• Our results demonstrate two-way facilitative interactions between the plant and fungal viruses that promote cross-kingdom virus infections and suggest the presence of plant-fungal-mediated routes for dissemination of fungal and plant viruses in nature. (elsevierpure.com)
  • Fungal infections in immuno-compromised patients may need intravenous systemic treatment and should be referred if they fail to respond to first line therapy. (hse.ie)
  • All relevant materials for patients and clinicians concerning the multistate outbreak of fungal meningitis and other infections are located on this page. (cdc.gov)
  • This relapse incidence is lower than the prevalence of relapse observed for other invasive fungal infections. (cdc.gov)
  • S. boulardii has caused fungal infections in people with diseases of the digestive tract. (medlineplus.gov)
  • S. boulardii has caused fungal infections in people with weakened immune systems. (medlineplus.gov)
  • Since the emergence of fungal pathogens is increasing considerably, investigating the interaction of the host-associated microbiome and fungal infections is timely. (uni-ulm.de)
  • Since preliminary data from my master thesis have confirmed for the first time that fusariosis infections are affecting the hatching success of a freshwater turtle, my current research is focused on the infection processes of this new emerging fungal disease. (uni-ulm.de)
  • A team of scientists has discovered a new component of the plant defense system against fungal infections. (sciencedaily.com)
  • This finding provides new tools for developing plants resistant to fungal infections. (sciencedaily.com)
  • Each year, fungal infections destroy at least 125 million tons of the world's five most important crops -rice, wheat, maize, soybeans and potatoes- a quantity that could feed 600 million people. (sciencedaily.com)
  • Farmers use fungicides to treat fungal infections, but these are not always 100% effective and, moreover, consumer demands pesticide-free products. (sciencedaily.com)
  • Now a team from the Centre for Research in Agricultural Genomics (CRAG), in Spain, has found that the regulation of the protein activity in the plant by the mechanism known as SUMOylation is crucial for the plant protection against fungal infections. (sciencedaily.com)
  • Using this new approach, CRAG's team found that plants with compromised SUMOylation showed an increased susceptibility to necrotrophic fungal infections by Botrytis cinerea and Plectosphaerella cucumerina . (sciencedaily.com)
  • In HIV-infected men who have sex with men, Pneumocystis carinii pneumonia (PCP), toxoplasmic encephalitis, fungal infections, and disseminated Mycobacterium avium complex (MAC) disease have decreased in incidence (9). (cdc.gov)
  • Most attention was focused on recent data related to chemoprophylaxis against disseminated MAC disease, cytomegalovirus (CMV), and fungal infections and to immunization against Streptococcus pneumoniae. (cdc.gov)
  • Most fungal infections in apparently healthy individuals are self-limiting or subclinical and have a good prognosis. (medscape.com)
  • Although most deep fungal infections respond to aggressive antifungal therapy, infections can be fatal, particularly mucormycosis and aspergillosis. (medscape.com)
  • Deep fungal infections should be viewed as serious and potentially life threatening. (medscape.com)
  • Update on oral fungal infections. (medscape.com)
  • Fungal infections of the mucous membrane. (medscape.com)
  • Fungal infections: a growing threat. (cdc.gov)
  • The frequency and diversity of serious fungal infections are increasing. (medscape.com)
  • Clinical manifestations from these unusual fungal infections range from colonization of airways to chronic localized lesions to acute invasive or disseminated disease. (medscape.com)
  • As a result, the incidence of invasive fungal infections of the lungs has risen substantially. (medscape.com)
  • This is significant because, despite marked advances in antifungal therapy, infections caused by opportunistic fungal infections (rare and emerging) continue to be associated with high morbidity, high mortality, and poor patient outcomes. (medscape.com)
  • Although Candida and Aspergillus species continue to be the fungal pathogens that most frequently cause invasive fungal disease in immunocompromised persons overall, infections due to previously uncommon hyaline and dematiaceous filamentous fungi are being reported with increasing frequency. (medscape.com)
  • The article also discusses the potential role of several new antifungal agents that may be useful to treat serious infections caused by rare and emerging fungal pathogens. (medscape.com)
  • However, despite progress made in developing new antifungal therapy, successful treatment of these unusual fungal infections remains rare and challenging. (medscape.com)
