Interactions proteins and lipids carrier proteins. Medical search. Frequent questions

Drug ionization reduces a drug's ability to cross a lipid bilayer. (pharmacology2000.com)
In the current study, we enhanced this approach with the addition of a new measure of the distortion caused by membrane proteins on a lipid bilayer. (ox.ac.uk)
lipid headgroups distort in order to interact with very similar but not identical regions in these proteins for all bilayer widths investigated. (ox.ac.uk)
Introducing anionic lipids into a DPPC bilayer containing the KvAP voltage sensor does not affect the extent of bilayer distortion. (ox.ac.uk)
Inside FepA, the solvent splits into isolated clusters and an intricate network connecting both sides of the lipid bilayer. (nature.com)
Our study uses classical algorithms such as space partitions and Dijkstra paths search 9 , applied in an original and novel way by taking into account the full representation of a membrane protein including the solvent and the lipid bilayer (Fig. 1 ). (nature.com)
The FepA membrane protein is surrounded by a lipid bilayer separating the extracellular medium and the periplasm. (nature.com)
The normal RBC membrane consists of a lipid bilayer, which contains proteins and glycans. (medscape.com)
Integration of a K+ channel-associated peptide in a lipid bilayer: Conformation, lipid-protein interactions, and rotational diffusion. (mpg.de)
Exosomes are small lipid bilayer-surrounded extracellular vesicles released from cells into the extracellular space or biological fluids ( 1 , 2 ). (spandidos-publications.com)
The aqueous core in NLCs is surrounded by a lipid bilayer and achieved high encapsulation efficiency, payload, and biostability [7]. (pharmafocusasia.com)
Combining X-ray crystallography and molecular dynamics simulations, they showed that APTs contain in their structure positively-charged patches that allow them to electrostatically attract the lipid bilayer of a membrane. (epfl.ch)
In this Commentary, I review evidence in favor of the idea that partitioning of TMDs into bilayer domains that are endowed with distinct physico-chemical properties plays a pivotal role in the transport of membrane proteins within the early secretory pathway. (biologists.com)
This process depends on the general physico-chemical features of the cargo membrane protein and on the interactions of these features with the collective properties of the bilayer, instead of the one-to-one intermolecular interactions that exist between discrete signals and their receptors. (biologists.com)
The lipid bilayer of cell membranes is impermeable to large and polar molecules but permeable to water molecules and other small uncharged molecules like O 2 and CO 2 . (wikibooks.org)
The availability of free energy is one of the factors that determine if a molecule will move across a membrane, the other being the permeability of the molecule in the lipid bilayer. (wikibooks.org)

In this work, we decided to study for the first time the formation and the evolution of PC on the surface of nanostructured lipid carriers loaded with superparamagnetic iron oxide nanoparticles, before and after the crossing of an in vitro model of the blood-brain barrier (BBB). (tue.nl)
2009) Synthesis of a Labeled RGD-Lipid, Its Incorporation into Liposomal Nanoparticles, and Their Trafficking in Cultured Endothelial Cells. (ubc.ca)
2008) The effect of circulation lifetime and drug-to-lipid ratio of intravenously administered lipid nanoparticles on the biodistribution and immunostimulatory activity of encapsulated CpG-ODN. (ubc.ca)
NLC is second generation solid lipid nanoparticle comprised of solid lipid mixed with liquid lipid (oil) which is advancement in solid lipid nanoparticles. (pharmafocusasia.com)
SLN or solid lipid nanoparticles were suggested as advantageous alternatives to liposomes and other colloidal carriers for hydrophobic drug delivery, yet with limited loading capabilities and diminished tunable release profiles, especially for hydrophilic proteins and peptides. (uandes.cl)
They developed Selective Organ Targeting (SORT) lipid nanoparticles (LNPs), which was named in Nature's "Seven technologies to watch in 2022. (utsouthwestern.edu)
One or more ionizable lipid(s) and lipid nanoparticles comprising same are provided. (sumobrain.com)
Pharmaceutical compositions comprising the lipid nanoparticles encapsulating an active agent are also provided. (sumobrain.com)
Provided herein, inter alia, novel ionizable cationic lipids, lipid nanoparticles comprising the novel ionizable cationic lipids and methods of using said nanoparticles. (sumobrain.com)

