Interaction with integrins. Medical search. Frequent questions

Defectively expressed β3 integrin subunit has been correlated with presence of endometriosis, and has been suggested as a putative marker of this condition. (wikipedia.org)
Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. (wikipedia.org)
In several examples, the α4 integrin antagonist is a monoclonal antibody that specifically binds to a α4, β1 or β7 integrin subunit or a cyclic hexapeptide with the amino acid sequence of CWLDVC. (justia.com)
SHARPIN is now shown to negatively regulate integrin activation by binding the α-integrin subunit and interfering with the association of the β cytodomain with activating proteins. (bris.ac.uk)
Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)

Integrin/cytokine receptor interaction provides permissive signals leading to neoangiogenesis, and integrins are crucial for differentiation of endothelial progenitor cells (EPCs). (unito.it)
We identify previously unreported components of integrin adhesion complexes and observe receptor-specific enrichment of molecules with previously reported links to cell migration and cell signaling processes. (nih.gov)
These datasets provide a resource for future studies of integrin receptor-specific signaling events. (nih.gov)
One of the primary conduits for cellular interactions is the membrane-embedded receptor family of integrins. (fabiodisconzi.com)
scDiffCom is an R package, relying on approximately 5,000 curated ligand-receptor interactions, that performs differential intercellular communication analysis between two conditions from single-cell transcriptomics data. (nature.com)
Adult SVZ progenitor cells express the laminin receptor alpha6beta1 integrin, and blocking this inhibits their adhesion to endothelial cells, altering their position and proliferation in vivo, indicating that it plays a functional role in binding SVZ stem cells within the vascular niche. (nih.gov)
The strategy underlying these CD4 based therapies, i.e. blocking the interaction between gp120 and the CD4 receptor, encompasses advantages distinct from current HAART regimens. (justia.com)
providing a ligand for the α6β1 integrin receptor expressed by OLs. (jneurosci.org)
Here we report that the modeled dynamics of the response to AXT050 revealed that receptor trafficking is sufficient to explain the effect of Met-integrin interactions on HGF signaling. (ebi.ac.uk)
Overall, the model provides a valuable framework for studying the efficacy of drugs targeting receptor tyrosine kinase interaction with integrins, and identification of synergistic drug combinations for the patients. (ebi.ac.uk)
The Collagen Receptor Discoidin Domain Receptor 1b Enhances Integrin beta 1-Mediated Cell Migration by Interacting With Talin and Promoting Rac1 Activation. (mpg.de)
There are specific receptor proteins like integrin on the external surface of focal attachments. (omicsonline.org)
And the internal surface has actin filaments such as talin, paxillin, vinculin, tensin and proteins that provide interactions between membrane receptor proteins [ 1 - 3 ]. (omicsonline.org)
Notwithstanding, to achieve the effectiveness and integration of the grafted tissue to the receptor site, it is necessary a strong cell adhesion, so that it demands many molecules interaction to induce cell differentiation and the bone matrix mineralization formed onto the graft. (bvsalud.org)

Integrin adhesion receptors mediate cell-cell and cell-extracellular matrix interactions, which control cell morphology and migration, differentiation, and tissue integrity. (nih.gov)
T/NK lymphocytes neither express CD21 nor HLA class II, but T/NK lymphocytes express some integrins, which increase when stimulated and can act as receptors for T/NK lymphocytes. (selfgrowth.com)
Antibodies, the complement system, and the cellular receptors regulating signaling, such as Fc receptors and integrins, are natural components to study. (lu.se)

The ability of the fusion proteins to interfere with IL-3Rβc/β1 integrin interaction was assessed on endothelial cells (ECs), EPCs and murine-derived ECs. (unito.it)
Pull-down experiments showed that Fc1.4 and Fc4 fusion proteins specifically interacted with β1 integrin. (unito.it)
Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. (wikipedia.org)
Many proteins in adhesion plaque such as integrin, cytoskeleton proteins, proteases, protein kinases, phosphatases take part in signal transferring by co-localizing with vinculin and talin [ 3 ]. (omicsonline.org)
To occur the adhesion of CAMs to the biomaterial, it is necessary their interaction with some components of extracellular matrix, such as proteoglycans, collagen and proteins 23 . (bvsalud.org)