  • With accurate diagnosis, rare fungal infections require treatments that may include adjunctive surgical debridement, reconstitution of the host immune system, and new and old antifungals singly or in combination, one case at a time. (medscape.com)
  • Cite this: Rare and Emerging Fungal Pulmonary Infections - Medscape - Apr 01, 2008. (medscape.com)
  • We'll be talking about antibiotic resistance and fungal infections. (cdc.gov)
  • I'm an infectious disease physician and I've been looking after patients for over thirty years with many different sorts of infections, including fungal diseases, which is my area of interest and specialty. (cdc.gov)
  • I'm also a professor at the University of Manchester and do quite a lot of research on different aspects of fungal disease, particularly aspergillosis, including resistance and new diagnostic tests, and I'm also the leader and president of the Global Action Fund for Fungal Infections, which has as its main objective to improve the quality of care and therefore the outcome of patients with fungal diseases across the world. (cdc.gov)
  • The opportunistic fungal pathogen Candida albicans is a good example, as it masks the inflammatory component β-glucan in its cell wall to evade detection by the immune receptor Dectin-1. (umaine.edu)
  • This research sought to understand C. albicans cell wall dynamics, particularly within the context of host-pathogen interactions. (umaine.edu)
  • Overall, this work helps elucidate the importance of host-pathogen interactions in influencing fungal cell wall dynamics during disseminated candidiasis. (umaine.edu)
  • Our analysis further identified pathogen's genes with a predicted role in the decay of plant cell wall polymers, in the utilization of latex components and in interspecific interactions between the pathogen and other fungi. (escholarship.org)
  • Is the Subject Area "Host-pathogen interactions" applicable to this article? (plos.org)
  • Oilseed rape residues are a crucial determinant of stem canker epidemiology, as they support the sexual reproduction of the fungal pathogen Leptosphaeria maculans . (biorxiv.org)
  • The role of the microbiota in the plant's response to a disease or in the pathogenicity of a fungal pathogen is currently being studied in various pathosystems, but remains poorly understood. (biorxiv.org)
  • Objective 3: Determine the genomic diversity of Fusarium Head Blight pathogens and identify species or population-specific differences in host-pathogen interactions, mycotoxin production, or pathogen fitness under different climatic conditions. (usda.gov)
  • We invite submissions on all aspects of plant-pathogen interactions with studies that focus on either the individual host or the pathogen as well as those that map their interactions. (biomedcentral.com)
  • Her research programme looks at epiphytic colonisation of leaf surfaces during early infection of wheat by the fungal pathogen Zymoseptoria tritici , using a mix of microscopy, genomics, and metabolomics. (biomedcentral.com)
  • Between 2017-2019, Sam took a secondment position at the Australian National University to complete the Australian Research Council Discovery Early Career Research Award project, where he extended his research further to understand the molecular interaction between Myrtaceae tree species and the myrtle rust pathogen. (biomedcentral.com)
  • Understand the role of EVs in host pathogen interaction and drug resistance. (pasteur.fr)
  • Aspergillus fumigatus is a respiratory fungal pathogen and an allergen, commonly detected in flooded indoor environments and agricultur al settings. (cdc.gov)
  • Sex-specific differences can influence host-pathogen interactions and allergic-asthma related outcomes. (cdc.gov)
  • Although this host-fungal interaction is often asymptomatic for immunocompetent individuals, for immunocompromised persons, due to a weakened competence of the immune system, they have an increased likelihood of fungal infection. (vt.edu)
  • In the in planta F. graminearum inoculation experiment, we demonstrated that TMV infection of either the plant or the fungus enabled the horizontal transfer of CHV1 from the fungus to the plant, whereas CHV1 infection enhanced fungal acquisition of TMV. (elsevierpure.com)
  • The following update provides information on clinical follow-up of patients affected in the unprecedented multistate invasive fungal infection outbreak associated with contaminated methylprednisolone injections in late 2012 and 2013. (cdc.gov)
  • Changes observable on MRI consistent with a fungal infection have proven valuable in the identification of cases, especially in patients with a history of significant baseline pain. (cdc.gov)
  • Older adults might have an increased risk of fungal infection when taking S. boulardii. (medlineplus.gov)
  • I am mainly interested in the processes of disease ecology, principally the interactions between the host-microbiome and pathogens, as well as co-infection processes. (uni-ulm.de)
