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  • bilayer
  • The overall goal of this proposed research is to determine the functional roles of membrane bilayer remodeling in overcoming the energy barrier of exocytic vesicle fusion, using the trafficking of the glucose transporter GLUT4 as a model system. (grantome.com)
  • Exocytosis
  • Regulated exocytosis is a stimulus-dependent membrane fusion event of fundamental importance to a range of physiological processes. (grantome.com)
  • bacterial
  • These results help us to understand how AMPs are selective for bacterial membranes and how their activity can be finely tuned by modifying their sequence. (springer.com)
  • biological processes
  • A brief summary of the intent and purpose of the symposium is as follows: "The adsorption of peripheral proteins and peptides to membranes plays an important role in many biological processes. (ccl.net)
  • vesicle fusion
  • This approach is based on vesicle capturing onto an ultrathin poly(ethylene glycol) (PEG) polymer brush functionalized with fatty acid moieties and subsequent vesicle fusion into a contiguous membrane. (diva-portal.org)
  • detergent
  • Membrane proteins are prone to unproductive aggregation resulting from poor detergent solvation, but the participating forces in this phenomenon remain ambiguous. (syr.edu)
  • We demonstrate that depleting the detergent in the sample well produced a two-state transition of membrane proteins between a fully detergent-solvated state and a detergent-desolvated state, the nature of which depended on the interfacial PDC interactions. (syr.edu)
  • interacts
  • Using two different approaches, preliminary evidence is provided that B. bacilliformis interacts with multiple surface-exposed proteins on human erythrocytes. (semanticscholar.org)
  • investigate
  • To investigate the interaction between Samp1 and Emerin in live cells, we performed FRAP experiments in cells overexpressing YFP-Emerin. (diva-portal.org)
  • The overall aim of this study was to investigate the importance of redox active proteins and cytokines in inflammation and cancer. (diva-portal.org)
  • structure
  • We proposed to apply a chemical cross-linking, mass spectrometry and modeling method called MS3D to the structure determination of the rhodopsin-transducin membrane protein complex (RTC). (unt.edu)
  • Herein we describe experimental progress made to adapt the MS3D approach for characterizing membrane protein systems, and computational progress in experimental design, data analysis and protein structure modeling. (unt.edu)
  • In summary, SDSL is rapidly becoming a mature technique with which to approach questions related to structure-function relationships in proteins. (springer.com)
  • This semiquantitative approach might be extended in the future to include studies of the interfacial PDC interactions of other challenging membrane protein systems of unknown structure. (syr.edu)
  • cellular
  • Trx is a multipotent protein and key regulator of cellular redox balance operating in synergy with Trx reductase and NADPH (the Trx system). (diva-portal.org)
  • induce
  • Calcium ions are known to induce anionic phospholipids to cluster, and we propose that clotting proteins assemble preferentially on such anionic lipid-rich microdomains. (nih.gov)
  • lateral
  • S. Lambert and V. Bennett , Axonal Ankyrins and Ankyrin-Binding Proteins: Potential Participants in Lateral Membrane Domains and Transcellular Connections at the Node of Ranvier. (elsevier.com)
  • Lateral interactions among membrane proteins. (semanticscholar.org)
  • We have studied the relationship between interprotein forces and the lateral distribution of proteins in disordered mouse liver gap junctions. (semanticscholar.org)
  • The interplay of many factors, including the alteration of the biophysical properties of the macromolecules upon association and their consequent lateral reorganization at the membrane surface, presents exciting challenges to biophysicists and biochemists. (ccl.net)
  • helix
  • Helix interactions are critical in large proteins, and we will develop methods to predict these by using marginally stable helices as a testbed. (su.se)
  • amino acids
  • Ubiquitin is a conserved protein of 76 amino acids, which is usually attached to the N terminus of proteins as a signal for their degradation ( 3 ). (pnas.org)
  • Role
  • Among them, the ubiquitin-like protein Atg8 (called LC3/GABARAP proteins in humans) plays a central role. (elifesciences.org)
  • The overall conclusion of the four papers included in this thesis is that redox-active proteins and cytokines plays an important role in control and regulation of cancer and inflammation. (diva-portal.org)
  • Next, we will assess the functional role of vesicle membrane bending in the fusion reaction. (grantome.com)
  • sensor
  • Here, we developed a surface plasmon resonance (SPR)-based concise method for quantitative analysis of lipid-MP interactions, coating the sensor chip surface with self-assembled monolayer (SAM) with C 6 -chain. (elsevier.com)
  • latter
  • The latter were selected based on the two proteins' GO biological process annotations being the most closely related. (nih.gov)
  • generally: Keel, Bennie, Southeastern Archaeological Conference latter Membrane Protein error zones in World Archaeology, 5: 1-92. (chessaid.com)
  • complex
  • Wbp1p and Ost1p are both subunits of the oligosaccharyl transferase membrane protein complex. (pnas.org)
  • Wbp1p is an essential component of the yeast oligosaccharyltransferase complex ( 5 , 6 ) and in close proximity to Ost1p, another essential protein of the same complex ( 7 - 10 ). (pnas.org)
  • systems
  • This ESR method is uniquely suited to membrane proteins, and it can provide information on systems that are not amenable to modern NMR and crystallographic methods. (springer.com)
  • Emphasis will be placed on how theory and experiment may be combined to provide more comprehensive and detailed information on protein/membrane systems than is attainable from one perspective alone and, thus, lead to new models and hypotheses. (ccl.net)
  • Crystal
  • Crystal structures revealed that the Atg8-Hfl1 interaction is not mediated by the typical Atg8-family-interacting motif (AIM) that forms an intermolecular β-sheet with Atg8. (elifesciences.org)
  • genes
  • The mutual phenotypic correction observed within particular pairs of mutant genes suggests that the normal morphogenetic cycle of growth and division may require direct interaction between the two membrane proteins which are the products of these genes. (asm.org)