Interactions pathways focal adhesions. Medical search. Frequent questions

KEGG pathways enrichment and PPI network indicate four major pathways, including extracellular matrix -receptor interaction, focal adhesion, phosphatidylinositol 3-kinase (PI3K)-Protein kinase B (Akt), and Ras signaling pathways were involved in the degeneration of cartilage. (nature.com)
Focal adhesion kinase (FAK) is a tyrosine kinase localized at the site of focal adhesions (FA). (aacrjournals.org)
Both vinY822F and vin −/− cells exhibit increased interaction between paxillin and focal adhesion kinase (FAK) and increased paxillin and FAK phosphorylation. (rupress.org)
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. (genetex.com)
IL-8-induced migratory responses through and CXCR2: Association with phosphorylation and cellular redistribution of focal adhesion kinase. (tau.ac.il)
The focal adhesion kinase (p125fak) is constitutively active in human malignant melanoma. (tau.ac.il)
The possible role of focal adhesion kinase (p125fak) in the malignancy of human melanoma. (tau.ac.il)
Open in another window Shape 1 Focal Adhesion Kinase Besifloxacin HCl can be overexpressed in tumor examples. (cahrr.org)
Open up in another window Shape 2 Focal Adhesion Kinase (FAK) framework. (cahrr.org)
This cascade causes following cytoskeletal adjustments and activation of RAS-MAPK (mitogen-activated protein kinase) signaling pathways (26, 28). (cahrr.org)
Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:11896197, PubMed:30290153). (icr.ac.uk)
Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. (icr.ac.uk)
Our recent research indicates that pancreatic CSCs are maintained by direct interactions with certain proteins in the tumor microenvironment (TME) and focal adhesion kinase (FAK) signaling. (grantome.com)
Moreover, Wnt-5a is known to inhibit migration of breast epithelial cells in culture and expression of Wnt-5a potentiates activation of the receptor tyrosine kinase DDR1, a collagen receptor implicated in cell adhesion and migration. (lu.se)
Finally, we found that phospho-DARPP-32 inhibited the activity of the focal adhesion kinase (FAK) in MCF-7 breast cancer cells, and that MCF-7 cells expressing phospho-DARPP-32 displayed less filopodia formation. (lu.se)

Proteomic results were analyzed with gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and protein-protein interactions (PPI). (nature.com)
KEGG and GO analyses further indicated the involvement of these genes in bioprocesses, such as gonadotropin secretion, immune cell infiltration, and the SMAD and MAPK pathways. (hindawi.com)
Using the most robust analysis, 20 out of 272 KEGG pathways and 43 out of 34,400 GO pathways were significantly altered for RA compared with OA and NL FLS. (biomedcentral.com)
Most interestingly, we found that the KEGG 'Rheumatoid Arthritis' pathway was consistently the most significantly enriched with differentially methylated loci. (biomedcentral.com)
Taken together, KEGG and GO pathway analysis demonstrates non-random epigenetic imprinting of RA FLS. (biomedcentral.com)
KEGG pathway analysis was performed to identify potential gene pathways that may be involved in the pathogenesis of meningiomas. (omicsdi.org)
Quantitative real-time PCR (qRT-PCR) was performed to validate the differentially expressed genes in the KEGG pathways. (omicsdi.org)
KEGG analysis also demonstrated that focal adhesion and ECM-receptor interaction pathways were activated in anaplastic meningioma. (omicsdi.org)
GO and KEGG pathway enrichment of DEGs was performed using the DAVID database. (springeropen.com)
The enriched pathways obtained in the KEGG pathway analysis were extracellular matrix (ECM)-receptor interaction and focal adhesion. (springeropen.com)
We performed further gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment of DEGs. (springeropen.com)
In addition, the KEGG analysis of multi-omics data demonstrated that numerous pathways related to immunity, inflammation, tumorigenesis and metabolism were enriched in the liver. (biomedcentral.com)
Comparison of mesangial cells grown in normal or high glucose conditions by RNA-sequencing showed significant expression changes in over 6000 genes and, when grouped by KEGG pathway analysis, identified the ECM-receptor interaction and focal adhesion pathways among the top 5 upregulated pathways. (princeton.edu)