  • Thus, my PhD research aims to understand the I) epidemiology and aetiology of Fusarium pathogens, II) interaction of the host-associated bacterial microbiome and fungal mycobiome with Fusariosis infection and hatching success of the yellow-spotted Amazon river turtle, and III) effects of pollution and forest fragmentation on the microbiome and how these stressors can affect disease susceptibility and adaptability processes. (uni-ulm.de)
  • This medication is also used to treat a skin condition known as pityriasis (tinea versicolor), a fungal infection that causes a lightening or darkening of the skin of the neck, chest, arms, or legs. (medscape.com)
  • Climate induced physiological changes that occur in the host and influence mycotoxins and/or Fusarium infection will be useful as markers in plant breeding programs aimed at developing climate resilient fungal resistance strategies. (usda.gov)
  • As Maria Lois explains, "the results of this research will be used to develop new strategies for crop protection against fungal infection. (sciencedaily.com)
  • In addition, the researchers observed that shortly after the fungal infection, protein SUMOylation was decreased in the infected plants. (sciencedaily.com)
  • This unit will be coordinated by three internationally renowned scientists: Guilhem Janbon, Head of the ARN Biology of Fungal Pathogens Unit at the Institut Pasteur in Paris, Marcio L. Rodrigues, Head of the Fungal Pathogens Group at the Carlos Chagas Institute, Fiocruz, Brazil and Robin C. May, Professor of Infectious Diseases & Gresham Professor of Physic, Institute of Microbiology & Infection and School of Biosciences, University of Birmingham, UK. (pasteur.fr)
  • If a deep fungal oral lesion develops, the likelihood of self-limiting disease is significantly reduced, and the lesion likely represents a potentially serious underlying infection. (medscape.com)
  • Unexpected Blastomyces dermatitidis etiology of fungal sinusitis and erosive palatal infection in a diabetic patient. (medscape.com)
  • However, the dynamics, mechanisms, and ecological implications of bacterial-fungal interactions (BFIs) are poorly understood, especially on the community level and under abiotic stress. (energy.gov)
  • The team hypothesize that bacterial-fungal interactions (BFIs) fundamentally determine the outcomes of soil ecosystem function by enabling C and N mineralization, competing for limited nutrients, and contributing to soil organo-mineral interactions and aggregate formation. (energy.gov)
  • In this work we (1) determine the shelf-life of ready-to-use microfluidics, (2) demonstrate biofilm-like colonization on fungi, (3) describe bacterial motility on fungal hyphae (fungal highway), (4) report material-dependent bacterial-fungal colonization, (5) demonstrate germination of vacuum-sealed Arabidopsis seeds in microfluidics stored for up to 2 weeks, and (6) observe bidirectional cytoplasmic streaming in fungi. (springer.com)
  • Next, researchers will fine-tune the mechanisms that control BFIs in a laboratory soil microcosm experiment that measures the molecules involved when bacteria and fungi come into direct contact and the functional outcomes of these interactions. (energy.gov)
  • A fungal prion is a prion that infects hosts which are fungi. (wikipedia.org)
  • In vitro germination studies confirm beneficial interactions between Alternaria and Aspergillus fungi and Astragalus utahensis seed. (byu.edu)
  • Fungal community structure differed between the two lines at harvest, but not subsequently, suggesting that the presence/absence of the resistance gene influences the microbiome at the base of the stem whilst the plant is alive, but that this does not necessarily lead to differential colonisation of the residues by fungi. (biorxiv.org)
  • PAF96 localized to fungal cell envelopes and was not internalized by the fungi . (bvsalud.org)
  • In contrast, pairs of fungi with small/moderate contributions to plant growth in single-inoculation contexts showed the greatest effects on plants among the 78 fungal pairs examined. (frontiersin.org)
  • Moreover, co-occurrence interactions between fungi and bacteria, mostly contributed by fungal Ascomycota and bacterial Proteobacteria in control, were reverted to co-exclusive interplay in CRC (p=0.00045). (bmj.com)
  • Researchers in the Centre for Host Microbiome Interactions study our relationship with these bacteria and fungi in health or in oral and systemic diseases such as periodontitis, candidiasis, oral cancer and Alzheimer's disease. (kcl.ac.uk)
  • The interaction between the mycelia of the different white-rot fungi was taken into account as a criterion for using their consortia to degrade the mixture of pollutants under solid conditions. (ac.be)
  • Fungal plant pathogens remain a serious threat to the sustainable agriculture and forestry, despite the extensive efforts undertaken to control their spread. (escholarship.org)