Rap1 and membrane lipids cooperatively recruit talin to trigger integrin activation. (mpg.de)

As the recruitment of circulating monocytes to the vessel wall plays a crucial role in the process of atherosclerosis, the purpose of this study was to examine the influence of homocysteine on the interaction of endothelial cells with monocytes. (uni-muenchen.de)
Incubation of THP-1 monocytes with Tiron abolished homocysteine-induced beta-2 integrin expression on these cells and adhesion to unstimulated endothelial cells. (uni-muenchen.de)
Postea, Otilia Adina (2005): Influence of homocysteine on the interaction between circulating monocytes and endothelial cells. (uni-muenchen.de)

CD18 is the common β2 integrin chain of LFA-1 (CD11a/CD18, αLβ2 integrin), Mac-1 (CD11b/CD18, αMβ2 integrin), and gp150, 95 (CD11c/CD18, αXβ2 integrin). (bdbiosciences.com)
Expression of CD18 is limited to leucocytes, where it is widely distributed in consort with each of the three integrin α chains (CD11a, CD11b, and CD11c). (bdbiosciences.com)
CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
Type 1 results from mutations in the integrin beta-2 gene ( ITGB2 ), encoding CD18 beta-2 integrins. (msdmanuals.com)

The capacity of F1 to mediate Rap1-dependent integrin activation depends on a unique loop in F1 that transforms into an amphipathic helix upon binding to membrane lipids. (biorxiv.org)
These findings suggest that superoxide anion radicals mediate homocysteine's effects on endothelium-monocyte interactions. (uni-muenchen.de)

Two decades later, pioneering studies suggested that lectin-like molecules constitutively expressed on the surface of macrophages can selectively recognize changes on glycans decorating the surface of apoptotic thymocytes, 4 , 5 although these studies likewise did not provide substantial insight into the mechanisms by which lectin-glycan interactions regulate cell death. (nature.com)
OPN through interaction with CD44 or several integrins is known to regulate multiple macrophage functions. (cdc.gov)
CD47 binding to α2β1 integrin could regulate cyclooxygenase-2 expression and cell migration on collagen I surface in intestinal epithelial cells. (lu.se)

The activity state of integrins is crucial for cell adhesion, migration and differentiation, and is regulated predominantly by protein interactions of the integrin β cytoplasmic domain. (bris.ac.uk)

In conclusion, these data identify the β1 integrin-interacting domain in the juxta-membrane IL-3Rβc extracellular domain, and provide the rational for targeting this interaction to impair vascular growth. (unito.it)
quantitative integrin protein-protein interactions and synergistic membrane effects on proteoliposomes. (abo.fi)
ProLIF requires no specific instrumentation and can be applied to measure a broad range of membrane-dependent protein-protein interactions with the potential for high-throughput/multiplex analyses.This article has associated First Person interviews with the first authors of the paper (see doi: 10.1242/jcs.223644 and doi: 10.1242/jcs.223719). (abo.fi)
Integrin, a membrane protein with a huge extracellular domain, participates in cell-cell and cell-extracellular-matrix interactions for metazoan. (elsevierpure.com)
CD47, also known as Integrin-Associated Protein (IAP), is a membrane protein of about 50 kD with an IgV-like extracelluluar domain, a five membrane-spanning segment and a short terminal cytoplasmic region. (biolegend.com)
α2β1γ1) stimulates oligodendrocytes to extend elaborate membrane sheets in vitro (cell spreading), mediated by integrin α6β1. (rupress.org)

It is disclosed herein that the HIV-1 envelope protein gp120 binds to α4β7 integrin on CD4+ T-cells, natural killer (NK) cells and CD8+ T-cells. (justia.com)