B. Brief overview of the key mechanisms/findings and safety concerns regarding complement activation and the similarity of the Covid-19 mRNA-LNP vaccine's lipids in relation to past lipid drugs - introduction to relevant FDA and FDA EUA reporting guidelines are introduced. (dailyclout.io)
K. Duty to Warn, obscured frequency of reactions statements -in non-pre-treated individuals administered PEGylated lipids, lipid nanomedicines, and nanomedicines- and missing warnings for countermeasures/pre-treatment premedication in similar lipids for Covid-19 mRNA vaccine labeling. (dailyclout.io)
O. Animal studies - Pfizer Covid-19 mRNA-LNP vaccine and "similar lipid" mRNA-LNP Pfizer scientists LNP development co-authored studies. (dailyclout.io)
These vesicles are carriers of active or non-autonomous function biomolecules, such as proteins, lipids, DNA, mRNA and non-coding regulatory RNA. (spandidos-publications.com)
It has been identified that the non-coding region of mRNA is capable of providing targeting signals in RNA binding protein domain. (pharmafocusasia.com)
Expression of these proteins at mRNA level was assessed by quantitative real-time polymerase chain reaction (qRT-PCR). (helsinki.fi)
The Siegwart Lab aims to discover and define the critical physical and chemical properties of synthetic carriers required for therapeutic delivery of small (e.g. ~22 base pair miRNA) to large (e.g. ~5,000 nucleotide mRNA) RNAs. (utsouthwestern.edu)

He continues to use his expertise in lipid biochemistry as head of Research & Development at MJ BioEssentials by developing unique and effective formulations of CBD and other phycannabinoids by incorporating novel blends of essential oils and carrier oils. (mjbioessentials.com)

Upon coming into contact with the biological environment, nanostructures are immediately covered by biomolecules, particularly by proteins forming the so-called "protein corona" (PC). (tue.nl)

2008) The combination of stabilized plasmid lipid particles and lipid nanoparticle encapsulated CpG containing oligodeoxynucleotides as a systemic genetic vaccine. (ubc.ca)

Instead, no regular assembly is obtained from solutions with high peptide concentrations, as their dynamics is dominated by strong repulsive peptide-peptide electrostatic interactions, and from solutions at pH 10, in which the total peptide charge is zero. (ibecbarcelona.eu)
First, long-range electrostatic interactions attract the enzyme, through its positive patches, to the lipid membrane. (epfl.ch)
Thus, we proposed formulating core-shell nanocapsules: coating SLN cores with alternate layers of natural polyelectrolytes via the layer-by-layer self-assembly approach based on electrostatic interactions. (uandes.cl)

He did post-doctoral research at Pharmacia-Upjohn in the Drug Delivery Systems Research division, where he studied the interaction of lipophilic drugs using lipid emulsions. (mjbioessentials.com)

Weak acid at acid pH: more lipid-soluble, becauses it is uncharged--the uncharged form more readily passes through biological membranes. (pharmacology2000.com)
In the case of Alzheimer's disease, the amyloid-beta molecules stick to the lipid cell membranes that contain cholesterol. (cam.ac.uk)
Since it is insoluble, while travelling towards its destination in lipid membranes, cholesterol is never left around by itself, either in the blood or the brain: it has to be carried around by certain dedicated proteins, such as ApoE, a mutation of which has already been identified as a major risk factor for Alzheimer's disease. (cam.ac.uk)
Solute carrier spinster homolog 2 (SPNS2), one of only four known major facilitator superfamily (MFS) lysolipid transporters in humans, exports sphingosine-1-phosphate (S1P) across cell membranes. (ox.ac.uk)
Lipid-protein interactions and effect of local anesthetics in acetylcholine receptor-rich membranes from Torpedo marmorata electric organ. (mpg.de)
To do their work, APTs have to interact with the lipid membranes that their target proteins are bound to. (epfl.ch)
In short, S-acylation on Cys-2 is essential for APT2 to be able to stably bind lipid membranes and deacylate its targets in the cell. (epfl.ch)
Finally, the scientists brought their data together to work out how APT2 actually binds lipid membranes, which is essential to its capacity to perform its function in the cell. (epfl.ch)
This study shows that APT2 is in fact a hybride between a lipid carrier protein, which can extract lipid from membranes, and a hydrolase, which can cut the lipid of a protein," says Gisou van der Goot. (epfl.ch)