Here, we show that MITF directly represses the expression of genes associated with the extracellular matrix (ECM) and focal adhesion pathways in human melanoma cells as well as of regulators of epithelial-to-mesenchymal transition (EMT) such as CDH2, thus affecting cell morphology and cell-matrix interactions. (uzh.ch)
The role of the interaction with different ECM proteins on the malignancy and invasiveness of human melanoma cells. (tau.ac.il)
Alterations in cytoskeletal organization and focal adhesion in human melanoma cells and their role in tumor progression. (tau.ac.il)

In particular, the study highlighted the differential expression of genes associated with crucial pathways such as phagosome, focal adhesion, cytokine-cytokine receptor interaction, and toll-like receptor signaling. (aquahoy.com)
AS genes targeted extracellular matrix (ECM)-receptor interaction and focal adhesion pathways, while RG genes were mainly enriched in cytokine-receptor interaction and Jak-STAT. When combined, AS/RG dependent alterations targeted pathways essential for T cell receptor signaling, cytoskeletal dynamics and cell cycle entry. (uni-wuerzburg.de)
In the results of microarray using back skin obtained from animals, we found that S. lappa 's properties are closely associated with cytokine-cytokine receptor interaction and the JAK-STAT signaling pathway. (molcells.org)

Pathways involved in PI3K-Akt signaling may play a role in the altered focal adhesion and extracellular matrix (ECM)‒receptor interactions noted in Hailey-Hailey disease. (medscape.com)
The biological annotations of these modules indicated some critical hallmarks of OA and aging, such as mitochondrial dysfunctions and abnormal energy metabolism, and the signaling pathways, such as MAPK, TNF, and PI3K/Akt signaling pathways. (frontiersin.org)
Results: Fibroblastic meningioma exhibited upregulated PI3K/Akt and TGFÎ² signaling pathways, and accelerated G1/S progression cell cycle. (omicsdi.org)
Conclusion: We proposed that deregulation of cell cycle and PI3K/Akt pathways might play important roles in the tumorigenesis of fibroblastic meningioma. (omicsdi.org)

It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating the Akt/PKB signaling pathway. (wikipedia.org)
After that we can pay focus on novel therapeutics methods to focus on these pathways and interaction in tumor. (cahrr.org)
One strategy to increase cure rates is the identification of patient-specific drug responses in tissue models that mimic the interaction between patient cancer cells and tumor environment. (regenhu.com)
This study revealed that acute inflammatory injury was rapidly triggered by initial infection by C. sinensis juveniles in the host, accompanied by the enrichment of detoxification, inflammation, fibrosis, tumor and metabolism-related pathways in the liver, which provides a new perspective for the early intervention and therapy of clonorchiasis. (biomedcentral.com)
Importantly, increasing numbers of novel reports suggest that the GFRα-mediated signaling pathway acts as an oncogenic promoter related to tumor proliferation, invasion, and metastasis as well as treatment resistance. (medsci.org)

To understand how differentially methylated genes (DMGs) might participate in the pathogenesis of RA, we evaluated the stability of the RA signature and whether DMGs are enriched in specific pathways and ontology categories. (biomedcentral.com)
To assess the enrichment of DMGs in specific pathways, DMGs were identified as genes that possess significantly differential methylated loci within their promoter regions. (biomedcentral.com)
[ 6 ] thus, defining specific pathways in vivo has been difficult. (medscape.com)

Thus, the key pathways and genes associated with CCRT in LACC should be identified urgently. (researchsquare.com)

Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed on differentially expressed genes (DEGs). (spandidos-publications.com)
Functional enrichment analysis discovered a plethora of metabolic and immune system-related pathways activated in all three tilapia lines. (aquahoy.com)
These sets of DMGs were then compared to pathway and ontology databases to establish enrichment in specific categories. (biomedcentral.com)
Furthermore, proteomic and transcriptomic analysis jointly verified that the detoxification and antioxidant defense system was activated by enrichment of glutathione metabolism and cytochrome P450-related pathways in response to acute liver injury. (biomedcentral.com)
Correspondingly, transcriptomic results showed significant enrichment of cell cycle pathway on day 3 and 7. (biomedcentral.com)

VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. (antibodies-online.com)

It was also suggested that the activated integrin-mediated signaling pathways were involved in the pathogenesis of anaplastic meningioma. (omicsdi.org)

Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. (genetex.com)

Gene expression may be affected in benign familial pemphigus, as may phosphorylation of adhesion molecules. (medscape.com)
Although previous studies have identified different chemotropic and adhesion molecules that influence axonal development, the molecular mechanism by which these signals control the cytoskeleton remains poorly understood. (biologists.com)
Adhesion complexes (i.e., focal adhesions and focal complexes) and cell-cell contacts are specialized structures that harbor a large number of cytoskeletal proteins and one of the highest concentrations of signaling molecules in cells ( Ruoslahti and Obrink, 1996 ). (rupress.org)
The interaction between microenvironmental factors and adhesion molecules in Colon Carcinoma. (tau.ac.il)
Inflammatory signaling pathways triggered by oncogenic Kras may synergize with other important molecules to upregulate mucin expression during the early advancement of Pc. (micrornainhibitors.com)

Involvement of C/EBPβ-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. (cancerindex.org)
The mechanism that contribute to functional alterations in RA FLS are only partially understood and include somatic mutations, alterations in cell survival and apoptosis genes, and persistent activation of signaling pathways [ 3 ]. (biomedcentral.com)
Proteomic data showed that apoptosis and junction-related pathways were enriched within 3 days of infection, indicating the occurrence of liver injury. (biomedcentral.com)

To mimic activation of Gα12 pathways, constitutively active Gα12 (QL) was conditionally expressed in podocytes using Nphs2-Cre and LacZ/floxed QLα12 transgenic mice. (medscape.com)

Integrin-FAK signaling has been shown to activate a number of biological mechanisms through phosphorylation and protein-protein interactions promoting tumorigenesis. (aacrjournals.org)
Oxidative phosphorylation 16 of 317 pathways' ## [1] 'Querying. (tu-dortmund.de)

This dephosphorylation is important because it results in inhibition of the Akt signaling pathway, which plays an important role in regulating cellular behaviors such as cell growth, survival, and migration. (wikipedia.org)
Inhibition of cell/substrate adhesion with specific anti-integrin antibodies demonstrated that P-FAKSer732 activation is not induced by integrin clustering. (aacrjournals.org)
DARPP-32 mediated inhibition of cell migration proved to be dependent on DDR1 expression, consolidating a functional relevance of the interaction between DARPP-32 and DDR1. (lu.se)

Properdin is a serum glycoprotein that up-regulates the alternative pathway of complement by stabilizing the C3b-Bb complex. (embl.de)
Thus, vinculin regulates survival and motility via ERK by controlling the accessibility of paxillin for FAK interaction. (rupress.org)

We identified 580 differentially expressed genes (DEGs) in LACCk, which were mainly invovled in Human papillomavirus infection, focal adhesion, and ECM-receptor interaction signaling pathways. (researchsquare.com)
Human papillomavirus infection, focal adhesion, and ECM-receptor interaction signaling pathway are related to the failure of CCRT for LACC, which warrants further research to improve CCRT sensitivity in LACC targeting on these candidate genes or pathways. (researchsquare.com)
Additional pathways involved with innate immunity (Complement and Coagulation, Toll-like Receptors, NOD-like Receptors, and Cytosolic DNA-sensing), cell adhesion (Focal Adhesion, Cell Adhesion Molecule), and cytokines (Cytokine-cytokine Receptor). (biomedcentral.com)
Targeting activated Gα subunits to specific cells in vivo permits identification of downstream effector pathways independent of receptor activation, and thus permits insight into disease mechanisms otherwise impossible to study in vivo . (medscape.com)