The structural basis for the divalent cation-dependent binding of heterodimeric alphabeta integrins to their ligands, which contain the prototypical Arg-Gly-Asp sequence, is unknown. (rcsb.org)
The developed framework will not only enable the identification of currently unknown integrin ligands, but will also lay the foundations for innovative approaches in the development of therapeutic agents for integrin-related diseases. (fabiodisconzi.com)

Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib. (nottingham.ac.uk)

Several molecules are involved in the process of cell adhesion to bone grafts, highlighting the role of integrins, the focal adhesion mechanism, the influence of the collagen matrix, and the activity of alkaline phosphatase in bone matrix formation. (bvsalud.org)

Leukocyte recruitment into the inflamed parenchyma requires successive interactions with cellular and stromal barriers that establish mechanical, chemotactic and haptotactic gradients to guide immune cells towards the inflammatory focus. (hindawi.com)
The first stage of this immune steeplechase, the leukocyte transendothelial migration, is a multi-step cascade of interactions that have been extensively studied in recent years in different vascular beds and experimental models, and some comprehensive reviews on this topic can be found in this special issue [ 1 - 5 ]. (hindawi.com)
The events that follow leukocyte extravasation are perhaps less well characterized, although significant advances have been made with the advent of high-resolution intravital microscopy and the development of more sophisticated culture systems to investigate leukocyte migration and interactions in three dimensions. (hindawi.com)
We believe that successfully combining our current knowledge about leukocyte extravasation, three-dimensional migration through the stroma and the sequential interactions with parenchymal cell barriers, which include adopting unified experimental models, will help shed light on the entire migratory route of each immune cell type and on the specificity of the innate inflammatory responses in each type of tissue. (hindawi.com)
Binding of Rap1 and Riam to Talin1 Fine-Tune beta 2 Integrin Activity During Leukocyte Trafficking. (mpg.de)
The β2 integrins are important mediators of leukocyte-endothelium interactions. (bdbiosciences.com)

2019) Integrins Have Cell-Type-Specific Roles in Development of Motor Neuron Connectivity. (assumption.edu)

and Temple, 2002), whereas b1 integrin was used to interscience.wiley.com). (lu.se)

CAMs have been classified into: cadherins, the immunoglobulin superfamily, integrins and selectins. (bvsalud.org)

Integrin-linked kinase (ILK) is a major structural adaptor protein governing signaling complex formation and cytoskeletal dynamics. (jneurosci.org)
Met interaction with integrins is shown to modulate the downstream signaling to Akt and ERK (extracellular-regulated kinase). (ebi.ac.uk)

Integrins recruit multimolecular adhesion complexes to their cytoplasmic domains, which provide structural and mechanosensitive signaling connections between the extracellular and intracellular milieux. (nih.gov)
2006) Combined integrin activation and intracellular cAMP cause Rho GTPase dependent growth cone collapse on laminin-1. (assumption.edu)

MIMIC will provide a structural basis for currently missing immune-specific interactions in atomic detail. (fabiodisconzi.com)
A group of integrins is known to perform a large-scale structural change when the protein is activated, but the activation mechanism and generality of the conformational change remain to be elucidated. (elsevierpure.com)

I will use this knowledge to design the first immunomodulatory peptide-based integrin inhibitor, serving as a proof-of-concept for future therapeutic applications. (fabiodisconzi.com)

MIMIC will provide the first structured description of integrin ligand specificity profiles, extending our current limited descriptions of extracellular integrin interactions. (fabiodisconzi.com)

however, this interaction makes a negligible contribution to integrin activation in CHO cells or platelets. (biorxiv.org)
However, while many studies demonstrated the importance of the ECM, its interactions with β-cells are still not fully understood. (nature.com)
The interactions with the various BM components differentially affect β-cells, although the underlying mechanism is largely unknown. (nature.com)
Compared to the endothelium, the molecular mechanisms involved in the interaction of infiltrated or tissue-resident immune cells with parenchymal barriers have not been so extensively studied. (hindawi.com)
10 Galectins can function inside the cells by modulating signaling pathways, 11 although they also act extracellularly by establishing multivalent interactions with cell surface glycans and delivering signals that lead to disruption of cellular homeostasis. (nature.com)
The Nordenfelt Lab is interested in the interplay between human cells and their environment and the cell biology that controls the outcome of the interactions. (lu.se)
This interaction enhanced cell migration of CRC cells and TAMs. (lu.se)