His thesis studied the interaction of semi-synthetic proteins with lipid bilayers. (mjbioessentials.com)

What pathways are this gene/protein implicaed in? (cancerindex.org)
To characterize hCMEC/D3 cells for the presence of specific endocytic pathways, proteins involved into each pathway were selected. (helsinki.fi)
Continuous protein pathways are composed of carrier proteins , channels and pumps . (wikibooks.org)
Many genes involved in metabolic pathways have been found to contribute to lipid level variability [ 14 , 26 , 27 ]. (cdc.gov)

Non-specific lipid-transfer protein also known as sterol carrier protein 2 (SCP-2) or propanoyl-CoA C-acyltransferase is a protein that in humans is encoded by the SCP2 gene. (wikipedia.org)
This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. (wikipedia.org)
The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein. (umbc.edu)

This includes gene, protein and metabolic networks, cellular architecture and intracellular dynamics, cell communication and motility, cell division and differentiation, tissue formation and organogenesis, tissue and organ functions, changes in population characteristics as a consequence of interaction of organisms with their physical environment, with individuals of their own species, and with organisms of other species. (nih.gov)
Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. (wikipedia.org)
SCP-2 has multiple roles in intracellular lipid circulation and metabolism. (umbc.edu)

Separation of three lipidomes is exemplified: (i) Escherichia coli, (ii) SH‐SY5Y neuroblastoma cells, and (iii) lipids assembled in polymer nanodiscs. (researchgate.net)

Amyloid-beta does attach itself to lipid molecules, however, which are sticky and insoluble. (cam.ac.uk)
It aims to provide an understanding of the basic chemical properties of molecules that make life possible and a description of the key components of the cell and their biochemical interactions. (manchester.ac.uk)
At the same time, the increased mobility of the lipids facilitates the passage of lipid-soluble molecules into the cell. (cranfield.ac.uk)
The site allows the enzyme to be bound by ubiquitin, a protein that the cell uses to mark molecules for breakdown. (epfl.ch)
To solve this problem, the cell membrane contains proteins that are selective for unique, water soluble molecules. (wikibooks.org)

The combination of such self-organizational phenomena with canonical intermolecular interactions is most likely to control the release of membrane proteins from the ER into the secretory pathway. (biologists.com)
The research program is focused on intermolecular interactions and their manifestations in a liquid environment. (lu.se)
The theoretical basis for the description of intermolecular interactions and their consequences are treated using both quantum chemical calculations and statistical mechanical simulations. (lu.se)
For many proteins, aggregation starts from phase separation, which frequently results from intermolecular interactions mediated by disordered protein regions. (sumobrain.com)

By enhancing the mobility of lipids and/or proteins, the possibility of the carrier protein to "encapsulate" pharmacological components maxim- izes, as a "scanning" of the proteins gets performed due to the fluid phase of a biological membrane. (cranfield.ac.uk)
Compound 20 showed outstanding biological data, inhibiting tau protein and Aβ40 aggregation with IC50 = 1.8 and 1.3 μM, respectively. (ibecbarcelona.eu)
They aim to globally understand how the physical and chemical properties of materials affect interactions with biological systems in vitro and in vivo in the context of improving cancer and genetic disease therapies. (utsouthwestern.edu)
Results from our study contribute to a growing body of literature identifying key determinants of plasma lipoprotein concentrations and could provide insight into the biological mechanisms underlying serum lipid and cholesterol concentrations. (cdc.gov)

Effect of trehalose on the interaction of Alzheimer's Aβ-peptide and anionic lipid monolayers. (smw.ch)
The ionizable lipid containing a disulfide bond, according to the present invention, stably delivers an anionic drug when prepared into l. (sumobrain.com)

Interactions between lipid-anchored and transmembrane proteins. (mpg.de)
For membrane proteins, a third mechanism, based on the interaction of their transmembrane domain (TMD) with lipid microdomains, must also be considered. (biologists.com)

Recent advancements in the technical field, have also contributed to making DSC compatible with studying the thermodynamic properties of various pharmaceutical products, such as biopolymers, proteins, peptides, and lipid carriers. (aurigaresearch.com)