  • This approach could be used to identify and promote micro-organisms with beneficial effects against residue-borne pathogens, and more broadly, to decipher the complex interactions between multi-species pathosystems and other microbial components in crop residues. (biorxiv.org)
  • Its short amino acid sequence facilitates the analysis of its structure-activity relationships using the fungal models Neurospora crassa and Saccharomyces cerevisiae , and human and plant pathogens Aspergillus fumigatus and Penicillium digitatum, respectively. (bvsalud.org)
  • Sam's research interest is centered on molecular genetics and plant pathology, focusing on understanding the interaction between cereal crops and its pathogens. (biomedcentral.com)
  • This international collaborative unit Fungal Extracellular Vesicles will bring together three scientific teams specializing in the study of extracellular vesicles produced by fungal pathogens. (pasteur.fr)
  • The Fungal Pathogens Group at the Carlos Chagas Institute of Fiocruz headed by Marcio L. Rodrigues. (pasteur.fr)
  • In this review, we explore the existing literature and most recent findings surrounding structure, functioning, and ecology of root-fungal symbiosis, which highlight the fact that plant fitness can be altered by taxonomically/ecologically diverse fungal symbionts regardless of root colonization and interface specialization. (reading.ac.uk)
  • These three experiments will be performed under a drought treatment that can help address how microbial interactions can change with environmental conditions. (energy.gov)
  • My particular focus lies in understanding the capacity of microorganisms to exploit spatial resources across various resource distribution levels, taking into account both initial ecophysiological conditions and interactions within the microbial community. (lu.se)
  • My special interest are emerging fungal diseases in non-model species threatened by anthropogenic factors like pollution, habitat fragmentation and climate change. (uni-ulm.de)
  • During my master thesis I examined the effects of the new emerging fungal diseases fusariosis on the microbiome of the yellow-spotted Amazon river turtle, including I) quantifying the egg microbiome and the influence of the nest environment, II) quantifying the influence of the egg microbiome on the gut microbiome of new hatchlings III) gut microbiome assemblage along with juvenile development and the influence of the river environment. (uni-ulm.de)
  • Leveraging the above methods and technologies, researchers will be able to identify the mechanisms important to BFIs across broad grassland ecosystems, quantify C and N dynamics, model interactions in natural soil environments, and use this powerful set of data to better predict terrestrial C and N cycles under climate change. (energy.gov)
  • Furthermore, transition from saprotrophy to biotrophy seems to be a common event that occurs in diverse fungal lineages (consisting of root endophytes, soil saprotrophs, wood decayers etc.), and which may be accompanied by development of specialized interface structures and/or mycorrhiza-like effects on plant growth and nutrition. (reading.ac.uk)
  • We seek to understand how global climate change affects the multiple interactions of vegetation, soil, and the terrestrial carbon cycle. (uzh.ch)
  • This process, dynamic and complex, is influenced in turn by the interaction of several factors including environmental components, soil management, plant effects but largely by soil properties. (scielo.cl)
  • Such interactions and reactions determine, for example, the transport and bioavailability of nutrients and pollutants in the environment, and whether soil organic material breaks down into carbon dioxide or is stored in soils for longer periods of time. (lu.se)
  • Fungal hyphal networks are important gateways for C and nutrient exchanges between plants and soils, and there is an increasing recognition that such processes are co-mediated by their interactions with bacteria. (energy.gov)
  • The human airway is continuously open to the nonsterile environment where fungal spores have the potential to reach lung tissue and produce disease. (medscape.com)
  • The beneficial germination response of fungal inoculated seeds indicates the efficacy of these treatments in dormancy contravention in hard-seeded species. (byu.edu)
  • Understanding these interactions can allow us to extend the knowledge about the susceptibility and the adaptability of host species threatened by new emerging diseases. (uni-ulm.de)
  • Evaluation of three individual fungal species, as well as various fungal consortia of these species, for the degradation of a mixture of dyes, brilliant blue - allura red, through solid-state fermentation. (ac.be)
  • Hence, this fungal species is suitable for application on recultivation sites of the brown coal area. (zalf.de)
