This genus of single-stranded negative sense enveloped RNA viruses causes relevant diseases (like measles or canine distemper) in human and animals. (biomedcentral.com)
In addition to acute viral encephalitis, other less established and more unusual manifestations of viral infections include progressive neurologic disorders, such as postinfectious encephalomyelitis (such as may occur after measles or Nipah virus encephalitis) and conditions such as postpoliomyelitis syndrome, which has been considered by some to be as a persistent manifestation of poliovirus infection. (medscape.com)
The H protein targets the cellular receptors of the CD46 and CD150. (bestessaywriters.com)
This is attributable to the cell-mediated memory that causes the creation of neutralising antibodies that target the H protein of the measles virus (Walsh, 2011). (bestessaywriters.com)
The measles virus life cycle starts with virus adsorption to host's cell membranes surface using the H protein. (bestessaywriters.com)
Due to the previous development of vaccine candidates against the related highly pathogenic coronaviruses SARS-CoV and MERS-CoV, the antigen that elicits immune protection is known: the surface spike protein of SARS-CoV-2 or specific domains encoded in that protein, e.g., the receptor binding domain. (bvsalud.org)
These proteins are the components of the viral envelope that together they mediate integration of the virus into the cells in the upper respiratory tract. (bestessaywriters.com)
Explore our comprehensive collection of recombinant Fc receptor proteins! (acrobiosystems.com)
Viral5
Measles is a viral disease that was first described by Rhazes- a Persian Physician in the 10th century. (bestessaywriters.com)
Clinically relevant involvement of the central nervous system (CNS) by viruses is an uncommon event, considering the overwhelming number of individuals affected by the different human viral infections. (medscape.com)
An unusual CNS involvement leading to microcephaly due to infection of pregnant women by Zika virus has also been recently reported and highlights the constant need to look for new types of neurological manifestations of viral infections in humans. (medscape.com)
Knowledge of this interaction is important in understanding viral spread, tropism, and pathogenesis. (medscape.com)
Instead of developing your own assays, explore our kits and services to quickly quantify viral antigens! (acrobiosystems.com)
However, recent studies have reported changes in the H glycoprotein of the virus. (bestessaywriters.com)
Antibody2
More recently, provocative studies have found high antibody seroprevalence to viruses such as Ebola, Marburg, and Lyssa viruses in multiple African countries, indicating the presence of a high number of undiagnosed cases every year, including high neutralizing titers of antibodies to rabies virus in 11% of a small cohort of asymptomatic Peruvians living in the Amazon with prior exposure to bats. (medscape.com)
The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com)
Infection1
In some cases, measles could lead to the infection of the respiratory tract or other organs including the skin, Kidney, bladder and viscera (Koehlmoos, Uddin, & Sarma, 2011). (bestessaywriters.com)
Diseases1
Although it is significantly managed in the USA, measles is still one of the major fatal diseases in the world. (bestessaywriters.com)
Single stranded1
The virus diameter is120-250 nm, and consists of single stranded RNA. (bestessaywriters.com)
Surface1
The initial event in the replicative cycle of a virus is its interaction with receptors present on the surface of a cell. (medscape.com)
Human1
The virus was isolated in 1954 in monkey and human kidney tissue by Enders and Peebles. (bestessaywriters.com)
Vaccines1
Current vaccines are based on live attenuated viruses that control the disease but cannot differentiate infected from vaccinated animals (the so-called DIVA approach) [ 9 ]. (biomedcentral.com)
Cells1
The virus then enters to the host cells where it uncoats. (bestessaywriters.com)
Developing countries1
Nevertheless, there have been many incidences of measles outbreak in developed and developing countries. (bestessaywriters.com)
Membrane2
We have compared the expression of the known measles virus (MV) receptors, membrane cofactor protein (CD46) and the signaling lymphocyte-activation molecule (SLAM), using immunohistochemistry, in a range of normal peripheral tissues (known to be infected by MV) as well as in normal and subacute sclerosing panencephalitis (SSPE) brain. (nih.gov)
Here, we show using the NCI-H460 lung and A431 epidermoid human cancer cell lines that EGFR binding to anterior gradient homolog 2 (AGR2) in the endoplasmic reticulum is required for receptor delivery to the plasma membrane and thus EGFR signaling. (bioxcell.com)