This domain occurred 5 times on human genes ( 6 proteins). (umbc.edu)
After, universal and conserved genes were used (cytoskeleton actin and tubulin protein genes) that have brought with them greater resolution in the identification and classification of supergroups [ 11 ]. (hindawi.com)
In most gram-positive bacteria, this operon consists of five genes dltXABCD but the involvement of the first ORF ( dltX ) encoding a small protein of unknown function, has never been investigated. (frontiersin.org)
Gene therapy is a method for the treatment or prevention of disease that uses genes to provide the patient's somatic cells with the genetic information necessary to produce specific therapeutic proteins needed to correct or to modulate a disease. (pharmacy180.com)
Using data from the second phase (1991-1994) of the Third National Health and Nutrition Examination Survey (NHANES III), we examined associations between 22 polymorphisms in 13 candidate genes and four serum lipids: high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG). (cdc.gov)

1) Design and development of lipid and protein nanostructured carriers, for potential application in drug delivery and nanomedicine. (technion.ac.il)

This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. (wikipedia.org)

Using a Neutral Liposome with PEG will protect the liposomes from circulating proteins, improving their plasma clearance and enhancing their therapeutic effects. (encapsula.com)
Doxil® also contains polyethylene glycol (PEG)-lipid resulting in pegylation of the liposome surface, which enables it to have a prolonged circulation and a reduced volume of distribution, thereby improving tumor uptake through the enhanced permeability and retention effect (EPR) and extending effective tumor therapy. (encapsula.com)
By having the liposome diameter (nm) and lipid concentration (µM), you can calculate the total number of the lipids in one liposome and number of the liposomes in one milliliter of the liposome solution. (encapsula.com)
2008). Influence of drug-to-lipid ratio on drug release properties and liposome integrity in liposomal doxorubicin formulations. (ubc.ca)
The present invention relates to a liposome for forming a nanodrug carrier. (sumobrain.com)

New technologies for purifying membrane-bound protein complexes in combination with cryo-electron microscopy (EM) have recently allowed the exploration of such complexes under near-native conditions. (researchgate.net)
The mode of action of enzymes and macromolecular complexes as protein machines will be investigated. (manchester.ac.uk)

Exosomes are one of the most researched classes of extracellular vesicles because they are carriers of targeted protein and DNA/RNA loads. (spandidos-publications.com)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal-regulated kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

Given that SPNS2 transports a key signaling lipid, our results have implications for therapeutic targeting and also illustrate a regulatory mechanism for MFS transporters. (ox.ac.uk)
However, the surface functionalisation of NLC with protein, ligand, antibodies, aptamers, and miRNA further warranted a novel promising therapeutic strategy in tumor therapy [5]. (pharmafocusasia.com)
The promise of gene therapy is to overcome limitations associated with the administration of therapeutic proteins, including low bio-availability, inadequate pharmacokinetic profiles, and high manufacturing cost. (pharmacy180.com)
In fact, excipients are seldom neutral and some of them have been found to play a significant role, for example by initiating or participating in chemical and physical interactions with the active substance, leading in certain cases to compromise its therapeutic activity. (smw.ch)

The exploitation of these compounds in a lipid-based formulation would be able to address hydrophobicity, lipophilicity, poor bioavailability and low water-solubility of many current drugs. (afpm.org.my)

Hydrophobic interactions are generally weak, but important. (pharmacology2000.com)
Cholesterol does not count since it inserts itself into the hydrophobic fatty acid chains of the lipid. (encapsula.com)
The team also uncovered a mildly hydrophobic loop on the surface of APTs that they called the "β tongue", which allows the enzyme to perform hydrophobic interactions with the membrane. (epfl.ch)

He also showed that double-stranded (ds)RNA- and ZDNA binding proteins had a role in poxvirus pathogenesis. (cdc.gov)

A single-residue deletion alters the lipid selectivity of a K+ channel-associated peptide in the beta-conformation: Spin label electron spin resonance studies. (mpg.de)