  • Here we have explored pulmonary innate recognition of a variety of fungal particles, including zymosan, Candida albicans and Aspergillus fumigatus, and demonstrate that opsonisation with surfactant components can limit inflammation by reducing host-cell fungal interactions. (nih.gov)
  • Moreover, we found that pulmonary inflammatory responses to resting Aspergillus conidia were initiated by these PRRs in acidified phagolysosomes, following the uptake of fungal particles by leukocytes. (nih.gov)
  • Conclusions This study revealed CRC-associated mycobiome dysbiosis characterised by altered fungal composition and ecology, signifying that the gut mycobiome might play a role in CRC. (bmj.com)
  • Fungal root endophytes, including the common form group of dark septate endophytes (DSEs), represent different taxonomic groups with potentially diverse life strategies. (researchgate.net)
  • Root-fungal symbioses such as mycorrhizas and endophytes are key components of terrestrial ecosystems. (reading.ac.uk)
  • Fungal endophytes can improve plant tolerance to abiotic stress conditions. (researchgate.net)
  • Fungal hyphae did not reach far into the mazes and forced bacteria to grow in deeper regions. (lu.se)
  • Abundances of 14 fungal biomarkers distinguished CRC from controls with an area under the receiver-operating characteristic curve (AUC) of 0.93 and validated AUCs of 0.82 and 0.74 in independent Chinese cohort V1 and European cohort V2, respectively. (bmj.com)
  • The research methods in this dissertation employ a systems biology approach, by incorporating mathematical modeling, RNA-seq analysis, and experimental biology techniques to assess the role of airway epithelial cells in the host-fungal interaction. (vt.edu)
  • The main objectives of the Pasteur International Joint Research Unit Fungal Extracellular Vesicles is to support the present common high quality research, to expand the fields of cooperation beyond those existing, especially in the study of the Extracellular Vesicles (EVs), combining unique tools and expertise in the three contributing centers in order to make major inroads into EV biology. (pasteur.fr)
  • abstract = "This study investigates the direct estrogen receptor interactions and the character of the biological activities of three estrogenic resorcylic acid lactones in the immature rat uterus. (illinois.edu)
  • Nevertheless, the gut fungal microbiota in CRC remains largely unexplored. (bmj.com)
  • The involvement of gut fungal microbiota in CRC is largely unexplored. (bmj.com)
  • Poster presentation and Guest Speaker: Investigation of the egg and cloacal microbiota of the Yellow-Spotted Amazon river turtle after the first report of egg hatching failure caused by the emerging fungal disease Fusariosis. (uni-ulm.de)
  • The comparison of single- and dual-inoculation experiments showed that combinations of the fungal isolates with the highest plant-growth promoting effects in single inoculations did not have highly positive impacts on plant performance traits (e.g., shoot dry weight). (frontiersin.org)
  • Recently, a plant virus was shown to be transmitted from a plant to a fungus, but it is unknown whether fungal viruses can also cross host barriers and spread to plants. (elsevierpure.com)
  • Germination trials conducted in the greenhouse revealed a beneficial relationship between fungal spore inoculation and seed germination. (byu.edu)
  • In support of this viewpoint, mycobiome studies using the state-of-the-art DNA sequencing technologies have unearthed much more complexity in root-fungal relationships than those discovered using the traditional morphology based approaches. (reading.ac.uk)
  • We illuminated the role of airway epithelial cells in fungal recognition and activation of the immune response in signaling cascades that consequently modify iron importer genes and hope to use this information as a platform to discover potential therapeutic targets. (vt.edu)
  • However, we found that this opsonisation does not contribute directly to innate fungal recognition and that this process is mediated through non-opsonic PRRs, including Dectin-1. (nih.gov)
  • Note that miconazole gel and fluconazole can interact with many drugs such as warfarin and statins - check for drug interactions before prescribing. (hse.ie)
  • Extensive drug interactions for clarithromycin, fluoroquinolones, azole antifungals and rifampicin. (hse.ie)
  • Dosing details, contraindications and drug interactions can also be found in the Irish Medicines Formulary (IMF) or other reference sources such as British National Formulary (BNF) / BNF for children (BNFC). (hse.ie)
  • Due to system maintenance, the drug interactions feature you are attempting to access is temporarily unavailable. (medscape.com)
  • The effects of drug interactions are usually unwanted and sometimes harmful. (msdmanuals.com)
  • Drug-drug interactions can involve prescription or nonprescription (over-the-counter) drugs. (msdmanuals.com)
  • Types of drug-drug interactions include duplication, opposition (antagonism), and alteration of what the body does to one or both drugs. (msdmanuals.com)