Integrin beta 3 is found along with the alpha IIb chain in platelets. (wikipedia.org)

alpha v-Class integrin binding to fibronectin is solely mediated by RGD and unaffected by an RGE mutation. (mpg.de)

Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene. (wikipedia.org)
A beta 2-Integrin/MRTF-A/SRF Pathway Regulates Dendritic Cell Gene Expression, Adhesion, and Traction Force Generation. (mpg.de)
In conclusion, exposure to MWCNT or asbestos induced gene expression of CD44 and OPN, protein release of OPN, and modifications of the interaction between CD44 and OPN at cellular and extracellular levels. (cdc.gov)

Here we report the crystal structure of the extracellular segment of integrin alphaVbeta3 in complex with a cyclic peptide presenting the Arg-Gly-Asp sequence. (rcsb.org)
The different functions of specific integrin heterodimers, such as α4β1 and α5β1, have been attributed to distinct signal transduction mechanisms that are initiated by selective recruitment of adhesion complex components to integrin cytoplasmic tails. (nih.gov)
Key developments in recent years includes (i) Determination of the first structure of an integrin/collagen complex. (nottingham.ac.uk)
Combination Therapy with a Bispecific Antibody Targeting the hERG1/β1 Integrin Complex and Gemcitabine in Pancreatic Ductal Adenocarcinoma. (unifi.it)
The cell biology of PVR is complex and involves the interaction of various growth factors and integrins, as well as cellular proliferation. (aao.org)

Integrins are crucial for several key biological processes, from blood clotting, to proper immune response. (fabiodisconzi.com)

Rap1 GTPases bind effectors, such as RIAM, to enable talin1 to induce integrin activation. (biorxiv.org)

A structure-guided point mutant (R118E) in F1, which blocks Rap1 binding, abolishes the capacity of Rap1 to potentiate talin1-induced integrin activation. (biorxiv.org)
Thus, a novel Rap1 binding site and a lipid-dependent amphipathic helix in talin1 F1 cooperate to enable a direct Rap1-talin1 interaction to cause integrin activation. (biorxiv.org)
Summary This work reveals that Rap1 GTPases bind directly to talin1 F1 domain and by cooperating with a unique lipid-dependent amphipathic helix in the F1 domain effects talin1-mediated integrin activation. (biorxiv.org)

Upon interaction with SIRPα, controls innate immune effector function, such as host cell phagocytosis. (biolegend.com)
In common with other study of adverse health effects that may result from forms of allergy, ACD develops in two phases which the interaction of xenobiotics with the immune sys- are defined operationally as induction and elicitation. (cdc.gov)

We discuss here the contribution of glycan-lectin interactions to the initiation, execution and resolution of apoptosis and their emerging roles in other cell death programs including autophagy. (nature.com)

However, the ICC analyses performed in some of those studies suffer from several limitations, as they rely on tools designed to detect interactions rather than to investigate how the interactions change between two biological conditions (for example, young/old and healthy/sick). (nature.com)
In this study, we developed a mechanistically detailed systems biology model of HGF/Met signaling pathway that incorporated specific interactions with integrins to investigate the efficacy of integrin-binding peptide, AXT050, as monotherapy and in combination with other therapeutics targeting this pathway. (ebi.ac.uk)

these glycoproteins facilitate cellular interactions, cell attachment to blood vessel walls, cell movement, and interaction with complement fragments. (msdmanuals.com)
To this end, molecular and cellular interactions may influence the tissue reactions to biomaterials. (bvsalud.org)
Likely other tissues, many events occur when a given biomaterial is in contact with the biological bone environment, with molecular and cellular interactions influencing on the tissue features surrounding the biomaterial. (bvsalud.org)