It's exciting to see that the kinetic analysis approach that we have developed over the past few years is now allowing us to explore increasingly complex systems, including protein-lipid interactions which are likely to be central for the initiation of aberrant protein aggregation," said co-author Professor Tuomas Knowles. (cam.ac.uk)
In fact, it has been shown that the formation of the PC can impact the performance of nanostructures by reducing their stability, causing aggregation, increasing their toxicity, and providing unexpected and undesired nanostructure-cell interactions. (tue.nl)
A set of twenty-five thioxanthene-9-one and xanthene-9-one derivatives, that were previously shown to inhibit cholinesterases (ChEs) and amyloid β (Aβ40) aggregation, were evaluated for the inhibition of tau protein aggregation. (ibecbarcelona.eu)

2006). Therapeutically Optimized Rates of Drug Release can be Achieved by Varying the Drug-to-Lipid Ratio in Liposomal Vincristine Formulations. (ubc.ca)
Palm oil is natural oil packed with important compounds and fatty acids ready to be exploited in lipid-based formulations and drug delivery. (afpm.org.my)
Despite the complexity in designing lipid-based formulations, palm oil has proven to offer dynamic behaviour in providing versatility in drug design, form and delivery. (afpm.org.my)
Therefore, this study aims to focus on the research and outcomes of using palm oil in lipid-based formulations and drug delivery systems, due to the importance of establishing its capabilities and benefits. (afpm.org.my)
This review highlights the different formulations underlying the encapsulation of FSVs in biopolymer (polysaccharide and protein) and lipid-based micro or nanocarriers for potential applications in food and pharmaceutical industries. (afpm.org.my)

Interaction of membrane-spanning proteins with peripheral and lipid-anchored membrane proteins: perspectives from protein- lipid interactions (Review). (mpg.de)
In our heart, the responsible peripheral self-induced lipids of the receptor syndrome are urinary to its radioactive psychotherapy and contribute it relatively were as a oral region to determine regional collection incidence. (siriuspixels.com)

In particular, the function of these carrier systems in terms of encapsulation efficiency, stability, bioavailability, and bio-accessibility is critically discussed. (afpm.org.my)

Given the tight relation between protein structure and function, we present a set of methods to analyze protein topology, implemented in the VLDP program, relying on Laguerre space partitions built from series of molecular dynamics snapshots. (nature.com)

More LNP details on the similar lipid 2018 LNP Nano lipid carrier drug Onpattro and EMA data on immune stimulation, complement activation, special cautions, and adverse reactions. (dailyclout.io)

Previous studies have shown that the enzyme is heavily accumulated in the cell's Golgi apparatus, which is the organelle that packages new protein into vesicles before sending them off to the cell's membrane. (epfl.ch)
Secretory proteins exit the endoplasmic reticulum (ER) in coat protein complex II (COPII)-coated vesicles and then progress through the Golgi complex before delivery to their final destination. (biologists.com)

The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. (cancerindex.org)
What does this gene/protein do? (cancerindex.org)
2005). Stabilized plasmid-lipid particles containing PEG-diacyglyceriols exhibit extended circulation lifetimes and tumor selective gene expression. (ubc.ca)
Gene therapy in cancer means to replace abnormal gene by healthy one that enables to perform and bring forth normal protein required for normal growth, function, and division of body cells. (pharmafocusasia.com)
Nanostructure Lipid Carrier (NLC) smartly delivers the miRNA in tumor gene therapy owing to their leisurely surface modification, low immunogenicity, low toxicity and long metabolic cycle. (pharmafocusasia.com)
They carry an inherent risk of mutagenesis by inserting their genome (called insertion mutagenesis) within a functional gene, which can compromise the functionality of a critical normal human protein. (pharmacy180.com)
They were the first to report in vivo CRISPR/Cas gene editing using non-viral carriers. (utsouthwestern.edu)
They have focused on hepatic and extrahepatic delivery for organ and cell specific protein delivery, gene delivery, and gene editing. (utsouthwestern.edu)
Recent candidate gene studies [ 13 - 16 ], as well as genome-wide association studies [ 17 - 25 ], have identified polymorphisms that account for a portion of the variation in blood lipid levels. (cdc.gov)
Inconsistencies might be caused by differences in study design, study populations (geographic and ethnic background), statistical methods and power, allele frequencies, and gene-environment interactions. (cdc.gov)

How APT2 interacts with the lipid membrane to deacylate proteins. (epfl.ch)

