CytokineCytokinesMediatorsInflammatoryReceptorBindsProteinsGeneChondrocytesChemokinePathwaysCellExpressionBoneMechanismsEffectsBloodProductionReceptorsReceptor antagonistIL1APhosphorylationExtracellular matrixLigandGenesKinasesMalignantInhibitorAnnotationCellularDeficiencyTumourMutationsPatientsInflammationNuclearEnhancesImmuneAlphaInsulinMolecularFormCancerArticleCentral
Cytokine5
- Interleukin-1 alpha (IL-1 alpha) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that in humans is encoded by the IL1A gene. (wikipedia.org)
- The quintessential pro-inflammatory cytokine Interleukin-1 (IL-1) canonically triggers a broad spectrum of physiological consequences. (biomedcentral.com)
- This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. (nih.gov)
- Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. (nih.gov)
- Interleukin-1beta (IL-1β) is the principal cytokine linked to cartilage degradation in osteoarthritis (OA). (biomedcentral.com)
Cytokines4
- Although there are many interactions of IL-1α with other cytokines, the most consistent and most clinically relevant is its synergism with TNF. (wikipedia.org)
- In vitro , wogonoside decreased the production of pro-inflammatory cytokines like Nitric oxide (NO), prostaglandin E2 (PGE 2 ), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6). (oncotarget.com)
- These discoveries revealed mechanisms underlying rapid gene expression mediated by a wide variety of extracellular polypeptides including cytokines, interleukins, and related factors. (bvsalud.org)
- This disease results from an inflammatory cascade generated by the interaction between periodontopathogenic bacteria and the host immune response, which includes a complex network of cytokines, reactive oxygen species, and proteolytic enzymes 1,2 . (bvsalud.org)
Mediators3
- Although EGF has been demonstrated to induce expression of angiogenic mediators, potential interactions in CRC between EGF-mediated signalling and the hypoxia/HIF pathway remain uncharacterised. (ox.ac.uk)
- The bi-stable switch would enable T cells to integrate signals from pathogens, hormones, cell-cell interactions, and soluble mediators and respond in a biologically appropriate manner. (frontiersin.org)
- The serum mediators responsible for the down-regulation of P450 isoforms were interferon-γ, interleukin-1β (IL-1β), and IL-2. (aspetjournals.org)
Inflammatory1
- Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β). (biomedcentral.com)
Receptor4
- It binds to the interleukin-1 receptor. (wikipedia.org)
- These additional genes included chemokines (CCL-11/eotaxin-1 and interleukin-8), collagen type IV α3 chain, integrin β3 chain, TGFα and VEGF receptor KDR. (ox.ac.uk)
- CAR receptor-fiber-knob adenovirus interaction and internalization process [46]. (genemedi.com)
- Western immunoblotting was used to analyze the effect of EGCG on the interleukin-1 receptor-associated kinase 1 (IRAK-1) and TNF receptor-associated factor 6 (TRAF-6) proteins in IL-1β-stimulated chondrocytes. (biomedcentral.com)
Binds3
- In interactions encoding expensive, The ratio of AIM2 with ASC is to % of wax including the ASC fulfilment which binds HIV-infected disorder variety by starting NER degree. (familie-vos.de)
- As associated from dopamine, RORA binds ROR proteins( ROREs) in fact and is the kinases PPARGC1A( PGC-1alpha) and p300( EP300, a promoter homeostasis) to channel tyrosine. (familie-vos.de)
- The digital cleavage of electron against excitatory proteins requires an Interleukin-1 factor of binds to the pathology of inositol-1,4,5-trisphosphate. (familie-vos.de)
Proteins2
- It was not until 1985 that interleukin 1 was discovered to consist of two distinct proteins, now called interleukin-1 alpha and interleukin-1 beta. (wikipedia.org)
- Gurlebeck D, Thieme Org 27569 F, Bonas U: Type III effector proteins from the plant pathogen Xanthomonas and their role in the interaction with host plant. (interleukin-receptor.com)
Gene2
- A deep understanding of molecular mechanisms relevant to gene-environment interactions is needed to deliver etiology-based autoimmune disease prevention and treatment strategies. (frontiersin.org)
- Gene-environment interactions, sunlight and vitamin D, and T lymphocytes as autoimmune disease initiators and vitamin D targets are discussed to explain the rationale for reviewing vitamin D mechanisms in T cells. (frontiersin.org)
Chondrocytes1
- Wogonoside also inhibited hypertrophy and the generation of vascular endothelial growth factor (VEGF) in interleukin-1β (IL-1β)-induced chondrocytes. (oncotarget.com)
Chemokine2
- Control of cell migration in the development of the posterior lateral line: antagonistic interactions between the chemokine receptors CXCR4 and CXCR7/RDC1. (wanfangdata.com.cn)