We provide a transcriptomic and phosphoproteomic atlas of fibrin-, iC3b- and lipopolysaccharide (LPS)-selective activation of innate immunity and reveal ligand-selective pathways with differential functions in MS and AD mice. (nature.com)

Prior studies with human tissues have implicated Kras activation in rigorous inflammatory responses in Computer, mostly by activating the NF B pathway. (micrornainhibitors.com)
The mechanisms of chronic kidney disease progression are not well defined, but may include activation of numerous vasoactive and inflammatory pathways. (medscape.com)

In conclusion, our results demonstrated that compared with OA, the differential abundance proteins and signaling pathways may contribute to the occurrence and development of joint damage in KBD. (nature.com)

Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. (icr.ac.uk)

It was uncovered that overexpressing CTHRC1 promoted LUAD cell migration and invasion, and inhibited cell adhesion, while knocked down CTHRC1 had the opposite effect. (biomedcentral.com)
Overexpressed miR-30a-5p suppressed cell invasion/migration, and increased cell adhesion, while overexpressing CTHRC1 as well reversed such impacts. (biomedcentral.com)
In conclusion, it was disclosed in this study that CTHRC1 worked as a cancer promoter in LUAD, and miR-30a-5p could target and downregulate CTHRC1 to regulate cell adhesion, and inhibited LUAD cell invasion and migration. (biomedcentral.com)
In vitro migration assays, transendothelial migration assays (iTEM), and cell adhesion assays were used to investigate the effects of SPON2 on monocyte/macrophage migration. (biomedcentral.com)

The gene ATP2C1 encodes the human secretory pathway Ca ++ -ATPase hSPCA1, which is dysfunctional and causes abnormal calcium release from the Golgi apparatus and endoplasmic reticulum. (medscape.com)
What pathways are this gene/protein implicaed in? (cancerindex.org)
DAVID was used to perform the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis for the different expression genes (DEGs). (medscimonit.com)
In the present study, we explored the interaction network of DEGs between responders and non-responders along with interrelated signaling pathways in LACC by analyzing the expression profile of gene expression microarray data (GSE56303-GPL10191, GSE56303-GPL16025, and GSE56363) using bioinformatics tools. (researchsquare.com)

The DEGs were also typed into protein-protein interaction (PPI) networks to get the interaction data. (medscimonit.com)
These DEGs were mainly enriched in extracellular matrix organization and cell adhesion. (springeropen.com)

VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. (antibodies-online.com)

These junctions consist of calcium-binding transmembrane glycoproteins, which contribute to cellular adhesion. (medscape.com)
We observed alteration in biological functions related to extracellular matrix function and organization, cellular adhesion, muscle growth, lipid metabolism and proteolysis. (biomedcentral.com)

Vitronectin is an abundantglycoprotein found in serum and the extracellular matrix and promotes celladhesion and spreading, inhibits the membrane-damaging effect of the terminalcytolytic complement pathway, and binds to several serpin serine protease inhibitors. (creativebiomart.net)

Purpose: In this study, we try to investigate the possible signaling pathways involved in the tumorigenesis of fibroblastic and anaplastic meningiomas. (omicsdi.org)

We hypothesize that the TME plays a critical role in regulating the equilibrium between CSCs and non-CSCs, and that specific signaling pathways activated by the TME regulate CSC functional characteristics. (grantome.com)
In 2003, Lamartine reclassified the ectodermal dysplasias into the following 4 functional groups based on the underlying pathophysiologic defect: (1) cell-to-cell communication and signaling, (2) adhesion, (3) development, and (4) other. (medscape.com)
[ 7 ] Similarly, in 2001, Priolo and Laganà reclassified the ectodermal dysplasias into 2 main functional groups: (1) defects in developmental regulation/epithelial-mesenchymal interaction and (2) defects in cytoskeleton maintenance and cell stability. (medscape.com)