Mutagenesis of proposed lipid binding sites and inhibition of PI(4,5)P2 synthesis reduce S1P transport, whereas the absence of the N terminus renders the transporter essentially inactive. (ox.ac.uk)
Mostajeran M, Wetterling F, Blixt FW, Edvinsson L, Ansar S. Acute mitogen-activated protein kinase 1/2 inhibition improves functional recovery and vascular changes after ischaemic stroke in rat-monitored by 9.4 T magnetic resonance imaging. (lu.se)

Variants within APOE (rs7412, rs429358), PON1 (rs854560), ITGB3 (rs5918), and NOS3 (rs2070744) were found to be associated with one or more blood lipids in at least one race/ethnic group in crude and adjusted analyses. (cdc.gov)
We report the significant associations of blood lipids with variants and haplotypes in APOE , ITGB3, NOS3 , and PON1 in the three main race/ethnic groups in the U.S. population using a large, nationally representative and population-based sample survey. (cdc.gov)

Induction of autophagy in the latter pathway is dependent on the interaction of Bcl-2 and Beclin 1. (helsinki.fi)
The aim of this study was to find out how PREP affects the interaction between Bcl-2 and Beclin 1 and how this affects autophagy. (helsinki.fi)
Since rate of autophagy in cells was not detected, it is impossible to determine, if there were changes in autophagy that were not reflected as changes in colocalization of these two proteins. (helsinki.fi)
It is possible that even a small change in colocalization can affect the rate of autophagy or there might be subpopulations where the interaction is interrupted and these changes are so small that they are not detectable with the methods used in this experiment. (helsinki.fi)
Adiponutrin Variant M148 Causes Resistance to Starvation-Mediated Lipid Droplet Autophagy in Hepatocytes. (lu.se)

Here, we explore the synergistic effects of lipid binding and conformational dynamics on SPNS2's transport mechanism. (ox.ac.uk)

The identification of genetic variants related to blood lipid levels within a large, population-based and nationally representative study might lead to a better understanding of the genetic contribution to serum lipid levels in the major race/ethnic groups in the U.S. population. (cdc.gov)

Exosomal markers include microRNAs like miR-21 and miR-141, plus various proteins that belong in functional groups such as tetraspanins (CD9, CD63 and CD81), heat shock proteins (Hsp70, Hsp73 and Hsp90) and membrane transporters (GTPases) ( 4 ). (spandidos-publications.com)
Sean's doctoral research focused on the structural and functional characterization of enzymes involved in the synthesis and recycling of bacterial cell wall carrier lipid, with a particular focus on membrane proteins. (urimss.ca)

CGDB: a database of membrane protein/lipid interactions by coarse-grained molecular dynamics simulations. (ox.ac.uk)

Lateral diffusion of membrane components (lipids and proteins) is an important membrane property to measure since the essential process of absorption of anti-cancer and other drugs -some of which are not soluble in lipids and therefore would not be able to penetrate the cell membrane through passive diffusion- lies on it. (cranfield.ac.uk)
In particular, the procedure of diffusion into the cell cytoplasm is reliant on free volumes in the membrane (passive diffusion) as well as carrier proteins (facilitated diffusion). (cranfield.ac.uk)
The transport may be active transport by carrier proteins with an energy source, or it may be facilitated diffusion or passive transport via channels. (wikibooks.org)

Weak acid: in the protonated form, the molecule will be electrically neutral (no charge) and therefore be more lipid-soluble. (pharmacology2000.com)
Weak base: in the protonated form, the molecule will carry a charge and as a result be less lipid-soluble. (pharmacology2000.com)

It is an important process of the cell that regulates the localization and function of numerous proteins. (epfl.ch)

The multi‑dimensional nature of their roles in cellular homeostasis, cell‑to‑cell and tissue‑to‑tissue communication at the level of the organism, as well as their actions on the holobiome (intra‑/interspecies interaction), have garnered the interest of a large number of researchers. (spandidos-publications.com)

5. Mechanism of drug action, drug-receptor interaction. (pharmatutor.org)

population: The state of phosphorus using a pack of illustration, metabolic or metastatic, been by a randomized condition for Protein and reduced antibody to have to diseases. (siriuspixels.com)
They have designed synthetic carriers for various genome editors and applied these technologies for correction of genetic diseases. (utsouthwestern.edu)
The pediatrics article Niemann-Pick Disease may be of interest, as may Lysosomal Storage Disease and Lipid Storage Diseases . (medscape.com)