Herpes1
Viral cultures from throat, stool samples, and antigen detection for herpes and respiratory viruses are recommended during the first week. (medscape.com)
Endogenous2
Moreover, the use of LV vectors as DC vaccines offers several advantages over other DC antigen-loading strategies, including more sustained antigen expression following integration into the target cell genomic DNA, endogenous production of antigen for more efficient MHC presentation, the ability to encode immunostimulatory genes and check point inhibitors to enhance T cell responses, and minimal vector immunity when using certain pseudotyped constructs [e.g. (frontiersin.org)
To visualize the interplay between individual circRNA-miRNA-target mRNA, important for HIV-1 and potentially other diseases, an Interactive Circos tool was developed to efficiently parse the intricately competing endogenous network of circRNA-miRNA-mRNA interactions originating from seven circRNA singled out in viremic versus non-viremic patients. (bvsalud.org)
Rabies1
Provocative studies have found high antibody seroprevalence to viruses such as Ebola, Marburg, and Lyssa viruses in multiple African countries, indicating the presence of a high number of undiagnosed cases every year, including high neutralizing titers of antibodies to rabies virus in 11% of a small cohort of asymptomatic Peruvians living in the Amazon with prior exposure to bats. (medscape.com)
Dendritic1
Dendritic cells (DCs) are the ideal LV vaccine targets as they are the most potent APCs and uniquely able to initiate primary immune responses and stimulate robust and durable antigen-specific T cell responses ( 31 ). (frontiersin.org)
Tumor1
This virus delivery (by both IV and IT dosing) was accompanied by high local CD8 + cell infiltration in 80% of tested tumor samples, suggesting a potential enadenotucirev-driven immune response. (bmj.com)
Respiratory1
A novel multiplex loop-mediated isothermal amplification (LAMP) method combined with DNA chromatography was developed for the simultaneous detection of three important respiratory disease-causing viruses: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A virus, and influenza B virus. (hokudai.ac.jp)
Complement1
This question was addressed through the use of C3-deficient mice, blockade of C3 cleavage to C3b, and accelerated degradation of iC3b by soluble complement receptor 1 (sCR1). (silverchair.com)
Expression1
HIV-1-based lentiviral (LV) vectors have inherent advantages as DC vaccine vectors due to their ability to transduce non-dividing cells and integrate into the target cell genomic DNA, allowing for expression of encoded antigens over the lifespan of the cell. (frontiersin.org)
Approaches2
Human trials of HIV vaccines that utilize vector-based antigen delivery approaches have primarily included Adenoviral and Pox vector platforms ( 3 - 11 , 13 ). (frontiersin.org)
Understanding EGFR regulatory mechanisms, and hence approaches for clinical intervention, has focused on ligand-receptor interactions and tyrosine kinase activity. (bioxcell.com)
Efficiently1
By contrast, LV vaccines for HIV target antigen-presenting cells (APCs) to deliver HIV antigens that are efficiently presented on MHC molecules. (frontiersin.org)
Clinical1
Thus, we propose that WPV with a reduced antigen dose should be evaluated for potential clinical usage, especially in naïve populations. (hokudai.ac.jp)
Detection3
Field-deployable multiplex detection method of SARS-CoV-2 and influenza virus using loop-mediated isothermal amplification and DNA chromatography. (hokudai.ac.jp)
ELISAs for detection of dengue virus IgM and IgG are available for serum and CSF. (medscape.com)
Responses1
Moreover, LV vectors may express additional immunostimulatory and immunoregulatory proteins that enhance DC function and direct antigen-specific T cells responses. (frontiersin.org)
Cell4
In lymphoid tissues and blood, subsets of cells were positive for SLAM, in comparison to CD46, which stained all nucleated cell types. (nih.gov)
The initial event in the replicative cycle of a virus is its interaction with receptors present on the surface of a cell. (medscape.com)
EGFR is a 170 kDa cell-surface receptor and belongs to the ErbB family of receptors. (bioxcell.com)
2015). "Epidermal growth factor receptor (EGFR) signaling requires a specific endoplasmic reticulum thioredoxin for the post-translational control of receptor presentation to the cell surface" J Biol Chem 290(13): 8016-8027. (bioxcell.com)
Vaccine1
Assessing the pyrogenicity of whole influenza virus particle vaccine in cynomolgus macaques. (hokudai.ac.jp)