Finally, the protein interaction network analysis revealed that VGLL3 is likely involved in the Hippo signaling pathway. (researchgate.net)
Additionally, protein-protein interaction network analysis identified 10 hub genes, six ( FLT1 , FLNB , FSTL3 , INHA , TREM1 , and SLCO4A1 ) of which were used to establish a logistic model for PE. (hindawi.com)

This study was designed to identify signaling pathways and crucial proteins involved in the pathological mechanism of KBD compared with osteoarthritis (OA). (nature.com)

Differentially methylated loci (DML) involve many key genes implicated in inflammation, immune responses, cell-cell interactions, and matrix regulation. (biomedcentral.com)
The results demonstrate a pattern of differentially methylated pathways in RA FLS that define pathogenic processes that could permit identification of novel therapeutic targets. (biomedcentral.com)

The present study aimed to screen and explore the key circRNA/microRNA (miRNA or miR)/mRNA interactions in head and neck squamous cell carcinoma (HNSCC) using bioinformatics. (spandidos-publications.com)

Synthesis and degradation of ketone bodies 11 of 317 pathways' ## [1] 'Querying. (tu-dortmund.de)

Glutathione metabolism 37 of 317 pathways' ## [1] 'Querying. (tu-dortmund.de)

Numerous conditions predispose patients to GS, including diabetes, hypertension, IgA nephropathy, FSGS (focal segmental GS) and immune-mediated injury. (medscape.com)

We will discuss the FAK framework, function, as well as the book FAK-p53 cross-talk pathways in the junction of loss of life and growth aspect receptors and apoptotic and success pathways. (cahrr.org)

Transcripts found in unfertilized oocytes also encoded a large number of proteins implicated in cell adherence, tight junction and focal adhesion, suggesting high complexity in terms of structure and cellular interactions in embryos prior to midblastula transition (MBT). (biomedcentral.com)

Glycine, serine and threonine metabolism 22 of 317 pathways' ## [1] 'Querying. (tu-dortmund.de)

In this proposal we will investigate signaling pathways that regulate extracellular matrix-induced CSC maintenance and function, and develop therapeutic strategies to disrupt these critical interactions. (grantome.com)

[ 8 ] Other classification systems categorize the ectodermal dysplasias based on defects in cell-cell communication and signaling, adhesion, transcription regulation, or development. (medscape.com)

The greater number of cells permitted a focused evaluation of promoter sequences and a more detailed pathway analysis. (biomedcentral.com)

Oncogenic activity of major protein in the integrin signaling pathway. (tau.ac.il)

Amino sugar and nucleotide sugar metabolism 43 of 317 pathways' ## [1] 'Querying. (tu-dortmund.de)

Anatomy37

Organisms5

Diseases8

Chemicals and Drugs132

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes48

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science4

Kinase15

KEGG13

Human melanoma cells3

Cytokine-receptor interaction3

PI3K-Akt4

Tumor5

Specific pathways3

Genes associated1

Enrichment5

Intracellular signalin1

Signaling pathways were involved1

Signal transduc1

Molecules5

Apoptosis3

Constitutively active1

Phosphorylation2

Inhibition3

Regulates2

Receptor4

Innate immunity1

Inflammatory2

Differential1

Complexes1

Migration4

Gene4

DEGs2

Actin1

Cellular adhesion2

Complement pathway1

Tumorigenesis1

Functional3

Protein interaction network analysis2

Proteins involved1

Differentially2

MRNA1

Synthesis1

Glutathione1

Segmental1

Receptors1

Tight junction1

Serine1

Investigate1

Regulation1

Analysis1

Oncogenic1

Amino1