E7 from human papil omavirus type 16 cooperate to cancer: the European prospective investigation into doi:10.1093/carcin/bgp321 PMID:20047954 target the PDZ protein Na/H exchange regulatory cancer and nutrition study. (who.int)

To overcome the α-adrenergic receptor blockade, new α-receptor protein must be synthesized in the inhibited receptor internalized by the cell and degraded. (pharmacology2000.com)
Lastly, the interaction with an in vitro BBB model strongly affects the PC composition: in particular, a large amount of the proteins forming the initial PC is lost after the BBB passage and they are partially replaced by new proteins derived from both the brain endothelial cells and the cell culture medium. (tue.nl)
This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. (cancerindex.org)
Like most biochemical processes in the cell, protein S-acylation is reversible to regulate the functions of acylated proteins. (epfl.ch)
King BC, Kulak K, Krus U, Rosberg R, Golec E, Zhang E, O'Connell D, Renström E, Blom AM. Complement component C3 is highly expressed in human pancreatic islets and protects against beta-cell death via ATG16L1 interaction. (lu.se)

At the IMSS, Sean will be focusing on the development and application of transposon insertion sequencing techniques to investigate genetic interaction networks in bacterial pathogens. (urimss.ca)
Her research involves the application of advanced genetic sequencing techniques to diverse fields of microbiology: zoonotic disease, agricultural plant-microbe interactions, bioremediation, and bacterial community geochemistry. (urimss.ca)
The genetic basis for elevation in lipid levels is not well understood, but substantial heritability has been demonstrated in twin [ 9 ] and family-based [ 10 - 12 ] studies, which have estimated that approximately 43% to 83% of the variance in blood lipid and lipoprotein levels is attributable to genetic factors. (cdc.gov)

S-acylation is reversed by the enzymes acyl protein thioesterases (APTs). (epfl.ch)

Decades of research have demonstrated that serum concentrations of blood lipids are associated with increased risk for cardiovascular disease and mortality [ 1 - 4 ]. (cdc.gov)

A new method was developed to extract non-starch lipids from wheat flour. (afpm.org.my)

Raina D.B., Larsson D., Mrkonjic F., Isaksson H., Kumar A., Lidgren L., Tägil L. Gelatin- hydroxyapatite- calcium sulphate based biomaterial for long term sustained delivery of bone morphogenic protein-2 and zoledronic acid for increased bone formation: In-vitro and in-vivo carrier properties. (lu.se)

Membrane protein function and stability has been shown to be dependent on the lipid environment. (ox.ac.uk)

This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. (cancerindex.org)
NLC as nanocarrier could able to provide controlled release of drug candidate and has been widely adopted as drug delivery carrier for tumor targeting. (pharmafocusasia.com)

Transport by partitioning is distinct from both bulk flow and receptor-mediated transport, because differently from bulk flow, cargo can be concentrated in transport carriers, yet the concentrating process does not depend on specific cargo receptors ( Fig. 1 and Box 1 ). (biologists.com)

Anatomy12

Organisms17

Diseases2

Chemicals and Drugs133

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes54

Disciplines and Occupations1

Technology, Industry, Agriculture9

Information Science4

Health Care3

Bilayer16

Nanoparticles9

MRNA7

Biochemistry1

Biomolecules1

Nanoparticle1

Electrostatic interactions3

Lipophilic drugs1

Membranes9

Bilayers1

Pathways4

Sterol carrier3

Intracellular3

Escherichia1

Molecules5

Intermolecular interactions4

Biological4

Anionic2

Transmembrane2

Peptides1

Genes5

Nanomedicine1

Metabolism1

Liposome5

Complexes2

Extracellular2

Therapeutic4

Solubility1

Hydrophobic3

Pathogenesis1

Alters1

Aggregation3

Formulations5

Peripheral2

Encapsulation efficiency1

Relation1

20181

Vesicles2

Gene10

Interacts1

Inhibition2

ApoE2

Autophagy5

Conformational1

Variants1

Functional2

Molecular dynamics1

Diffusion3

Molecule2

Regulates1

Roles1

Drug-receptor1

Diseases3

PMID1

Cell5

Genetic3

Enzymes1

Concentrations1

Extract1

Vitro1

Stability1

Tumor2

Receptors1