  • Two functional motifs define the interaction, internalization and toxicity of the cell-penetrating antifungal peptide PAF26 on fungal cells. (bvsalud.org)
  • Standard methods for fungal brood disease research. (usda.gov)
  • Sub-objective 3.2: Characterize competitive interactions of Fusarium graminearum populations on spring and winter wheat. (usda.gov)
  • Fungal prions are naturally occurring proteins that can switch between multiple, structurally distinct conformations, at least one of which is self-propagating and transmissible to other prions. (wikipedia.org)
  • Study of fungal prions has led to a characterisation of the sequence features and mechanisms that enable prion domains to switch between functional and amyloid-forming states. (wikipedia.org)
  • CRC-associated fungal markers and ecological changes were also validated in additional independent cohorts of 90 patients with CRC, 42 patients with adenoma and 66 control subjects of published repository sequences from Germany and France. (bmj.com)
  • In feremycorrhiza (with Austroboletus occidentalis and eucalypts), the fungal partner markedly enhances plant growth and nutrient acquisition without colonizing roots, emphasizing that a conventional focus on structural form of associations may have resulted in important functional components of rhizospheres being overlooked. (reading.ac.uk)
  • In this study, we investigated the infectivity of Cryphonectria hypovirus 1 (CHV1, family Hypoviridae), a capsidless, positive-sense (+), single-stranded RNA (ssRNA) fungal virus in a model plant, Nicotiana tabacum. (elsevierpure.com)
  • Sarah Gregory] What are some of the fungal complications that are often misdiagnosed? (cdc.gov)
  • Fungal prions have provided a model for the understanding of disease-forming mammalian prions. (wikipedia.org)
  • Transcending sea turtles: First report of hatching failure in eggs of an Amazonian freshwater turtle with symptoms of the fungal emerging disease fusariosis. (uni-ulm.de)
  • There are 5 disease interactions with fluocinolone topical. (drugs.com)
  • This process improves access to microfluidics for controlling biological microenvironments, and further enabling visual and quantitative analysis of fungal cultures. (springer.com)
  • In this study, we tested how a gradient of spatial habitat complexity in the form of fractal mazes influenced the growth, substrate degradation, and interactions of the bacterial strain Pseudomonas putida and the fungal strain Coprinopsis cinerea. (lu.se)
  • We identified CRC-associated faecal fungal dysbiosis with increased Basidiomycota:Ascomycota ratio in patients with CRC compared with healthy subjects. (bmj.com)
  • Peptide containment within vacuoles preserves fungal cells from peptide toxicity . (bvsalud.org)
  • Here we present the co-crystal structure of yeast PCNA with a peptide encompassing the conserved PCNA interaction motif of Cdc9, yeast DNA ligase I. The Cdc9 peptide contacts both the inter-domain connector loop (IDCL) and residues near the C-terminus of PCNA. (nih.gov)
  • Studying growing branched structures and the dynamics of cellular interactions with both biotic and abiotic cues provides context for molecule production and genetic manipulations. (springer.com)
  • Here, I will illustrate how the qualitative behaviour of a simple system describing excitable plankton bloom dynamics, for physically distinct phytoplankton and zooplankton, depends critically on the flow and induced interaction rates. (google.com)
  • These cycles are regulated by interactions at interfaces between microorganisms, mineral particles and aqueous solutions, and are often driven by electron transfer reactions. (lu.se)
  • We assessed the alterations in gut bacterial and fungal populations associated with a history of appendectomy. (frontiersin.org)
  • Is the Subject Area "Fungal genetics" applicable to this article? (plos.org)
  • Complementary mutational and biochemical results demonstrate that these two interaction interfaces are required for complex formation both in the absence of DNA and when PCNA is topologically linked to DNA. (nih.gov)
  • Together these results demonstrate the functional significance of the beta-zipper structure formed between the C-terminal domain of PCNA and Cdc9 and reveal differences in the interactions of FEN-1 and Cdc9 with the two PCNA interfaces that may contribute to the co-ordinated, sequential action of these enzymes. (nih.gov)
  • Yet the understanding of these interactions has generally been correlative, and the mechanisms of these interactions in the context of nutrient cycling are far from understood. (energy.gov)
  • However, a detailed mechanistic understanding of functional PCNA:ligase I interactions has been incomplete. (nih.gov)
  • All these micro-organisms are grouped into structured communities that can be defined in terms of their composition and interactions. (biorxiv.org)