Yet, our current drugs are not capable of efficiently combating these diseases, as we do not have sufficient molecular and network level knowledge of how integrins work. (fabiodisconzi.com)
We performed normal-mode analysis of the elastic network model on integrin α V β 3 ectodomain in the bent form and identified key residues that influenced molecular motions. (elsevierpure.com)
This conservation pattern suggests that the molecular mechanism of the conformational change relying on the interactions found in integrin α V β 3 is unique to the limited types of integrins. (elsevierpure.com)

The main research objective of MIMIC is to develop an original hybrid in silico/in vitro framework that allows the identification and characterization of unknown elements of integrin signaling. (fabiodisconzi.com)
01). Conclusions - In postinjury migrating SMCs, β 3 - rather than β 1 -integrin-matrix interactions are of greater functional significance in adhesive processes essential for SMC migration in vitro and in vivo. (arizona.edu)

incorporation, on protein recruitment to the integrin CTs can be analysed. (abo.fi)

Cell surface integrin-extracellular matrix interactions are essential for cell migration. (arizona.edu)
In this study, we examined the relative functional roles of β 1 - and β 3 -integrin-matrix interactions in postinjury SMC migration. (arizona.edu)
Blockade of dominant SMC integrin (/33)-matrix interactions may be a valuable approach for limiting injury-induced SMC migration and late arterial renarrowing. (arizona.edu)

2008) Integrin signaling is integral to regeneration. (assumption.edu)

Methods and Results - Flow cytometry and fluorescence microscopy of migrating SMCs immunostained with anti-β 1 and anti-α(v)β 3 / 5 antibodies (Abs) revealed expression of both β 1 - andβ 3 - integrins, with β 1 observed as linear streaks and β 3 found in focal contacts. (arizona.edu)
In cholangiocytes, CCN1 activated NF-κB through integrin α v β 5 /α v β 3 , leading to Jag1 expression, JAG1/NOTCH signaling, and cholangiocyte proliferation. (jci.org)
In addition, incubation of monocytes with D,L- homocysteine and L-homocysteine resulted in significant increase in the number of adhering monocytes to unstimulated endothelial monolayer by upregulating the expression of beta-2 integrins. (uni-muenchen.de)

The importance of the key residues for the conformational change was further verified by mutation experiments, in which integrin α IIb β 3 was used. (elsevierpure.com)

The ITGB3 protein product is the integrin beta chain beta 3. (wikipedia.org)
It is widely expressed on many cell types and often associated with beta 3 integrins. (biolegend.com)

The conservation pattern of amino acid residues among the integrin family showed that the characteristic pattern of residues seen around these key residues is found in the limited groups of integrin β-chains. (elsevierpure.com)

Surface molecules, morphology, and biomechanical forces govern these interactions. (lu.se)

The weight-of evidence evaluations are qualitative in nature, although ATSDR recognizes that observations of toxicological interactions depend greatly on exposure doses and that some interactions appear to have thresholds. (cdc.gov)

Anatomy28

Organisms4

Diseases1

Chemicals and Drugs100

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes30

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Subunit5

Receptor14

Receptors3

Proteins5

Talin1

Endothelial cells3

CD184

Mediate2

Regulate3

Cytoplasmic domain1

Membrane6

Binds1

Ligands2

Platelet glycoprotein1

Focal adhesion1

Leukocyte6

20191

20021

Selectins1

Kinase2

Intracellular2

Structural2

Inhibitor1

Specificity1

Cells7

Platelets1

Fibronectin1

Gene3

Complex5

Crucial1

Induce1

Activation3

Immune2

Contribution1

Investigate2

Cellular interactions3

Molecular3

Vitro2

Protein recruitment1

Migration3

Integral1

Expression3

Mutation1

Beta2

Amino1

Molecules1

Observations1