in these documents to evaluate the influence of interactions in the overall toxicity of the mixture. (cdc.gov)
Direct2
- We illustrate the discussion with examples and briefly present the method we are developing for acquiring control knowledge to direct the planner to consider the quality-goal interactions. (aaai.org)
- This interaction explains beta decay of a neutron by direct coupling of a neutron with an electron , a neutrino (later determined to be an antineutrino ) and a proton . (wikipedia.org)
Result1
- Most of the important drug interactions result from a change in the absorption, metabolism, or elimination of a drug. (rxlist.com)
Site1
- Mutagenesis of the BAX interaction site impairs activation and BAX-mediated apoptosis. (nature.com)
Important2
- The change in an organism's response upon administration of a drug is an important factor in pharmacodynamic interactions. (wikipedia.org)
- In particular, it was shown that the J=0 T=1 two-particle pairing interaction is important even at relatively high spin. (lu.se)
Doctor1
- If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist. (healthline.com)
Similar1
- 1 pairing interactions) have similar spin dependence. (lu.se)
People3
- Customer experience, or CX, is the sum of all the interactions people have with your brand. (salesforce.com)
- According to DigitalGov , it "deals with people interacting with your product and the experience they receive from that interaction. (salesforce.com)
- Early on, the cases that occurred outside of China occurred either in people who were exposed in China, traveled out, became ill after they returned home, or in their household contacts. (cdc.gov)
Disease1
- Antimicrobial treatments and vaccines can alter bacterial interactions in the nasopharynx, thereby altering disease processes. (cdc.gov)