- Interactions of chemokines and chemokine receptors mediate the migration of mesenchymal stem cells to the impaired site in the brain after hypoglossal nerve injury. (wanfangdata.com.cn)
Pathways2
- Insulin-induced phosphatidylinositol 3-kinase (PI3K)/Akt signaling and interleukin-6 (IL-6)-instigated JAK/STAT3-signaling pathways in the liver inhibit the expression of gluconeogenic genes to decrease hepatic glucose output. (diabetesjournals.org)
- Interactions of Monocytes, HIV, and ART Identified by an Innovative scRNAseq Pipeline: Pathways to Reservoirs and HIV-Associated Comorbidities. (academictree.org)
Cell2
- Western blotting was used to determine the role of HIF-1alpha, HIF-2alpha and MAPK cell signalling in mediating the angiogenic responses. (ox.ac.uk)
- To test whether beta-defensin expression was inducible, gingival keratinocyte cell cultures were treated with interleukin-1beta (IL-1beta) or bacterial lipopolysaccharide (LPS) for 24 h. (lookformedical.com)
Expression1
- However, significant downregulation of IL-1alpha expression in frontal cortex may indicate that IL-1alpha molecules were accumulated near the surface of GNPs, which reduced their interaction with interleukin receptors. (cdc.gov)
Bone1
- Interleukin-3 induces hepatocyte-specific metabolic activity in bone marrow-derived liver stem cells. (wanfangdata.com.cn)
Mechanisms1
- Increased community involvement in GO annotation of more symbiont genomes, along with the development CBL0137 of additional GO terms, will provide valuable resources for more comprehensive cross-kingdom effector analyses, which ultimately will lead to a better understanding of mechanisms underlying symbiont interactions with hosts. (interleukin-receptor.com)
Effects1
- Intent-to-treat analysis of within-subject differences (Student's paired t-test or Wilcoxon sign ranks test) and between-subject differences (mixed-effects models with a group-by-time interaction term, adjusted for baseline health outcome) was conducted. (cdc.gov)
Blood1
- Interactions with blood members during the interview may care for more details regarding group stressors. (wgc2010.sk)
Production1
- In general, Interleukin 1 is responsible for the production of inflammation, as well as the promotion of fever and sepsis. (wikipedia.org)
Receptors4
- However, significant downregulation of IL-1alpha expression in frontal cortex may indicate that IL-1alpha molecules were accumulated near the surface of GNPs, which reduced their interaction with interleukin receptors. (cdc.gov)
- They are guided into the tumor through interactions between chemokines and their receptors. (frontiersin.org)
- Confirmation of mRNA and protein expression changes in key genes of this response revealed that genes for interleukin 1β, interleukin 1 receptor, a number of toll-like receptors, and several cytokines and cytokine receptors were significantly altered in the lungs of As-exposed mice. (nih.gov)
- The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com)
Receptor antagonist1
- Inhibition of the function of IL-1 by the inhibitor of IL-1, interleukin-1 receptor antagonist (IL-1Ra), reduces tumour invasiveness and alleviates tumour-mediated suppression, pointing to its feasible use in cancer therapy. (biologicalworld.com)
IL1A1
- Interleukin-1 alpha (IL-1 alpha) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that in humans is encoded by the IL1A gene. (wikipedia.org)
Phosphorylation2
- 6. Ovarian epithelial carcinoma tyrosine phosphorylation, cell proliferation, and ezrin translocation are stimulated by interleukin 1alpha and epidermal growth factor. (nih.gov)
- Interleukin (IL)-6-induced phosphorylation of STAT3 at Tyr-705 was significantly blocked by DIM. (biomedcentral.com)
Extracellular matrix1
- Integrin alpha (ITGA)6 and 2 were enriched in several pathways, including focal adhesion and extracellular matrix‑receptor interaction. (spandidos-publications.com)
Ligand2
- The cytokines that most differed between the patients and controls were interleukin 1-beta, platelet activator inhibitor 1, CD-40 ligand, MIP-1alpha, and interferon-gamma. (medscape.com)
- The binding of this receptor to its ligand causes its favorable interaction with INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN and the formation of an activated receptor complex. (nih.gov)
Genes3
- Its nature is complex, and currently, it appears that the combined effects of the interactions among multiple genes should receive more attention. (nih.gov)
- In the PPI network and subnetwork, matrix metallopeptidase 1 (MMP1), also known as interstitial collagenase, and interleukin 8 (IL8) were the hub genes with the highest degree of connectivity (degree =8). (spandidos-publications.com)
- However, the interactions between the carcinogenic genes that lead to SCC remain to be elucidated. (spandidos-publications.com)
Kinases1
- STAT3 is a receptor tyrosine kinase that is activated either by upstream receptor kinases such as Janus activated kinases (JAKs) or cytokines such as interleukin (IL)-6 [ 7 ]. (biomedcentral.com)
Malignant3
- Effects of micro-environment- and malignant cell-derived interleukin-1 in carcinogenesis, tumour invasiveness and tumour-host interactions. (biologicalworld.com)
- We propose that membrane-associated IL-1alpha expressed on malignant cells stimulates anti-tumour immunity, while secretable IL-1beta derived from the micro-environment or the malignant cells, activates inflammation that promotes invasiveness and induces tumour-mediated suppression. (biologicalworld.com)
- Differential manipulation of IL-1alpha and IL-1beta in malignant cells or in the tumour's micro-environment may open new possibilities for using IL-1 in cancer immunotherapy. (biologicalworld.com)
Inhibitor1
- To investigate the role of interleukin-6 (IL-6) and transforming growth factor beta 1 (TGF beta 1) in the regulation of tissue inhibitor of metalloproteinases-1 (TIMP-1) synthesis in human articular chondrocytes. (uni-bielefeld.de)
Annotation1
- Gene Ontology (GO) and pathway enrichment analysis of DEGs were performed, followed by functional annotation and construction of a protein‑protein interaction (PPI) network. (spandidos-publications.com)
Cellular1
- An interleukin-1 receptor subtype that is involved in signaling cellular responses to INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA . (nih.gov)
Deficiency1
- Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. (nih.gov)
Tumour2
- IL-1 is abundant at tumour sites, where it may affect the process of carcinogenesis, tumour growth and invasiveness and the patterns of tumour-host interactions. (biologicalworld.com)
- DHEA appears to mediate its protective effect by a mechanism that blocks the toxin-induced production of pathophysiological levels of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1. (lookformedical.com)
Mutations1
- reduced class in dimerization chains Phosphodiesterase 3B( PDE3B) which is subsequent interaction( mutations)( targeted in Manning and Toker 2017). (evakoch.com)
Patients1
- IL-1alpha is detectable in the majority of patients with infrarenal abdominal aortic aneurysms. (cusabio.com)
Inflammation2
- In general, Interleukin 1 is responsible for the production of inflammation, as well as the promotion of fever and sepsis. (wikipedia.org)
- LIF, CCL2 and IL-1alpha and the brain inflammation. (cdc.gov)
Nuclear2
- Comparison of the solution nuclear magnetic resonance and crystal structures of interleukin-8. (nih.gov)
- A comparison of the solution structure of the interleukin-8 dimer determined by nuclear magnetic resonance spectroscopy with that of the 2 A resolution X-ray structure, solved by molecular replacement using the solution structure as a starting model, is presented. (nih.gov)
Enhances1
- Myeloma cell-osteoclast interaction enhances angiogenesis together with bone resorption: a role for vascular endothelial cell growth factor and osteopontin. (nature.com)
Immune2
- Neuroendocrine-immune interactions in fish: a role for interleukin-1. (biologicalworld.com)
- Shahriar's research focuses on exploring host-pathogen interaction, immune evasion and vaccine development. (surrey.ac.uk)
Alpha1
- The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. (nih.gov)
Insulin1
- The models carried by looking the unerwünschte folgen der deutschen in the attack on illustration emergency GIP and GLP-1, artery modulation by the blood to an long interaction tract duodenum and Isogurisemikku( Isoglycemic) Intravenous stimulation insulin( myasthenia under the bypass( AUC)) It is. (amdamdes.com)
Molecular1
- Molecular docking revealed an additional hydrogen-bonding interaction between the unique amide scaffold and Phe497, contributing to sEH inhibition potency enhancement. (inra.fr)
Form2
- IL-1beta is active solely in its secreted form, whereas IL-1alpha is active mainly as an intracellular precursor. (biologicalworld.com)
- In the X-ray structure residues 4 to 6 are well ordered and the charged groups of Glu4 of one subunit and Lys23' of the other are in close enough proximity to form an electrostatic interaction. (nih.gov)
Cancer1
- 5. Lipid raft association restricts CD44-ezrin interaction and promotion of breast cancer cell migration. (nih.gov)
Article1
- This article examines the interaction of IL-1 with different trophic factors in the brain. (biologicalworld.com)
Central2
- Interactions of interleukin-1 with neurotrophic factors in the central nervous system: beneficial or detrimental? (biologicalworld.com)
- Uncovering the interactions between hAECs, macrophages, and T-cell subsets is central to understanding the mechanisms by which hAECs elicit lung repair. (biomedcentral.com)